• FGF7 is a neighbour of FAM227B in the 15q21.2 locus (rs10519227), and encodes for the fibroblast growth factor, which is involved in processes such as embryonic development, cell growth, tissue repair, tumor growth, invasion, and morphogenesis. (wikipedia.org)
  • This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. (nih.gov)
  • This gene encodes one of the mitochondrial translation elongation factors. (nih.gov)
  • This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. (nih.gov)
  • from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin. (lookformedical.com)
  • The gene network of ADHD included 599 genes/proteins and 148,978 interactions, while that of dyslexia included 167 genes/proteins and 27,083 interactions. (biomedcentral.com)
  • When the ANDSystem and GeneCards data were combined, a total of 213 genes/proteins for ADHD and dyslexia were found. (biomedcentral.com)
  • This suggests that variants of other genes and proteins may also be involved in providing protection. (elifesciences.org)
  • Conclusion】 The expression trends of ADAMTS 1, PI 3 K and A k t genes and proteins were consistent and showed a positive correlation in ovary and granulosa cells of Mongolian sheep,suggested that ADAMTS 1 gene played an important role in twin birth of Mongolian sheep mediated by PI3K/Akt signaling pathway. (chvm.net)
  • Analysis of GFM1 gene mutations in a family with combined oxidative phosphorylation deficiency 1]. (nih.gov)
  • Note=The disease is caused by mutations affecting the gene represented in this entry. (diabetestalk.net)
  • Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. (nih.gov)
  • FAM227B is not present in choanoflagellates, and gene alignment sequences have shown that FAM227B is a rapidly evolving gene due to its evolution trajectory compared to cytochrome c and fibrinogen alpha. (wikipedia.org)
  • Orthologs are sequences of genes that evolved from a common ancestor and can be traced evolutionarily through different species. (pharmaceuticalintelligence.com)
  • The TCMSP and HERB databases were searched to identify the active ingredients and drug targets, and the core gene target datasets related to NSCLC were merged to identify the intersecting targets of drugs and diseases for GO and KEGG pathway enrichment analysis. (bvsalud.org)
  • METHODS: We collected NSCLC-related gene datasets from the GEO database and performed differential gene analysis, followed by using WGCNA to identify the core set of genes associated with NSCLC development. (bvsalud.org)
  • RESULTS: We obtained the GSE33532 dataset that met the screening criteria, and a total of 2211 differential genes were identified using differential gene analysis. (bvsalud.org)
  • We performed GSEA analysis and WGCNA analysis for a crossover with differential genes, resulting in 891 key targets for NSCLC. (bvsalud.org)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis. (lookformedical.com)
  • The method put forth to rank genes by their importance for the comorbid condition of ADHD and dyslexia was employed to predict genes that play key roles in the development of the comorbid condition. (biomedcentral.com)
  • Ectopic expression in mouse cells and CRISPR/Cas9 base editing of endogenous AGS loci revealed causal roles of one AGS-specific amino acid substitution in mediating cytoprotection by AGS ATP5G1. (elifesciences.org)
  • Method】 The sequence of TLR 4 gene CDS in Cygnus olor was amplified by PCR and cloned.NCBI-BLAST and Mega-X were used for sequence comparison and phylogenetic tree construction.The structure and function of TLR4 protein and its interaction with host protein were predicted using ProtParam,SWISS-MODEL,etc. (chvm.net)
  • Dimerization is required for specific binding to a DNA sequence known as the TPA response element (TRE) found in the promoter region of many genes. (biomedcentral.com)
  • It identifies gene-nutrient interactions associated with the nutritional deficiencies that people with IBD commonly experience, and the role of the Western diet in influencing these. (mdpi.com)
  • Gene-nutrient interactions may help explain this variability in response to food that is associated with IBD. (mdpi.com)
  • Additionally, it was revealed that the most relevant genes are involved in biological processes related to signal transduction, positive regulation of transcription from RNA polymerase II promoters, chemical synaptic transmission, response to drugs, ion transmembrane transport, nervous system development, cell adhesion, and neuron migration. (biomedcentral.com)
  • Fluoride induced down-regulation of IKBKG Gene expression inhibits hepatocytes senescence. (nih.gov)
  • Gene disruption studies placed c-Jun as an oncogene at the early stage of a mouse model of hepatocellular carcinoma. (biomedcentral.com)
  • Conclusion】 The PERP 1 gene had the function of promoting granulosa cell apoptosis,and regulating its expression was of great significance for follicular development. (chvm.net)
  • Objective】 This study was aimed to analyze the expression pattern of a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) on PI3K/Akt pathway in ovary of twin and singleton Mongolian sheep at different stages of estrous cycle,and explore the mechanism of ADAMTS 1 gene influencing reproductive traits in Mongolian sheep. (chvm.net)
  • The approach is based on ten criteria for ranking genes by their importance, including relevance scores of association between disease and genes, standard methods of gene prioritization, as well as original criteria that take into account the characteristics of an associative gene network and the presence of known polymorphisms in the analyzed genes. (biomedcentral.com)
  • Using the ANDSystem tool, the reconstruction and analysis of gene networks associated with ADHD and dyslexia was carried out. (biomedcentral.com)
  • The application of methods of reconstruction and analysis of gene networks is a powerful tool for studying the molecular mechanisms of comorbid conditions. (biomedcentral.com)
  • We then constructed a protein-protein interaction (PPI) network map of drug diseases using the MCODE algorithm and identified key genes using topology analysis. (bvsalud.org)
  • The disease-gene matrix underwent immunoinfiltration analysis, and we analyzed the association between intersecting targets and immunoinfiltration. (bvsalud.org)
  • As such, the search for candidate genes related to the comorbid conditions of ADHD and DD can help in elucidating the molecular mechanisms underlying the comorbid condition, and can also be useful for genotyping and identifying new drug targets. (biomedcentral.com)
  • The results can be utilized to plan experiments for the identification of novel candidate genes and search for novel pharmacological targets. (biomedcentral.com)
  • By constructing a PPI network, the active ingredients of QJHT decoction were intersected with the targets of NSCLC, resulting in 31 intersected genes. (bvsalud.org)
  • An approach for ranking genes implicated in the comorbid condition of the two diseases was proposed. (biomedcentral.com)
  • According to the proposed approach, the genes OPRM1, CHRNA4 and SNCA had the highest priority in the development of comorbidity of these two diseases. (biomedcentral.com)
  • On the other hand, the JDP2 locus was found at a recurring viral integration site in T-cell lymphoma. (biomedcentral.com)
  • So, for example, one gene will code for the protein insulin, which is important role in helping your body to control the amount of sugar in your blood. (diabetestalk.net)
  • Current studies have determined the location of this gene to be in the nuclear region of the cell. (wikipedia.org)
  • Conclusion】 TLR4 gene in Cygnus olor was closely related to Anser anser and Anser cygnoides ,with obvious codon species selectivity,and contained 6 consecutive rare codons.TLR4 protein had transmembrane domains and signal peptides,and was closely related to innate immune response,signal transduction and stress response. (chvm.net)
  • Recent studies indicated that pathogen recognition receptors such as Toll-like receptor 4 may have a role in pathogenesis of MS. The aim of the study was to evaluate the association of rs1927911 polymorphism in TLR4 gene with MS. (bvsalud.org)
  • The current study was carried out to investigate the possible relationship between body mass index (BMI) elevation and differentiation in 25-hydroxyvitamin D (VD), vitamin D receptor (VDR) gene expression, and genetic polymorphism besides oxidative stress in adult Egyptian individuals. (bvsalud.org)
  • A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome , aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma. (wikipedia.org)
  • In 1995 and 1996, scientists in Europe had identified the polymorphism 5-HTTLPR , a serotonin-transporter in the gene SLC6A4 . (wikipedia.org)
  • BTNL2 gene polymorphism and sarcoid uveitis. (nih.gov)
  • Altered expression of Butyrophilin ( BTN ) and BTN-like ( BTNL ) genes in intestinal inflammation and colon cancer. (nih.gov)
  • The objectives of this study are threefold: to estimate the genetic parameters of female reproduction traits, to determine the genetic architecture of these traits by the identification of quantitative trait loci (QTL), and to assess the expected efficiency of a pedigree-based selection (BLUP) or genomic selection for these traits. (biomedcentral.com)
  • Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). (nih.gov)
  • FAM227B is a protein that in humans is encoded by FAM227B gene. (wikipedia.org)
  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). (nih.gov)
  • This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. (nih.gov)
  • Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. (nih.gov)
  • The serotonin transporter ( SERT or 5-HTT ) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene . (wikipedia.org)
  • Current studies have determined the location of this gene to be in the nuclear region of the cell. (wikipedia.org)