Gene testis. Medical search. Frequent questions

The NUTM1 gene is located in band 14 on the long (or "q") arm of chromosome 15. (wikipedia.org)
The BRD4-NUTM1 fusion gene is a translocation that encodes a fusion protein that has merged most of the protein coding region of the NUTM1 gene with a large part of the BRD4 gene located in band 13 on the short (i.e. "q") arm of chromosome 19. (wikipedia.org)
Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (nih.gov)
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
It was originally postulated that a gene on the Y chromosome (gonadoblastoma locus on the Y chromosome, GBY ) acted as an oncogene in the microenvironment of the dysgenetic gonad. (medscape.com)
Each chromosome contains many genes, the basic physical and functional units of heredity. (jainworld.com)
Chromosomes are pairs and each chromosome contain 1000 or so genes that also occur in pairs. (jainworld.com)
Transcription of the SRY gene (testis-determining factor region) on the Y chromosome ultimately leads to sex differentiation. (medscape.com)

ABSTRACT: BACKGROUND: Benzo[a]pyrene (B[a]P) exposure induces DNA adducts at all stages of spermatogenesis and in testis, and removal of these lesions is less efficient in nucleotide excision repair deficient Xpc-/- mice than in wild type mice. (maastrichtuniversity.nl)
However, the level in which these B[a]P regulated genes are expressed differs between Wt and Xpc-/- mice (p = 0.000000141), and were predominantly involved in the regulation of cell cycle, translation, chromatin structure and spermatogenesis, indicating a general stress response. (maastrichtuniversity.nl)
Hemicastration is a unilateral orchiectomy to remove an injured testis, which can induce hormonal changes and compensatory hypertrophy of the remaining testis, and may influence spermatogenesis. (animbiosci.org)
Moreover, RNA-seq results indicated that 46 differentially expressed genes (DEGs) involved in meiotic cell cycle, synaptonemal complex assembly and spermatogenesis were upregulated in the hemicastration group, while 197 DEGs were downregulated, which were related to arachidonic acid metabolism. (animbiosci.org)
Nevertheless, the mechanism of compensatory response and the consequent influence on spermatogenesis in the remaining testis is still poorly understood. (animbiosci.org)
Morphological analysis of testes based on H&E staining showed that the spermatogenesis was observed normally in the breeding season of wild mice in the heavily contaminated area. (intechopen.com)
In conclusion, even if the testes and the process of spermatogenesis are hypersensitive to radiation, we could not detect radiation effects on the spermatogenesis and Cs in the examined large Japanese field mice testes following chronic radiation exposure associated with the FDNPP accident. (intechopen.com)
Spermatogenesis in testis and ovotestis is rare given the high circulating estrogen levels. (medscape.com)

To resolve this controversy, we analyzed DNA sequence data of 71 mammals and discovered that these African mammals possess non-functional remnants of two genes that are strictly required for testicular descent in other mammals' explains Virag Sharma, the first author of the study. (mpg.de)
This shows that functional versions of these genes were once present in the ancestors of African mammals that lack testicular descent today. (mpg.de)
Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals. (mpg.de)
Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor. (nih.gov)
The present study shows that the SRD5A2 and CYP21 genes were not involved in the testicular biosynthesis of androstenone. (inra.fr)
Moreover, we profiled the testicular gene expression patterns by RNA sequencing (RNA-seq) to examine whether methylation changes affected gene expression in hemicastrated mice. (animbiosci.org)
Global profiling of DNA methylation and gene expression demonstrated that hemicastration-induced compensatory response maintained normal growth and testicular morphological structure in mice. (animbiosci.org)
Male Bmal1−/− mice are infertile with low serum testosterone levels and decreased expression of testicular steroidogenic genes, suggesting that circadian clock genes regulate testosterone biosynthesis by activating steroidogenic gene transcription. (tmu.edu.tw)
WT and Bmal1−/− mouse testes sections had similar normal morphologies, although there was a decrease in testicular spermatozoa in the Bmal1−/− mice. (tmu.edu.tw)
Bmal1−/− mice showed severely reduced expression of testicular circadian clock genes at three time points (CT4, CT12, and CT20), and a reduction in mRNA expression levels of Apo (Apoa1, Apoa2, and Apoc3) and steroidogenic (StAR, Cyp11a1, Hsd3b2, and Hsd17b3) genes. (tmu.edu.tw)
The Illumina HiSeq2000 sequencing platform was used to construct testicular and ovarian transcriptomes to identify genes involved in reproduction and sex determination in A. schrenckii . (geneticsmr.com)
Twenty-six gene families involved in reproduction and sex determination were identified from the A. schrenckii testicular and ovarian transcriptomes based on functional annotation of non-redundant transcripts and comparisons with the published literature. (geneticsmr.com)
The goal of this study was to fine map and identify the cdm gene, a gene that when mutated prevents cadmium-induced testicular toxicity in mouse strains with a mutation in this gene. (cdc.gov)
Ppp3ca-/- mice were investigated but were found to exhibit endogenous testicular abnormalities, making them an inappropriate model for determining whether the inactivation of the Ppp3ca gene would afford protection from cadmium-induced testicular toxicity. (cdc.gov)
Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)

Those specific genes proved to be active in early development of the human ovary. (sciencedaily.com)
These discrepancies can be manifested in different gonadal combinations, including ovotestis with ovary, ovary and testis, bilateral ovotestis, and ovotestis and tesis. (medscape.com)
The gonads present may be bilateral ovotestes, or they may be a combination of a unilateral ovary or testis with an ovotestis on the contralateral side. (medscape.com)
Without the SRY gene, the gonad would develop into an ovary. (medscape.com)

Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (nih.gov)
To explore the metabolism of steroids in the pig species, a qualitative PCR analysis was performed for the main transcript of 27 genes involved in steroid metabolism. (inra.fr)
This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. (nih.gov)
Using RT-PCR, 5'- and 3'-RACE approaches we clearly show that PDE10A transcript variants X3 and X5 are expressed in bovine testis as well as in primary spermatocytes and spermatids. (plos.org)
The presence of CTCs in 43 blood samples from patients with metastatic melanoma was evaluated using a combination of immunocytochemistry and transcript analyses of five genes by RT-PCR and 19 genes by droplet digital PCR (ddPCR), whereby a CTC score was calculated. (nature.com)

NUTM1 gene) encodes (i.e. directs the synthesis of) a 1,132-amino acid protein termed NUT that is expressed almost exclusively in the testes, ovaries, and ciliary ganglion (i.e. a parasympathetic ganglion of nerve cells located just behind the eye). (wikipedia.org)
Exploration of steroidogenesis-related genes in testes, ovaries, adrenals, liver and adipose tissue in pigs. (inra.fr)
We compared samples of testes, adipose tissue and liver from immature and peripubertal males, adrenal cortex from peripubertal males, ovaries from cyclic females and adipose tissue from peripubertal females. (inra.fr)
Two of them were expressed only in testes, ovaries and adrenals: CYP11A1 and CYP11B. (inra.fr)
Main differences between ovaries and testes were observed for HSD17B1/2/3, AKR1C-pig6 and sulfotransferase genes (SULT2A1/SULT2B1). (inra.fr)
Furthermore, 1309 unigenes showed significant differences between the testes and ovaries, including 782 genes that were up-regulated in the testes and 527 that were up-regulated in the ovaries. (geneticsmr.com)
They found 348 genes that were active in ovaries in the mice lacking Foxo3, but not in other tissues, indicating that they could function specifically in follicle growth. (sciencedaily.com)
The researchers also randomly selected a small number of genes from the 348 and looked for them in human ovaries. (sciencedaily.com)

We previously identified a novel cancer/testis antigen gene CAGE by screening cDNA expression libraries of human testis and gastric cancer cell lines with sera of gastric cancer patients. (molcells.org)
course="kwd-title" Keywords: malignancy testis antigen, co-stimulation, gene manifestation, ovarian malignancy INTRODUCTION There is significant evidence that intra-tumoral CD8+ cytotoxic T lymphocytes (CTL) are beneficial for prognosis in ovarian malignancy [1] as well as other malignancy types. (monossabios.com)

BRD4 is the bromodomain-containing protein 4 gene. (wikipedia.org)
The product of the BRD4-NUTM1 fusion gene, BRD4-NUT protein, stimulates the expression of at least 4 relevant genes, MYC, TP63, SOX2, and MYB in cultured cells. (wikipedia.org)
Further studies are needed to confirm and expand these views and to determine if any of the overexpressed gene products of the BRD4-NUT protein contribute to the development and/or progression, or can serve as targets for the treatment, of the neoplasms associated with the BRD4-NUTM1 fusion gene. (wikipedia.org)
Genes contributing to the similarity include ribosomal protein (RP) genes as well as genes involved in transcription, translation and cell division. (karger.com)
This gene provides instructions for making a protein called TSPY-like 1, whose function is unknown. (medlineplus.gov)
The genome-wide DNA methylation pattern of remaining testis suggested that substantial genes harbored differentially methylated regions (1,139) in gene bodies, which were enriched in process of protein binding and cell adhesion. (animbiosci.org)
Integrative analysis revealed that proteasome 26S subunit ATPase 3 interacting protein gene, which encodes a protein crucial for homologous recombination in spermatocytes, exhibited promoter hypomethylation and higher expression level in hemicastrated mice. (animbiosci.org)
Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)
mutations of the prion protein gene (3). (cdc.gov)
[ 4 ] This locus contains several known genes including amelogenin Y ( AMELY ), RNA-binding motif ( RBM ), protein kinase Y ( PRKY ), protein tyrosine phosphatase ( PTP )-BL related Y ( PRY ), testis transcripts Y1 and Y2 ( TTY1 and TTY2 ), and testis-specific protein Y-encoded ( TSPY ). (medscape.com)
PRKRA, a protein kinase, interferon-inducible double stranded RNA dependent activator protein kinase, also known as PACT, a protein activator of the interferon-induced protein kinase, is a product of PRKRA gene [ 1 , 2 ] and is a member of the dsRNA binding protein family [ 3 ]. (hindawi.com)
Genes are now known to be implemented as sequences of genetic code that direct specific cells to produce a particular protein at a particular time. (jainworld.com)
NHE11) Is a Testis-Specific Protein Localized to the Head of Mature Mammalian Sperm. (bvsalud.org)
DNA Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body or the code for functional ribonucleic. (msdmanuals.com)

Male mice that lacked the mouse Nutm1 gene using a gene knockout method had abnormally small testes, lacked sperm in their cauda epididymis (i.e. tail of the epididymis which contains sperm in fertile male mice), and were completely sterile. (wikipedia.org)
These findings indicate that Nutm1 gene is essential for the development of normal fertility in male mice and suggest that the NUTM1 gene may play a similar role in men. (wikipedia.org)
In this study, we investigated by using microarray technology whether compromised DNA repair in Xpc-/- mice may lead to a transcriptional reaction of the testis to cope with increased levels of B[a]P induced DNA damage. (maastrichtuniversity.nl)
RESULTS: Two-Way ANOVA revealed only 4 genes differentially expressed between wild type and Xpc-/- mice, and 984 genes between testes of B[a]P treated and untreated mice irrespective of the mouse genotype. (maastrichtuniversity.nl)
A slightly higher induction of average gene expression was observed at the G2-M checkpoint in Xpc-/- mice, but this did not reach statistical significance (P=0.086). (maastrichtuniversity.nl)
CONCLUSIONS: Gene expression in testis of untreated Xpc-/- and wild type mice were very similar, with only 4 genes differentially expressed. (maastrichtuniversity.nl)
Subsequently, we determined testis DNA methylation patterns using reduced representation bisulfite sequencing of normal and hemicastrated mice. (animbiosci.org)
Using Bmal1−/− mice and their wild-type (WT) siblings, we aimed to identify additional genes by which the circadian clock regulates testosterone synthesis. (tmu.edu.tw)
The cholesterol metabolism pathway was significantly enriched in the KEGG pathway analysis, and there was lower expression of three apolipoprotein genes (Apoa1, Apoa2, and Apoc3) at CT2 in the testes of Bmal1−/− mice than in those of WT mice. (tmu.edu.tw)
The expression of circadian clock genes was relatively stable in WT mice over a 20-h period, whereas there was clear circadian rhythmic expression of Apoa1, Apoa2, Apoc3, StAR, Cyp11a1, Hsd3b2, and Hsd17b3. (tmu.edu.tw)
In this study, we evaluated the effect of chronic radiation exposure associated with FDNPP accident on the testes of large Japanese field mice. (intechopen.com)
However, caesium (Cs) was not detected in all testes of wild mice from FDNPP ex-evacuation zone. (intechopen.com)

Hence, it means that human testis could also play a crucial role in human speciation if these two tissues exhibit similar gene expression patterns. (karger.com)
Present results provide evidence to support the proposal that human testis and brain share the highest similarity of gene expression patterns. (karger.com)

WT1 and SF1 are down-regulated and SOX9 is up-regulated in regressed mole testes, suggesting that the modulation of the expression of these genes may be involved in the control of circannual gonad variation. (mdc-berlin.de)
Identification of a tubulin-α gene specifically expressed in testis and adductor muscle during stable reference gene selection in the hermaphrodite gonad of the lion's paw scallop Nodipecten subnodosus. (univ-brest.fr)
Here we report on the isolation of five partial gene sequences from gonad tissue cDNA in the functional hermaphrodite scallop Nodipecten subnodosus to be evaluated as reference genes: 18S-rRNA, riboprotein l8 (rp-l8), actin-β (act-β), elongation factor 1α (ef-1α) and alpha-tubulin-α (tub-α). (univ-brest.fr)
Stability analysis for the five putative reference genes with geNorm and NormFinder indicated that 18S together with rp-l8 were the most stable genes for normalization of gene expression during gonad development in both, male and female sexual regions of the hermaphrodite N. subnodosus. (univ-brest.fr)
The least stable gene was tub-α, showing a biased expression profile between sexual regions of the gonad, therefore this gene was analyzed thereafter as a target gene together with vitellogenin (vit) and a DEAD-box RNA helicase (dbx) gene. (univ-brest.fr)
Transcriptomes from the tissues of the brain-pituitary-gonad (BPG) axis of T10 samples revealed a differential gene expression profile compared to the other experimental groups, with clustering in a principal component analysis and in heat maps of all differentially expressed genes. (biomedcentral.com)

Research findings suggest that mutations in the TSPYL1 gene are not associated with sudden infant death syndrome (SIDS) in the general population. (medlineplus.gov)
which means both copies of the gene in each cell have mutations. (medlineplus.gov)
Sporadics are heterogeneous, and different genes undergo point mutations. (frontiersin.org)
A specific sequence of mutations triggers with the APC gene following with mutations in the KRAS, TP53, and DCC genes are observed in approximately 70% of CRC cases ( Fearon and Vogelstein, 1990 ). (frontiersin.org)
Two well-known examples for polyposis and HNPCC are familial adenomatous polyposis (FAP) and Lynch syndrome, respectively, in which occurs as a result of mutations in DNA repair genes ( Lynch and de la Chapelle, 2003 ). (frontiersin.org)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)

A ) The mammalian testis is composed of seminiferous tubules intertwined so that the "start" and "end" of these tubules are both connected to the rete testis. (jci.org)
In the present study, we investigated the localization of PRKRA in the mammalian testis by immunofluorescence and immunoelectron microscopic techniques. (hindawi.com)

Furthermore, a functional analysis of differentially expressed genes revealed enriched gene ontology terms involved in the regulation of circadian rhythm, histone modification, meiotic nuclear division, and others. (biomedcentral.com)
This thermoception may have caused the observed effects through epigenetic mechanisms, since all analysed tissues further revealed differentially expressed genes involved in histone modification. (biomedcentral.com)

The aim of this study is to evaluate the association among serum ucOCN, rs2247911 GPRC6A gene polymorphism and the endocrine/reproductive pattern in a cohort of Syrian infertile males, possibly confirming the role of ucOCN/GPRC6A axis on testis function. (endocrine-abstracts.org)
Conclusions: The novel ucOCN/GPRC6A axis was confirmed to participate in the regulation of the endocrine and reproductive function of the testis through the production of T. (endocrine-abstracts.org)
Although it is generally assumed that testis size can predict reproductive fitness, our results indicate that this objective parameter can provide insights also on overall health and [cardiovascular disease] risk," the researchers wrote in the July 11 issue of the Journal of Sexual Medicine. (livescience.com)
Our study was performed to evaluate the ADIPOR1 presence and location and its gene expression in reproductive tissues of the male ram, during its non-breading season. (unipg.it)
The different portions of the male ram reproductive system (testis, epididymis, seminal vesicle, ampoule vas deferens, bulb-urethral gland) were collected in a slaughterhouse. (unipg.it)
The testis (from the Greek word orchis ) is the male gland important for both reproductive (exocrine) and endocrine functions. (medscape.com)
The testis is a paired, ovoid male reproductive organ that sits in the scrotum, separated from its mate by a scrotal septum. (medscape.com)

Hence, reduced serum ucOCN and/or inactivating gene variants of GPRC6A, are supposed to affect testis function in humans. (endocrine-abstracts.org)
However, the impacts of these variants on gene expression and splicing have not been investigated in cattle. (ed.ac.uk)

Here, we genotyped and characterized 19,408 SVs and 374,821 STRs in 183 bovine genomes and investigated their impact on molecular phenotypes derived from testis transcriptomes. (ed.ac.uk)
Exonic duplications predominantly increased gene expression either through alternative splicing or other mechanisms, whereas expression- and splicing-associated STRs primarily resided in intronic regions and exhibited bimodal effects on the molecular phenotypes investigated. (ed.ac.uk)

0.01) in the testis, epididymis, and bulbourethral glands. (unipg.it)
Immotile sperm flow from the lumen of the seminiferous tubules into the epididymis via the rete testis. (jci.org)
An image depicting the testes and epididymis can be seen below. (medscape.com)
The tunica vaginalis testis (a remnant of the processus vaginalis) envelopes the testis in a double layer, except at the superior and posterior borders where the spermatic cord and epididymis adhere to the testes. (medscape.com)
The visceral layer of the tunica vaginalis testis is closely applied to the testis, epididymis, and ductus deferens. (medscape.com)
On the posterolateral surface of the testis, this layer invests a slit-like recess between the body of the epididymis and the testis that is called the sinus of epididymis. (medscape.com)
The epididymal head overhangs the upper pole of the testis, receives the seminal fluid from the ducts of the testis (which pierce the upper portion of the mediastinum), then allows the passage of the sperm into the distal portion of the epididymis. (medscape.com)

Determining the large scale anatomy of gene expression patterns of various human tissues could draw a more convincing conclusion, and better our understanding of the correlation/inter-correlation among different tissues. (karger.com)
Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
Very few differences were observed between transcriptional patterns of peripubertal testes and adrenal glands as well as between male and female fat tissues. (inra.fr)
CAGE is expressed in many cancers and cancer cell lines, but not in normal tissues apart from the testis. (molcells.org)

A team of researchers from the Max Planck Institute of Molecular Cell Biology and Genetics, the Max Planck Institute for the Physics of Complex Systems, the Senckenberg Natural History Collections Dresden and the Natural History Museum Frankfurt now provide a new approach to resolve the evolution of soft-tissue structures, focusing on the evolution of testes in mammals. (mpg.de)
Michael Hiller, who is affiliated with the two Max Planck Institutes and the Center for Systems Biology Dresden, says: 'Instead of investigating soft-tissue structures directly, we traced the evolution of genes that are required for their formation. (mpg.de)
Some genes were shown to have a tissue-specific expression. (inra.fr)

Molecular cloning and analysis of novel cDNAs specifically expressed in adult mouse testes. (jax.org)
RNA sequencing identified 37 and 48 genes that were differentially expressed between WT and Bmal1−/− mouse testes at circadian time (CT2 and CT14), respectively. (tmu.edu.tw)
Oil Red O staining showed decreased lipid aggregation in the Leydig cells of Bmal1−/− mouse testes. (tmu.edu.tw)

This gene is X-linked and is expressed in only male germ cells. (nih.gov)
The objective of this study was to identify the PDE10A isoforms expressed in the testis and germ cells, and to determine the presence and localization of PDE10A in mature spermatozoa. (plos.org)

Eleven genes were involved in reproduction and sex determination mechanisms. (geneticsmr.com)

Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. (lu.se)

A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)

Vertebrate testes are arranged into recurring cellular associations that vary with time and distance along the tubule. (jci.org)

In the transcriptomic results, genes related to thermoception were observed. (biomedcentral.com)

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (nih.gov)

In Vertebrates, Nanos paralogous genes were associated to partial redundancies and specific functional evolutions. (nature.com)

New genomic research associations that magic size multiple genes could have solid relevance for immunotherapy [10] carefully. (monossabios.com)
For non-model species, as many used for aquaculture, with minimal or no genomic information, relative quantification of gene expression studies requires preliminary research including the isolation of potential reference genes and the identification of those stably expressed under the biological conditions of interest. (univ-brest.fr)
Seventeen ETV6/RUNX1-positive pediatric acute lymphoblastic leukemias were investigated by high-resolution array-based comparative genomic hybridization ( array CGH), gene expression profiling and fluorescence in situ hybridization. (lu.se)
Comparing the array CGH and gene expression patterns revealed that genomic imbalances conferred a great impact on the expression of genes in the affected regions. (lu.se)

Our results provide a comprehensive catalogue of polymorphic STRs and SVs in the bovine genome and show that they contribute substantially to gene expression and splicing variation in cattle. (ed.ac.uk)
Goupil S, Maréchal L, El Hajj H, Tremblay M-È, Richard FJ, Leclerc P (2016) Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. (plos.org)

Previous data has reported similarity between human brain and testis gene expression patterns. (karger.com)

A fusion gene is an abnormal gene consisting of parts from two different genes that form as a result of a large scale gene mutation such as a chromosomal translocation, interstitial deletion, or inversion. (wikipedia.org)
A single mutation in the TSPYL1 gene has caused all identified cases of SIDDT. (medlineplus.gov)
The TSPYL1 gene mutation that causes SIDDT eliminates the function of TSPY-like 1. (medlineplus.gov)
My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. (globalgenes.org)

In almost all adult mammals, testes are located either in a scrotum or in the lower abdomen. (mpg.de)
Testes are usually found in the scrotum, although they can be found at any level along the path of embryonic descent from abdomen to scrotum, frequently presenting as inguinal hernias. (medscape.com)
Over the last 3 months of gestation, the testis must course its way down from its original retroperitoneal position to its final destination in the scrotum. (medscape.com)
Inferiorly, the testis is anchored to the scrotum by the scrotal ligament, a remnant of the gubernaculum. (medscape.com)

The CYP21 and HSD17B3 genes, were expressed respectively only in adrenals and only in testes. (inra.fr)
These decreases in Apoa1, Apoa2, and Apoc3 expression were verified by quantitative polymerase chain reaction analysis, which also revealed downregulation of the expression of the circadian clock (Per2, Dbp, and Nr1d1) and steroidogenic (StAR, Cyp11a1, and Hsd17b3) genes. (tmu.edu.tw)

Both SVs and STRs were more than two-fold enriched among expression and splicing QTL (e/sQTL) relative to SNPs/Indels and were often associated with differential expression and splicing of multiple genes. (ed.ac.uk)

Using the Drosophila testis model, we show that germline stem cells (GSCs) lacking the transcription factor Chinmo gain a competitive advantage for niche access. (lu.se)

Morphological analysis and electron-prove X-ray microanalysis (EPMA) was undertaken on the testes. (intechopen.com)

Testis-specific serine kinase 3 (Tssk3) is a conserved gene, but TSSK3 kinase functions and phosphorylation substrates of TSSK3 are not known. (cdc.gov)

This locus represents a member of the cancer/testis gene family 47. (nih.gov)

Genes are specific sequences of bases that encode instructions on how to make proteins. (jainworld.com)

B ) Histological cross section through an adult mouse testis depicting seminiferous tubules, the peritubular myoid cells, and the interstitium (space between tubules). (jci.org)

Using immunological detection techniques and RT-Q-PCR, we have studied the spatio-temporal expression pattern of WT1, SF1, SOX9, AMH, and DMRT1 in 4 representative stages of the circannual cycle of the testes of Talpa occidentalis, a mole species with strict seasonal reproduction. (mdc-berlin.de)

However, whether the circadian clock regulates testosterone production via other genes remains unknown. (tmu.edu.tw)
Considering the vital role of Apo genes in high-density lipoprotein formation and cholesterol transport, the present data suggest that the circadian clock system regulates testosterone production by orchestrating the rhythmic expression of Apo genes. (tmu.edu.tw)
When the testes fail to produce an adequate level of endogenous testosterone, men develop hypogonadism. (aafp.org)
As the fetus develops, the functioning testis produces the male hormone testosterone to allow development of male genitalia. (medscape.com)

However, several African species such as elephants, tenrecs, golden moles, elephant shrews, manatees, and rock hyraxes differ from the other mammals by lacking any descent and having testes at their initial abdominal position. (mpg.de)
Chondrichthyan species display two nanos1 genes (named nanos1A / 1B ), which were both retrieved in some Osteichthyes at basal positions in Sarcopterygii and Actinopterygii lineages. (nature.com)

Based on phylogenetic and synteny analyses, this study reveals that nanos1 gene has undergone multiple duplications and gene copies losses in Vertebrates. (nature.com)

Genes Chromosomes Cancer, 2006 Apr. (nih.gov)
These chromosomes carry heredity factors or genes. (jainworld.com)
Gene abnormalities Chromosomes are structures within cells that contain a person's genes. (msdmanuals.com)

Hemicastration is a unilateral orchiectomy to remove a testis injured by external force, biochemistry or illness. (animbiosci.org)

The two successive nanos gene duplications may result from the second and third whole genome duplication events at the basis of Vertebrates and Teleosts respectively. (nature.com)

Since these genes encode genetic regulatory factors, it is reasonable to suspect that they could play some role in the control of the adult testis function. (mdc-berlin.de)

Anatomy18

Organisms1

Diseases9

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes18

Disciplines and Occupations1

Information Science3

Chromosome8

Spermatogenesis8

Testicular15

Ovary4

Transcript5

Ovaries8

Antigen2

Protein14

Mice12

Human testis2

Gonad6

Mutations6

Mammalian testis2

Differentially expressed genes2

Reproductive7

Variants2

Phenotypes2

Epididymis7

Tissues5

Tissue3

Mouse testes3

Germ cells2

Involved in reproduction and1

Methylation patterns1

Specifically expressed1

Vertebrate1

Transcriptomic1

Ontology1

Functional1

Genomic4

Bovine2

Expression patterns1

Mutation4

Scrotum4

HSD17B32

Multiple genes1

Drosophila1

Morphological1

Serine1

Locus1

Sequences1

Adult mouse1

Immunological1

Testosterone4

Species2

Analyses1

Chromosomes3

Unilateral1

Duplications1

Encode1