Gene regulatory sequences nucleic acid. Medical search. Frequent questions

Host adaptation is central to pathogen evolution and is associated with gene acquisition, genome degradation (gene inactivation or deletion), or both. (cdc.gov)
The comparative genome-wide analysis and mode of evolution of KCS and ELO gene families have not been investigated in tetraploid Brassica carinata and its diploid progenitors. (nature.com)
Genome sequencing of normal cells reveals developmental lineages and mutational processes. (genomeweb.com)
Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity. (genomeweb.com)
Exploring genetic variation in the tomato ( Solanum section Lycopersicon) clade by whole-genome sequencing. (genomeweb.com)
Variant detection sensitivity and biases in whole genome and exome sequencing. (genomeweb.com)
The Marmoset Genome Sequencing and Analysis Consortium. (genomeweb.com)
A chromosome-based draft sequence of the hexaploid bread wheat ( Triticum aestivum ) genome. (genomeweb.com)
International Wheat Genome Sequencing Consortium (IWGSC). (genomeweb.com)
Whole-genome sequence analysis reveals differences in population management and selection of European low-input pig breeds. (genomeweb.com)
We report here the genome sequence of the Brown Norway (BN) rat strain. (nih.gov)
The sequence represents a high-quality 'draft' covering over 90% of the genome. (nih.gov)
The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. (nih.gov)
This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution. (nih.gov)
Large tumor genome sequencing projects have now uncovered a few hundred genes involved in the onset of tumorigenesis, or drivers, in some two dozen malignancies. (biomedcentral.com)
The catalog of driver genes involved in the development of several malignancies has grown in recent years, as a result of whole-exome and whole-genome analyses of cohorts of tumors, mainly within the framework of large international consortia [ 3 , 4 ]. (biomedcentral.com)
These findings challenge the concept that the genome is organized into discrete, insulated regulatory domains. (ox.ac.uk)
There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. (lookformedical.com)
To identify early driver mutations in ovarian cancer cells, we used dense whole genome sequencing of micrometastases and microscopic residual disease collected at three time points over three years from a single patient during treatment for high-grade serous ovarian cancer (HGSOC). (ox.ac.uk)
The functional and clinical significance of the identified mutations was examined using a combination of population-based whole genome sequencing, targeted deep sequencing, multi-center analysis of protein expression, loss of function experiments in an in-vivo reporter assay and mammalian models, and gain of function experiments in primary cultured fallopian tube epithelial (FTE) cells. (ox.ac.uk)
This work describes the complete genome sequence of this phage. (biomedcentral.com)
Compared to the genome of gh-1, the sequence of ϕIBB-PF7A is longer and contains more genes with unassigned function and lacks a few potentially essential and non-essential T7 genes, such as gene1.1, 3.8, and 7. (biomedcentral.com)
Today, phage genome sequencing is commonly performed for classification and characterization purposes and is based on the arrangement of conserved genes and the nucleotide and protein sequence identity [ 5 , 6 ]. (biomedcentral.com)
All these phages, most of which have members of the Enterobacteriaceae as their host, present a highly conserved genome organization and mainly differ at sequence level through the presence or absence of nonessential genes [ 8 ]. (biomedcentral.com)
The genome of coliphage T7 has 56 genes encoding potential proteins [ 8 ], of which 35 have known function or functions. (biomedcentral.com)
This work focuses on the determination of the complete genome sequence of the P. fluorescens phage ϕIBB-PF7A. (biomedcentral.com)
Horizontal gene transfer plays a major role in microbial evolution by innovating the bacterial genome with new genetic blueprints to adapt to previously unexploited niches. (mcmaster.ca)
A Whole-Genome Analysis Framework for Effective Identification of Pathogenic Regulatory Variants in Mendelian Disease. (lu.se)
Cost-effective complete genome sequencing using the MinION platform for identification of recombinant enteroviruses. (cdc.gov)
Coding-complete genome sequences of rotavirus A reference strains EDIM, Ph158, and CC425. (cdc.gov)

Although only type I and type II could transactivate XIMGP, the truncated isoforms identified in this study, which result from alternative splicing, could be involved in negative regulation of MGP expression, as described for other RUNX2 truncated isoforms acting in other target genes. (bath.ac.uk)
In summary, our studies have provided evidence that E2A is directly involved in the transcriptional regulation of a number of early B-lineage genes. (duke.edu)
FAE ( Fatty Acid Elongation ) like genes take part in the biosynthesis of VLCFAs, growth regulation, and stress responses, and are further comprised of KCS ( Ketoacyl-CoA synthase ) and ELO ( Elongation Defective Elongase ) sub-gene families. (nature.com)
Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. (biomedcentral.com)
In spite of the importance of this tissue in the quality and production of pollen grains, studies on promoter gene regulation of tapetal expressed genes are very few and there are no reports on specific cis regulatory sequences that control tapetal gene expression. (tamu.edu)
A complex interaction between the cleavage and polyadenylation molecular complex and cis -elements determine the polyadenylation site, which may result in the choice of non-canonical sites, resulting in alternative polyadenylation events, involved in the regulation of more than 80% of the genes expressed in plants. (frontiersin.org)
Specifically, anteriorly localized MAPK substrates, such as Bicoid, antagonize MAPK-dependent downregulation of Capicua, a repressor that is involved in gene regulation along the dorsoventral axis of the embryo. (princeton.edu)
To understand the transcriptional regulation of Gal-T-II gene expression, we cloned a 1448 bp 5′-flanking fragment from the mouse Gal-T-II gene. (elsevierpure.com)
These data indicate that the basal regulation of Gal-T-II gene transcription involves multiple transcription factors, some of which may be present in complexes. (elsevierpure.com)
Focus of my research for the last 10 years has been on gene regulation, initially based on transcription factors, promoters and enhancers, but increasingly also including epigenetics, in particular histone modifications. (ntnu.edu)
This review focuses on the effects that vasopressin exerts on the regulation of glucose and fatty acids with a particular emphasis on the potential repercussions of metabolic dysregulation in kidney disease. (bvsalud.org)
Long-range regulation of alpha-globin gene expression. (ox.ac.uk)
Consequently, further studies are necessary to understand the intricate molecular mechanisms of hsp70 gene regulation in D. subobscura. (uab.cat)

Runx2 is a transcription factor essential for bone formation in mammals, affecting osteoblast and chondrocyte differentiation by regulating key genes crucial for bone and cartilage development. (bath.ac.uk)
In A6 cells, Runx2 was found to modulate MGP transcription and deletion analysis of MGP distal and proximal promoter-luciferase constructs identified cis-regulatory regions. (bath.ac.uk)
The transcription factors encoded by the E2A gene are known to be essential for B lymphocyte development, and ectopic expression or gene inactivation studies have revealed several potential lineage-specific E2A target genes. (duke.edu)
String-based protein-protein interaction analysis suggested that bZIP53, a transcription factor might be involved in the activation of transcription of ELO / KCS genes. (nature.com)
The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. (lu.se)
However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. (lu.se)
We developed TS-REX, a database/software system that supports the analysis of tissue and cell type-specific transcription factor-gene networks based on expressed sequence tag abundance of transcription factor-encoding genes in UniGene EST libraries. (lu.se)
The use of expression levels of transcription factor-encoding genes according to hierarchical anatomical classifications covering different tissues and cell types makes it possible to filter out irrelevant binding site predictions and to identify candidates of potential functional importance for further experimental testing. (lu.se)
The software allows users to interactively visualize transcription factor-gene networks, as well as to export data for further processing. (lu.se)
Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)
In this paper we examine evidence for a direct crosstalk of the NF-κB and IRF3 signaling pathways at the lowest level, between main transcription factors and genes coding for these transcription factors. (biomedcentral.com)
We analyzed respective gene promoters' sequences using in silico methods for identification of transcription binding sites, mainly in the NF-κB- and IRF-coding genes. (biomedcentral.com)
Developing tissues are patterned by coordinated activities of signaling systems, which can be integrated by a regulatory region of a gene that binds multiple transcription factors or by a transcription factor that is modified by multiple enzymes. (princeton.edu)
Based on a combination of genetic and imaging experiments in the early Drosophila embryo, we describe a signal integration mechanism that cannot be reduced to a single gene regulatory element or a single transcription factor. (princeton.edu)
Analysis of the promoter sequence revealed a number of potential binding sites for known transcription factors. (elsevierpure.com)
To determine which transcription factors bind to the promoter, we carried out a systematic search for the binding proteins using the 1142 bp Gal-T-II promoter fragment containing both positive and negative regulatory regions in a combination of DNA pull-down assay and transcription factor array analysis. (elsevierpure.com)
Previous findings indicate that circRNAs mainly function as microRNA (miRNA) sponges to regulate the transcription and posttranscription of miRNA-targeted genes. (hindawi.com)
In general, these elements contain a high density of evolutionarily conserved, transcription factor-binding sites and in many ways resemble the upstream regulatory elements found adjacent to the promoters of genes in simpler organisms, differing only in the distance over which they act. (ox.ac.uk)
The region of DNA which borders the 3' end of a transcription unit and where a variety of regulatory sequences are located. (lookformedical.com)
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. (lookformedical.com)
The present invention is based on successful expression cloning of a transcription factor that binds to the GTII element of the GLUT2 and insulin genes from a differentiated insulin-secreting cDNA library. (justia.com)
In 2007, autosomal dominant mutations in signal transducer and activator of transcription-3 (STAT3) gene were identified as the molecular cause of this disease. (medscape.com)
Dimerized STATs then translocate to the nucleus, where they bind DNA in the promoter sequences of target genes to activate transcription. (medscape.com)

The expression analysis of both gene family members reflect their preferential seed-specific expression, especially during the mature embryo development stage. (nature.com)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
A cis regulatory element in the TAPNAC promoter directs tapetal gene expression. (tamu.edu)
The TAPNAC promoter was studied in detail to identify cis regulatory sequences that confer tapetal specific expression. (tamu.edu)
For this purpose, TAPNAC promoter elements were fused to the -glucuronidase (GUS) reporter gene, and spatial and temporal GUS expression was monitored. (tamu.edu)
The 3' regulatory regions have a great diversity of cis -regulatory elements directly involved in polyadenylation, stability, transport and mRNA translation, essential to achieve the desired levels of gene expression. (frontiersin.org)
Although a small number of 3' regulatory regions have been identified and validated so far, many studies have shown that plant 3' regulatory regions have a higher potential to regulate gene expression in plants compared to widely used 3' regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. (frontiersin.org)
In this review, we discuss the role of 3' regulatory regions in gene expression, and the superior potential that plant 3' regulatory regions have compared to NOS, OCS and 35S 3' regulatory regions. (frontiersin.org)
A mathematical model of this interaction can explain gene expression patterns with both anteroposterior and dorsoventral polarities. (princeton.edu)
In contrast, in other cell types including hepatocytes and under stress, AANCR does not form a stable R-loop as its sequence is not modified, so it is transcribed into a full-length enhancer that promotes APOE expression. (bvsalud.org)
DNA sequence variants in AANCR are associated significantly with APOE expression and Alzheimer's Disease, thus AANCR is a modifier of Alzheimer's Disease. (bvsalud.org)
Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition. (ox.ac.uk)
It is well established that all of the cis-acting sequences required for fully regulated human alpha-globin expression are contained within a region of approximately 120 kb of conserved synteny. (ox.ac.uk)
Here, we show that activation of this cluster in erythroid cells dramatically affects expression of apparently unrelated and noncontiguous genes in the 500 kb surrounding this domain, including a gene (NME4) located 300 kb from the alpha-globin cluster. (ox.ac.uk)
Changes in NME4 expression are mediated by physical cis-interactions between this gene and the alpha-globin regulatory elements. (ox.ac.uk)
Polymorphic structural variation within the globin cluster, altering the number of alpha-globin genes, affects the pattern of NME4 expression by altering the competition for the shared alpha-globin regulatory elements. (ox.ac.uk)
Over the past 20 years, there has been an increasing awareness that gene expression can be regulated by multiple cis-acting sequences located at considerable distances (10-1000 kb) from the genes they control. (ox.ac.uk)
In turn, we have addressed how, during this process, the upstream elements control the correct spatial and temporal expression from the alpha-gene promoter which lies approximately 60 kb downstream of these elements. (ox.ac.uk)
These findings do not match the similar hsp70 genomic organization between arrangements, where gene expression levels are expected to be similar. (uab.cat)
In order to test this hypothesis and understand the molecular basis for hsp70 expression, we compared basal hsp70 mRNA levels in males and females, and analysed the 5′ and 3′ regulatory regions of hsp70 genes in warm- and cold-climate isochromosomal O 3 + 4 + 7 and O ST lines of D. subobscura. (uab.cat)
Results: We observed comparable mRNA levels between the two arrangements and a sex-biased hsp70 gene expression. (uab.cat)
Conclusions: The equivalent hsp70 mRNA amounts in O ST and O 3 + 4 + 7 arrangements provide the first evidence of a parallelism between gene expression and genetic organization in D. subobscura lines having these arrangements. (uab.cat)
The presence of GTI, II and III are both sufficient and necessary to confer pancreatic-specific expression to a reporter gene in vitro or in vivo, using a transgenic mice approach (3,51). (justia.com)
Production of the fusion polypeptide involves the introduction of the hybrid gene into a biological host cell system, for example yeast cells, which permits the expression and accumulation of the fusion polypeptide. (justia.com)
However, to benefit from these genetic acquisitions, the bacterium must integrate the expression of these new genes into existing regulatory nodes and deploy them at the right time. (mcmaster.ca)
There is much to gain from uncovering the genetic diversity in noncoding DNA that is selective during host infection because of the beneficial effect it has on bacterial gene expression. (mcmaster.ca)
Insights into H 2 O 2 -induced signaling in Jurkat cells from analysis of gene expression. (otago.ac.nz)

Significant E2A binding was detected at the promoters and enhancers of several essential B-lineage genes, including the Igkappa intronic and 3' enhancers, lambda5 and VpreB surrogate light chain promoters, the EBF locus promoter region, and the mb-1 (Igalpha) promoter. (duke.edu)
The presence of biotic and abiotic stress-related cis-regulatory elements in the promoter region suggests that both KCS and ELO genes might also play their role in stress tolerance. (nature.com)
The SoxS site is in the forward orientation and its location suggests that the ompW gene has a class I SoxS-dependent promoter. (uandes.cl)
Important cis-regulatory sequences were identified within this promoter region including a functionally responsive PDX-1 element, a cyclic AMP responsive element, and three cis elements termed GTI, GTII and GTIII (3,36,53). (justia.com)
When tested in vitro, IB1 bound specifically to the GTII cis element of the GLUT2 gene and to an homologous regulatory sequence of the insulin promoter termed RIPE3. (justia.com)
This rat insulin promoter element 3 (RIPE3) is an important enhancer sequence sufficient to confer .beta. (justia.com)
Mendelian regulatory variations including 42 enhancer, 142 promoter, 153 5' UTR, 43 3' UTR, 65 RNA gene, 3 imprinting control region, and 5 microRNA gene variations. (lu.se)

Scholars@Duke publication: Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. (duke.edu)
However, it remains unknown whether these target genes are directly regulated by E2A at the transcriptional level. (duke.edu)
We therefore generated mice carrying an affinity-tagged E2A knock-in allele to provide a system for the direct elucidation of E2A target genes based on E2A binding to target regulatory regions. (duke.edu)

DNA sequences are replicated by the cell prior to cell division and may include genes, intergenic spacers, and regions that bind to regulatory proteins. (wordnik.com)
Twenty eight (46.7%) of the proteins encoded by this virus exhibit sequence similarity to coliphage T7 proteins while 34 (81.0%) are similar to proteins of Pseudomonas phage gh-1. (biomedcentral.com)
Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)

The availability of multiple PAS in the same 3' regulatory region enables the inclusion or exclusion of 3' untranslated region (3'UTR) sequences, resulting in transcripts that may differ in particularities involving post-transcriptional processes such as stability, transport and translation ( Mayr, 2016 ), and even protein localization ( Berkovits and Mayr, 2015 ). (frontiersin.org)
This was gradually expanded into various methods in bioinformatics, in particular for sequence analysis and protein structure prediction. (ntnu.edu)
Figure 3: Protein locations of private disruptive variants in new candidate NDD risk genes. (nature.com)
The IB1cDNA encodes a 714 amino acid protein with a proline-rich region and a putative basic helix-loop-helix domain (bHLH). (justia.com)
F2 contains 6550 variants randomly sampled from the set of common human SNVs without clinical assertion associated with protein-coding genes in F1. (lu.se)
F3 contains 770 variants as a validation set including 70 SNVs in 'positive' set in non-coding regions of protein-coding genes newly reported and 700 randomly sampled common human variants, matched per type of region to the 'positive' set. (lu.se)

Targeted chromatin capture (T2C): a novel high resolution high throughput method to detect genomic interactions and regulatory elements. (genomeweb.com)
AAV type 2 wild-type and vector-mediated genomic integration profiles in human diploid fibroblasts analyzed by 3rd generation PacBio DNA sequencing. (genomeweb.com)
Aotearoa genomic data repository: An āhuru mōwai for taonga species sequencing data. (otago.ac.nz)

Low levels of E2A binding were observed at several other lymphoid-restricted regulatory regions including the Ig heavy chain (IgH) intronic enhancer, the IgH 3' enhancers hs3b/hs4, the RAG-2 enhancer, and the 5' regions of the B29 and TdT loci. (duke.edu)
The non-coding regions downstream of coding sequences (CDS) is usually termed terminators. (frontiersin.org)
The research in this thesis was focused on further characterizing these areas, since they are very large, contain many different genes and also regions that regulate whether a gene is turned 'on' or 'off' (or something in between). (knaw.nl)
We have focused on these regulatory regions and discovered that the DNA that is linked to intracranial aneurysms often overlaps with such regulatory DNA regions. (knaw.nl)
Next, we have identified six genes that have an interaction with the regulatory regions and may be regulated by these regions. (knaw.nl)
Lastly, we have tested whether these regulatory DNA regions can really regulate gene activity and found that most of them can. (knaw.nl)
Transposition of this element into coding and regulatory regions of genes is responsible for many heritable diseases. (lookformedical.com)
This is reinforced by the lack of important differential features in the number and structure of regulatory elements between both arrangements, despite the genetic differentiation observed when the complete 5′ and 3′ regulatory regions were considered. (uab.cat)
4462 functional sequence variations in regulatory DNA regions in training dataset F1 and 1116 functional SNVs in test datasets F2. (lu.se)
WHO regions and advised by some 10 scientific academic experts from such areas as public health, fundamental applied research and regulatory agencies, was subsequently established and has met three times. (who.int)

We have identified a NAC gene, TAPNAC (At1g61110), specifically expressed in the Arabidopsis tapetum via transcriptional profiling. (tamu.edu)
In silico analyses suggested a putative binding site for the SoxS transcriptional factor at the ompW regulatory region. (uandes.cl)
Synaptic, transcriptional and chromatin genes disrupted in autism. (nature.com)
Transcriptional activator Islet-Brain 1 (IB1) is disclosed which is involved in the control of the GLUT2 and insulin genes by interacting with homologous cis-regulatory elements of the GLUT2 and insulin promoters, and to materials and methods deriving from this work. (justia.com)

The research group has established rigorous methods for benchmarking methods for motif discovery (BMC Bioinformatics 2007, 2008) and ChIP-seq data analysis (Nucleic Acids Res 2011). (ntnu.edu)
High-throughput RNA sequencing and bioinformatics analysis have led to the identification of several novel circRNAs that exhibit biological characteristics and regulatory functions [ 6 , 9 ]. (hindawi.com)

Abelson-transformed pre-B cell lines derived from these mice were used in chromatin immunoprecipitation experiments to identify regulatory sequences bound by E2A in the context of an early B lymphocyte environment. (duke.edu)
An E2A target gene, the predicted butyrophilin-like gene NG9 (BTL-II), was also identified by using a chromatin immunoprecipitation-based cloning strategy. (duke.edu)
Exploiting the aforementioned catalogs of driver genes, for example, we recently revealed the mutational landscape of chromatin regulatory factors (CRFs) in cancer [ 5 ]. (biomedcentral.com)

2001. A sequence-ready map of the human chromosome 1q telomere. . (cornell.edu)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Gene-disruptive mutations contribute to the biology of neurodevelopmental disorders (NDDs), but most of the related pathogenic genes are not known. (nature.com)
We identified 91 genes, including 38 new NDD genes, with an excess of de novo mutations or private disruptive mutations in 5.7% of cases. (nature.com)
Figure 2: Targeted sequencing highlights genes reaching significance for de novo mutations and private disruptive variant burden. (nature.com)
Recurrent de novo mutations implicate novel genes underlying simplex autism risk. (nature.com)
We identified frequent mutations involving a 40kb distal repressor region for the key stem cell differentiation gene SOX2. (ox.ac.uk)
Mutations in the STAT3 gene cause most cases of AD-HIES. (medscape.com)
STAT3 gene is diagrammed with depiction of hotspots (areas where higher numbers of patients were noted to have mutations). (medscape.com)
Mutations in the STAT3 gene have been identified in almost all cases of clinically verified autosomal dominant hyper-IgE syndrome (AD-HIES). (medscape.com)

Restriction site associated DNA sequencing for tumour mutation burden estimation and mutation signature analysis. (otago.ac.nz)

MToolBox: a highly automated pipeline for heteroplasmy annotation and prioritization analysis of human mitochondrial variants in high-throughput sequencing. (genomeweb.com)

Recently, traditional isolation methods, complemented by high-throughput sequencing metagenomics technology, have greatly increased our understanding of the diversity of bacteriophages. (biomedcentral.com)
Assessing the impact of water treatment on bacterial biofilms in drinking water distribution systems using high-throughput DNA sequencing. (genomeweb.com)
Optimization of high-throughput 16S rRNA gene amplicon sequencing: an assessment of PCR pooling, mastermix use and contamination. (cdc.gov)

In this study, 53 KCS genes were identified in B. carinata compared to 32 and 33 KCS genes in B. nigra and B. oleracea respectively, which suggests that polyploidization might has impacted the fatty acid elongation process during Brassica evolution. (nature.com)
Gene structure analysis indicated that the maximum number of genes were intron-less and remained conserved during evolution. (nature.com)
The neutral type of selection seemed to be predominant in both KCS and ELO genes evolution. (nature.com)
The current study provides a basis to understand the evolution of both KCS and ELO genes in fatty acid elongation and their role in stress tolerance. (nature.com)
Over time U-triangle developed on polyploidization of Brassica 's proved its usefulness in studying the evolution of various genes and phenotypes 3 . (nature.com)
Cis-regulatory programs in the development and evolution of vertebrate paired appendages. (uchicago.edu)
By identifying genes that have undergone regulatory evolution, a deeper understanding of the arms race between host and pathogen is gained. (mcmaster.ca)

Stepwise threshold clustering: a new method for genotyping MHC loci using next-generation sequencing technology. (genomeweb.com)
Región reguladora que fue identificada por primera vez en el locus de la globina beta humana pero que se halló posteriormente en otros loci. (bvsalud.org)
A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. (bvsalud.org)

The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). (lookformedical.com)

Gene prediction List of RNA structure prediction software Comparison of software for molecular mechanics modeling Banerjee S, Bhandary P, Woodhouse M, Sen TZ, Wise RP, Andorf CM (Apr 2021). (wikipedia.org)
Click molecule labels to explore molecular sequence information. (nih.gov)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)

Experiments involving the deliberate formation of synthetic or recombinant DNA containing genes for the biosynthesis of select toxins lethal for vertebrates at an LD 50 <100 ng/kg body weight (ie, nucleic acids that encode select toxins). (cdc.gov)

DI-fusion A web site for the computational analysis of yeast regulatory. (ac.be)
A web site for the computational analysis of yeast regulatory sequences. (ac.be)
There are two main reasons why the catalogs of cancer drivers produced by the aforementioned projects and others need to be broken down into related sets of genes for deeper analysis. (biomedcentral.com)

TS-REX was applied to predict regulators of Polycomb group genes in six human tumor tissues and in human embryonic stem cells. (lu.se)

Laboratories and facilities that have SARS-CoV-2 positive specimens and intend to report SARS-CoV-2 lineages, including variants, should upload sequence data to a public database (e.g. (cdc.gov)
27558 Mendelian disease regulatory variants from OMIM and ClinVar, 20963 complex disease regulatory variants from VarDi and NHGRI GWAS Catalog and 43364 recurrent cancer somatic variations. (lu.se)
Disease-associated variants in different categories of disease located in distinct regulatory elements. (lu.se)
Quantifying deleterious effects of regulatory variants. (lu.se)
F1 contains 655 high-confidence pathogenic non-coding variants associated with monogenic Mendelian disease genes. (lu.se)

It is also called nucleotide sequence. (lookformedical.com)

Through the service and infrastructure activities the group has also been involved in several other projects, like research on prokaryotes, including oil well metagenomics, biodegradation, pathogenic bacteria, and characterization of novel bacterial genes. (ntnu.edu)

The parts of a transcript of a split GENE remaining after the INTRONS are removed. (lookformedical.com)

However, the regulatory role of RNA sequence and structure and how dysregulation leads to diseases remain largely unknown. (bvsalud.org)
In particular, the use of IB1 nucleic acid, IB1 polypeptides and anti-IB1 antibodies in the diagnosis, and prophylactic and therapeutic treatment of conditions such as diabetes and neurological diseases such as dementia and/or parkinsonism is disclosed. (justia.com)
In particular, the present invention relates to the uses of IB1 nucleic acid, IB1 polypeptides and anti-IB1antibodies in the diagnosis, and prophylactic and therapeutic treatment of conditions such as diabetes and neurological diseases such as dementia and/or parkinsonism. (justia.com)
225 Functional regulatory SNVs in monogenic and complex diseases and 241910 SNVs from dbSNP as a negative control dataset. (lu.se)

These techniques are based upon the preparation of hybrid genes, i. e. genes comprising genetic material encoding the polypeptide of interest linked to genetic material additional to the gene of interest. (justia.com)

One step in this direction is thus to understand exactly which downstream genes and cellular processes become affected in the outcome of driver alterations. (biomedcentral.com)
Nevertheless, to date, the actual misregulation of genes or processes downstream these cliques has not been systematically proven or exploited with the purpose of identifying them. (biomedcentral.com)

SigFuge: single gene clustering of RNA-seq reveals differential isoform usage among cancer samples. (genomeweb.com)
Through APA, a single gene containing multiple PAS can generate a considerable number of transcript isoforms, thereby producing a highly diversified transcriptome ( Tian and Manley, 2013 ). (frontiersin.org)

2017. Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites. . (cornell.edu)
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing[J]. Cell 2017, 169(7):1342-1356. (cnic.cn)

Sequence homology is an indication of the genetic relatedness of different organisms and gene function. (lookformedical.com)

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. (lookformedical.com)

DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom. (lookformedical.com)

noun A nucleic acid that carries the genetic information in cells and some viruses, consisting of two long chains of nucleotides twisted into a double helix and joined by hydrogen bonds between the complementary bases adenine and thymine or cytosine and guanine. (wordnik.com)
Experiments involving the creation of SARS-CoV/SARS-CoV-2 chimeric viruses resulting from any deliberate manipulation of SARS-CoV-2 to incorporate nucleic acids coding for SARS-CoV virulence factors or vice versa. (cdc.gov)
Wooden shafts or calcium alginate swabs may contain substances that inhibit some viruses and nucleic acid detection reactions. (medscape.com)

Such reactions employ agents that act by hydrolysis of peptide bonds and the specificity of the cleavage agent is determined by the identity of the amino acid residue at or near the peptide bond which is cleaved. (justia.com)

The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)

Very long-chain fatty acids (VLCFAs) possess more than twenty carbon atoms and are the major components of seed storage oil, wax, and lipids. (nature.com)
Fatty acids of this group can be found abundantly in the form of suberins, sphingolipids, leaf cuticles, pollen epidermis, and cork cells. (nature.com)

Nucleic Acids Research. (wikipedia.org)
Nucleic Acids Research, 45(5), 2307-2317. (lu.se)
DSAT continues to encourage entities to practice due diligence and request a review of research that could potentially meet the regulatory definition of a restricted experiment out of an abundance of caution to protect public health and safety and prevent any potential compliance action. (cdc.gov)

Detailed investigation of a few specialized mammalian genes, including the genes controlling the synthesis of hemoglobin, provide important models to understand how such long-range regulatory elements act. (ox.ac.uk)

The impact of global warming on the signature virulence gene, thermolabile hemolysin, of Vibrio parahaemolyticus. (cdc.gov)

Anatomy7

Organisms11

Diseases1

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes85

Disciplines and Occupations2

Information Science8

Health Care2

Genome30

Regulation13

Transcription23

Expression27

Promoter7

Target genes3

Proteins4

Protein6

Genomic3

Regions10

Transcriptional4

Bioinformatics2

Chromatin3

Telomere1

Mutations9

Mutation1

Mitochondrial1

High throughput3

Evolution7

Loci3

Humans1

Molecular3

Vertebrates1

Analysis3

Tumor1

Variants5

Nucleotide sequence1

Pathogenic1

Introns1

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Polypeptide1

Downstream2

Single gene2

20172

Homology1

Molecule1

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Identity1

Human2

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