• Transcriptomic analysis revealed that PS-MPs exacerbated the expression levels of neutrophil extracellular traps in mice treated with LPS/d-GalN, and weakened the expression of genes involved in pathways related to peroxisome, taurine, and hypotaurine metabolism, which was further validated by reverse-transcription quantitative polymerase chain reaction. (bvsalud.org)
  • A number of genes concerned in IFN associated pathways have been upregulated within the head kidney. (esb2017.org)
  • These metabolic disorders are typically caused by genetic mutations that result in the impairment or deficiency of enzymes involved in the metabolism of β-alanine or related pathways. (healthmatters.io)
  • GABA-transaminase deficiency is caused by mutations in the ABAT gene, which provides instructions for making the GABA-transaminase enzyme. (medlineplus.gov)
  • Mutations in the ABAT gene lead to a shortage (deficiency) of functional GABA-transaminase enzyme. (medlineplus.gov)
  • Two nucleotides were different between the E. coli (Tn3) and H. ducreyi (pCb) genes that affected the amino-acid sequence. (lu.se)
  • Amino acid sequencing of some beta-lactamases has shown that substitution of only a few amino acids in the bla gene leads to high-level resistance against specific cephalosporins. (lu.se)
  • The non-essential amino acid beta-alanine has antioxidant properties, according to Nutrition. (consumerhealthdigest.com)
  • L-Arginine is a semi-essential amino acid naturally found in various foods and is necessary for the manufacturing of proteins in the body. (consumerhealthdigest.com)
  • Approximately 50% of patients with severe recessive HS have a point mutation at codon (969) that results in an amino acid substitution (alanine [Ala]/aspartic acid [Asp]) at the corresponding site in the alpha-spectrin protein. (medscape.com)
  • In practice, the Scalar Light Amino Acid & Protein Program administers scalar light instructions in order to assemble and maintain amino acids and proteins inside the quantum body or scalar light force field. (scalarlight.com)
  • Below are the lists of amino acids and proteins that are assembled by way of the Scalar Light Amino Acid and Protein Program. (scalarlight.com)
  • The Scalar Light Amino Acid and Protein Program operates twenty-four (24) hours per day seven (7) days per week thereby assuring a constant creation and delivery of amino acids and proteins to the quantum, human body. (scalarlight.com)
  • The Scalar Light Amino Acid & Protein Program administers scalar light upon photographs of people, animals, plants, and objects. (scalarlight.com)
  • Some steroids, such as anabolic steroids, also result in protein and amino acid levels turning into fat in the bloodstream and this increases the risk of a possible cardiovascular problem such as stroke. (lexingtonplaceassistedliving.com)
  • There are several rare inborn errors of metabolism that can cause elevations of β-alanine, a non-essential amino acid. (healthmatters.io)
  • This can result from an identified a homozygous 1336G-A transition in the gene, resulting in a change in the 446th residue from glycine to arginine. (wikipedia.org)
  • SCO3285 putative large glycine/alanine rich protein 3628804:3634122 reverse MW:187287 0014. (kitasato-u.ac.jp)
  • Mutations in the ALDH6A1 gene are associated with methylmalonate semialdehyde dehydrogenase deficiency, a rare autosomal recessive inborn error of metabolism with a highly variable phenotype. (wikipedia.org)
  • 1 L/d of drinking water was associated with concurrent changes in carbohydrate, protein, lipid, and micronutrient metabolism, a metabolomic pattern of carbohydrate oxidation via the tricarboxylic acid (TCA) cycle, instead of glycolysis to lactate, and a reduction of chronic disease risk factors in Week 6. (ppexmed.com)
  • These genes increase oxygen availability by inducing erythropoiesis and angiogenesis, and also reduce its demand via regulation of energy metabolism by reducing oxidative phosphorylation and inducing non-oxygen-demanding glycolysis [ 5 , 6 , 7 ]. (springer.com)
  • L-Ornithine supports kidney health and protein metabolism by converting ammonia (toxic by product of protein metabolism) into urea in urine (5). (gmawarriorsupplements.com)
  • The breakdown and metabolism of β-alanine requires vitamin B6-dependent enzymes. (healthmatters.io)
  • Hereditary spherocytosis (HS) is a familial hemolytic disorder associated with a variety of mutations that lead to defects in red blood cell (RBC) membrane proteins. (medscape.com)
  • In HS, intrinsic defects in erythrocyte membrane proteins result in RBC cytoskeleton instability. (medscape.com)
  • I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
  • I further investigated membrane proteins and the targeting of tail-anchored proteins at Sheffield Hallam University. (brookes.ac.uk)
  • Quantitative and functional abnormalities of certain RBC membrane proteins (alpha- and beta-spectrin, protein 4.1, F-actin, ankyrin) cause hemolytic anemias. (msdmanuals.com)
  • The sequence of the beta-lactamase gene was also determined. (lu.se)
  • Phylogenetic tree showing the relationship of the three E. anophelis strains HKU36-38 to closely related bacterial species using 16S rRNA gene sequence analysis. (cdc.gov)
  • The constituent proteins are normally synthesised in specialised glands where the epithelial cells are responsible for the biosynthesis. (bioone.org)
  • This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)
  • My additional independent research on ER localisation and splicing in auxin biosynthesis showed for the first time ER-localisation for an auxin biosynthetic protein. (brookes.ac.uk)
  • Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) is an enzyme that in humans is encoded by the ALDH6A1 gene. (wikipedia.org)
  • It confirmed that the enzyme belonged to a class A beta-lactamase which had 99% identity to the ampicillin resistance transposon Tn3 of pBR322. (lu.se)
  • I have designed proof-of-concept experiments to validate this approach, including targeting of the transcription factor PDX1, followed by experiments designed to simultaneously target two regulatory elements of the key beta cell enzyme, PCSK1. (einsteinmed.edu)
  • The DNA polymerase beta from the trypanosomatid Crithidia fasciculata, however, was the first mitochondrial enzyme of this type described. (neb.com)
  • One is approximately 70% identical to the C. fasciculata pol beta and is likely the homolog of this enzyme. (neb.com)
  • GapMind searches the predicted proteins for candidates by using ublast (a fast alternative to protein BLAST) to find similarities to characterized proteins or by using HMMer to find similarities to enzyme models (usually from TIGRFams ). (lbl.gov)
  • Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam ). (lbl.gov)
  • Human IKKgamma does not interact with mammalian Atg8-family proteins. (cusabio.com)
  • A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)
  • This is partially explained by numerous gene-poor regions that display a remarkable degree of non-coding and syntenic conservation with non-mammalian vertebrates , suggesting they are functionally constrained. (wikidoc.org)
  • SCO0127 putative multi-domain beta keto-acyl synthase 112932:119654 forward MW:235996 0009. (kitasato-u.ac.jp)
  • SCO0126 putative multi-domain beta keto-acyl synthase 106637:112885 forward MW:214716 0012. (kitasato-u.ac.jp)
  • SCO3869 putative WD-40 repeat protein 4252856:4257886 forward MW:177236 0015. (kitasato-u.ac.jp)
  • SCO2383 putative secreted protein 2552256:2556893 forward MW:161489 0017. (kitasato-u.ac.jp)
  • SCO4508 putative cell division-related protein 4928990:4933567 reverse MW:163295 0018. (kitasato-u.ac.jp)
  • SCO7015 putative membrane protein. (kitasato-u.ac.jp)
  • SCO5710 putative large Pro/Ala/Gly-rich protein 6221737:6225837 forward MW:141045 0022. (kitasato-u.ac.jp)
  • SCO2450 putative protein kinase (regulator) 2632795:2636844 forward MW:145674 0024. (kitasato-u.ac.jp)
  • SCO2259 putative multi-domain regulatory protein. (kitasato-u.ac.jp)
  • SCO6457 putative beta-galactosidase 7142206:7146129 forward MW:145522 0027. (kitasato-u.ac.jp)
  • SCO6219 putative ATP/GTP binding protein 6832135:6835920 forward MW:133958 0029. (kitasato-u.ac.jp)
  • SCO4263 putative transcriptional regulatory protein 4675582:4679337 forward MW:132620 0030. (kitasato-u.ac.jp)
  • SCO7037 putative secreted protein 7826610:7830005 forward MW:118466 0036. (kitasato-u.ac.jp)
  • SCO2672 putative membrane protein 2908366:2911707 forward MW:112750 0039. (kitasato-u.ac.jp)
  • SCO0369 putative secreted protein 373998:377255 reverse MW:117277 0043. (kitasato-u.ac.jp)
  • SCO0372 putative secreted protein 383578:386592 reverse MW:107736 0050. (kitasato-u.ac.jp)
  • SCO0505 putative multi-domain protein (fragment) 539123:542131 forward MW:108602 0051. (kitasato-u.ac.jp)
  • SCO4874 putative integral membrane protein 5303718:5306603 forward MW:99145 0060. (kitasato-u.ac.jp)
  • The valine at position 82 (ABL 84) was changed to isoleucine and the alanine at position 182 (ABL 184) was changed to valine. (lu.se)
  • Methylmalonate semialdehyde dehydrogenase deficiency is caused by mutations in this gene and the resulting protein. (wikipedia.org)
  • This is a rare autosomal recessive disorder caused by mutations in the BCKDHA gene, which encodes the alpha subunit of the branched-chain alpha-ketoacid dehydrogenase complex. (healthmatters.io)
  • The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. (wikipedia.org)
  • Reference: Trypanosoma brucei has two distinct mitochondrial DNA polymerase beta enzymes. (neb.com)
  • Remarkably, green fluorescent protein fusion proteins and immunofluorescence demonstrate that both are mitochondrial, but their locations with respect to the mitochondrial DNA (kinetoplast DNA network) in this organism are strikingly different. (neb.com)
  • Mitochondrial defects associated with beta-alanine toxicity: relevance to hyper-beta-alaninemia. (healthmatters.io)
  • Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases). (umbc.edu)
  • As a result, GABA is not properly broken down, so this neurotransmitter and another molecule called beta-alanine accumulate abnormally in brain cells. (medlineplus.gov)
  • which means both copies of the gene in each cell have mutations. (medlineplus.gov)
  • Mutations of alpha-spectrin are associated with recessive forms of HS, whereas mutations of beta-spectrin occur in autosomal dominant forms of HS. (medscape.com)
  • 2, 3, 4] Mutations in at least 11 genes that play a role in regulating beta-cell insulin secretion have been implicated in the pathogenesis of HI. (medscape.com)
  • Mutations involving the alpha-spectrin beta-spectrin gene also occur, each resulting in spectrin deficiency. (medscape.com)
  • Several other beta-spectrin mutations have been identified. (medscape.com)
  • Some of these mutations result in impaired beta-spectrin synthesis. (medscape.com)
  • The difference can be attributed to the methyl group of the alanine residue clashing with a critical carboxyl group in the gammaC hole but being accommodated in the roomier betaC hole where the equivalent carboxyl is situated more flexibly. (rcsb.org)
  • Others produce unstable beta-spectrins or abnormal beta-spectrins that do not bind to ankyrin and undergo proteolytic degradation. (medscape.com)
  • HS is described in patients with translocation of chromosome 8 or deletion of the short arm of chromosome 8, where the ankyrin gene is located. (medscape.com)
  • The rate of glucose entry into the beta cell is facilitated by a glucose transporter, and the entry rate exceeds the oxidation rate of glucose. (medscape.com)
  • Taurine and β-alanine share the same skeletal muscle transporter, whereby β-alanine can inhibit taurine's uptake into muscle. (healthmatters.io)
  • The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
  • Farnesyltransferase is a dimer, composed of an alpha and beta subunit and requires Mg 2+ and Zn 2+ ions as cofactors. (guidetopharmacology.org)
  • For this reason, supplementation with β-alanine is sometimes used to enhance carnitine and therefore improve athletic performance. (healthmatters.io)
  • Also, other proteins which involved in the same pathway with IL10RB were listed below. (creativebiomart.net)
  • Each pathway is defined by a set of rules based on individual steps or genes. (lbl.gov)
  • Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
  • Upon searching the nearly completed genome data base of the related parasite Trypanosoma brucei, we discovered genes for two pol beta-like proteins. (neb.com)
  • Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction ). (wikidoc.org)
  • GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. (lbl.gov)
  • β-alanine is a breakdown product of carnosine and anserine, which are dipeptides from meat consumption. (healthmatters.io)
  • Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by beta-alanine transamination. (healthmatters.io)
  • Levels may be elevated in meat consumption when dipeptides anserine and carnosine are elevated since they both contain β-alanine. (healthmatters.io)
  • High (millimolar) concentrations of the histidine containing dipeptide - carnosine (β-alanine-L-histidine) are present in the skeletal muscle. (frontiersin.org)
  • Pretreatment of murine myoblast (C2C12) cells with octyl-D-carnosine or carnosine enhanced HIF-1α protein expression, VEGF mRNA levels and VEGF release under hypoxic conditions. (frontiersin.org)
  • Carnosine (β-alanine-histidine) is an endogenous histidyl dipeptide, present in high concentration in the skeletal muscle (1-20 mM), heart (0.1-1 mM), and brain (1-2 mM). (frontiersin.org)
  • Given their limited diets, vegetarians and vegans have lower levels of β-alanine and muscle carnosine compared to omnivores. (healthmatters.io)
  • Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized? (healthmatters.io)
  • Since β-alanine comes from meat consumption, endogenous production is the only source in vegetarian and vegan populations. (healthmatters.io)
  • BCAA supplements contain Beta-Alanine, HMB (beta-hydroxy-beta-methylbutyrate), l-lysine, etc., which help retain skeletal muscle and curtail muscle catabolism aiding your post-workout recovery. (twinlab.com)
  • There is also an interesting interplay between taurine and β-alanine. (healthmatters.io)
  • Elevated beta-alanine can sometimes deplete taurine leading to oxidative stress, causing tissue damage. (healthmatters.io)
  • Elevated β-alanine can contribute to renal wasting of taurine. (healthmatters.io)
  • The reports on base sequences of spider silk protein genes have gained importance as the mechanical properties of silk fibers have been revealed. (bioone.org)
  • A pCb plasmid encoding a beta-lactamase from Haemophilus ducreyi was transferred to Escherichia coli, purified, and characterized. (lu.se)
  • Moreover, a crystal structure of AHRPam complexed with fragment D from human fibrinogen shows that AHRPam binds exclusively to the beta-chain hole and, unlike GHRPam, not at all to the homologous gamma-chain hole. (rcsb.org)
  • The mature protein that this gene translates in humans is 503 amino acids long, which is similar to other enzymes of this family, which all comprise around 500 amino acids. (wikipedia.org)
  • Additionally, enzymes and micro-nutrients are likewise assembled as these nutrients serve to abet and catalyze the assembling of amino acids and proteins. (scalarlight.com)
  • The mRNA expression levels of this gene are highest in the kidney and liver, although mRNA levels have been found in many other tissues. (wikipedia.org)
  • Kidney failure or failure - it is thought that steroids damage the kidneys due to increased levels of protein and other hormones (proteins). (lexingtonplaceassistedliving.com)
  • Subsequently, to check gene expression between experimental AO-infested ESB tissues and uninfested ESB tissues (gills and head kidney) RNA-seq was adopted. (esb2017.org)
  • The RNA-seq revealed a number of differentially expressed genes (DEG), particularly 679 upregulated genes and 360 downregulated genes within the gills, and 206 upregulated genes and 170 downregulated genes in head kidney. (esb2017.org)
  • Adjustments within the expression of innate immune genes in gills and head kidney at 2, 3, 5, 7 and 23 dpi have been analysed utilizing real-time PCR. (esb2017.org)
  • This now enables investigation of how parameters such as clonal expansion relate to gene expression phenotypes [ 28 ], thereby providing novel insights not accessible by bulk sequencing (e.g. (nature.com)
  • A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. (edu.sa)
  • SCO6428 hypothetical protein 7097567:7104511 reverse MW:242150 0007. (kitasato-u.ac.jp)
  • SCO6220 hypothetical protein SC2H4.02 6836057:6842608 forward MW:233391 0011. (kitasato-u.ac.jp)
  • SCO6626 hypothetical protein SC1F2.23 7348537:7353210 forward MW:169206 0016. (kitasato-u.ac.jp)
  • SCO6432 hypothetical protein 7111866:7116089 forward MW:148817 0021. (kitasato-u.ac.jp)
  • SCO6348 hypothetical protein SC3A7.16c 7006807:7010892 reverse MW:144986 0023. (kitasato-u.ac.jp)
  • SCO2975 hypothetical protein SCE50.03 3236736:3240773 forward MW:135331 0025. (kitasato-u.ac.jp)
  • SCO6572 hypothetical protein SC3F9.07 7275867:7279583 forward MW:133432 0031. (kitasato-u.ac.jp)
  • SCO6431 hypothetical protein 7108264:7111779 forward MW:126560 0034. (kitasato-u.ac.jp)
  • SCO0072 hypothetical protein 60740:64093 reverse MW:119295 0038. (kitasato-u.ac.jp)
  • SCO4250 hypothetical protein SCD8A.23 4656900:4660235 forward MW:103694 0040. (kitasato-u.ac.jp)
  • SCO5271 hypothetical protein 5731309:5734599 forward MW:117582 0041. (kitasato-u.ac.jp)
  • SCO6994 hypothetical protein SC8F11.20c. 7762852:7766112 reverse MW:113220 0042. (kitasato-u.ac.jp)
  • SCO5717 hypothetical protein SC3C3.03c 6233478:6236729 reverse MW:112052 0044. (kitasato-u.ac.jp)
  • SCO0069 hypothetical protein 56225:59383 forward MW:114192 0046. (kitasato-u.ac.jp)
  • SCO0335 hypothetical protein 336333:339467 forward MW:111223 0047. (kitasato-u.ac.jp)
  • SCO4331 hypothetical protein SCD12A.14 4742776:4745904 forward MW:110720 0048. (kitasato-u.ac.jp)
  • SCO5842 hypothetical protein SC9B10.09 6394529:6397648 forward MW:107570 0049. (kitasato-u.ac.jp)
  • SCO4548 hypothetical protein 4964060:4967068 forward MW:105802 0052. (kitasato-u.ac.jp)
  • SCO0305 hypothetical protein 299213:302092 forward MW:106033 0061. (kitasato-u.ac.jp)
  • SCO4254 hypothetical protein SCD8A.27 4663248:4666118 forward MW:101164 0062. (kitasato-u.ac.jp)
  • SCO2116 hypothetical protein 2273596:2276427 forward MW:100732 0063. (kitasato-u.ac.jp)
  • Both proteins, when expressed recombinantly, are active as DNA polymerases and deoxyribose phosphate lyases, but their polymerase activity optima differ with respect to pH and KCl and MgCl2 concentrations. (neb.com)
  • Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9). (gmawarriorsupplements.com)
  • Most protein supplements also contain peptides that enable blood flow to your muscles, so it's best take them as soon as you complete your workout. (twinlab.com)
  • Whey protein also contains peptides that can improve blood flow to your muscles. (estilo-tendances.com)
  • This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. (creativebiomart.net)
  • Chromosome 5 is the 5th largest human chromosome, yet has one of the lowest gene densities . (wikidoc.org)
  • The following are some of the gene count estimates of human chromosome 5. (wikidoc.org)
  • The following is a partial list of genes on human chromosome 5. (wikidoc.org)
  • Impaired gall bladder motility was evident in patients with beta- thalassaemia and it may be related to disease duration, serum ferritin and total serum bilirubin level. (who.int)
  • Toward understanding the immune mechanism(s) that prevents patients with RRP from clearing or controlling their HPV infection, we previously performed a paired messenger RNA (mRNA) microarray study that characterized the repertoires of genes expressed in papillomas versus those expressed by autologous clinically normal laryngeal tissues ( 6 ). (biomedcentral.com)
  • I published the first report of plant ER reticulon protein interactors by Co-IP and FRET-FLIM. (brookes.ac.uk)
  • Heterozygotes for alpha-spectrin defects produce sufficient normal alpha-spectrin to balance normal beta-spectrin production. (medscape.com)
  • Defects of beta-spectrin are more likely to be expressed in the heterozygous state because synthesis of beta-spectrin is the rate-limiting factor. (medscape.com)
  • The proteins are subsequently secreted into the glandular lumen where they are stored until extrusion. (bioone.org)
  • Because it is thought to increase intramuscular buffering capacity, beta-alanine is a common ingredient in sports supplements that are used to improve athletic performance. (consumerhealthdigest.com)