• Heme oxygenase, or haem oxygenase, (HMOX, commonly abbreviated as HO) is an enzyme that catalyzes the degradation of heme to produce biliverdin, ferrous ion, and carbon monoxide. (wikipedia.org)
  • Heme oxygenase (alternatively spelled using haem or oxidase) catalyzes the degradation of heme to biliverdin/bilirubin, ferrous ion, and carbon monoxide. (wikipedia.org)
  • Heme oxygenase 1 (HMOX1, commonly HO-1) is a member of the heat shock protein (HSP) family identified as HSP32. (wikipedia.org)
  • Heme oxygenase 2 (HMOX2 or HO-2) is a constitutive isoform that is expressed under homeostatic conditions in the testes, gastrointestinal tract, endothelial cells and the brain. (wikipedia.org)
  • A controversial third heme oxygenase (HO-3) is considered to be catalytically inactive and has been speculated to work in heme sensing or detoxification. (wikipedia.org)
  • Heme oxygenase is conserved across phylogenetic kingdoms. (wikipedia.org)
  • Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. (nih.gov)
  • Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. (nih.gov)
  • Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. (nih.gov)
  • HMOX1 and HMOX2 belong to the heme oxygenase family. (nih.gov)
  • Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism. (nih.gov)
  • Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation. (nih.gov)
  • Hypoxia-induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase-1 in multiple myeloma. (nih.gov)
  • Association between heme oxygenase one and sepsis development in patients with moderate-to-critical COVID-19: a single-center, retrospective observational study. (nih.gov)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • Heme oxygenase (HO)-1 is a stress-inducible enzyme protecting cells against oxidative stress, and mechanisms have been considered to depend exclusively on its enzyme activity. (elsevierpure.com)
  • The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. (tmu.edu.tw)
  • Recombinant protein encompassing a sequence within the center region of human Heme Oxygenase 1. (genetex.com)
  • Wild-type (WT) and Heme Oxygenase 1 knockout (KO) HeLa cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Heme Oxygenase 1 antibody (GTX101147) diluted at 1:500. (genetex.com)
  • Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at endoplasmic reticulum and nucleus by immunofluorescent analysis. (genetex.com)
  • Green: Heme Oxygenase 1 stained by Heme Oxygenase 1 antibody (GTX101147) diluted at 1:500. (genetex.com)
  • Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at cytoplasm on human renal carcinoma by immunohistochemical analysis. (genetex.com)
  • Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Heme Oxygenase 1 antibody (GTX101147) diluted at 1:1500. (genetex.com)
  • Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at cytoplasm by immunohistochemical analysis. (genetex.com)
  • Both conditions can be accompanied by decreased levels of heme oxygenase-1 (HMOX1), cytoprotective, heme-degrading enzyme. (hindawi.com)
  • On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer-NRF2. (hindawi.com)
  • The researchers applied hemin, an inducer of heme oxygenase-1 (HO-1), to increase nitric oxide production. (isaaa.org)
  • Rat lung metallothionein and heme oxygenase gene expression following ozone and zinc oxide exposure. (cdc.gov)
  • Heme-oxygenase (HO) mRNA values returned to control levels 24 hours after exposure. (cdc.gov)
  • The presence of heme-oxygenase and biliverdin reductase in human cranial ganglia indicates a role for carbon monoxide in neural transmission. (nel.edu)
  • HO-1, the inducible isoform of heme oxygenase, gave only very weak immunoreactivity in all ganglia examined. (nel.edu)
  • Heme oxygenase-1 (HO-1), intercellular adhesion molecule-1 (ICAM-1) and matrix metalloproteinase-1 (MMP-1) are reported to be UVA1/UVB radiation-inducible genes. (nutraingredients.com)
  • Sequence analysis of HFE, beta2M, and both human heme oxygenase genes failed to identify any causal mutations in nuclear NH families but our study points to the existence of a cohort of patients likely to suffer from an autosomal recessive trait. (nih.gov)
  • HO-1 is a 32kDa enzyme which contains 288 amino acid residues encoded by the HMOX1 gene. (wikipedia.org)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The 37-Mb genome was predicted to contain a total of 12,074 genes encoding proteins with a length greater than 100 amino acid residues (see Methods). (nature.com)
  • Because only about 1% of the genome actually codes for genes that end up making proteins. (thenakedscientists.com)
  • Keap1 may be viewed as the regulator of Nrf2, and reactive species/free radicals and electrophiles react with the Nrf2-Keap1 complex causing the release of Nrf2, which migrates to the cell nucleus and triggers the expression of selected genes whose products, i.e. proteins with or without enzymatic activity, participate in the antioxidant defense and in the metabolism of xenobiotics in mammals. (databasefootball.com)
  • IMPORTANCE Human cytomegalovirus (HCMV) is an opportunistic pathogen that owes part of its success to the capture, duplication, and tuning of cellular genes to generate modern viral proteins which promote infection and persistence in the host by interfering with many cell biochemical and physiological pathways. (bvsalud.org)
  • The enzyme β-carotene 9',10'-oxygenase (BCO2), which catalyzes asymmetric cleavage of several carotenoids, is the principal regulator of lycopene metabolism, but the range of BCO2 biological functions is incompletely understood. (nih.gov)
  • Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. (nih.gov)
  • Fig. 1: Extent of characterization of the Rieske oxygenase enzyme superfamily. (nature.com)
  • nidA and nidB genes are encoding genes for large and small subunits of napthalene-inducible dioxygenase [ 7 , 8 ]. (omicsonline.org)
  • One approach is based on the stimulation of a specific inducible stress protein known as haem oxygenase-1 (HO-l), which may act by producing antioxidant, anti-inflammatory and cytoprotective molecules. (ucl.ac.uk)
  • The intron/exon structure is highly conserved in relation to the clofibrate inducible genes CYP4A1, CYP4A2, and CYP4A6. (dundee.ac.uk)
  • The sequence divergence within the class presents a challenge in assigning one of these functions to a given Rieske oxygenase, let alone predict the substrate, site of reactivity, or type of reaction (Fig. 1a ). (nature.com)
  • a Sequence similarity network of Rieske oxygenases (Pfam PF00355) generated by the EFI-EST 59 server at an E-value of 5 and alignment score of 65, visualized in Cytoscape v3.7.1 60 . (nature.com)
  • The blocks of A. oryzae -specific sequence are enriched for genes involved in metabolism, particularly those for the synthesis of secondary metabolites. (nature.com)
  • Jendrossek, D. and Reinhardt, S. Sequence analysis of a gene product synthesized by Xanthomonas sp. (enzyme-database.org)
  • The isolated gene, CYP4A4, encodes a protein that differs at one amino acid position from the predicted sequence of a previously isolated cDNA. (dundee.ac.uk)
  • Like other CYP4A genes the CYP4A4 promoter does not contain a TATA consensus sequence. (dundee.ac.uk)
  • They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). (bvsalud.org)
  • Studies of human umbilical vein endothelial cells (HUVEC) and arterial endothelial cells (HAEC) showed that therapeutically relevant concentrations of MTX phosphorylate AMPKα Thr172 , and induce cytoprotective genes including manganese superoxide dismutase (MnSOD) and haem oxygenase-1 (HO-1). (bmj.com)
  • We found a highly transcribed gene cluster encoding a presumed anaerobic benzene carboxylase (AbcA and AbcD) and a benzoate-coenzyme A ligase (BzlA). (deltares.nl)
  • Moreover, a dioxygenase gene, nidA3B3, was detected in Mycobacterium vanbaalenii PYR-1 as an alternate degradation pathway which could catalyze both the initial dihydroxylation of pyrene [ 11 ] to be pyrene cis-4,5-dihydrodiol, and an alternate detoxification pyrene pathway to be pyrene cis-1,2-dihydrodiol [ 12 ]. (omicsonline.org)
  • On top of that, as part of the photo-aging process we have evidence of the effect of our ingredients on the levels of expression of genes involved in collagen degradation, suggesting a link not only to skin health but also to skin appearance. (nutraingredients.com)
  • In this study, we report transcription of genes involved in aerobic and anaerobic benzene degradation pathways in a benzene-degrading denitrifying continuous culture. (deltares.nl)
  • 96% amino acid identity and similar gene order to the corresponding benzene degradation gene cluster described previously, providing further evidence for anaerobic benzene activation via carboxylation. (deltares.nl)
  • For subsequent benzoyl-CoA dearomatization, bam-like genes analogous to the ones found in other strict anaerobes were transcribed, whereas gene transcripts involved in downstream benzoyl-CoA degradation were mostly analogous to the ones described in facultative anaerobes. (deltares.nl)
  • The concurrent transcription of genes encoding enzymes involved in oxygenase-mediated aerobic benzene degradation suggested oxygen presence in the culture, possibly formed via a recently identified nitric oxide dismutase (Nod). (deltares.nl)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • CREB siRNA inhibited upregulation of both cytoprotective genes by MTX, while chromatin immunoprecipitation demonstrated CREB binding to the MnSOD promoter in MTX-treated EC. (bmj.com)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Rieske oxygenases in particular are underexplored in this regard, with only twelve available structures of different enzymes in the Protein Data Bank 21 . (nature.com)
  • Birke, J. and Jendrossek, D. Rubber oxygenase and latex clearing protein cleave rubber to different products and use different cleavage mechanisms. (enzyme-database.org)
  • The prnD gene was amplified from RajNB11, sequenced, translated, and 3-D modeled to its protein structure. (tubitak.gov.tr)
  • Indeed, deletion of the US21 gene impaired the ability of HCMV-infected cells to migrate, whereas expression of US21 protein stimulated cell migration and adhesion, as well as focal adhesion (FA) dynamics, in a way that depended on its ability to manipulate ER Ca2+ content. (bvsalud.org)
  • Here, we report the structures of two Rieske monooxygenases involved in the biosynthesis of paralytic shellfish toxins (PSTs), SxtT and GxtA, adding to the short list of structurally characterized Rieske oxygenases. (nature.com)
  • The prnABCD gene cluster codes for enzymes involved in biosynthesis of pyrrolnitrin. (tubitak.gov.tr)
  • The identification and functional characterization of 24 genes that are involved in iron homeostasis in A. fumigatus and/or Aspergillus nidulans , respectively, revealed significant insights into iron metabolism and its regulation (Table 1 ). (frontiersin.org)
  • Characterization of the gene cluster for biosynthesis of macrocyclic trichothecenes in Myrothecium roridum. (ucdenver.edu)
  • These results provided evidence that gene transfection of the activity-lacking mutant HO-1 protects cells against oxidative stress through multiple mechanisms involving up-regulation of catalase and glutathione contents. (elsevierpure.com)
  • The study's findings, published in the British Journal of Dermatology ​ ​, indicated that oral supplementation with the carotenoids changed the expression of genes that are indicators of oxidative stress, photo-dermatoses and photo-aging. (nutraingredients.com)
  • This study suggests that we are slowing down the aging process, because it prevents the damages caused by UV exposure, including expressions of genes that are biomarkers for skin photo-aging, and oxidative stress on the skin. (nutraingredients.com)
  • Therefore, we suggest that oral supplementation with lycopene-rich TNC and with lutein may be efficient in inhibiting UVA1 radiation-induced oxidative stress responses in general and gene regulatory events involved in photoaging, photocarcinogenesis and photodermatoses specifically. (nutraingredients.com)
  • The induction of target genes in the lung following exposure to occupationally relevant levels of zinc-oxide (1314132) (ZnO) and ozone (10028156) was investigated in rats. (cdc.gov)
  • Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation. (nature.com)
  • This study has revealed the involvement of TFs, transporters, and photosynthetic genes, and has also given a glimpse of hormonal cross talk under the extreme water regimes, which will aid as an important resource for soybean crop improvement. (frontiersin.org)
  • Here we show that the 37-megabase (Mb) genome of A. oryzae contains 12,074 genes and is expanded by 7-9 Mb in comparison with the genomes of Aspergillus nidulans 5 and Aspergillus fumigatus 6 . (nature.com)
  • And once we had the whole genome together, we then had to figure out where genes in the genome are. (thenakedscientists.com)
  • The expression of photosynthesis and chlorophyll synthesis related genes were significantly reduced under both types of stresses, which limit the metabolic processes and thus help prolong survival under extreme conditions. (frontiersin.org)
  • These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
  • Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
  • The inositol oxygenase gene family of Arabidopsis is involved in the biosynthesis of nucleotide sugar precursors for cell-wall matrix polysaccharides. (mpg.de)
  • Braaz, R., Fischer, P. and Jendrossek, D. Novel type of heme-dependent oxygenase catalyzes oxidative cleavage of rubber ( poly - cis -1,4-isoprene). (enzyme-database.org)
  • The prnD gene product of P. fluorescens RajNB11 that catalyzes the final step of production of pyrrolnitrin was characterized in the present study with regards to its stability and catalytic activity. (tubitak.gov.tr)
  • MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (nih.gov)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via EGFR and HIF-1α signaling. (nih.gov)
  • Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. (cancerindex.org)
  • Mutations can occur in any area of the gene. (medscape.com)
  • Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)
  • This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
  • Pathological and Prognostic Indications of the mdig Gene in Human Lung Cancer. (nih.gov)
  • Stable transfectants of rat wild type HO-1 cDNA (HO-1-U937) and those of its H25A mutant gene (mHO-1-U937) were established using human monoblastic lymphoma cell U937. (elsevierpure.com)
  • Double immunostaining revealed that in the human trigeminal ganglion HO-2 and BVR co-localized with calcitonin gene-related peptide. (nel.edu)
  • The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus' cell tropism and its evasion of host innate immune responses. (bvsalud.org)
  • [ 11 ] In the CALERIE phase 1 study, however, we demonstrated that 6 months of 25% CR in healthy human s increased the expression of genes involved in mitochondrial biogenesis and mitochondrial DNA (mtDNA) copy number. (medscape.com)
  • Therefore, Zcf29p regulates stress response probably through its control of other genes not tested in our study. (ncl.edu.tw)
  • These genes comprise 289 Transcription Factors (TFs) representing Basic Helix-loop Helix (bHLH), Ethylene Response Factors (ERFs), myeloblastosis (MYB), No apical meristem (NAC), and WRKY amino acid motif (WRKY) type major families known to be involved in the mechanism of stress tolerance. (frontiersin.org)
  • The RGM Mycobacterium obuense , an en- with 16S rRNA and 99.6% with hsp65 to the sequences vironmental pigmented mycobacterium, is mobile and eas- of M . obuense strain CIP 106803 (GenBank accession no. ily adaptable to the environment and possesses oxygenases AF547954.1). (cdc.gov)
  • However, the 5′ flanking sequences of these genes exhibit little identity. (dundee.ac.uk)
  • Oxygenases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Below are the most recent publications written about "Oxygenases" by people in Profiles. (ucdenver.edu)
  • This resulted to significant expression of several structures and regulatory genes involved in anthocyanin production. (isaaa.org)
  • Inactivation of 10 of the 19 A. fumigatus genes caused defects in virulence. (frontiersin.org)
  • To further validate the results pathway study was performed to identify the involvement of the coding genes in type II diabetes. (researchgate.net)
  • The genes obtained from this study showed a significant involvement in causing the disease, which may be used as a potential drug target. (researchgate.net)
  • The lack of effect of ozone exposure on MT and HO gene expression suggests no involvement of these genes in the acute respiratory response to this oxidant compound. (cdc.gov)
  • Distribution and expression of the genes on chromosome 1. (nature.com)
  • A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)
  • We performed amplifi- pproximately 75 species of rapidly growing mycobac- cation and sequencing of the 16S rRNA gene (498 bp) and teria (RGM) have been isolated from soil, animals, hsp65 gene (400 bp). (cdc.gov)
  • We aimed to examine whether the length of (GT) n repeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL. (tmu.edu.tw)
  • Stroke patients tended to have more proportions of hypertension, diabetics and genotype L, than those of genotype S. Patients with genotype L of HO-1 gene promoter have higher stroke risk in comparison with genotype S especially in dyslipidemia individuals. (tmu.edu.tw)
  • Subjects carrying longer (GT) n repeats in HO-1 gene promoter may have greater susceptibility to develop cerebral ischemic only in the presence of low HDL-C, suggesting the protective effects in HO-1 genotype S in the process of ischemic stroke, particularly in subjects with poor HDL-C status. (tmu.edu.tw)
  • We aimed to examine whether the length of (GT) nrepeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL. (tmu.edu.tw)
  • For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. (bvsalud.org)
  • This leads to translation of an alternative and functional open reading frame of the ATF4 gene ( atf-5 in C. elegans ) [ 20 , 21 ]. (biomedcentral.com)
  • Genomic DNA containing the entire gene encoding P450 4A4, a cytochrome P450 that is elevated during pregnancy, was isolated on two overlapping recombinant phage. (dundee.ac.uk)
  • The results were validated both by gene expression analysis and immunohistochemistry study in an independent 55 clinical samples from Fudan University Shanghai Cancer Center. (cancerindex.org)
  • In this study, differentially expressed genes (DEGs) under drought and flooding conditions were investigated using Illumina RNA-Seq transcriptome profiling. (frontiersin.org)
  • "The precise mechanism through which lycopene and lutein inhibit UVA1 radiation-induced gene expression is currently not known but most likely involves anti-oxidative mechanisms," ​wrote the researchers. (nutraingredients.com)
  • These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)