Gene inositol phosphates. Medical search. Frequent questions

In enzymology, an inositol-3-phosphate synthase (EC 5.5.1.4) is an enzyme that catalyzes the chemical reaction D-glucose 6-phosphate ⇌ {\displaystyle \rightleftharpoons } 1D-myo-inositol 3-phosphate Hence, this enzyme has one substrate, D-glucose 6-phosphate, and one product, 1D-myo-inositol 3-phosphate. (wikipedia.org)
Other names in common use include myo-inositol-1-phosphate synthase, D-glucose 6-phosphate cycloaldolase, inositol 1-phosphate synthatase, glucose 6-phosphate cyclase, inositol 1-phosphate synthetase, glucose-6-phosphate inositol monophosphate cycloaldolase, glucocycloaldolase, and 1L-myo-inositol-1-phosphate lyase (isomerizing). (wikipedia.org)
In Saccharomyces cerevisiae (Baker's yeast), the transcriptional regulation of the INO1 gene encoding inositol-3-phosphate synthase has been studied in detail and its expression is sensitive to the availability of phospholipid precursors as well as growth phase. (wikipedia.org)
The regulation of the structural gene encoding 1L-myo-inositol-1-phosphate synthase has also been analyzed at the transcriptional level in the aquatic angiosperm, Spirodela polyrrhiza (Giant duckweed) and the halophyte, Mesembryanthemum crystallinum (Common ice plant). (wikipedia.org)
In prokaryotes, myo-D-inositol phosphate synthase was discovered by Bachhawat and Mande in 1999 (reported in Journal of Molecular Biology). (wikipedia.org)
Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme. (wikipedia.org)
1594\1533\BAB40956.2\Avena sativa\Avena sativa MIP mRNA for myo-inositol-1-phosphate synthase,complete cds. (or.jp)
Nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate-oxidase (NOX) enzymes play an important role in Dox-induced production of ROS [ 15 ]. (oncotarget.com)
2 ]. The genes were myo -inositol-1-phosphate synthase (Ino1) from Saccharomyces cerevisiae , myo -inositol oxygenase (MIOX) from Mus musculus , and uronate dehydrogenase (UDH) from Pseudomonas syringae . (biomedcentral.com)

This enzyme participates in streptomycin biosynthesis and inositol phosphate metabolism. (wikipedia.org)
At T1, the significantly more abundant enzyme-coding genes were related to threonine metabolism and those genes related to the glycolytic pathway, explained by the abundance of sugars in the medium. (frontiersin.org)
At T2, the genes linked to the metabolism of ceramides and hopanoids lipids were clearly dominant, which are associated with the resistance of microbial species to extreme temperatures and pH values. (frontiersin.org)
In T3, genes linked to trehalose metabolism, related to the response to heat stress, dominated. (frontiersin.org)
Genes coding for defense-related transcription activators, reactive oxygen species metabolism, terpene biosynthesis, and energy conversion pathways were upregulated in inoculated samples of L. dendroidea , indicating an integrated defensive system in seaweeds. (asm.org)
Analysis of weighted co-regulatory networks in maize provides insights into new genes and regulatory mechanisms related to inositol phosphate metabolism. (caas.cn)
The results of this study provide a first look at changing gene expression patterns in human blood during an acute rise in blood ethanol concentration and its depletion because of metabolism and excretion, and demonstrate that it is possible to detect changes in gene expression using total RNA isolated from whole blood. (biomedcentral.com)
Under the scenario of a defective cellular energy metabolism, any process that results in a decrease in the level of ATP impairs the performance of secondary active transport mechanisms, such as those of glucose, phosphate, or amino acids. (medscape.com)
The rice OsLpa1 gene encodes a novel protein involved in phytic acid metabolism , 2008, Theor Appl Genet. (github.io)

Nucleotide divergence among the different Oryza and Porteresia INO1 genes were calculated and compared. (uky.edu)

Two new PcINO1 genes, with characteristic promoter activity and upstream cis-elements were identified and cloned, but whether these proteins can be translocated to the chloroplast or not is yet to be ascertained. (uky.edu)
Acid phosphatases are a heterogeneous group of proteins that hydrolyse phosphate esters, optimally at low pH. (embl.de)
The catalytic functions of these proteins include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. (embl.de)
Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
Pasteurella multocida toxin (PMT, produced by Pasteurella multocida ) offers the possibility to discriminate between Gα q and Gα 11 proteins, since it stimulates inositol phosphate formation in a strictly Gα q -dependent manner. (sigmaaldrich.com)

Recently, we reported that functional wheat inositol penta kis phosphate kinase ( TaIPK1 ) is involved in PA biosynthesis, however, the functional roles of the IPK1 gene in wheat remains elusive. (frontiersin.org)
Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with amyotrophic lateral sclerosis. (nih.gov)
Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. (nih.gov)
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. (nih.gov)
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. (nih.gov)
Introduction: CDKN1B gene, which encodes a cyclin-dependent kinase (Cdk) inhibitor, regulates the progression throughout G1 to S cell cycle progression. (endocrine-abstracts.org)

However, in human follicular cells and in rat FRTL-5 cells, TSH can also stimulate the β-isoforms of PLC that catalyzes the hydrolysis of phosphatidyl-inositol 4,5-phosphate, yielding the second messengers DAG and inositol 1,4,5-phosphate facil. (endocrine-abstracts.org)
Inositol monophosphatase (IMPase) catalyses the hydrolysis of inositol monophosphate to inositol and is crucial in the phosphatidylinositol (PI) signalling pathway. (ox.ac.uk)

This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). (nih.gov)

It is well established that most TSH effects on the thyroid gland, including stimulation of proliferation, thyroid hormone synthesis and expression of thyroid-specific genes, are transmitted mainly by the adenylate cyclise pathway. (endocrine-abstracts.org)
UNC7844 inhibits several kinases in the inositol (pyro)phosphate pathway, including IP6K and IPMK, in a low nanomolar range. (nih.gov)
We then constructed the biosynthesis pathway of d -glucaric acid in S. cerevisiae INVSc1 opi1Δ and obtained two engineered strains, LGA-1 and LGA-C, producing record-breaking titers of d -glucaric acid: 9.53 ± 0.46 g/L and 11.21 ± 0.63 g/L d -glucaric acid from 30 g/L glucose and 10.8 g/L myo -inositol in fed-batch fermentation mode, respectively. (biomedcentral.com)
Candidate genes showing distinctive expression patterns in response to ethanol were clustered by pattern and further analyzed for related function, pathway membership and common transcription factor binding within and across clusters. (biomedcentral.com)
Network and pathway-based approaches have become one of the most promising methods to understand drivers due to their ability to model gene-gene interactions by aggregating small effect sizes from individual genes. (biomedcentral.com)
Namely, the natural polyol Inositol (and its phosphate derivatives) is investigated thoroughly, given that inositol showed to modulate epithelial-mesenchymal transition (EMT vs MET) by targeting the expression of several genes, the activation of the PI3K pathway, as well as the apoptotic process. (sbglab.org)
Each pathway is defined by a set of rules based on individual steps or genes. (lbl.gov)

EC 5.5.1.4) has been identified by matrix-assisted laser desorption time-of-flight mass spectrometry analysis of the purified and immunologically cross-reactive approximately 60 kDa chloroplastic protein following two-dimensional polyacrylamide gel electrophoresis, which exhibited sequence identity with the cytosolic MIPS coded by OsINO1-1 gene. (uky.edu)
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. (nih.gov)
The gene oo18 RNA-binding protein is referred to in FlyBase by the symbol Dmel\orb (CG10868, FBgn000. (yeastrc.org)
691\621\BAA25433.1\Avena sativa\Avena sativa gene for auxin-binding protein, complete cds. (or.jp)
This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. (creativebiomart.net)
7.Liu X, Yang W, Li Y, Li S, Zhou X, Zhao Q, Fan Y, Lin M, Chen R*. The intergenic region of the maize defensin-like protein genes Def1 and Def2 functions as an embryo-specific asymmetric bidirectional promoter. (caas.cn)
ATP + a protein tyrosine = ADP + protein tyrosine phosphate. (lu.se)

The interaction network of all identified differentially expressed genes and metabolites was constructed to outline the regulatory genes and dominant pathways in response to acid stress. (springeropen.com)
The statistical evaluation of the most abundant genes in each group and time studied allowed us to identify the potential metabolic pathways involved in the success of the different microorganisms. (frontiersin.org)
Transcriptomic changes in L. dendroidea in the presence of V. madracius include the upregulation of genes that participate in signaling pathways described here for the first time as a response of seaweeds to microbes. (asm.org)
According to Dr. Shamsuddin, when IP6 is administered it is rapidly taken into the cells and dephosphorylated to lower inositol phosphates, which further affect signal transduction pathways. (naturalnews.com)
There are several recent methods that use additional information to help predict driver genes and driver pathways. (biomedcentral.com)
Other methods such as PARADIGM-Shift are designed to determine drivers in small pathways and often require detailed previous knowledge of specific pathways and focus genes to operate effectively. (biomedcentral.com)
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. (genome.jp)

This gene encodes a member of the annexin family. (creativebiomart.net)
The thick aleurone1 Gene Encodes a NOT1 Subunit of the CCR4-NOT Complex and Regulates Cell Patterning in Endosperm. (caas.cn)

Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. (embl.de)
Lignocellulose is a preferable substrate over myo -inositol. (biomedcentral.com)
AtSAL1 phosphatase activity is suppressed by dimerization, intramolecular disulfide formation, and glutathionylation, allowing accumulation of its substrate, PAP, a chloroplast stress retrograde signal that regulates expression of plastid redox associated nuclear genes (PRANGs). (nih.gov)

QTLs and candidate genes detected in our study for yield-related traits under stripe rust stress will facilitate elucidating genetic basis of yield-related trait and could be used in marker-assisted selection in wheat yield breeding. (biomedcentral.com)
The candidate genes of interest (GOI) identified from the microarray analysis and clustered by expression pattern across the five BAC points showed seven coordinately expressed groups. (biomedcentral.com)

A phosphate group at the C1-atom of inositol-monophosphate (IMP) and fructose-1,6-bisphosphate (FBP) is hydrolyzed by a phosphatase IMPase and FBPase in a metal-dependent way, respectively. (rcsb.org)

A biosynthesis route from d -glucose to d -glucaric acid involving three heterologous genes was constructed in recombinant Escherichia coli by Moon et al. (biomedcentral.com)

Yeast constitutive and repressible acid phosphatases (genes PHO3 and PHO5). (embl.de)

Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). (endocrine-abstracts.org)
The Mediator subunit OsMed15a is a transcriptional co-regulator of seed size/weight-modulating genes in rice. (nipgr.ac.in)

Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens. (ox.ac.uk)

Escherichia coli pH 2.5 acid phosphatase (gene appA). (embl.de)

In addition, we identify a third critical component of the jasmonate co-receptor complex, inositol pentakisphosphate, which interacts with both COI1 and JAZ adjacent to the ligand. (nature.com)
Identification of an inositol pentakisphosphate cofactor in COI1. (nature.com)

The mechanism of glucose 6-phosphate-D-myo-inositol 1-phosphate cyclase of rat testis. (wikipedia.org)
E. coli glucose-1-phosphatase ( EC 3.1.3.10 ) (gene agp). (embl.de)
The diagnosis of Fanconi syndrome is made based on tests that document the excessive loss of substances in the urine (eg, amino acids, glucose, phosphate, bicarbonate) in the absence of high plasma concentrations. (medscape.com)

3.Zhang L, Luo Y, Liu B, Zhang L, Zhang W, Chen R, Wang L. Overexpression of the maize γ-tocopherol methyltransferase gene (ZmTMT) increases α-tocopherol content in transgenic Arabidopsis and maize seeds. (caas.cn)

As inositol undergoes a complex metabolic transformation inside the cell, an in depth metabolomic study is currently ongoing to evaluate its metabolic fate. (sbglab.org)

The gene cornichon is referred to in FlyBase by the symbol Dmel\cni (CG5855, FBgn0000339). (yeastrc.org)
The gene Fmr1 is referred to in FlyBase by the symbol Dmel\Fmr1 (CG6203, FBgn0028734). (yeastrc.org)
The gene baiser is referred to in FlyBase by the symbol Dmel\bai (CG11785, FBgn0045866). (yeastrc.org)
The gene skittles is referred to in FlyBase by the symbol Dmel\sktl (CG9985, FBgn0016984). (yeastrc.org)
The gene par-1 is referred to in FlyBase by the symbol Dmel\par-1 (CG8201, FBgn0260934). (yeastrc.org)
The gene glorund is referred to in FlyBase by the symbol Dmel\glo (CG6946, FBgn0259139). (yeastrc.org)
The gene krimper is referred to in FlyBase by the symbol Dmel\krimp (CG15707, FBgn0034098). (yeastrc.org)
The gene growl is referred to in FlyBase by the symbol Dmel\growl (CG14648, FBgn0037245). (yeastrc.org)
The gene gurken is referred to in FlyBase by the symbol Dmel\grk (CG17610, FBgn0001137). (yeastrc.org)
The gene female sterile (1) K10 is referred to in FlyBase by the symbol Dmel\fs(1)K10 (CG3218, FBgn0. (yeastrc.org)
The gene Kinesin heavy chain is referred to in FlyBase by the symbol Dmel\Khc (CG7765, FBgn0001308). (yeastrc.org)
The gene Lissencephaly-1 is referred to in FlyBase by the symbol Dmel\Lis-1 (CG8440, FBgn0015754). (yeastrc.org)
The gene tsunagi is referred to in FlyBase by the symbol Dmel\tsu (CG8781, FBgn0033378). (yeastrc.org)
The gene slalom is referred to in FlyBase by the symbol Dmel\sll (CG7623, FBgn0038524). (yeastrc.org)
The gene snake is referred to in FlyBase by the symbol Dmel\snk (CG7996, FBgn0003450). (yeastrc.org)
The gene short gastrulation is referred to in FlyBase by the symbol Dmel\sog (CG9224, FBgn0003463). (yeastrc.org)
The gene spatzle is referred to in FlyBase by the symbol Dmel\spz (CG6134, FBgn0003495). (yeastrc.org)
gene symbol (e.g. (genscript.com)

This compound also significantly inhibits liver infection in mice infected with MHV accompanied by reduced expression of inflammatory and fibrosis genes. (nih.gov)

Phytic acid ( myo -inositol hexa kis phosphate, PA, IP 6 ) is one of the major anti-nutritional component in grains of wheat, rice, soybean, and other crops, that limit the bioavailability of micronutrients. (frontiersin.org)

Inositol phosphates play an important role in signal transduction. (wikipedia.org)

Using culture medium supplemented with CFS (pH 3.6) or lactic acid (pH 3.6) at a 1:1 ratio, 677 differentially transcribed genes and 374 metabolites were detected in G. anatis . (springeropen.com)

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. (uky.edu)

The reaction this enzyme catalyses represents the first committed step in the production of all inositol-containing compounds, including phospholipids, either directly or by salvage. (wikipedia.org)
The modulatory role of natural pharmacological compounds (like inositol, melatonin and α-lipoic acid) is under scrutiny to evaluate is such nutraceutical manipulation can improve the oocyte maturation process. (sbglab.org)

The organism (and its development) is currently considered an epiphenomenon of its genes. (sbglab.org)

Up to 4.85 g/L of d -glucaric acid was produced from 10.8 g/L myo -inositol in recombinant E. coli [ 4 ]. (biomedcentral.com)

2.Li Y, Liu X, Chen R, Tian J, Fan Y, Zhou X. Genome-scale mining of root-preferential genes from maize and characterization of their promoter activity. (caas.cn)

A key question in cancer genomics is the identification of driver genes. (biomedcentral.com)

The present study used shotgun metagenomics to determine the enzyme-coding genes of the microbiota found in two different groups of cocoa beans varieties during the fermentation process. (frontiersin.org)
Changes in the microbiota enzyme-coding genes over time pointed to the distinct ordering of fermentation at 24-48 h (T1), 72-96 h (T2), and 120-144 h (T3). (frontiersin.org)

βγ Dimers are heterogeneous and encoded in five β and thirteen γ genes. (sigmaaldrich.com)

NewsTarget) Three recent studies have confirmed the role of inositol hexaphosphate (IP6) in cancer prevention and control of experimental tumor growth. (naturalnews.com)
Drs. Kim Vanderlinden and Ivana Vucenik describe what is presently known about how IP6 works to help normalize the rate of cell division, normalize cell physiology, enhance Natural Killer (NK) cells, increase tumor suppressor P53 gene activity, inhibit inflammation, and inhibit angiogenesis. (naturalnews.com)
Modulation of EMT is also at the core of the gene reprogramming that occur during tumor reversion . (sbglab.org)

Many studies demonstrated that somatic BRAF gene mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma (PTC), even from very small samples. (endocrine-abstracts.org)

Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. (bvsalud.org)

α Subunits are encoded in 15 genes and several transcripts are alternatively spliced (five α s , two α i2 , two α o forms). (sigmaaldrich.com)

Bioinformatic analysis mapped the chloroplastic MIPS (OsINO1-1) gene on chromosome 3, and a second MIPS gene (OsINO1-2) on chromosome 10 which lacks conventional chloroplast transit peptide sequence as in OsINO1-1. (uky.edu)

Here we identify the 3'-phosphoadenosine 5'-phosphate (PAP) phosphatase SAL1 as a previously unidentified and conserved oxidative stress sensor in plant chloroplasts. (nih.gov)

Subsequently, a new steady state is reached whereby the amount of phosphate present in the urine closely matches the intake. (medscape.com)

A possible chloroplastic transit peptide sequence was identified upstream of the OsINO1-1 gene upon analysis of rice genome. (uky.edu)

There have been significant advances in the genetic epidemiology of lung function, but the causal genetic variants and causal genes, and the mechanisms by which they influence lung function, chronic obstructive pulmonary disease (COPD) and other respiratory diseases remain incompletely understood. (nottingham.ac.uk)

The change of aminoacid Arginine (CGG) to Glutamine (CAG) at position 171 (R171Q) in the MEN1 gene has been occasionally reported in MEN1 carriers, but also in 1.4 to 5% subjects among the general population, therefore it is still unclear whether it might represent a polymorphism and/or it has a role in tumourigenesis. (endocrine-abstracts.org)

Rickets in children or osteomalacia in adults is the result of the excessive urinary losses of calcium and phosphate and of a defect in the hydroxylation of 25-hydroxyvitamin D3 into 1,25-dihydroxyvitamin D3. (medscape.com)
No defect is apparent in intestinal reabsorption of phosphate in Fanconi syndrome. (medscape.com)

Introgression of Bacterial Blight Resistance Genes in the Rice Cultivar Ciherang: Response against Xanthomonas oryzae pv. (mdpi.com)

The amplified cDNA was used in microarray and quantitative real-time polymerase chain reaction (RT-qPCR) analyses to evaluate differential gene expression. (biomedcentral.com)

For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)

In this study, RNAi-mediated gene silencing was performed for IPK1 transcripts in hexaploid wheat. (frontiersin.org)

A comprehensive evaluation of potential lung function associated genes in the spirometa general population sample. (nottingham.ac.uk)

Are there any known genetic variations or mutations in the ANXA3 gene? (creativebiomart.net)
Yes, genetic variations and mutations in the ANXA3 gene have been reported. (creativebiomart.net)

Schizosaccharomyces pombe acid phosphatase (gene pho1). (embl.de)
The opi1 gene was knocked out because of its negative regulation on myo -inositol synthesis, which is the limiting step of d -glucaric acid production by S. cerevisiae . (biomedcentral.com)
Moreover, an N-terminal small ubiquitin-related modifier (SUMO) fusion to MIOX gave rise to a 75% increase in d -glucaric acid production from myo -inositol. (biomedcentral.com)
Lysophosphatidic acid (LPA) consists of an acyl chain at the sn-1 (or sn-2) position of a glycerol backbone and a phosphate head group. (hindawi.com)

The seaweed RNA was sequenced, providing an unprecedentedly high coverage of the transcriptome of Laurencia , and the gene expression levels were compared between control and inoculated samples after 24, 48, and 72 h. (asm.org)

Anatomy16

Organisms12

Diseases1

Chemicals and Drugs183

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes29

Technology, Industry, Agriculture1

Information Science3

Synthase9

Metabolism9

INO11

Proteins5

Kinase6

Hydrolysis2

Hexakisphosphate1

Pathway7

Protein7

Pathways7

Encodes2

Substrate3

Candidate genes2

Monophosphate1

Biosynthesis1

Phosphatases1

Subunit2

Monophosphatase1

Escherichia1

Pentakisphosphate2

Glucose3

Arabidopsis1

Metabolic1

Symbol18

Mice1

Phytic1

Signal transduction1

Differentially1

Acta1

Compounds2

Organism1

Coli1

Promoter activity1

Identification1

Fermentation2

Heterogeneous1

Tumor3

Mutation1

Operate1

Subunits1

Chromosome1

Plant1

Urine1

Genome1

Mechanisms1

Role1

Defect2

Rice1

Reaction1

Transcriptional1

Transcripts1

Evaluation1

Genetic2

Acid4

Transcriptome1