• The genus Coxiella is morphologically similar to Rickettsia, but with a variety of genetic and physiological differences. (wikipedia.org)
  • As it became clear that the species differed significantly from other Rickettsia, it was first elevated to a subgenus named after Cox, Coxiella, and then in 1948 to its own genus of that name, proposed by Cornelius B. Philip, another RML researcher. (wikipedia.org)
  • C. kelleyi nymphs and adults were collected from residential and community buildings in Jackson County, Iowa, and tested by polymerase chain reaction for Rickettsia, Borrelia, Bartonella, Coxiella, and Anaplasma. (canlyme.com)
  • Sequences of the 17-kDa and rOmpA genes suggest that this agent is a novel spotted fever group Rickettsia. (canlyme.com)
  • Rickettsia Deregulates Genes Coding for the Neurotoxic Cell Response Pathways in Cerebrocortical Neurons In Vitro. (sav.sk)
  • A total of 887 adult Ixodes ricinus ticks (469 females and 418 males) from 29 different localities in Sweden were screened for Rickettsia, Anaplasma, and Coxiella DNA using PCR and then subjected to gene sequencing. (scilifelab.se)
  • 2. Sobotta K, Hillarius K, Jiménez PH, Kerner K, Heydel C, Menge C. Interaction of Coxiella burnetii Strains of Different Sources and Genotypes with Bovine and Human Monocyte-Derived Macrophages. (ijmm.ir)
  • 4. Heinzen R, Stiegler G, Whiting L, Schmitt S, Mallavia L, Frazier M. Use of Pulsed Field Gel Electrophoresis to Differentiate Coxiella burnetii Strains a. (ijmm.ir)
  • citation needed] The bacteria use a type IVB secretion system known as Icm/Dot (intracellular multiplication / defect in organelle trafficking genes) to inject over 100 effector proteins into the host. (wikipedia.org)
  • Additionally, as it happens in other referential bacterial systems, temporal acidification of cell-free media results in over expression of all four P. salmonis genes, a well-known strategy by which SSTIV-containing bacteria inhibit phagosome-lysosome fusion to survive. (pucv.cl)
  • Mongolia (26.60%, 54/203), Coxiella- like endosymbiont (CLE) (53.69%, 109/203), and Babesia venatorum (7.88%, 16/203) were detected in D. nuttalli , while R. raoultii (30.56%, 11/36), Anaplasma sp. (biomedcentral.com)
  • Anaplasma phagocytophilum, and Coxiella burnetii in adult Ixodes ricinus ticks from 29 study areas in central and southern Sweden. (scilifelab.se)
  • Coxiella burnetii is an obligate intracellular bacterial pathogen, and is the causative agent of Q fever. (wikipedia.org)
  • In general, these bacterial pathogens are considered "highly clonal," meaning that the overall gene content of each species is very similar. (sciencedaily.com)
  • However, the study said, "The evolution of pathogenic bacterial species from nonpathogenic ancestors is … marked by relatively small changes in the overall gene content. (sciencedaily.com)
  • Our previous studies show that Coxiella manipulates host LD metabolism via the Type 4 Secretion System (T4SS), a major virulence factor which secretes bacterial effector proteins into the host cell cytoplasm to manipulate cellular processes. (pcom.edu)
  • Additionally, inhibiting LD breakdown almost completely inhibits bacterial growth suggesting that LD-derived lipids are critical for Coxiella intracellular survival. (pcom.edu)
  • Collectively, this study identified host mRNAs and miRNAs that were influenced by Coxiella and/or Leishmania infections, and our data indicate that although their PVs are morphologically similar, Coxiella and Leishmania have evolved different strategies that perturb distinct host processes to create and thrive within their respective intracellular niches. (pdx.edu)
  • The study also identified distinct methyltransferase subtypes in human pathogens such as Coxiella, Legionella, and Pseudomonas. (sciencedaily.com)
  • The Dot/Icm System, the major virulence mechanism of phylogenetically related pathogens Legionella pneumophila and Coxiella burnetii, is responsible for their intracellular survival and multiplication, conditions that may also apply to P. salmonis. (pucv.cl)
  • Coxiella burnetii, an obligate intracellular bacterium, causes potentially fatal endocarditis several years after intial infection suggesting the bacterium's ability to persist long-term in the host. (pcom.edu)
  • The database will also include published whole genome sequences to provide a curated standard for all genomic based analyses (epidemiology, transcriptomics, virulence genes, molecular typing). (q-gaps.de)
  • Differentiation was also obtained by sequence determination of the isocitrate dehydrogenase gene ( 12 ), com1 gene, and mucZ gene, which was renamed djlA when the whole genome of C . burnetii was sequenced ( 13 , 14 ). (cdc.gov)
  • We decided to investigate parts of the genome located between 2 open reading frames (ORFs) because they are considered potentially variable since they are subject to lower selection pressure than the adjacent genes. (cdc.gov)
  • More than half (23 of 39) of the articles represent epidemiologic studies including candidate gene and genome-wide association studies (GWAS) examining genetic effect modification on disease risk. (cdc.gov)
  • Given a set of genes, GeneMerge can tell you, for example, whether these genes are statistically over-represented in a particular functional or biochemical class, clustered in a region of the genome, or are associated with a particular RNAi or deletion phenotype. (g6g-softwaredirectory.com)
  • These text files link each gene in a genome with a particular datum of information. (g6g-softwaredirectory.com)
  • The population set is comprised of those genes from which the study set was drawn, often a genome. (g6g-softwaredirectory.com)
  • Recent success in the cultivation of Tropheryma whipplei [4] (which causes Wipple's disease) and Coxiella burnetii [5] (which causes Q fever) using genome-based metabolic pathway analyses has renewed interest in formulating axenic growth media for M. leprae . (internationaltextbookofleprosy.org)
  • The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene. (up.ac.za)
  • Coxiella burnetii is a strict intracellular bacterium with potential as a bioterrorism agent. (cdc.gov)
  • Coxiella burnetii is a bacterium that thrives in an acidic parasitophorous vacuole (PV) derived from lysosomes . (pdx.edu)
  • 6. Savinelli EA, Mallavia LP. Comparison of Coxiella burnetii plasmids to homologous chromosomal sequences present in a plasmidless endocarditis-causing isolate. (ijmm.ir)
  • While Coxiella initially infects alveolar macrophages, in endocarditis patients, it is also found in foamy macrophages containing neutral lipid storage organelles called lipid droplets (LDs). (pcom.edu)
  • Future studies will determine the potential of blocking PGE2 production as a supplemental therapy for Coxiella endocarditis. (pcom.edu)
  • Coxiella or A. phagocytophilum DNA were not detected in these ticks. (canlyme.com)
  • Coxiella burnetii and Leishmania Mexicana Residing Within Similar Para" by Jess A. Millar, Raquel Valdés et al. (pdx.edu)
  • As Coxiella and Leishmania are highly divergent organisms that cause different diseases, we reasoned that their respective infections would likely elicit distinct host responses despite producing phenotypically similar parasite-containing vacuoles. (pdx.edu)
  • Infection of THP-1 (human monocyte/macrophage) cells with Coxiella and Leishmania elicited disparate host responses. (pdx.edu)
  • Additionally, we detected 257 micro RNAs (miRNAs) that were expressed in THP-1 cells, and identified miRNAs that were specifically expressed during Coxiella or Leishmania infections. (pdx.edu)
  • The first description of what may have been Coxiella burnetii was published in 1925 by Hideyo Noguchi, but since his samples did not survive, it remains unclear as to whether it was the same organism. (wikipedia.org)
  • Several methods have been employed to identify Coxiella burnetii isolates based on the specific Coxiella burnetii QpH1 plasmid to distinguish the acute form from the chronic form of Q fever disease in humans and animals owing to the presence of unique gene sequences in this plasmid. (ijmm.ir)
  • A total of 86 isolates of Coxiella burnetii QpH1 plasmid, which were confirmed by the Nested-PCR method in 2018, were used to determine the RFLP panel of the QpH1 plasmid. (ijmm.ir)
  • Hence, all isolates were genetically identical, and the infection in animals could originate from one Coxiella burnetii strain (Nine Mile RSA493 strain). (ijmm.ir)
  • 3. Hendrix LR, Samuel JE, Mallavia LP. Differentiation of Coxiella burnetii isolates by analysis of restriction-endonuclease-digested DNA separated by SDS-PAGE. (ijmm.ir)
  • Molecular characterization of Coxiella burnetii isolates by infrequent restriction site-PCR and MLVA typing. (ijmm.ir)
  • For example, the name of a gene and its chromosomal location, molecular function, or its identity as over-expressed in a particular type of cancer. (g6g-softwaredirectory.com)
  • 2018) Valoración de un nuevo ensayo quimioluminiscente en comparación con ELISA en la detección de IgG contra el virus de la hepatitis E. Revista de la Sociedad Andaluza de Microbiología y Parasitología Clínica. (vircell.com)
  • 5. Willems H, Ritter M, Jäger C, Thiele D. Plasmid-homologous sequences in the chromosome of plasmidless Coxiella burnetii Scurry Q217. (ijmm.ir)
  • This report provides evidence of the functional presence in P. salmonis of four genes homologous to those described for Dot/Icm Type IV Secretion Systems. (pucv.cl)
  • The gene Oligomycin sensitivity-conferring protein is referred to in FlyBase by the symbol Dmel\Oscp. (yeastrc.org)
  • Silencing of gene also decreased NAMPT protein levels ( (forgetmenotinitiative.org)
  • A minimal set of DNA repair genes is sufficient for survival of Coxiella burnetii under oxidative stress. (tamu.edu)
  • Our overall goal is to determine the mechanisms Coxiella employs for its long-term survival. (pcom.edu)
  • To explore work on gene-environment interaction (GxE) at the Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR), we examined the CDC-Authored Genomics and Precision Health Publications Database (CDC-Authored GPHPD) , which includes articles published by CDC/ATSDR authors since 2011. (cdc.gov)
  • To test this, we quantified PGE2 synthesis enzyme cyclooxygenase-2 (cox-2) gene expression in differentially infected alveolar macrophages. (pcom.edu)
  • At 5 days post-infection, when compared to uninfected cells, 1057 genes were differentially expressed (746 genes up-regulated and 311 genes downregulated) in C. burnetii infected cells, whereas 698 genes (534 genes up-regulated and 164 genes down-regulated) were differentially expressed in L. mexicana infected cells. (pdx.edu)
  • Interestingly, of the 1755 differentially expressed genes identified in this study, only 126 genes (∼7%) are common to both infections. (pdx.edu)
  • GeneMerge offers a web-based & standalone version written in PERL (a high-level general-purpose, interpreted, dynamic programming language) that returns a range of functional and genomic data for a given set of study genes and provides statistical rank scores for over- representation of particular functions or categories in the data set. (g6g-softwaredirectory.com)
  • ELISA further demonstrated Coxiella infection-dependent increase in PGE2 levels. (pcom.edu)
  • These studies indicate that during infection Coxiella T4SS actively manipulates cox-2 expression resulting in increased PGE2. (pcom.edu)
  • We also discovered that 1090 genes produced mRNA isoforms at significantly different levels under the two infection conditions, suggesting that alternate proteins encoded by the same gene might have important roles in host response to each infection. (pdx.edu)
  • Yuan-Ping Pang and Paul R. Carlier has developed three series of homo/hetero dimeric acetylcholinesterase inhibitors derived from tacrine and/or huperzine A. The representative dimers bis(3)-Cognitin (B3C), bis(12)-hupyridone, and tacrine(10)-hupyridone might possess disease-modifying effects through the modulation of N-methyl-d-aspartic acid receptors, the activation of myocyte enhancer factor 2D gene transcription, and the promotion of neurotrophic factor secretion. (inrae.fr)
  • Do co- regulated genes show non-random enrichment for a certain family of transcription factor binding sites? (g6g-softwaredirectory.com)
  • These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)
  • The goal of our search was to identify publications describing the role of specific genes, gene signatures, or molecular pathways and their effects in response to environmental exposures. (cdc.gov)
  • We find a circadian rhythm in antigen processing that correlates with rhythms in both mitochondrial morphology and metabolism, dependent on the molecular clock gene, Bmal1. (biomed.news)
  • Hence we hypothesize that Coxiella manipulates host cell LD metabolism to promote a PGE2-mediated immunosuppressive environment and survive long-term in the host. (pcom.edu)
  • The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. (up.ac.za)
  • The results of the nucleic acid sequencing of all 4 samples indicated that they had a Coxiella burnetii type (Nine Mile RSA493 strain). (ijmm.ir)
  • The CDC-Authored GPHPD was searched using the terms "environment," "gene environment," "gene environment interaction," and others* returning 54 unique articles, of which 15 were excluded because their primary focus was on other topics. (cdc.gov)
  • Mutation of gene is usually associated with Chediak-Higashi syndrome (CHS), a rare autosomal recessive lysosomal disorder with hematological and immunological abnormalities [13]. (forgetmenotinitiative.org)
  • Besides CHS, mutation in gene is usually one of the important factors that trigger hemophagocytic lymphohistiocytosis, a insufficiency in resistant program function, and life-threatening disease characterized by uncontrolled macrophage and T-cell account activation [14]. (forgetmenotinitiative.org)
  • David M. Wagner has researched Burkholderia pseudomallei in several fields, including Gene mutation, Melioidosis, Multilocus sequence typing and Burkholderia. (research.com)
  • 7. Jäger C, Lautenschläger S, Willems H, Baljer G. Coxiella burnetii plasmid types QpDG and QpH1 are closely related and likely identical. (ijmm.ir)
  • Coxiella was difficult to study because it could not be reproduced outside a host. (wikipedia.org)
  • Our study exhibited that and play pivotal functions in the molecular pathogenesis of MM. This is usually the first statement describing the possible functions of in myelomagenesis and its potential role as a SU 11654 therapeutic target in MM. gene promotes tumorigenesis through constant NAD resynthesis to provide adequate energy for rapidly proliferating malignancy cells [9]. (forgetmenotinitiative.org)
  • The study set is comprised of genes that are currently under investigation. (g6g-softwaredirectory.com)
  • It contains functional or categorical data associated with each gene in the study set and rank scores for over-represented functions/categories, as well as other pertinent data. (g6g-softwaredirectory.com)
  • Rank scores for functional or categorical overrepresentation within the study set of genes is obtained using the hypergeometric distribution. (g6g-softwaredirectory.com)
  • or gene silencing significantly inhibited cell proliferation and induced apoptosis in RPMI 8226 cells ( (forgetmenotinitiative.org)
  • His research in Phylogenetics intersects with topics in Coxiella burnetii, Burkholderia pseudomallei, Dermacentor variabilis and Dermacentor. (research.com)
  • The big advantage of GeneMerge over other similar programs is that you are Not limited to analyzing your data from the perspective of a pre- packaged set of gene-association data. (g6g-softwaredirectory.com)
  • Sometimes molecular methods can be used to detect specific resistance genes. (msdmanuals.com)
  • This paper studies the functional and regulatory role of RecA, but further investigations are necessary to clarify the control mechanism of the SOS response gene expression in C. burnetii. (tamu.edu)
  • Coxiella burnetii small RNAs (CbSRs 1, 11, 12, and 14) are encoded within intergenic region (IGR). (wikipedia.org)
  • Our results offer a even more unique understanding of the jobs of and genes in the molecular pathogenesis of MM. MATERIALS AND METHODS Cell collection The myeloma cell collection RPMI 8226 was purchased from the American Type Culture Collection (ATCC, USA). (forgetmenotinitiative.org)
  • Compared to uninfected cells, cox-2 was upregulated in Coxiella-infected macrophages but not T4SS mutant-infected cells. (pcom.edu)
  • Studies are ongoing to identify the direct correlation between LDs and PGE2 production in Coxiella-infected cells and their contribution to PGE2-mediated immunosuppression. (pcom.edu)
  • No.: SR300809, USA) were used to silence the respective gene in RPMI 8226 cells. (forgetmenotinitiative.org)
  • Effects of aliskiren-loaded nanoparticles on (pro-)renin and renin receptor gene expression in the heart and kidney of spontaneously hypertensive rats. (sav.sk)
  • Cytochrome P genes CYP are highly expressed in the fat body of several insects and thus play a key role in their metabolic resistance. (xbrander.com)