We assessed the effect of acteoside, a naturally occurring antioxidative phenylethanoid, on hepatic apoptosis and the subsequent liver failure induced by D-Galactosamine (D-GalN) and lipopolysaccharide (LPS). (elsevierpure.com)
The purpose of this study was to investigate the effects of fetuin-A on d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver failure in mice. (hofstra.edu)
Methods: An acute rat liver injury model induced by D-galactosamine was used. (bvsalud.org)
Galactose3
Galactosamine is a hexosamine derived from galactose with the molecular formula C6H13NO5. (wikipedia.org)
In the Leloir pathway galactosamine is metabolized into galactosamine-1-phosphate (by galactokinase) and UDP-galactosamine (by UDP-galactose uridyltransferase). (wikipedia.org)
The E histolytica galactose/ N -acetyl-D-galactosamine (Gal/GalNAc) lectin is an adhesion protein complex that sustains tissue invasion. (medscape.com)
Liver7
Galactosamine is a hepatotoxic, or liver-damaging, agent that is sometimes used in animal models of liver failure. (wikipedia.org)
Galactosamine is used to induce hepatitis in rodent liver for research purposes. (wikipedia.org)
The result of using galactosamine to induce hepatitis is a disease model in which there is necrosis and inflammation of the liver. (wikipedia.org)
This type of tissue damage triggered by galactosamine resembles drug-induced liver disease in humans. (wikipedia.org)
Another recent hypothesis states that overexpression of pro-inflammatory cytokines (such as tumor necrosis factor (TNFα) and NFκB-dependent inducible nitric oxide synthase (iNOS) over expression play a role in galactosamine-induced damage to liver cells. (wikipedia.org)
This study explored the effects of a classical Chinese medicine formula- Xiao-Chai-Hu Tang(XCHT) on the model mice with D-galactosamine -induced liver injury. (nih.gov)
It may be through decreasing the serum IL-6 and TNF-α levels and FasmRNA, FasLmRNA, Bax protein expression and increasing the Bcl-2 mRNA expression of the liver tissues that XCHT significantly relieved the D-galactosamine -induced liver injury. (nih.gov)
Sulfatase1
In 1976, the enzyme deficiency in Morquio syndrome type IVA (galactosamine-6-sulfatase deficiency [ie, N -acetyl-galactosamine-6-sulfate sulfatase deficiency]) was identified. (medscape.com)
Glucosamine2
Precursors such as uridine diphosphate (UDP), UDP-N-acetyl-D-glucosamine, or glucosamine are used to synthesize galactosamine in the human body. (wikipedia.org)
Wogonin pretreatment prevented the lethal shock in mice injected with D-galactosamine (D-GaIN) and LPS, but not in mice injected with a high dose of LPS. (fujita-hu.ac.jp)
Derivative2
A derivative of this compound is N-acetyl-D-galactosamine. (wikipedia.org)
A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates. (nih.gov)
Articles1
Based on a literature review very few articles have been published on N-Acetyl-D-galactosamine 1-phosphate. (hmdb.ca)
Class1
N-Acetyl-D-galactosamine 1-phosphate belongs to the class of organic compounds known as n-acyl-alpha-hexosamines. (hmdb.ca)
GalNAc3
Only HPA, which is specific for N-acetyl-galactosamine (GalNAc), bound to the midgut. (nih.gov)
The E histolytica galactose/ N -acetyl-D-galactosamine (Gal/GalNAc) lectin is an adhesion protein complex that sustains tissue invasion. (medscape.com)
The purpose of this research is to systematically evaluate the diastereomeric composition of LEQVIO (Inclisiran), an FDA-approved, N-acetyl galactosamine (GalNAc)-conjugated siRNA drug, and to understand the biological/pharmacological activity of each diastereomer in LEQVIO through stereo chemically controlled synthesis and biological activity assessment using in vitro and animal models. (nih.gov)
Liver injury2
Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury. (bvsalud.org)
In this study, we aimed to investigate the protective effects of S. boulardii on D- Galactosamine -induced liver injury in mice . (bvsalud.org)
Hepatoprotective1
Hepatic cysteamine and non-protein sulfhydryl (NPSH) levels were determined in galactosamine (GAL)-poisoned rats following hepatoprotective cystamine or cysteamine treatments to determine whether alterations of hepatic NPSH status could contribute to their observed protective actions. (nih.gov)
Glucose1
In addition to lactose, milk also contains trace amounts of other natural sugars , like glucose, fructose, glucosamine and galactosamine. (livestrong.com)
Humans1
This type of tissue damage triggered by galactosamine resembles drug-induced liver disease in humans. (wikipedia.org)
Saccharomyces1
4. Galactosamine is an inducer of Gal genes in Saccharomyces cerevisiae. (nih.gov)
Rats3
ALF was induced by the intraperitoneal injection of D-galactosamine (D-GalN) in experimental rats, who then received either sham (ALF), manual acupuncture (MA), electroacupuncture (EA), or silymarin (PC, positive control) treatment. (hindawi.com)
Hepatic cysteamine and non-protein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats. (nih.gov)
D(+)-Galactosamine HC1 (400 mg/kg, ip) was administered to male Sprague-Dawley rats at 8 pm. (nih.gov)
Inflammatory1
Another recent hypothesis states that overexpression of pro-inflammatory cytokines (such as tumor necrosis factor (TNFα) and NFκB-dependent inducible nitric oxide synthase (iNOS) over expression play a role in galactosamine-induced damage to liver cells. (wikipedia.org)
Cells1
It is hypothesized that this leads to UDP-galactosamine accumulation within cells, and uridine triphosphate (UTP), UDP, and uridine monophosphate (UMP) decrease. (wikipedia.org)
Model1
The result of using galactosamine to induce hepatitis is a disease model in which there is necrosis and inflammation of the liver. (wikipedia.org)