Gtp bound alpha subunits gtp binding protein beta subunits. Medical search. Frequent questions

The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. (nih.gov)
High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members. (nih.gov)
Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. (raybiotech.com)
GTP/G-alpha complex dissociates from the trimer and associates to an effector until the intrinsic GTPase activity of G-alpha returns the protein to GDP bound form. (embl-heidelberg.de)
Two classes of intracellular proteins act as inhibitors of G protein activation: GTPase activating proteins (GAPs), which enhance GTP hydrolysis and guanine dissociation inhibitors (GDIs), which inhibit GDP dissociation. (embl-heidelberg.de)
The highly conserved Asp-Gln-Arg triad within the GoLoco motif participates directly in GDP binding by extending the arginine side chain into the nucleotide binding pocket, highly reminiscent of the catalytic arginine finger employed in GTPase-activating protein. (embl-heidelberg.de)
A GTPase activator for the nuclear ras-related regulatory protein RAP-1A. (embl-heidelberg.de)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:21158412). (icr.ac.uk)
GTPase catalyses the breakdown of GTP on the α-subunit into GDP + Pi . (teachmephysiology.com)
They all share a common GTPase cycle, being turned on by binding GTP and off by hydrolyzing GTP to GDP. (biomedcentral.com)
Additional regulatory proteins are often required to induce the conformational changes that occur during this cycle: guanine nucleotide exchange factors, which catalyze release of bound GDP and promote its replacement by GTP, and GTPase-activating proteins, which accelerate GTP hydrolysis. (biomedcentral.com)

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. (anticorps-enligne.fr)
The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. (anticorps-enligne.fr)
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. (icr.ac.uk)
The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. (icr.ac.uk)
The alpha chain contains the guanine nucleotide binding site (PubMed:8521505, PubMed:24596087, PubMed:25037222). (icr.ac.uk)
this inhibits guanine nucleotide exchange and GTP binding (PubMed:11121039). (icr.ac.uk)

This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. (nih.gov)
Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. (nih.gov)
Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:21158412). (icr.ac.uk)
this strongly enhances GTP hydrolysis. (icr.ac.uk)

In heterotrimeric G-protein signalling, cell surface receptors (GPCRs) are coupled to membrane-associated heterotrimers comprising a GTP-hydrolysing subunit G-alpha and a G-beta/G-gamma dimer. (embl-heidelberg.de)
The inactive form contains the alpha subunit bound to GDP and complexes with the beta and gamma subunit. (embl-heidelberg.de)
Reassociation of GDP bound G-alpha with G-beta/G-gamma dimer terminates the signal. (embl-heidelberg.de)
alpha, beta and gamma. (icr.ac.uk)
Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1 (PubMed:24596087). (icr.ac.uk)
Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2 (PubMed:8521505). (icr.ac.uk)
Guanosine diphosphate (GDP) bound to the alpha-subunit is exchanged for guanosine triphosphate (GTP), and the GTP-bound alpha-subunit then dissociates from beta- and gamma-subunits. (statuskduniya.in)
The G-protein is heterotrimeric and is made up of three different subunits: alpha ( α ), beta ( β ) and gamma ( γ ). (teachmephysiology.com)

They may have various functions within the cell: catalysis of chemical reactions (enzyme-substrate), defense of the organism through the immune system (antibodies antigen complexes), signal transduction (receptor-ligand complexes) that consists of a transmembrane receptor that upon binding the ligand activates an intracellular cascade. (wikipedia.org)
Glucagon receptor (GCGR) is a family of G-protein coupled receptors (GPCRs) in humans that plays an important role in maintaining glucose concentration within the blood during periods of low energy state. (wikipedia.org)
The higher rate of Gβγ release is attributable to a faster G protein coupled receptor - G protein trimer association rate in M2R compared to β2AR. (elifesciences.org)
The activated receptor catalyzes removal of GDP from the G protein alpha subunit (Gα i ), which allows intracellular GTP to bind. (elifesciences.org)
Scholars@Duke publication: Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. (duke.edu)
Several G-protein coupled receptors, such as the beta1-adrenergic receptor (beta1-AR), contain polyproline motifs within their intracellular domains. (duke.edu)
Thus, our studies demonstrate a role of the SH3p4/p8/p13 protein family in beta1-AR signaling and suggest that interaction between proline-rich motifs and SH3-containing proteins may represent a previously underappreciated aspect of G-protein coupled receptor signaling. (duke.edu)
The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. (utsouthwestern.edu)
When the ligand is associated to the receptor, GDP is displaced from G-alpha and GTP is bound. (embl-heidelberg.de)
Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
All six receptors belong to the G protein-coupled receptor (GPCR) superfamily which initiates intracellular signalling cascades via four G protein classes differentiated by their α subunit type: Gαs, Gαi/o, Gαq/11, Gα12/13. (smpdb.ca)
This results in the dissociation of a Gα-GTP monomer and a Gβγ dimer from the receptor which allows both complexes to begin signalling cascades via downstream effectors. (smpdb.ca)
This receptor can couple with the G proteins Gαi/o, Gαq/11, and Gα12/13. (smpdb.ca)
IP3 diffuses through the cytoplasm to the ER and binds to the inositol 1,4,5-trisphosphate (Ins3P) receptor, releasing calcium from the endoplasmic reticulum into the cytoplasm. (smpdb.ca)
An agonist (ligand) is a substance which binds to a receptor and brings about a cellular response. (teachmephysiology.com)
Ligands bind to the extracellular portion of the G-protein coupled receptor, binding either at the N-terminus or a binding site within the transmembrane region. (teachmephysiology.com)
Despite the fact that one G-protein coupled receptor only contains one α-subunit, this can interact with several secondary messengers , which can in turn activate multiple enzymes and catalyse many reactions. (teachmephysiology.com)
The G-protein then reassociates with the transmembrane receptor, reforming the GPCR for the next ligand binding. (teachmephysiology.com)
This is a bond-graph model of the metabolism of the G-protein coupled receptor ( β -1 adrenergic receptor, R) and the associated Gs protein in the cardiac cell. (physiomeproject.org)
Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin. (medindex.am)

The superfamily of G proteins includes three main classes: Ras-like GTPases, G α subunits of heterotrimeric G proteins, and the translation elongation factors. (biomedcentral.com)

Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
Both calcium and DAG activate the kinase activity of protein kinase C beta (PKC). (smpdb.ca)
SCO2450 putative protein kinase (regulator) 2632795:2636844 forward MW:145674 0024. (kitasato-u.ac.jp)

Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
Signaling is mediated via effector proteins, such as adenylate cyclase. (icr.ac.uk)
GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins. (icr.ac.uk)
By producing the second messenger cGMP, which regulates various effector systems such as phosphodiesterases, ion channels, and protein kinases, sGC plays an important role in different physiological processes, thus representing a very attractive pharmacological target. (nih.gov)

Gα(GTP) and Gβγ subunits subsequently dissociate from the GPCR. (elifesciences.org)
In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. (utsouthwestern.edu)
This activates the G-protein, causing the α-subunit and bound GTP to dissociate from the transmembrane portion of the GPCR and βγ-subunit. (teachmephysiology.com)

Glucagon binding to GPCRcauses a conformational change in the intracellular domain, allowing interaction with the heterotrimeric Gs protein. (wikipedia.org)
Accordingly, we used the proline-rich third intracellular loop of the beta1-AR either as a glutathione S-transferase fusion protein in biochemical 'pull-down' assays or as bait in the yeast two-hybrid system to search for interacting proteins. (duke.edu)
In vitro and in human embryonic kidney (HEK) 293 cells, SH3p4 specifically binds to the third intracellular loop of the beta1-AR but not to that of the beta2-AR. (duke.edu)
Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. (medindex.am)

18874) imidazoleglycerol phosphate synthase%2C cyclase subunit CP001857 CDS Arcpr_0021 19046. (go.jp)
38678) Cobalamin-independent synthase MetE domain protein CP001857 CDS Arcpr_0044 complement(38683. (go.jp)
ATP synthase membrane subunit c loc. (gsea-msigdb.org)
SCO0127 putative multi-domain beta keto-acyl synthase 112932:119654 forward MW:235996 0009. (kitasato-u.ac.jp)
SCO0126 putative multi-domain beta keto-acyl synthase 106637:112885 forward MW:214716 0012. (kitasato-u.ac.jp)

The affinity between protein and ligand is given by the equilibrium dissociation constant Kd or the inverse of the association constant 1/Ka (or binding constant 1/Kb) that relates the concentrations of the complexed and uncomplexed species in solution. (wikipedia.org)

Stimulated muscarinic acetylcholine receptors (M2Rs) release Gβγ subunits, which slow heart rate by activating a G protein-gated K + channel (GIRK). (elifesciences.org)
Stimulated β2 adrenergic receptors (β2ARs) also release Gβγ subunits, but GIRK is not activated. (elifesciences.org)
These two branches control heart rate by stimulating different G protein-coupled receptors (GPCRs), which in turn activate ion channels that modify the electrical properties of cardiac pacemaker cells ( DiFrancesco, 1993 ). (elifesciences.org)
Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. (smpdb.ca)
G-protein coupled receptors (GPCRs) are a diverse family of receptors found in a huge range of tissues throughout the body. (teachmephysiology.com)
G-protein coupled receptors are composed of a transmembrane region crossing the lipid bilayer seven times (hence they are also referred to as 7-transmembrane receptors). (teachmephysiology.com)
This allows for many GPCR combinations created by different receptors being coupled with G proteins comprised of different subunits. (teachmephysiology.com)
For G-protein coupled receptors, this consists of 5 main steps. (teachmephysiology.com)

The roles of the individual subunits composing this complex remain to be defined. (frontiersin.org)

Agonist binding promotes the formation of a GPCR-Gα(GDP)βγ complex. (elifesciences.org)
The activated GPCR then triggers the exchange of GDP to GTP on the Gα subunit. (elifesciences.org)
Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:19703466, PubMed:24596087, PubMed:25037222). (icr.ac.uk)
Furthermore, one GPCR can be associated with many G proteins, hence one signal can have many downstream cellular reactions. (teachmephysiology.com)
Binding at the extracellular ligand binding site causes a conformational change in the GPCR, resulting in the release of GDP from the α-subunit of the G-protein. (teachmephysiology.com)
This creates a cascade response whereby one agonist binding to the GPCR can bring about the catalysis of many reactions (signal amplification) . (teachmephysiology.com)
There are several different types of G-protein that can be present in a GPCR, which vary based on their α -subunit. (teachmephysiology.com)

A protein-ligand complex is a complex of a protein bound with a ligand that is formed following molecular recognition between proteins that interact with each other or with other molecules. (wikipedia.org)
Formation of a protein-ligand complex is based on molecular recognition between biological macromolecules and ligands, where ligand means any molecule that binds the protein with high affinity and specificity. (wikipedia.org)
The protein-ligand complex is a reversible non-covalent interaction between two biological (macro)molecules. (wikipedia.org)
The molecules (protein and ligand) recognize each other also by stereospecificity i.e. by the form of the two molecules. (wikipedia.org)
The highest possible affinity from a protein towards the ligand, or target molecule, can be observed when the protein has a perfect mirror image of the shape of the target surface together with a charge distribution that complements perfectly the target surface. (wikipedia.org)
The lower the Kd value the higher the affinity of the protein for the ligand and vice versa. (wikipedia.org)
The Kd value is equivalent to the concentration of the ligand at which one-half of the proteins contain bound ligand. (wikipedia.org)
Protein-ligand complexes can be found in almost any cellular process. (wikipedia.org)
Binding of a ligand causes a conformational change in the protein and often also in the ligand. (wikipedia.org)
Protein-Ligand complex is essential in many of the cellular processes that occur within organisms. (wikipedia.org)

To search for novel proteins that interact with Galphao, a mouse brain library was screened using the yeast two-hybrid interaction system. (embl-heidelberg.de)
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
One-hundred and twenty-seven of 17,225 human full-length proteins were identified that interact with CRYAA. (molvis.org)

The most important physiological activator of sGC is nitric oxide, which activates the enzyme upon binding to the heme moiety. (nih.gov)
The Gαi/o subunit inhibits the enzyme adenylyl cyclase (AC) which catalyzes the production of the important secondary messenger 3',5'-cyclic AMP (cAMP) from adenosine triphosphate (ATP). (smpdb.ca)
GPCRs have no integral enzyme activity or ion channel, therefore all their downstream effects are mediated via their G-protein. (teachmephysiology.com)
These α-subunit interacts with their relevant effectors and cause downstream effects , e.g. ion channel opening or enzyme activity regulation. (teachmephysiology.com)
Each alpha-subunit stimulates an enzyme, which acts to either increase or decrease the concentration of a secondary messenger . (teachmephysiology.com)
1,4-alpha-glucan branching enzyme 1. (gsea-msigdb.org)

Domain commonly found in eukaryotic signalling proteins. (embl.de)
Eukaryotic elongation factor 1 alpha (eEF1A) is one of the four subunits composing eukaryotic translation elongation factor 1. (biomedcentral.com)
The eukaryotic translation elongation factor 1 alpha, currently termed eEF1A, is a member of the G protein family, and one of the four subunits that compose the eukaryotic elongation factor 1 [ 5 , 6 ]. (biomedcentral.com)

Upon stimulation, acetylcholine (ACh) released from the vagus nerve binds to and activates M2Rs in sinoatrial node (SAN) pacemaker cells, promoting the engagement of the GDP-bound G protein trimer (Gα i (GDP)βγ). (elifesciences.org)
Dissociated Gβγ directly binds to and activates GIRK channels. (elifesciences.org)
The binding of LPA to an LPAR allosterically activates the heterotrimeric G protein by exchanging GDP for GTP at the G protein's alpha subunit. (smpdb.ca)
The Gαq/11 subunit activates phospholipase C (PLC) which cleaves the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) into the secondary messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). (smpdb.ca)

By using sequence alignment of herpesviruses homologs, we identified conserved amino acids in the putative pUL105 ATP binding site and in the putative pUL70 zinc finger pattern. (frontiersin.org)
SCO3285 putative large glycine/alanine rich protein 3628804:3634122 reverse MW:187287 0014. (kitasato-u.ac.jp)
SCO3869 putative WD-40 repeat protein 4252856:4257886 forward MW:177236 0015. (kitasato-u.ac.jp)
SCO2383 putative secreted protein 2552256:2556893 forward MW:161489 0017. (kitasato-u.ac.jp)
SCO4508 putative cell division-related protein 4928990:4933567 reverse MW:163295 0018. (kitasato-u.ac.jp)
SCO7015 putative membrane protein. (kitasato-u.ac.jp)
SCO5710 putative large Pro/Ala/Gly-rich protein 6221737:6225837 forward MW:141045 0022. (kitasato-u.ac.jp)
SCO2259 putative multi-domain regulatory protein. (kitasato-u.ac.jp)
SCO6457 putative beta-galactosidase 7142206:7146129 forward MW:145522 0027. (kitasato-u.ac.jp)
SCO6219 putative ATP/GTP binding protein 6832135:6835920 forward MW:133958 0029. (kitasato-u.ac.jp)
SCO4263 putative transcriptional regulatory protein 4675582:4679337 forward MW:132620 0030. (kitasato-u.ac.jp)
SCO7037 putative secreted protein 7826610:7830005 forward MW:118466 0036. (kitasato-u.ac.jp)
SCO2672 putative membrane protein 2908366:2911707 forward MW:112750 0039. (kitasato-u.ac.jp)
SCO0369 putative secreted protein 373998:377255 reverse MW:117277 0043. (kitasato-u.ac.jp)
SCO0372 putative secreted protein 383578:386592 reverse MW:107736 0050. (kitasato-u.ac.jp)
SCO0505 putative multi-domain protein (fragment) 539123:542131 forward MW:108602 0051. (kitasato-u.ac.jp)
SCO2000 putative ATP-binding RNA helicase 2135883:2138879 forward MW:105806 0053. (kitasato-u.ac.jp)
SCO4874 putative integral membrane protein 5303718:5306603 forward MW:99145 0060. (kitasato-u.ac.jp)

For example DNA-replication depends on recognition and binding of DNA double helix by helicase, DNA single strand by DNA-polymerase and DNA segments by ligase. (wikipedia.org)
chromodomain helicase DNA binding p. (gsea-msigdb.org)

Guanylate cyclase (GC) catalyzes the biosynthesis of cyclic guanosine 3',5'- monophosphate (cGMP) from GTP. (nih.gov)
A particular example is the ability of enzymes to discriminate between adenosine triphosphate (ATP) and guanosine triphosphate (GTP) (Figure 1). (statuskduniya.in)

O-linked found in mucous fluids, but can also be present in membrane and secretory proteins, 3 or more sugars linked by N-acetylglalactosamine (GalNAc)--connected to serine, theronine. (freezingblue.com)

Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
The Gα12/13 subunit regulates cell motility and cytoskeletal remodelling by activating the Rho/ROCK and Rho/SRF pathways. (smpdb.ca)
Such transition between active and inactive forms allows for them to serve as molecular switches and to make G proteins suitable for the regulation of a wide range of cellular processes such as signal transduction, cytoskeletal reorganizations, vesicular transport and protein synthesis [ 4 ]. (biomedcentral.com)

The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. (icr.ac.uk)
Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains) (PubMed:11387333, PubMed:16870394, PubMed:17635935, PubMed:21158412). (icr.ac.uk)
In its inactive state, GDP is bound to the α-subunit of the G-protein. (teachmephysiology.com)

G proteins constitute a large superfamily of regulatory proteins that show a high similarity in primary structure and organization of the functional center [ 1 - 3 ]. (biomedcentral.com)

In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)

Mammalian regulators of G-protein signalling 12 and 14 (RGS12 and RGS14), multifaceted signal transduction regulators. (embl-heidelberg.de)

ˌjē-(ˌ)tē-ˈpē: an energy-rich nucleotide analogous to ATP that is composed of guanine, ribose, and three phosphate groups and is necessary for peptide-bond formation during protein synthesis. (statuskduniya.in)

allows binding of transcription factors on outer DNA helix gene silencing (NO TRANSCRIPTION)! (freezingblue.com)
40535) Transcription factor TFIIB cyclin-related protein CP001857 CDS Arcpr_0047 complement(40887. (go.jp)

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. (nih.gov)
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. (nih.gov)
GTP is used in protein synthesis. (statuskduniya.in)
It catalyzes the binding of aminoacyl-tRNA to the A-site of the ribosome in a GTP-dependent manner during protein synthesis, although it also seems to play a role in other non-translational processes. (biomedcentral.com)

PFK has two binding sites and inhibitor and substrate site. (flashcardmachine.com)

CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)

During elongation, GTP facilitates the binding of a new aminoacyl tRNA to the A site of a ribosome. (statuskduniya.in)

The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. (anticorps-enligne.fr)
Modeling beta-adrenergic control of cardiac myocyte contractility in silico. (physiomeproject.org)

Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. (utsouthwestern.edu)

Galphao and Pcp2 binding was confirmed in vitro using glutathione S-transferase-Pcp2 fusion proteins and in vitro translated [35S]methionine-labeled Galphao. (embl-heidelberg.de)
A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)

The process is reversed by the alpha subunit, which hydrolyses GTP to GDP followed by reformation of the Gα i (GDP)βγ complex. (elifesciences.org)
GDP increases the α-subunit's affinity for the βγ-subunit, allowing the reformation of the heterotrimeric complex of the G-protein. (teachmephysiology.com)

The protein encoded by this gene represents the alpha subunit of an inhibitory complex. (anticorps-enligne.fr)
This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. (nih.gov)
Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. (nih.gov)
Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. (utsouthwestern.edu)
During the initiation of translation, the GTP is associated with an initiation factor 2 (IF2) and is hydrolyzed upon the assembly of the initiation ribosomal complex. (statuskduniya.in)
SCO6954 probable NADH dehydrogenase I complex, subunit. (kitasato-u.ac.jp)
It provides unique identifiers, names and synonyms, list of complex members with their unique identifiers (UniProt, ChEBI, RNAcentral), function, binding and stoichiometry annotations, descriptions of their topology, assembly structure, ligands and associated diseases as well as cross-references to the same complex in other databases (e.g. (stanford.edu)
Act1: Bundled reactions representing the transient exchange of GDP for GTP on the active RG complex, which forms Gs α GTP , Gs β γ , GDP and R tag . (physiomeproject.org)
Moreover, endosomal sorting complex required for transport (ESCRT)-related proteins and their transcripts are most abundant at early and mid-development. (nature.com)

In fact, the proteins that form complexes are able to pick a substrate out of a myriad of different molecules. (wikipedia.org)

This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. (raybiotech.com)
The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. (raybiotech.com)
There are 7862 GoLoco domains in 3705 proteins in SMART's nrdb database. (embl-heidelberg.de)
Taxonomic distribution of proteins containing GoLoco domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with GoLoco domain is also avaliable . (embl-heidelberg.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing GoLoco domain in the selected taxonomic class. (embl-heidelberg.de)

alpha 2-HS glycoprotein [Source:HGN. (gsea-msigdb.org)

This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. (nih.gov)

C. elegans hypothetical proteins C04D8.1, K06H7.4 and ZK632.12. (embl.de)
S. cerevisiae hypothetical proteins YBR129c and YHR155w. (embl.de)
9766 conserved hypothetical protein CP001857 CDS Arcpr_0009 complement(9767. (go.jp)
10378) hypothetical protein CP001857 CDS Arcpr_0010 complement(10422. (go.jp)
13428) hypothetical protein CP001857 CDS Arcpr_0013 complement(13425. (go.jp)
13751) hypothetical protein CP001857 CDS Arcpr_0014 complement(13789. (go.jp)
19702 hypothetical protein CP001857 CDS Arcpr_0022 complement(19723. (go.jp)
21298 hypothetical protein CP001857 CDS Arcpr_0025 complement(21287. (go.jp)
23242 hypothetical protein CP001857 CDS Arcpr_0028 23232. (go.jp)
29158) hypothetical protein CP001857 CDS Arcpr_0035 complement(29143. (go.jp)
29526) hypothetical protein CP001857 CDS Arcpr_0036 29596. (go.jp)
36678) hypothetical protein CP001857 CDS Arcpr_0042 complement(36769. (go.jp)
42520) hypothetical protein CP001857 tRNA Arcpr_R0002 complement(42639. (go.jp)
43572) hypothetical protein CP001857 CDS Arcpr_0052 43655. (go.jp)
47353) hypothetical protein CP001857 CDS Arcpr_0058 complement(47350. (go.jp)
52977 conserved hypothetical protein CP001857 CDS Arcpr_0062 complement(52960. (go.jp)
53727) hypothetical protein CP001857 CDS Arcpr_0063 complement(53793. (go.jp)
SCO6428 hypothetical protein 7097567:7104511 reverse MW:242150 0007. (kitasato-u.ac.jp)
SCO6220 hypothetical protein SC2H4.02 6836057:6842608 forward MW:233391 0011. (kitasato-u.ac.jp)
SCO6626 hypothetical protein SC1F2.23 7348537:7353210 forward MW:169206 0016. (kitasato-u.ac.jp)
SCO6432 hypothetical protein 7111866:7116089 forward MW:148817 0021. (kitasato-u.ac.jp)
SCO6348 hypothetical protein SC3A7.16c 7006807:7010892 reverse MW:144986 0023. (kitasato-u.ac.jp)
SCO2975 hypothetical protein SCE50.03 3236736:3240773 forward MW:135331 0025. (kitasato-u.ac.jp)
SCO6572 hypothetical protein SC3F9.07 7275867:7279583 forward MW:133432 0031. (kitasato-u.ac.jp)
SCO6431 hypothetical protein 7108264:7111779 forward MW:126560 0034. (kitasato-u.ac.jp)
SCO0072 hypothetical protein 60740:64093 reverse MW:119295 0038. (kitasato-u.ac.jp)
SCO4250 hypothetical protein SCD8A.23 4656900:4660235 forward MW:103694 0040. (kitasato-u.ac.jp)
SCO5271 hypothetical protein 5731309:5734599 forward MW:117582 0041. (kitasato-u.ac.jp)
SCO6994 hypothetical protein SC8F11.20c. 7762852:7766112 reverse MW:113220 0042. (kitasato-u.ac.jp)
SCO5717 hypothetical protein SC3C3.03c 6233478:6236729 reverse MW:112052 0044. (kitasato-u.ac.jp)
SCO0069 hypothetical protein 56225:59383 forward MW:114192 0046. (kitasato-u.ac.jp)
SCO0335 hypothetical protein 336333:339467 forward MW:111223 0047. (kitasato-u.ac.jp)
SCO4331 hypothetical protein SCD12A.14 4742776:4745904 forward MW:110720 0048. (kitasato-u.ac.jp)
SCO5842 hypothetical protein SC9B10.09 6394529:6397648 forward MW:107570 0049. (kitasato-u.ac.jp)
SCO4548 hypothetical protein 4964060:4967068 forward MW:105802 0052. (kitasato-u.ac.jp)
SCO0305 hypothetical protein 299213:302092 forward MW:106033 0061. (kitasato-u.ac.jp)
SCO4254 hypothetical protein SCD8A.27 4663248:4666118 forward MW:101164 0062. (kitasato-u.ac.jp)
SCO2116 hypothetical protein 2273596:2276427 forward MW:100732 0063. (kitasato-u.ac.jp)

This gene encodes a member of the regulator of G-protein signaling family. (nih.gov)
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
The protein encoded by this gene is a member of the importin beta family. (utsouthwestern.edu)

They form a G-protein regulator family that also contains TPR repeats. (embl-heidelberg.de)

Non-covalent binding may depend on hydrogen bonds, hydrophobic forces, van der Waals forces, π-π interactions, electrostatic interactions in which no electrons are shared between the two or more involved molecules. (wikipedia.org)
The complexes are formed by different molecules like macromolecules as in protein complexes, protein DNA or protein RNA complexes as well as by proteins that bind smaller molecules like peptides, lipids, carbohydrates, small nucleic acids. (wikipedia.org)

It is the second-most abundant protein after actin, comprising 1-3% of the total protein content in normal growing cells [ 7 , 8 ]. (biomedcentral.com)
actin alpha cardiac muscle 1 [Sourc. (gsea-msigdb.org)

notably, integration of proteomics data with in situ subcellular microscopic analyses showed a high abundance of cytoskeleton proteins associated with acidified PBs at the early development stages. (nature.com)

Interacts (GDP-bound form) with RIC8A (via C-terminus) (PubMed:21158412). (icr.ac.uk)

Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)

Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)

39504) translation initiation factor 2%2C alpha subunit CP001857 CDS Arcpr_0045 complement(39546. (go.jp)

The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)

55699) Ribosomal protein L15e CP001857 CDS Arcpr_0066 complement(55738. (go.jp)

20325) RNase P subunit p30 CP001857 CDS Arcpr_0023 complement(20322. (go.jp)

Both approaches identified SH3p4/p8/p13 (also referred to as endophilin 1/2/3), a SH3 domain-containing protein family, as binding partners for the beta1-AR. (duke.edu)
25637 PKD domain containing protein CP001857 CDS Arcpr_0030 complement(25624. (go.jp)

7524) oxaloacetate decarboxylase alpha subunit CP001857 CDS Arcpr_0006 complement(7556. (go.jp)

Affinity is influenced also by the properties of the solution, like pH, temperature and salt concentration, that may affect the stable state of the proteins and ligands and hence also their interaction and by the presence of other macromolecules that causes macromolecular crowding. (wikipedia.org)

Anatomy20

Organisms15

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes52

Disciplines and Occupations2

Information Science3

GTPase12

Guanine nucleotide6

Hydrolysis4

Gamma8

Receptor21

Heterotrimeric G protei1

Kinase3

Effector4

Dissociate3

Intracellular4

Synthase5

Dissociation1

Receptors8

Individual subunits1

GPCR7

Ligand10

Interact3

Enzyme6

Eukaryotic3

Activates4

Putative18

Helicase2

Guanosine2

Secretory proteins1

Cytoskeletal3

Inactive3

Regulatory proteins1

Humans1

Signal transduction1

Phosphate1

Transcription2

Synthesis4

Inhibitor1

Target proteins1

Ribosome1

Adrenergic2

Cytoplasm1

Glutathione2

Reformation2

Complex9

Substrate1

GoLoco6

Glycoprotein1

Motif1

Hypothetical38

Gene4

Repeats1

Molecules2

Actin2

Cytoskeleton1

Interacts1

Kinases1

Nuclear1

Initiation factor1

Inositol1

Ribosomal protein1

00231

Domain-contain2

00061

Ligands1