• Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene. (wikipedia.org)
  • GATA4 is a critical transcription factor for proper mammalian cardiac development and essential for survival of the embryo. (wikipedia.org)
  • GATA4 works in combination with other essential cardiac transcription factors as well, such as Nkx2-5 and Tbx5. (wikipedia.org)
  • Their proliferation and fusion leads to division of the ventricular inlet into two different passageways with two AV valves, and they are thought to be under the influence of the GATA4 transcription factor. (wikipedia.org)
  • This data could have important implications for human medicine by suggesting that mutations with the GATA4 transcription factor could be responsible for AV cushion defects in humans with improper septal formation leading to congenital heart disease. (wikipedia.org)
  • Tbx20 physically interacted with cardiac transcription factors Nkx2-5, GATA4, and GATA5, collaborating to synergistically activate cardiac gene expression. (nih.gov)
  • In inhibin-alpha/Simian Virus 40 T antigen (SV40Tag) (inh alpha/Tag) mice, gonadectomy-induced (OVX) elevated LH triggers the growth of transcription factor GATA4 (GATA4)-positive adrenocortical tumors in a hyperplasia-adenoma-adenocarcinoma sequence. (abo.fi)
  • GATA4, a zinc finger domain transcription factor, is critical for jejunal identity, and intestinal GATA4 deficiency leads to a jejunoileal transition. (elsevierpure.com)
  • Here, we coupled a bioinformatics-based approach with mass spectrometry analyses to demonstrate that CHD4 interacts with the core cardiac transcription factors GATA4, NKX2-5, and TBX5 during embryonic heart development. (princeton.edu)
  • A) Actual time PCR showed a considerable enhance in cardiac transcription element Nkx2.5, GATA4 and professional-angiogenic factor SDF-one, Ang-1 genes expression in left ventricle tissue at 3 days right after transplantation. (idhinhibitor.com)
  • To address some of the limitations of these models, here we used two complementary ex vivo models based on Xenopus embryos: pluripotent animal cap explants expressing Gata4 transcription factor and conjugates of gastrula -stage AE with animal caps (AC). (xenbase.org)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. (bvsalud.org)
  • Mutations or defects in the GATA4 gene can lead to a variety of cardiac problems including congenital heart disease, abnormal ventral folding, and defects in the cardiac septum separating the atria and ventricles, and hypoplasia of the ventricular myocardium. (wikipedia.org)
  • GATA4 is not only important for cardiac development, but also development and function of the mammalian fetal ovary and contributes to fetal male gonadal development and mutations may lead to defects in reproductive development. (wikipedia.org)
  • Effect of GATA4 mutations on ANP promoter activation in NIH3T3 cells. (figshare.com)
  • The gene view histogram is a graphical view of mutations across GATA4. (sanger.ac.uk)
  • This section shows the drugs associated with GATA4 resistance mutations. (sanger.ac.uk)
  • Based on the TBX5, GATA4, and HEY2, often simultaneously incidence of somatic mutations described in the within the same patient.9-13 The observation of two previously published reports, our study was adequately or more somatic sequence variants in the same powered to replicate the previous studies. (cdc.gov)
  • GATA4 has been shown to interact with NKX2-5, TBX5, Serum response factor HAND2, and HDAC2. (wikipedia.org)
  • Using transcriptomics and genome-wide occupancy data, we characterized the genomic landscape of GATA4, NKX2-5, and TBX5 repression and defined the direct cardiac gene targets of the GATA4-CHD4, NKX2-5-CHD4, and TBX5-CHD4 complexes. (princeton.edu)
  • and Heikinheimo, Markku, "FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells. (wustl.edu)
  • In contrast to Lhcgr-ko, Gata4-ko Ca1 cells presented decreased proliferation, increased apoptosis, decreased expression of Inha, SV40Tag and Lhcgr tumor markers, as well as up-regulated adrenal-and down-regulated sex steroid gene expression. (abo.fi)
  • Although intestinal GATA4 ablation is known to misregulate jejunal gene expression, its pathophysiological impact on various components of metabolic syndrome remains unknown. (elsevierpure.com)
  • Chemically induced gene expression changes were characterized by qRT-PCR, global run-on sequencing (GRO-seq) and immunoblotting, and the network of cooperative proteins of GATA4 and NKX2-5 were further explored by the examination of the GATA4 and NKX2-5 interactome by BioID. (biomedcentral.com)
  • GATA4-targeted compounds 3i-1000 and 3i-1103 were identified as differential modulators of atrial and ventricular gene expression. (biomedcentral.com)
  • In this line, reporter gene assays with combinatorial treatment of 3i-1000 and the BET bromodomain inhibitor (+)-JQ1 demonstrated the cooperative role of GATA4 and BRD4 in the modulation of chamber-specific cardiac gene expression. (biomedcentral.com)
  • The single nucleotide polymorphism in GATA4 is associated with various congenital heart disease phenotypes. (uni-mysore.ac.in)
  • In the present study, we analysed the nonsynonymous single nucleotide polymorphism of GATA4, which are involved in congenital heart disease by predicting the changes in protein structures. (uni-mysore.ac.in)
  • Total of 49 nonsynonymous single nucleotide polymorphisms of GATA4 was screened from congenital heart disease patients of Mysore and also globally reported nonsynonymous single nucleotide polymorphisms. (uni-mysore.ac.in)
  • Thus, the structural changes in the mutated proteins impaired the normal function of GATA4. (uni-mysore.ac.in)
  • Additionally, BioID analysis indicated broad interaction between GATA4 and BET family of proteins, such as BRD4. (biomedcentral.com)
  • Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. (musc.edu)
  • Inhibition of p62 leads to increased GATA4 levels, resulting in NF-kB activation and subsequent SASP induction. (wikipedia.org)
  • GATA4 is regulated through the autophagy-lysosome pathway in eukaryotic cells. (wikipedia.org)
  • Furthermore, depletion of GATA4 abrogated SASP-dependent senescence through suppression of NF-?MCP-1 and B in hMSCs with progerin or prelamin A. Hence, our results indicate that unusual lamin A protein cause paracrine senescence through a GATA4-reliant pathway in hMSCs. (ap26113.com)
  • During the procedure for mobile senescence, GATA4 includes a regulatory function in the SASP of fibroblasts through the NF-?B pathway. (ap26113.com)
  • FGF pathway is not necessary for Gata4 -induced liver specification in animal cap explants but is required for prolonged period in sandwiches of AE and AC. (xenbase.org)
  • Conclusion: Our data indicate that LH/LHCGR signaling is critical for the adrenal cell reprogramming by GATA4 induction prompting adenoma formation and gonadal-like phenotype of the adrenocortical tumors in inha/Tag mice. (abo.fi)
  • Induction of hepatogenesis in Gata4 -expressing AC explants and AC/AE conjugates. (xenbase.org)
  • B) qPCR showing fold difference in expression between Gata4 treated animal caps and control animal caps grown to st. 33, induction of expression of myl7 , nr1h5 , hhex and marker of endoderm foxa2 is shown. (xenbase.org)
  • GATA4 inactivation, with GATA4-null mice, leads to down regulation of Erbb3 and altered Erk expression, two other important molecules in EMT and ventricular inlet separation. (wikipedia.org)
  • Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. (medscape.com)
  • Here, we used intestine-specific GATA4 knockout (GATA4iKO) mice to dissect the contribution of GATA4 on obesity development. (elsevierpure.com)
  • Among the elements reported to modify the SASP, GATA4 continues to be defined as a regulator of LY294002 pontent inhibitor senescence and irritation23 lately,24. (ap26113.com)
  • GATA4 has also been discovered to have an integral role in controlling the early stages of pancreatic and hepatic development. (wikipedia.org)
  • To view all methylation probes within or in close proximity to GATA4 please use the COSMIC Genome Browser . (sanger.ac.uk)
  • Impact of a modified CGI on the methylation pattern of Gata4 locus. (mpg.de)
  • GATA4 is expressed in both embryo and adult cardiomyocytes where it functions as a transcriptional regulator for many cardiac genes, and also regulates hypertrophic growth of the heart. (wikipedia.org)
  • Both Gata4-ko and Lhcgr-ko Ca1 cells had decreased expression of steroidogenic genes resulting in decreased basal progesterone production. (abo.fi)
  • As seen from the abnormalities from deletion of GATA4, it is essential for cardiac formation and the survival of the embryo during fetal development. (wikipedia.org)
  • By knocking out Lhcgr and Gata4 in C alpha 1 adrenocortical cells (Lhcgr-ko, Gata4-ko) we tested their role in tumor progression. (abo.fi)
  • A) RT-PCR showing expression of cardiac fate marker myl7 , liver fate marker nr1h5 and control marker odc1 in Gata4 mRNA-injected ACs , control ACs and stage 33 sibling control embryo . (xenbase.org)
  • This molecular hyperlink between faulty lamin A and GATA4 can offer insights into physiological maturing and pathological maturing disorders. (ap26113.com)
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
  • Development of the mammalian liver and ventral pancreas is dependent on GATA4. (musc.edu)
  • 2010. Hopx and Hdac2 Interact to Modulate Gata4 Acetylation and Embryonic Cardiac Myocyte Proliferation . (umd.edu)
  • GATA4 has also been shown to interact with Erbb3, FOG-1, and FOG-2. (wikipedia.org)
  • Mouse insertional mutagenesis experiments support the designation of GATA4 as a cancer causing gene. (sanger.ac.uk)
  • Purified GATA4 mouse monoclonal antibody, clone 9F9 by OriGene Technologies Inc. (absave.com)
  • Human recombinant protein fragment corresponding to amino acids 296-442 of human GATA4 (NP_002043) produced in E.coli. (absave.com)
  • GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. (nih.gov)
  • In contrast, BMP signaling is shown to be essential for Gata4 -induced liver specification. (xenbase.org)
  • Because GATA4-reliant mobile senescence is certainly connected with DDR, the role of GATA4 in other senescence choices and other cell types might reveal a fresh mechanism. (ap26113.com)
  • GATA4 expression during cardiac development has been shown to be essential to proper atrioventricular (AV) formation and function. (wikipedia.org)
  • B) Effect of mutated GATA4 on synergy with NKX2-5 and (C) on synergy with KLF13. (figshare.com)
  • In summary, our findings show that the absence of intestinal GATA4 has a beneficial effect on decreasing intestinal lipid absorption causing resistance to hyperlipidemia and obesity. (elsevierpure.com)
  • More detailed structure-function analysis revealed a distinct subclass of GATA4/NKX2-5 inhibitory compounds with an acetyl lysine-like domain that contributed to ventricular cells (%Myl2-eGFP+). (biomedcentral.com)
  • Atrial septal defects, tetralogy of Fallot, and ventricular septal defects associated with GATA4 mutation were also seen in South Indian patients. (wikipedia.org)
  • This section gives an overview of GATA4, along with links to any related data and resources. (sanger.ac.uk)
  • See all drug sensitivity data for GATA4. (sanger.ac.uk)
  • A′) Western blotting shows efficient translation of exogenous Gata4 protein. (xenbase.org)
  • OVX inha/Tag/LuRKO only developed SV40Tag positive hyperplastic cells that were GATA4 negative, cleaved caspase-3 positive and did not progress into adenoma. (abo.fi)
  • The -699bp ANP promoter was utilized to study the transcriptional activity of the GATA4 mutants on a validated GATA4 target gene. (figshare.com)
  • CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart. (princeton.edu)