GATAProteinAllergic and humoral immune responsesRegulatesMethylationILCsLncRNAEpithelial cells10p14Gene expressionCytoplasmicTissuesAntisenseGenesMRNATBX21TranscriptionalMiceParathyroidDownstreamDifferentiationUnclearProgressionTumorCellsPromotesInflammatoryDysregulationHumansVariantExpressionNegativePrimaryCancerMouseNuclearFoundRoleStudiesSpecificHumanStrong
GATA6
- GATA3 belongs to the GATA family of transcription factors. (wikipedia.org)
- GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. (bmj.com)
- Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in. (oncotarget.com)
- GATA3 is characterized by two conserved zinc finger domains, which bind DNA at the nucleotide sequence GATA. (ms-validatedantibodies.com)
- Like other proteins of the GATA family (GATA1-6), GATA3 is a transcription factor that regulates various cellular programs during embryogenesis and differentiation in several organ systems, including parathyroid gland, kidney, breast epithelium, urothelium, and the nervous system. (ms-validatedantibodies.com)
- GATA-binding protein 3 (GATA3) is a transcription factor that is crucial to mammary gland morphogenesis and differentiation of progenitor cells, and has been suggested to have a tumor suppressor function. (eur.nl)
Protein6
- GATA3 variant 1 is a linear protein consisting of 444 amino acids. (wikipedia.org)
- GATA3 variant 2 protein is an identically structured isoform of, but 1 amino acid shorter than, GATA3 variant 1. (wikipedia.org)
- Specific methylation assays confirmed the hypomethylation of GATA3 in neuroblastoma, which correlated with high expression at both the RNA and protein level. (edu.sa)
- Neuroblastomas that had completely absent GATA3 methylation and/or very high levels of protein expression, were associated with poor prognosis. (edu.sa)
- GATA3 is frequently found mutated in breast cancer, and downregulation of the protein has been linked to poor prognosis of the disease. (ms-validatedantibodies.com)
- KIAA1429 induced m6A methylation on the 3′ UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA. (biomedcentral.com)
Allergic and humoral immune responses3
- Group 2 ILCs and Th2 cells, and thereby GATA3, are critical for the development of allergic and humoral immune responses in humans. (wikipedia.org)
- Comparable studies in animals implicate GATA3 in the development of lymphocytes that mediate allergic and humoral immunity as well as allergic and humoral immune responses. (wikipedia.org)
- A key role has been identified in T cell development, where GATA3 is the downstream of Notch in differentiation of T-helper cells and important for allergic and humoral immune responses. (ms-validatedantibodies.com)
Regulates2
- The GATA3 transcription factor regulates the expression of genes involved in the development of various tissues as well as genes involved in physiological as well as pathological humoral inflammatory and allergic responses. (wikipedia.org)
- GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. (bmj.com)
Methylation5
- Demethylation with azacytidine in cultured sympathetic ganglia cells led to increased GATA3 expression, suggesting a mechanistic link between GATA3 expression and DNA methylation. (edu.sa)
- The purpose of this study was to investigate whether an aberrant DNA methylation of transcriptional and inflammatory factors, including TBX21, GATA3, RORγt, FOXP3, IFN-γ, IL-4, IL-17A and TGF-β , in CD4 + T confers risk to BD. (oncotarget.com)
- We found that the promoter methylation level of GATA3, IL-4 and TGF-β was significantly up-regulated in active BD patients and negatively correlated with the corresponding mRNA expression. (oncotarget.com)
- Treatment with corticosteroids and cyclosporine (CsA) resulted in a decrease of the methylation level of GATA3 and TGF-β in inactive BD patients. (oncotarget.com)
- Our results suggest that an aberrant DNA methylation of GATA3 and TGF-β is associated with their mRNA expression and participates in the pathogenesis of BD. (oncotarget.com)
ILCs5
- 2) In humans, GATA3 is required for the development and/or function of innate lymphoid cells (ILCs), particularly Group 2 ILCs as well as for the development of T helper cells,(Th cells), particularly Th2 cells. (wikipedia.org)
- After the ILCs had fully developed, GATA3 remained important for the maintenance and functions of ILC2s. (nih.gov)
- Thus, GATA3 plays parallel roles in regulating the development and functions of CD4(+) T cells and IL-7Rα(+) ILCs. (nih.gov)
- G ) Intranuclear GATA3 staining in skin ILCs. (elifesciences.org)
- Non-T cells and T cells are presented as internal references for the high level of GATA3 expressed by ILCs. (elifesciences.org)
LncRNA3
- Strikingly, a long noncoding RNA (lncRNA) GATA3-AS, transcribed from the antisense strand of the GATA3 gene, functioned as a cis -acting element for the preferential interaction of KIAA1429 with GATA3 pre-mRNA. (biomedcentral.com)
- Lin S , Zhao M , Lv Y , Mao G , Ding S , Peng F , . The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway. (aging-us.com)
- Combination of the results from expression, survival, correlation analysis and functional experiments analysis demonstrated the link between lncRNA GATA3-AS1/miR-495-3p/CENPU axis and prognosis of breast cancer. (aging-us.com)
Epithelial cells5
- All three of these interleukins serve to promote allergic responses, 4) GATA3 induces the maturation of precursor cells into breast epithelial cells and maintains these cells in their mature state in mice and possibly humans. (wikipedia.org)
- Strong GATA3 positivity in all epithelial cells. (ms-validatedantibodies.com)
- Moderate to strong GATA3 positivity of a epithelial cells. (ms-validatedantibodies.com)
- Variable (weak to strong) GATA3 positivity in squamous epithelial cells. (ms-validatedantibodies.com)
- Weak to moderate GATA3 positivity in epithelial cells including hair follicles. (ms-validatedantibodies.com)
10p143
- The location of GATA3 borders that of other critical sites on chromosome 10, particularly a site located at 10p14-p13. (wikipedia.org)
- GATA3 gene at 10p14 consists of 8 exons and codes for GATA3, variant 1, and GATA3, variant 2, proteins of 48 KDa that which differ in one amino acid and may have identical functions. (ms-validatedantibodies.com)
- A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). (medscape.com)
Gene expression1
- Genome-wide gene expression analyses indicated that GATA3 regulated a similar set of cytokines and receptors in Th2 cells and ILC2s, but not in ILC3s. (nih.gov)
Cytoplasmic2
- A weak cytoplasmic GATA3 staining can occur in goblet cells of respiratory epithelium (probably non-specific staining). (ms-validatedantibodies.com)
- A weak cytoplasmic GATA3 staining can occur in gastric glands (probably non-specific staining). (ms-validatedantibodies.com)
Tissues3
- The GATA3 transcription factor is critical for the embryonic development of various tissues as well as for inflammatory and humoral immune responses and the proper functioning of the endothelium of blood vessels. (wikipedia.org)
- Gene-deletion studies in mice indicate that Gata3 (mouse gene equivalent to GATA3) is critical for the embryonic development and/or function of various cell types (e.g. fat cells, neural crest cells, lymphocytes) and tissues (e.g. kidney, liver, brain, spinal cord, mammary gland). (wikipedia.org)
- 5) In mice, GATA3 is responsible for the normal development of various tissues including the skin, fat cells, the thymus, and the nervous system. (wikipedia.org)
Antisense1
- Expression of GATA3 may be regulated in part or at times by the antisense RNA, GATA3-AS1, whose gene is located close to the GATA3 gene on the short arm of chromosome 10 at position p14. (wikipedia.org)
Genes3
- GATA3 haploinsufficiency (i.e. loss of one or the two inherited GATA3 genes) results in a congenital disorder termed the Barakat syndrome. (wikipedia.org)
- Knockout of both GATA3 genes in mice is fatal: these animals die at embryonic days 11 and 12 due to internal bleeding. (wikipedia.org)
- in this paper we report on 67 hypomethylated genes, which were filtered to select genes that showed transcriptional over-expression and an association with poor prognosis in neuroblastoma, highlighting GATA3 for detailed studies. (edu.sa)
MRNA1
- The mRNA expression of GATA3 and TGF-β was markedly down-regulated in active BD patients compared to healthy individuals. (oncotarget.com)
TBX212
- TBX21 (Th1) , GATA3 (Th2) , RORγt (Th17) and FOXP3 (Treg) are the primary subset-specific transcription factors of these CD4 + T cell subsets and can regulate T cell differentiation. (oncotarget.com)
- An earlier study found that the ratio of Th1/Th17 cells was decreased in BD patients with uveitis [ 5 ], and another study reported an increase in the ratios of RORC / FOXP3 and TBX21 / GATA3 in neuro-Behçet's disease, suggesting a dysregulation of Th1, Th2, Th17 and Tregs in this disease [ 6 ]. (oncotarget.com)
Transcriptional2
- These results identify GATA3 as an epigenetically regulated component of the neuroblastoma transcriptional control network, that is essential for neuroblastoma proliferation. (edu.sa)
- This suggests that the GATA3 transcriptional network is a promising target for novel neuroblastoma therapies. (edu.sa)
Mice1
- Conditionally Gata3-deficient mice had no lymph nodes and were susceptible to Citrobactor rodentium infection. (nih.gov)
Parathyroid1
- Studies in humans implicate GATA3 in the following: 1) GATA3 is required for the development of the parathyroid gland, sensory components of the auditory system, and the kidney in animals and humans. (wikipedia.org)
Downstream1
- GATA3 was identified as the direct downstream target of KIAA1429-mediated m6A modification. (biomedcentral.com)
Differentiation3
- During development, GATA3 plays a key role in cell differentiation. (bmj.com)
- Knock-down of GATA3 in neuroblastoma cells lines inhibited cell proliferation and increased apoptosis but had no effect on cellular differentiation. (edu.sa)
- Broadly speaking, Gata3 is a transcription factor involved in neurosensory specification and hair cell differentiation. (wmich.edu)
Unclear1
- However, the role, if any, of GATA3 in the development of these cancers is under study and remains unclear. (wikipedia.org)
Progression1
- A role of GATA3 has also been demonstrated for tumor development and progression. (ms-validatedantibodies.com)
Tumor1
- Accordingly, we found that the tumor growth and metastasis driven by KIAA1429 or GATA3-AS were mediated by GATA3. (biomedcentral.com)
Cells9
- 3) GATA3 promotes the secretion of IL-4, IL-5, and IL-13 from Th2 cells in humans and has similar actions on comparable mouse lymphocytes. (wikipedia.org)
- Here, we report that GATA3 was indispensable for the development of all IL-7Rα(+) ILC subsets and T cells but was not required for the development of classical natural killer cells. (nih.gov)
- GATA3 increases the GFAP/SOX2-positive cells and ASCL1 after injury in 3D. (frontiersin.org)
- The Activated Caspase3 labelling follows the general pathway of the neurons, leading to the belief that neurons were the cells that were dying when Gata3 was conditionally knocked out. (wmich.edu)
- GATA3 is expressed in breast epithelium, urothelial cells, and a subset of lymphocytes. (ms-validatedantibodies.com)
- Weak GATA3 staining of glandular cells (mostly mucinous). (ms-validatedantibodies.com)
- Weak GATA3 positivity in some basal cells (not in all samples). (ms-validatedantibodies.com)
- Weak GATA3 positivity in amnion cells. (ms-validatedantibodies.com)
- The tumour cells are positive for GATA3 and are negative. (jawabkom.com)
Promotes1
- GATA3 promotes neural progenitor state but not neurogenesis. (frontiersin.org)
Inflammatory1
- Current clinical and laboratory research is focusing on determining the benefits of directly or indirectly blocking the action of GATA3 in inflammatory and allergic diseases such as asthma. (wikipedia.org)
Dysregulation2
- These differences reflect the expression of GATA3, as demonstrated by silencing, suggesting a link between this transcription factor and gene dysregulation. (unife.it)
- Our study proposed a complex KIAA1429-GATA3 regulatory model based on m6A modification and provided insights into the epi-transcriptomic dysregulation in hepatocarcinogenesis and metastasis. (biomedcentral.com)
Humans1
- GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. (wikipedia.org)
Variant1
- We conclude that there is no evidence that either GATA3 rs570613, or any variant in strong linkage disequilibrium with it, is associated with breast cancer risk in women. (eur.nl)
Expression3
- GATA3 expression is a feature of the luminal subtype of bladder cancer and has implications for immune status and therapeutic response. (bmj.com)
- Lentivirus-mediated overexpression of GATA3 significantly increased the number of GFAP/SOX2 double positive astrocytes and expression of pro-neural factor ASCL1, but failed to induce neurogenesis, suggesting that GATA3 is required for enhancing the neurogenic potential of primary human astrocytes and is not sufficient to induce neurogenesis alone. (frontiersin.org)
- When Gata3 was conditionally knocked out and reduced in its expression, fewer neurons appear to have formed compared to the mutant and the neurons that do form lack normal projection patterns. (wmich.edu)
Negative1
- The rs570613 single nucleotide polymorphism (SNP) in intron 4 of GATA3 was previously found to be associated with a reduction in breast cancer risk in the Cancer Genetic Markers of Susceptibility project and in pooled analysis of two case-control studies from Norway and Poland (P (trend) = 0.004), with some evidence for a stronger association with estrogen receptor (ER) negative tumours [Garcia-Closas M et al. (eur.nl)
Primary3
- Therefore, in this report, we investigated how overexpression of GATA3 in primary human astrocytes would affect the neurogenic potential before and after injury in 2D and 3D cultures. (frontiersin.org)
- We found that primary human astrocytes are unable to induce GATA3 after injury. (frontiersin.org)
- Primary human astrocytes do not induce GATA3 after injury. (frontiersin.org)
Cancer3
- Mutations in GATA3 are linked to breast and bladder cancer. (bmj.com)
- This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical marker. (bmj.com)
- We genotyped GATA3 rs570613 in 6,388 cases and 4,995 controls from the Breast Cancer Association Consortium (BCAC) and 5,617 BRCA1 and BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). (eur.nl)
Mouse1
- Figure 1: Western blot analysis using GATA3 mouse mAb against GATA3(AA: full length)-hIgGFc transfected HEK293 cell lysate. (promab.com)
Nuclear1
- GATA3 immunostaining is always nuclear. (ms-validatedantibodies.com)
Found1
- Gata3 was previously found to be a mechanism that zebrafish brain uses to injury-dependent induction of neural progenitors. (frontiersin.org)
Role2
- GATA3 plays central role in allergy and immunity against worm infections. (wikipedia.org)
- To better understand the role of Gata3 in spiral ganglion neurons of the inner ear, a Neurod1-cre model was used to conditionally knock out Gata3 at E9-E9.5, the timepoint when neuroblasts first begin to delaminate from the otic placode. (wmich.edu)
Studies1
- Previous studies have shown that Gata3 null mutants do not develop neurons, so Gata3 appears to be necessary for neuronal survival. (wmich.edu)
Specific1
- An immunohistochemical investigation of the gingival tissue was performed to detect the presence of the Th2 specific transcription factor (GATA3). (bvsalud.org)
Human1
- However, the effects of GATA3 in human astrocytes after injury are not known. (frontiersin.org)
Strong1
- Strong GATA3 positivity collecting ducts, moderate staining in glomerular podocytes. (ms-validatedantibodies.com)