• PGK1: Phosphoglycerate kinase 1 (e). (bioz.com)
  • d ) Validation of the yeast mRNA interactome using western blotting of input samples and eluate after interactome capture with specific antibodies (ADH1, alcohol dehydrogenase 1, PUB1) or against TAP-tagged proteins (PGK1, phosphoglycerate kinase 1, TDH1, triose phosphate dehydrogenase, TRX2, thioredoxine 2, SHE2, Swi5p-dependent HO Expression 2). (nature.com)
  • The reconstituted system, consisting of phosphoglycerate kinase, glyceraldehyde 3-phosphate dehydrogenase, triose phosphate isomerase and the fructose 1,6-bisphosphate aldolase/phosphatase, maintained a constant consumption rate of 3-phosphoglycerate and production of fructose 6-phosphate over a 1-h period. (seek4science.org)
  • DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a member of the phosphatidylinositol 3-kinase related kinase family is a well-known player in repairing DNA double strand break through non-homologous end joining pathway. (molcells.org)
  • DNA-dependent protein kinase catalytic subunit (DNA-PKcs), encoded by PRKDC gene, is a member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, which also includes the two DNA damage repair proteins, ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein (ATR). (molcells.org)
  • KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
  • Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (EC 1.2.1.9) (GAPN) is an enzyme that irreversibly catalyzes the oxidation of glyceraldehyde-3-phosphate (GAP) to 3-phosphoglycerate (3-PG or 3-PGA) using the reduction of NADP+ to NADPH. (wikipedia.org)
  • The most familiar variant of glycolysis uses glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase to produce ATP. (wikipedia.org)
  • GAPDH: Glyceraldehyde-3-phosphate dehydrogenase (d). (bioz.com)
  • Here, we report that three consecutive triose-phosphate-processing enzymes involved in cytosolic glycolysis, triose-phosphate-isomerase (TPI), glyceraldehyde-3-phosphate dehydrogenase (GAPC), and phosphoglycerate kinase (PGK), designated TGP, negatively regulate autophagy. (bvsalud.org)
  • Moreover, analysis of endogenous glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in HEK293T cells allowed us to follow its behavior spatially and temporally in response to prolonged oxidative stress, correlating the increased number of oxidation-induced inactive catalytic sites in GAPDH with its translocation from cytosol to nucleus. (bvsalud.org)
  • Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading to rapid inactivation of the enzyme. (bvsalud.org)
  • Step 6: Glyceraldehyde-3-phosphate Dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme that takes away hydrogen and adds an inorganic phosphate to glyceraldehyde 3-phosphate, creating 1,3-bisphosphoglycerate. (traverse.link)
  • These proteins were L-lactate dehydrogenase B(LDHB), glyceraldehyde-3-phosphate dehydrogenase, glucose-6-phosphate isomerase (GPI), phosphoglycerate mutase 2 (PGAM2), gelsolin and isoform 8 of titin. (biomedcentral.com)
  • For example, a major regulator of metabolism is phosphoinositol 3 kinase (PI3K). (hindawi.com)
  • 2-Phosphoglycerate (2PG) is an important intermediate in the glycolysis pathway, a critical mechanism of ATP generation. (sigmaaldrich.com)
  • The enzyme responsible for this reaction is GAPDH. (traverse.link)
  • Furthermore, HIF-1 actively limits the mitochondrial consumption of pyruvate at two levels: (i) through the enzyme PDK (PDH-kinase), which in turn inhibits PDH activity preventing the conversion of pyruvate into acetyl CoA, and thereby limiting mitochondrial metabolism of pyruvate [ 6 ] and (ii) through the direct activation of LDH [ 7 , 8 ]. (hindawi.com)
  • TGF-β signaling is initiated when the ligand binds to type II serine/threonine kinase receptor (TGFBR2), which then phosphorylates and activates type I serine/threonine kinase receptor (TGFBR1) [ 13 ]. (degruyter.com)
  • Depletion of TGP enzymes causes spontaneous autophagy induction and increases AUTOPHAGY-RELATED 1 (ATG1) kinase activity. (bvsalud.org)
  • Suitable for the detection of 2-Phosphoglycerate in tissue and cell culture samples. (sigmaaldrich.com)
  • The 2-Phosphoglycerate Colorimetric/Fluorometric Assay Kit is a simple assay that measures 2PG in various samples (ranging from 2-10 nmole/well for the colorimetric assay and from 50-250 pmole/well for the fluorometric assay). (sigmaaldrich.com)
  • Reasonably specific markers for blood tests including creatine kinase muscle/brain isoform (CK-MB), cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are released after the onset of significant necrosis instead of early ischemia, and they all require a level of myocardial necrosis to prompt their release from myocytes before they can be detected. (biomedcentral.com)
  • Iodoacetic acid, an inhibitor of GAPDH, eliminated 45 Ca transport supported by fructose-1,6-diphosphate, the substrate for aldolase, but transport was completely restored by phosphoenolpyruvate (the substrate for PK), indicating that both of the ATP-producing glycolytic enzymes, GAPDH/PGK and PK, were associated with the SR and functionally capable of providing ATP for the Ca 2+ pump. (johnshopkins.edu)
  • We discuss the likelihood that the trypanosome GAPDH-like and PGK-like proteins constitute molecular evidence for evolutionary loss of a flagellar glycolytic pathway, either as a consequence of niche adaptation or the re-localization of glycolytic enzymes to peroxisomes and the extensive changes to glycolytic flux regulation that accompanied this re-localization. (ox.ac.uk)
  • Phosphoglycerate kinase (PGK), a glycolytic enzyme, is isolated from a broad variety of organisms. (sigmaaldrich.com)
  • Phosphoglyceratekinase (PGK) plays a vital role in the glycolytic pathway by catalyzing one of the two ATP-producing reactions. (sigmaaldrich.com)
  • Yet, bioinformatics interrogation and structural modelling indicate neither the trypanosome PGK-like nor the GAPDH-like protein is catalytically active. (ox.ac.uk)
  • Orthologs are present in a free-living ancestor of the trypanosomatids, Bodo saltans: the PGK-like protein from B. saltans also lacks key catalytic residues, but its GAPDH-like protein is predicted to be catalytically competent. (ox.ac.uk)
  • A possibility that trypanosome GAPDH-like protein additionally represents a degenerate example of a moonlighting protein is also discussed. (ox.ac.uk)
  • ribosomal protein S6 kinase C1 [Source. (gsea-msigdb.org)
  • 5. Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma. (nih.gov)
  • Gene Ontology analysis showed that genes upregulated in the epithelial cells were enriched for extracellular matrix production, cell division, migration, protein kinase activity, growth factor binding, and calcium ion binding. (molvis.org)
  • Guidelines for Genetic Nomenclature of Human Enzymes (as already reported) Addendum: Two enzymes not listed above, adenosine kinase and B-glu- curonidase, were assigned to chromosomal loci at the Baltimore meeting. (nih.gov)
  • KIT is a receptor tyrosine kinase type III, which binds to stem cell factor. (inhibitorkit.com)