• A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • 11) Malignant neoplasm. (who.int)
  • A benign neoplasm cannot be distinguished from a malignant neoplasm on the basis of cytologic analysis of a fine-needle aspiration (FNA) biopsy specimen. (medscape.com)
  • Increased incidences of non-viral, non-alcohol liver hepatitis, that ultimately progress to cirrhosis, occur in certain workers, such as painters and printers, presumably due to solvent exposure. (cdc.gov)
  • Correction of both prothrombin time and primary haemostasis by recombinant factor VII during therapeutic alcohol injection of hepatocellular cancer in liver cirrhosis. (ox.ac.uk)
  • We evaluated the efficacy of recombinant factor VII to correct impaired haemostasis in a patient with liver cirrhosis requiring an invasive procedure. (ox.ac.uk)
  • Thus, recombinant factor VII represents a therapeutic advance, as it can correct fully both coagulation and platelet function defects in cirrhosis and allow invasive procedures to be performed safely. (ox.ac.uk)
  • However, DC-SIGNR as a family member of selectin participates in gastric cancer liver metastasis remains unknown. (biomedcentral.com)
  • Investigation the biological effects of DC-SIGNR were verified by MTT, wounding and transwell in vitro and experiments on animals to confirm gastric cancer liver metastasis by IVIS. (biomedcentral.com)
  • DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and suppressed the liver metastasis in vivo. (biomedcentral.com)
  • DC-SIGNR promoted gastric cancer liver metastasis mediated with HNRNPKP2 which expression was regulated by STAT5A. (biomedcentral.com)
  • These findings indicated potential therapeutic candidates for gastric cancer liver metastasis. (biomedcentral.com)
  • Despite surgical resection and chemoradiotherapy can control most cancer cells [ 5 ], a surgical resection has been rarely indicated for liver metastasis from gastric cancer [ 6 ]. (biomedcentral.com)
  • So far, the complex molecular mechanism of liver metastasis has still remained essentially unknown. (biomedcentral.com)
  • In experimental metastasis studies, researchers demonstrate that liver sinusoidal endothelial cell lectin (LSECtin) mediated colon cancer cells metastasis to liver displays enhanced abilities to the specific organ [ 8 ]. (biomedcentral.com)
  • Moreover, using an E-selectin-specific monoclonal antibody reduces liver metastasis, showing that E-selectin is involved in metastatic formation in this organ [ 11 ]. (biomedcentral.com)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
  • For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
  • Tumors or cancer of the LIVER. (lookformedical.com)
  • Experimentally induced tumors of the LIVER. (lookformedical.com)
  • Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
  • Pre-operative hepatic artery chemoembolization followed by orthotopic liver transplantation for HCC. (aetna.com)
  • Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
  • Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
  • Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
  • Similarly, hepatic sinusoidal endothelial E-selectin expression is up regulated by highly metastatic cells entering the liver [ 10 ]. (biomedcentral.com)
  • Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. (lookformedical.com)
  • Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. (lookformedical.com)
  • A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. (lookformedical.com)
  • Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C. (lookformedical.com)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
  • The presence of dense adhesions, advanced liver disease, unexpected cancer, or a severely inflamed gallbladder or encountering troublesome bleeding should prompt assessment of the need to convert to an open procedure. (medscape.com)
  • Inflammatory responses resulting from workplace exposures are usually observed in specific target organs, such as the lung, skin and liver and, if persistent, may progress to fibrosis, granulomatous disease or even cancer. (cdc.gov)
  • Co-occurring Fatigue and Lymphatic Pain Incrementally Aggravate Their Negative Effects on Activities of Daily Living, Emotional Distress, and Overall Health of Breast Cancer Patients. (duke.edu)
  • This trial is studying how well SPECT/CT with technetium Tc-99m sulfur colloid works in measuring liver function in patients with liver cancer. (withpower.com)
  • Male construction workers have an increased risk for esophageal cancer, liver cancer, lung cancer, and non-Hodgkin's cancer. (kjccm.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Previous studies revealed pivotal functions of WNT family members in colorectal cancer, as well as their prognostic values. (researchsquare.com)
  • Colorectal cancer (CRC) is one of most prevalent malignant neoplasms of the digestive system [1]. (researchsquare.com)
  • Recurrences of cancer in the liver, lung or peritoneal are major outcomes of CRC treatment failure. (researchsquare.com)
  • In contrast, anaplastic carcinoma is quite aggressive and has a poor prognosis, while patients with metastatic medullary carcinoma may live for many years but generally succumb to their cancer. (msdmanuals.com)
  • Papillary and follicular carcinoma together are called differentiated thyroid cancer because of their histologic resemblance to normal thyroid tissue and because differentiated function (eg, thyroglobulin secretion) is preserved. (msdmanuals.com)
  • Hepatocellular carcinoma (HCC) typically arises in fibrotic or cirrhotic livers, which are characterized by pathogenic angiogenesis. (cancerindex.org)
  • Acute Respiratory Distress Syndrome (ARDS) is a condition that endangers the lives of many Intensive Care Unit patients through gradual reduction of lung function. (researchgate.net)
  • Metastatic spreading and the formation of secondary neoplasms from primary site are not random, exhibiting organ selectivity [ 7 ]. (biomedcentral.com)
  • Electro-coagulation for the treatment of liver metastases. (aetna.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • These ideas motivated a comparison between results of molecular genetic studies of experimental evolution in yeast and the molecular genetic phenomena associated with tumorigenesis and tumor progression. (nih.gov)
  • The composition of the tumor microenvironment changes during tumor development, evolving to meet the demands of the growing neoplasm [ 6 ]. (degruyter.com)
  • You have liver disease that can be measured, or a blood clot in a blood vessel near a tumor. (withpower.com)
  • This Clinical Policy Bulletin addresses treatment approaches for liver and other neoplasms. (aetna.com)
  • Increasing experimental and clinical evidence indicates that the immune system is a target for certain physical and chemical agents found in the workplace. (cdc.gov)
  • A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment. (lookformedical.com)
  • 7 10 - 14 Several pieces of clinical and experimental data have confirmed that LPS significantly contributes to the development of obesity-related inflammatory liver diseases such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. (bmj.com)
  • Journal of Clinical and Experimental Hepatology. (mssm.edu)
  • Along with recommendations for additional animal studies of neoplasms, the panel suggested conducting clinical trials in patients with comorbid conditions, such as diabetes and CVD. (drsharma.ca)
  • Clinical consideration for BPH should include the elements of male sexual function, patients' age, and the characteristics and comprehensive effects of each group of drugs. (medscape.com)
  • Mice homozygous for a different knock-out allele exhibit increased susceptibility to experimental autoimmune encephalomyelitis with increased Th17 response. (jax.org)
  • The biological activity of glatiramer acetate is determined by its ability to block the induction of experimental autoimmune encephalomyelitis (EAE) in mice. (rxlist.com)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • and increased incidences of hepatocellular neoplasms in male and female mice. (who.int)
  • 8) Concomitant chronic disease such as chronic renal failure (CKD), nephrotic syndrome, acute or chronic liver disease, chronic obstructive pulmonary disease (COPD), decompensated ischemic heart disease, hypertensive encephalopathy, cerebrovascular disease (CVA), diabetes mellitus with metabolic decompensation, arterial insufficiency acute peripheral and complications in other organs such as kidney (Kinmestiel - Wilson, Necrotizing papillitis). (who.int)
  • Uric acid levels are affected by age, sex, and renal function. (medscape.com)
  • Exposure of fish to EDCs has also been associated with abnormal thyroid function, decreased fertility, decreased hatching success, de-feminization and masculinization of female fish and alteration of immune function. (wikipedia.org)
  • In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (lookformedical.com)
  • Amino acids link together by peptide bonds to form proteins, or function as chemical messengers and as intermediates in metabolism. (nih.gov)
  • Likewise, there is limited but increasing epidemiologic and experimental studies linking autoimmune diseases and occupational exposure to agents such as silica, solvents, pesticides and UVR. (cdc.gov)
  • David Botstein's fundamental contributions to modern genetics include the development of genetic methods for understanding biological functions and the discovery of the functions of many yeast and bacterial genes. (nih.gov)
  • Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS. (lookformedical.com)
  • Nonalcoholic fatty liver disease (NAFLD) is a globally observed metabolic disease with high prevalence both in adults and children. (mdpi.com)
  • a soluble thermostable fraction of mammalian liver is used in the treatment of pernicious anemia. (lookformedical.com)
  • Hence, this chapter summarizes the biological plausibility of EDCs exposure and elucidates the mechanism of action underlying EDCs affecting the regulatory circuits of the mammalian HPG axis and reproductive function. (intechopen.com)
  • The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. (lookformedical.com)
  • Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. (lookformedical.com)
  • Systemic mastocytosis, often termed systemic mast cell disease (SMCD), is characterized by infiltration of clonally derived mast cells in different tissues, including bone marrow (see the image below), skin, the gastrointestinal (GI) tract, the liver, and the spleen. (medscape.com)
  • Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells. (lookformedical.com)
  • aim: This liver is on the deposition of studies that have of monomethanesulfonate in the body of effects with carbon delivery. (hone.world)
  • Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (lookformedical.com)
  • We found that a selective gut microbiota change controls and increases endogenous GLP-2 production, and consequently improves gut barrier functions by a GLP-2-dependent mechanism, contributing to the improvement of gut barrier functions during obesity and diabetes. (bmj.com)
  • Emerging evidence has been given in the last years that angiocrine signaling - molecules produced and secreted by blood vessel components - play a major role in regulating and orchestrating physiological and pathophysiological processes of the liver. (tum.de)
  • Transarterially administered gene therapy for primary and secondary liver malignancies. (aetna.com)
  • A mode of action-based physiologi- cally based pharmacokinetic (PBPK) model was developed to predict the concentration of ST and SO in blood, liver, and the respiratory-tract tissues, particularly in terminal bron- chioles (target tisue), in order to conduct interspecies extrapolations and determine the extent to which there is a pharmacokinetic basis for the observed species specificity. (cdc.gov)
  • [ 4 ] The enzyme has two isoforms: type 1 (found in the liver and skin) and 2 (found in reproductive tissues). (medscape.com)
  • For instance, neuroimaging is now central to research and drug development in the neurosciences since it can be used to detect the pharmacological and physiological consequences of drug action within the living brain. (pharmaceutical-business-review.com)
  • Clinics in Liver Disease. (mssm.edu)
  • Clearly, the committee appeared unswayed by the weight-loss efficacy of lorcaserin ( which only narrowly made the categorical criterium of the FDA but failed the placebo-substracted 5% weight loss margin) and harboured continuing concerns regarding potential risks of neoplasms and valvular heart disease. (drsharma.ca)
  • Overview of Thyroid Function The thyroid gland, located in the anterior neck just below the cricoid cartilage, consists of 2 lobes connected by an isthmus. (msdmanuals.com)
  • Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported. (nih.gov)
  • The implications of the WNPRC findings were important as they extended CR findings beyond the laboratory rodent and to a long-lived primate. (nih.gov)
  • Our study suggests a separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate. (nih.gov)
  • Vascular and histopathological classification of rodent models for liver tumorigenesis to improve the reproducibility of histopathological results in biomedical research. (tum.de)
  • Our research interest is focused on the vascular biology of the liver. (tum.de)
  • Over the last 20 years, the so-called post-highly active antiretroviral therapy (post-HAART) era, we assisted to an increase in the mean age of People Living With HIV (PLWH) and comorbidities related to ageing, immune suppression and persistent inflammation [ 1 - 65 ]. (oncotarget.com)