• Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
  • Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
  • Oxidative stress has been implicated in a wide range of diseases including atherosclerosis, hypertension, diabetes, ischemia reperfusion injury and a range of neurodegenerative disorders (Flora, 2007). (scialert.net)
  • Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury. (biomedcentral.com)
  • Apelin protects heart against ischemia/reperfusion injury in rat. (ac.ir)
  • Wang D, Guo X, Zhou M, Han J, Han B, Sun X. Cardioprotective effect of the aqueous extract of lavender flower against myocardial ischemia/reperfusion injury. (ac.ir)
  • Cardioprotective properties of Crataegus oxycantha extract against ischemia-reperfusion injury. (ac.ir)
  • Molecular oxygen: friend and foe: the role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. (jamanetwork.com)
  • These applications include but are not limited to aging, Parkinson's and Alzheimer's diseases, cardiac atrial fibrillation, and ischemia-reperfusion injury. (epiphanyasd.com)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • In addition, ozone was able to induce an adaptation to oxidative stress with a preservation of the antioxidant endogenous systems in an animal model of renal ischemia-reperfusion (20). (lomr.org)
  • Background: The deleterious effect of oxidative stress on myocardial ischemia-reperfusion (I/R) has already been shown in previous studies. (ac.ir)
  • Conclusions: Our findings indicated that T. polium could provide protection for heart against the I/R injury which may be related to the improvement of myocardial oxidative stress states. (ac.ir)
  • Extract from Clerodendron colebrookianum Walp protects rat heart against oxidative stress induced by ischemic-reperfusion injury (IRI). (ac.ir)
  • Tissue necrosis caused by both oxidative stress and the inflammatory response further prevents nutrients and oxygen from reaching viable cells, which contributes to expanding the necrotic area and leads to implant failure [ 7 ]. (biomedcentral.com)
  • To provide in vivo evidence that DJ‑1 is involved in the delayed cardioprotection induced by ischemic preconditioning (IPC) against oxidative stress caused by ischemia/reperfusion (I/R), the present study subjected male Sprague‑Dawley rats to IPC (3 cycles of 5‑min coronary occlusion/5‑min reperfusion) 24 h prior to I/R (30‑min coronary occlusion/120‑min reperfusion). (spandidos-publications.com)
  • Although oxidative stress is thought to be a major pathogenic mechanism predisposing the PreOLs to injury, no effective therapies have been identified to date. (ijbs.com)
  • Even though the exact mechanisms underlying ischemic injury in the muscle are not completely understood, hypoxia-inducible factor-1 alpha (HIF-1α) has emerged as an attractive target to enhance post ischemic angiogenesis. (frontiersin.org)
  • The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
  • Sperm cell membranes are high in polyunsaturated fatty acids and are sensitive to oxygen free radical induced damage mediated by lipid peroxidation. (scialert.net)
  • small artery or anterior spinal artery occlusion, "…microthrombi, and altered perfusion due to internal recoil of the spinal architecture following decompression", "… direct trauma from blood flow itself or by the oxygen free radicals…", or "…lipid peroxidation of the neuronal membrane…as a main cause in the secondary injury-induced degenerative cascade. (surgicalneurologyint.com)
  • F2-isoprostanes are a series of prostaglandin (PG) F2-like compounds produced in vivo independent of cyclooxygenase, as products of the radical-catalyzed lipid peroxidation. (drlauda.at)
  • Microscopic studies of tissues exposed to ischemia/reperfusion (I/R) have revealed an acute inflammatory response. (lomr.org)
  • Cardiomyocytes were isolated and subjected to 6 h hypoxia followed by 18 h reperfusion. (biomedcentral.com)
  • Our previous study revealed that hypoxia preconditioning of H9c2 cardiomyocytes significantly increased the de novo synthesis of DJ-1 and induced cardioprotection against prolonged hypoxic injury 24 h later ( 17 ). (spandidos-publications.com)
  • Hypoxia and acidosis activate complement and prime leukocytes, resulting in the generation of oxygen free radicals and cytokine release. (tandf.co.uk)
  • Elaboration of IL-1 was dependent on the oxygen tension and duration of hypoxia (optimal at lower pO2s, approximately 14-20 torr, and after 9 h), as well as the time in reoxygenation (maximal IL-1 release at 6-9 h). (jci.org)
  • Hypoxia and Ischemia are both diseases caused due to the insufficiency of oxygen supply in the body, but there is a difference between hypoxia and ischemia. (mcpcourse.com)
  • Hypoxia refers to a state in which the oxygen supply is insufficient for the demand, whereas hypoxemia refers to states that have low arterial oxygen concentration. (mcpcourse.com)
  • Generalized hypoxia can occur in healthy people at a high altitude where oxygen concentration of the air is low. (mcpcourse.com)
  • Hypoxia refers to a state where the oxygen supply is insufficient for the demand. (mcpcourse.com)
  • Causes of Hypoxia can be the high altitude where oxygen concentration of the air is low, breathing mixtures of gasses with a low oxygen concentration, etc. (mcpcourse.com)
  • Hypoxia can be reversed when the oxygen supply is restored. (mcpcourse.com)
  • This concept of an adaptive process that shuts down the contractile process and decreases myocardial oxygen demand in the presence of chronically or intermittently reduced blood flow has generated considerable interest in clinical and experimental settings. (medscape.com)
  • However, the over production of oxygen free radicals in sperm membrane decreases the antioxidant defense activity thereby leading to low sperm motility and viability, DNA fragmentation and protein denaturation. (scialert.net)
  • Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism. (jamanetwork.com)
  • Here, we demonstrate that OP2113 (5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione, CAS 532-11-6), synthesized and used as a drug since 1696, does not act as an unspecific antioxidant molecule (i.e., as a radical scavenger) but unexpectedly decreases mitochondrial reactive oxygen species (ROS/H2O2) production by acting as a specific inhibitor of ROS production at the IQ site of complex I of the mitochondrial respiratory chain. (epiphanyasd.com)
  • Additionally, excess nitric oxide is converted to peroxynitrite, a free radical that damages mitochondria and decreases ATP ( adenosine triphosphate) production. (msdmanuals.com)
  • The heart was preperfused with Krebs-Henseleit (K-H) solution containing T. polium extract for 20 min before 20 min global ischemia, and then the reperfusion with K-H bicarbonate buffer was conducted for 40 min. (ac.ir)
  • Oxygen free radicals are naturally produced by mitochondrial and sperm plasma membrane and have beneficial and detrimental effects that cannot be overlooked. (scialert.net)
  • Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. (ac.ir)
  • A high intracellular calcium concentration and the production excess reactive oxygen species inhibit the mitochondrial electron transport chain causing cell damage [ 5 ]. (biomedcentral.com)
  • Pretreatment with 0.5 mM catalpol for 1 h prior to OGD treatment significantly reversed ischemia-induced apoptosis in PreOLs and myelination deficits by inhibiting intracellular Ca 2+ increase, reducing mitochondrial damage, and ameliorating overproduction of reactive oxygen species (ROS). (ijbs.com)
  • Most importantly, it is believed that an increase in free radical production, intracellular calcium overload, and excessive activation of inflammatory response are cumulatively responsible for IRI. (frontiersin.org)
  • Death may occur rapidly because of a profound state of shock or may occur later because of the consequences: of organ ischaemia and reperfusion injury. (tandf.co.uk)
  • Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
  • In hibernating myocardium, contractile function can be partially or totally restored by improving coronary blood flow or by reducing oxygen demand of the myocardium. (medscape.com)
  • Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
  • Ischemic preconditioning, short periods of ischemia with intermittent reperfusion, has been shown to protect the myocardium from a subsequent longer ischemic insult (21-23). (lomr.org)
  • Induction of the haem oxygenase gene expression during the reperfusion of ischemic rat myocardium. (ac.ir)
  • are able to initiate a range of oxidative chemistry with similar reactivity to the hydroxyl radical (Sutton and Winterbourn, 1989). (scialert.net)
  • In the presence of various transition metals, especially iron and copper, H 2 O 2 is rapidly converted to the extremely reactive hydroxyl radical (15). (lomr.org)
  • In addition, sperm preparation techniques such as centrifugation, used prior to in vitro fertilization, are associated with the generation of reactive oxygen species (ROS) and an increase in the level of DNA damage. (propoleo.cl)
  • Recent studies have demonstrated that the autoantigens targeted in diffuse scleroderma are unified by their enrichment in nucleolini and by their susceptibility to fragmentation in a novel metal-dependent reaction that requires the generation of reactive oxygen species. (drlauda.at)
  • In times of high metabolic demand and adequate availability of oxygen, elevated calcium in mitochondria can increase ATP production by stimulation of three enzymes in the Krebs citric acid cycle: pyruvate dehydrogenase, alpha-ketoglutarate and isocitrate dehydrogenase. (benbest.com)
  • With ischemia in coronary heart disease, impairment of the oxygen supply and metabolic disorder both occur [ 2 ]. (biomedcentral.com)
  • The present study aimed to investigate the direct protective effects of catalpol, a potent antioxidant and free radical scavenger, on ischemia-induced oxidative damage in PreOLs and to explore whether the ERK1/2 signaling pathway contributed to the protection provided by catalpol. (ijbs.com)
  • The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial ischemia/reperfusion (I/R) injury. (biomedcentral.com)
  • Additionally, machine reperfusion induces the production of ROS, which results in I/R injury to the heart. (gotomydoctor.com)
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
  • Any organ of the body can get ischemia damage due to inadequate oxygen supply to meet the continuous demand for cellular metabolism. (mcpcourse.com)
  • Once perfusion declines and oxygen delivery to cells is inadequate for aerobic metabolism, cells shift to anaerobic metabolism with increased production of carbon dioxide and elevated blood lactate levels. (msdmanuals.com)
  • Systolic wall thickening after coronary artery occlusion and subsequent reperfusion in normal and ischemic zones. (medscape.com)
  • Heyndrickx et al observed that after 5 minutes of occlusion in the left anterior descending coronary artery, surface electrocardiogram (ECG) findings and regional contraction (with reperfusion) rapidly normalized. (medscape.com)
  • Coronary heart disease is a leading cause of death in the world and therapy to reduce injury is still needed. (biomedcentral.com)
  • In the second minute of reperfusion (5 ml/min), a bolus dose of 6 x 10(5) PMNs was injected into the coronary system. (silverchair.com)
  • Therefore, the patient cannot benefit from most of the positive effects of HBOT, which are systemic or occur at a level deeper than topical oxygen can penetrate (see Hyperbaric Physics and Physiology section below). (medscape.com)
  • Polymorphonuclear neutrophils (PMNs) contribute to postischemic reperfusion damage in many organs and tissues, a prerequisite being adhesion of PMNs to vascular endothelial cells. (silverchair.com)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • We studied the effect of DMSO, DMSO-ascorbic acid and DMSO- N -acetylcysteine administration on renal injury induced by I/R. Thirty minutes renal ischemia was induced in 50 male, New Zealand rabbits. (biomedcentral.com)
  • It has been demonstrated that ozone, probably by means of an oxidative preconditioning (OP) mechanism, protected the liver against the damage mediated by reactive oxygen species. (lomr.org)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • Also, ozone therapy applied in an experimental model of liver ischemia-reperfusion, protected the organ against the injury caused by this surgical procedure, decreasing transaminases and lactate figures, preserving the hepatocellular integrity and reducing the ROS by the stimulation and/or preservation of the endogenous antioxidant systems (19). (lomr.org)
  • This report describes the role of neuroprotection in acute disorders such as stroke and injuries of the nervous system as well as in chronic diseases such as neurodegenerative disorders because many of the underlying mechanisms of damage to neural tissues are similar in all these conditions and several products are used in more than one disorder. (researchandmarkets.com)
  • The "microclots" they've found are quite variable in size but can be large enough to jam up the smallest blood vessels of the body - the microcapillaries - preventing oxygen from getting to the tissues. (healthrising.org)
  • Ischemia is caused by problems with the circulatory system causing damage or dysfunction of oxygen sensitive tissues . (mcpcourse.com)
  • Most tissues cannot survive more than few minutes without a continuous oxygen supply. (mcpcourse.com)
  • Reintroduction of blood supply brings more oxygen back to the damaged tissues. (mcpcourse.com)
  • It causes a greater production of oxygen free radicals and reactive oxygen species that in turn damage cells and tissues. (mcpcourse.com)
  • Ischemia is damage or dysfunction of oxygen sensitive tissues due to reduction of blood supply. (mcpcourse.com)
  • However, oxygen sensitive tissues such as brain and heart may not recover unless the blood supply is restored rapidly. (mcpcourse.com)
  • To examine the possible involvement of cytokines in reperfusion injury, we have studied production of IL-1 by human vascular cells, including smooth muscle and mononuclear phagocytes. (jci.org)
  • Hypoxic vascular endothelial cells activate white blood cells, which bind to the endothelium and release directly damaging substances (eg, reactive oxygen species, proteolytic enzymes) and inflammatory mediators (eg, cytokines, leukotrienes, tumor necrosis factor). (msdmanuals.com)
  • 0.0417dl · g -1, Cp=0.2663 cal/(g · °C). The hepatoprotective effect of ACN2a was evaluated using a mouse model of hepatic injury that was induced by Propionibacterium acnes (P. acnes) and lipopolysaccharide (LPS). (simpsonbiotech-usa.com)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • The ischemia-reperfusion syndrome commonly seen in different clinical scenarios leads to acute renal failure and it is known that the free oxygen radicals play an important role in the pathophysiology of this injury. (biomedcentral.com)
  • Ambrosio G, Tritto I. Reperfusion injury: experimental evidence and clinical implications. (jamanetwork.com)
  • Materials and Methods: The myocardial I/R injury of rat was created by Langendorff retrograde perfusion technology. (ac.ir)
  • 1 - 8 ] In theory, such acute cord decompression, and re-expansion disrupts the blood-spine barrier allowing for "rush-in reperfusion", a "…triggered cascade of reperfusion injuries…", and potentially, "…oxygen-derived free radical damage" [ Table 1 ]. (surgicalneurologyint.com)
  • It causes altitude sickness causing potentially fatal outcomes such as high altitude pulmonary edema (HAPE) and high altitude cerebral edema 由于缺氧损伤(HACE)。缺氧也可以occurred in healthy people when breathing mixtures of gasses with a low oxygen concentration, e.g. (mcpcourse.com)
  • Therefore, this review will attempt to discuss the relevance of free radicals and antioxidants in spermatozoa production and function. (scialert.net)
  • The findings imply that reactive oxygen species play a causal role in I/R-induced renal injury, and that antioxidants exert renoprotective effects, probably by radical scavenging and antioxidant activities, in this way diminishing renal function deterioration. (biomedcentral.com)
  • Several other studies highlight the importance of reactive oxygen species as mediators of damage during ischemia-reperfusion and present evidence for increased generation of these radicals in patients with scleroderma. (drlauda.at)
  • Distributive shock describes the pattern of cardiovascular responses characterising a variety of conditions, including septic shock, anaphylaxis and spinal cord injury. (tandf.co.uk)
  • All the cells living under aerobic conditions constantly face the oxygen paradox. (scialert.net)
  • RPI/WCS is typically defined as an acute spinal cord injury that follows cervical spine surgery where postoperative MR studies document intrinsic cord edema/ischemia, swelling, and/or hemorrhage in the absence of significant new/residual extrinsic pathology. (surgicalneurologyint.com)
  • Hyperbaric oxygen therapy (HBOT) is breathing 100% oxygen while under increased atmospheric pressure. (medscape.com)
  • His research included looking at the effects on a donor heart after reperfusion therapy following a period of low oxygen. (wikipedia.org)
  • His research included looking at the effects on a donor heart after reperfusion therapy following a period of low oxygen, and in 1981, he published the original description of the effects of oxygen-free radicals on donor heart muscle after they were re-suppplied with blood. (wikipedia.org)
  • Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)
  • The authors concluded that thrombolytic therapy may be useful in improving the delivery of agents, such as SOD, which attenuate reperfusion injury in skin flaps. (mssm.edu)
  • The present invention relates to an inhibitor of production of reactive oxygen species (ROS) for treating or for use in the treatment of free oxygen-radicals related diseases. (epiphanyasd.com)
  • 2011). Larger quantities of free radicals (reactive disease, diabetes, chronic respiratory diseases, and oxygen species [ROS]) present in the cigarette cancer (WHO, 2012). (bvsalud.org)
  • There has been accumulating evidence that an additional mechanism to generate reactive oxygen species occurs in vivo (Moore et al . (scialert.net)
  • The present study therefore provided novel evidence that DJ‑1 is involved in the delayed cardioprotection of IPC against I/R injury in vivo. (spandidos-publications.com)
  • However, whether the increase in DJ-1 expression mediates protection against ischemia/reperfusion (I/R) injury in vivo during the late phase of IPC remains to be determined. (spandidos-publications.com)
  • Specific pathogen-free male Sprague-Dawley (SD) rats, weighing 200-250 g were purchased from the Laboratory Animal Center of Nanchang University (Nanchang, Jiangxi, China). (frontiersin.org)
  • Objective: To investigate the influence of gender on early cerebral damage of rats after focal ischemia reperfusion. (cnki.net)
  • The rats were subjected to MCAO for 2 h and killed after reperfusion 24 h. (cnki.net)
  • Results: After 2 h ischemia and 24 h reperfusion,the rats mortality rates of F and M group were 8. (cnki.net)
  • 05). Conclusion: The reperfusion injury in female rats is less serious in the short term,whose mechanism may be related to estrogen in brain of female rats inhibiting oxygen free radical. (cnki.net)
  • The low survival rate or dysfunction of extracellular matrix (ECM)-based engineered organs caused by the adverse effects of unfavourable local microenvironments on seed cell viability and stemness, especially the effects of excessive reactive oxygen species (ROS), prompted us to examine the importance of controlling oxidative damage for tissue transplantation and regeneration. (biomedcentral.com)
  • Many studies (9-10) indicate that oxygen free-radical formation after reoxygenation of liver may initiate the cascade of hepatocellular injury. (lomr.org)
  • Current methods of cold static storage have reached their limits in storage time due to the extent of ischemia-reperfusion (I/R) injury induced during static cold storage. (gotomydoctor.com)
  • The extent of reperfusion injury is directly proportional to preservation time in cold storage, and research has shown that with static storage methods, heart storage time will not exceed six hours. (gotomydoctor.com)
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • The vulnerability of pre-myelinating oligodendrocytes (PreOLs) to ischemic injury plays an important role in the pathogenesis and progression of perinatal white matter injury. (ijbs.com)
  • After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)