Formation imidazoles. Medical search. Frequent questions

Miconazole is an imidazole antifungal compound that inhibits ergosterol synthesis and fungal cell wall formation. (lktlabs.com)
The effect of the antifungal agent is based on destroying the cell wall formation of harmful fungi. (healthandmedicineinfo.com)
Ketoconazole cream is an imidazole antifungal. (medsamazing.com)

The most prevalent amino acid is 'histidine,' which has an imidazole on the side chain [ 3 ]. (tsijournals.com)
Imidazole is a compound that is incorporated into the various biological molecules, and it is the most prevalent amino acid histidine overall. (databasefootball.com)
Copper in biological systems is usually found surrounded by imidazole moieties from histidine residues [ 13 , 14 ]. (hindawi.com)
Thanks to the position of the thiol group on the imidazole ring of histidine, these compounds exhibit unusual antioxidant properties. (unibas.ch)
OvoA catalyzes the insertion of the sulfur atom of cysteine on the imidazole ring of histidine, leading to the formation of a sulfoxide intermediate. (unibas.ch)
Multiple scattering contributions from the outer-shell atoms of a histidine-imidazole rings are observed at ~ 3 and 4 Å for Zn(II)- and Co(II)-loaded ArgE suggesting at least one histidine ligand at each metal binding site. (marquette.edu)

Recent studies suggest that the biosynthesis of these dimeric pyrrole-imidazole alkaloids involves a single-electron transfer (SET)-promoted [2 + 2] cycloaddition to form their cyclobutane core skeletons. (elsevierpure.com)

Clotrimazole belongs to the group of triazoles and imidazoles. (healthandmedicineinfo.com)

To create imidazole, he employed glyoxal and formaldehyde in ammonia. (tsijournals.com)
The active site was modelled by Zn(HS) 2 XL (H 2 O) 0-2 , where X denotes ammonia or imidazole and L denotes water, methanol, ethanol or the corresponding aldehydes or anions. (lu.se)

As a result, the goal of this article is to examine published research on the introduction, chemistry, synthesis, properties, industrial, biological and medicinal applications with efficacy of imidazole derivatives in order to better understand and explore their various properties and pharmacological potentials. (tsijournals.com)
1394). 'Nano-TiO2: A novel, efficient and recyclable catalyst for the synthesis of 1, 2, 4, 5-tetrasubstituted imidazoles in solvent-free conditions', فیزیولوژی و بیوتکنولوژی آبزیان , 2(1), pp. 1-9. (ac.ir)
A convenient and efficient one-pot four-component synthesis of 1, 2, 4, 5-tetrasubstituted imidazoles using nano TiO2 as a recyclable catalyst is reported. (ac.ir)
Therefore, to avoid these limitations, there is still a need for the development of a new protocol for the synthesis of 1, 2, 4, 5-tetrasubstituted imidazoles in terms of operational simplicity, reusability of the catalyst, highyielding, and economic viability. (ac.ir)

Research has shown that heterocyclic amine formation in meat occurs at high cooking temperatures. (wikipedia.org)
In the arena of five membered heterocyclic structures, the imidazole nucleus exhibits a range of properties. (tsijournals.com)
In this chapter, we will introduce the recent advances of the tetradentate cyclometalated platinum(II) complexes, including pyrazole, N-heterocyclic carbene, imidazole and pyridine-based complexes, molecular design, photophysical properties, and some of their device performances. (intechopen.com)
Recent advances in green chemistry and organometallic catalysis has extended the application of imidazoles as ionic liquids [7], and N-heterocyclic carbenes [8]. (ac.ir)

The chemistry of imidazole and its synthetic derivatives is reviewed in this article. (tsijournals.com)
A new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives were synthesized by using the different bioactive heteroaralkyl halides with 2-butyl-4-chloro-1H-imidazole-5-carbaldehyde in presence of powdered potassium carbonate in DMF medium. (eurekaselect.com)
Our results show that treatment of imidazole derivatives inhibit proliferation EAT cells, decreases the ascites volume and increases the survivability of the animals in vivo. (eurekaselect.com)
Further, these compounds could induce apoptosis, which is evident by the nuclear condensation of imidazole derivatives treated EAT cells in vivo by the cytological analysis. (eurekaselect.com)

Imidazole is observed in a variety of key genetic compounds. (tsijournals.com)
With Imidazole as a catalyst, DAP could have successfully made that critical jump between the early chemical compounds like cytidine and uridine to the formation of the key ingredients for life. (databasefootball.com)
Nitrogen-containing organic compounds (NOCs) substantially contribute to light-absorbing organic aerosols, although the atmospheric processes responsible for the secondary formation of these compounds are poorly understood. (copernicus.org)

The histamine molecule is a good ligand, which contains not only N atoms (from imidazole ring and aliphatic ammine) but also hydrogen atoms that are good for hydrogen bond formation and therefore are useful in molecular recognition. (hindawi.com)
In this MOF, the imidazole group is deprotonated, so each carnosine molecule can bind to 4 metal atoms. (chemtube3d.com)

These inhibitors could represent as promising candidates for anticancer therapies, where the formation of peritoneal malignant ascites is a major cause of morbidity and mortality. (eurekaselect.com)

The proposed reaction route for product formation involves the reaction of the CAR amino group with ACR via a Schiff base formation followed by dehydration and cyclization through Michael addition in the imidazole ring forming an instable compound with m/z = 265. (usp.br)
We have identified that pyrrolidine substituted imidazole derivative as potent anti-tumor compound. (eurekaselect.com)

1) A bis-cyclometalated chiral-at-metal rhodium complex (designated as RhS) in combination with the photoredox catalyst [Ru(bpy)3](PF6)2 enables visible-light-activated asymmetric α-amination and α-alkylation of 2-acyl imidazoles with aryl azides or α-diazo carboxylic esters as radical precursors, respectively (Chapter 3.1). (uni-marburg.de)
The catalyst/substrate complexation enhances visible-light-absorption, achieves selective direct photoexcitation, and enables stereocontrolled direct bond formation from the photoexcited state. (uni-marburg.de)

The imidazole ring is a five-membered ring structure with 3C and 2N atoms, with N present in the first and third positions and containing a hydrogen attachment sphere and an electron contributor nitrogen system [ 1 ]. (tsijournals.com)

In view of different biological and chemical applications of imidazoles, the development of suitable synthetic methodologies for their generation has been a topic of great interest in recent times. (ac.ir)

By mutant screening, we showed a knock-out mutant of fabR , encoding a repressor of unsaturated fatty acid biosynthesis (UFA), to have impaired biofilm formation. (biomedcentral.com)
Next to UFA biosynthesis, a number of these direct targets and other indirect targets identified by transcriptomics (e.g. ribosomal genes, ompA , ompC , ompX , osmB , osmC, sseI ), could possibly contribute to the effect of FabR on biofilm formation. (biomedcentral.com)
Overall, our results point at the importance of FabR and UFA biosynthesis in Salmonella biofilm formation and their role as potential targets for biofilm inhibitory strategies. (biomedcentral.com)

It works by killing sensitive fungi by interfering with the formation of the fungal cell membrane and weakening it. (medsamazing.com)

And prevented the mortality risk from poisoning by methanol or ethylene glycol impedes the formation of drug-dependent antiplatelet antibodies , hepatic conjugation does not provide you with an isolated seizure. (reflectionsbodysolutions.com)

Imidazole is used in the decontamination of His-tagged proteins using restrained Metal Attraction Chromatography (IMAC). (tsijournals.com)
It plays a key role in the formation of many enzymes and proteins. (databasefootball.com)

Ligand exchange at the zinc ion is likely to proceed by an associative mechanism with intermittent formation of a five-coordinate complex. (lu.se)
In the first part of this thesis, the interaction between the rat CD2 (rCD2) adhesion protein and its ligand rat CD48T92A (rCD48T92A), a high-affinity mutant of the wild type rat CD48, was used to establish a new method of obtaining single-cell binding affinities of T cells interacting with SLBs using imidazole titrations. (lu.se)
The imidazole rings of the two independent ligand mol-ecules are inclined to one another by 70.04 (15), 69.3 (3) and 61.55 (12) degrees in (I), (II) and (IIb), respectively, while the benzene rings are inclined to one another by 82.83 (13), 83.0 (2) and 88.16 (12) degrees , respectively. (who.int)

The Diels-Alder reaction is one of the most important processes for carbon-carbon-bond formation in organic chemistry [1,2] . (beilstein-journals.org)
Unfortunately, no activity was detected possibly due to imidazole being a reducer inhibiting the assay reaction. (willamette.edu)
Dermatophyte infection occasionally leads to formation of a kerion, which is a large, boggy, inflammatory scalp mass caused by a severe inflammatory reaction to the dermatophyte. (msdmanuals.com)

Molecular recognition entails shape complementarity with the ZMP 5-amino and carboxamide groups paired with the Watson-Crick edge of an invariant uracil and the imidazole ring sandwiched between guanines while the sugar hydroxyls form intermolecular hydrogen bond contacts. (hiv-proteases.com)

A review of the literature on several research papers and other publications that give thorough information on the chemistry of imidazole. (tsijournals.com)

However, despite phosphorylation playing such a key role in the formation of early life, no one had ever managed to find a phosphorylating agent that could have successfully created the three different molecules necessary for life under realistic conditions and was also present upon the early Earth. (databasefootball.com)
The flexibility of this MOF is driven by the formation of hydrogen bonds between the guest molecules and carnosine. (chemtube3d.com)
The CD4-MHC II interaction is so weak that adhesion molecules are needed to ensure a successful CD4-MHC II contact formation. (lu.se)

Theoretical description of mixed film formation at the air/water interface: carboxylic acids-fatty amines. (mpg.de)

Imidazole could have enabled the formation of fatty acids and glycerol , and DAP could have linked these structures together into the vesicles, which are primitive versions of the phospholipid bi-layers seen in cell membranes. (databasefootball.com)

Results from circular dichroism and denaturation of calf thymus DNA (CT-DNA) suggested that increased amounts of copper complex were able to stabilize the double helix of DNA in vitro mainly by formation of hydrogen bonds between chn and the sugars of DNA minor groove. (hindawi.com)
They report that the His15 imidazole group of the lysozyme binds to the Cu(II) center of CuST in the equatorial position while the CuST unit is fixed axially by several weak coordination and hydrogen bonds. (tus.ac.jp)
There are a number of C-Hcdots, three dots, centeredhalide hydrogen bonds in each mol-ecule involving the CH groups of the imidazole units. (who.int)

Body 1 Chemical substance Formulas of ZMP and its own Analogs the Supplementary Structure from the Sensing Area from the Nor1 ZMP Riboswitch as well as the Influence of Mg2+ Cations on Organic Formation Our framework from the sensing area from the lately determined ZMP-bound riboswitch (Kim et al. (hiv-proteases.com)

ZTP the pyrophosphorylated analog of ZMP (5- amino-4-imidazole carboxamide ribose-5′-monophosphate) was identified as an alarmone that senses 10-formyl-tetrahydroflate deficiency in bacteria. (hiv-proteases.com)

Clotrimazole is an anti-fungal agent that comes from the group of imidazoles. (healthandmedicineinfo.com)

This results in a disruption of the cell wall formation in the course of cell division. (healthandmedicineinfo.com)

Quantum chemical clarification of the alkyl chain length threshold of nonionic surfactants for monolayer formation at the air/water interface. (mpg.de)
Quantum chemical analysis of thermodynamics of 2D cluster formation of alkanes at the water/vapor interface in the presence of aliphatic alcohols. (mpg.de)

Heinrich Debus synthesised imidazole for the first time in 1858, but several imidazole products had been found as young as the 1840's. (tsijournals.com)

Biofilm formation is an important survival strategy of Salmonella in all environments. (biomedcentral.com)

The physical properties, including thermal stability, of the prepared DESs were analyzed, and an enhancement in thermal stability, attributed to DES formation, was verified. (elsevierpure.com)

Imidazole-containing medicines have a greater reach in clinical medicine for treating a variety of conditions. (tsijournals.com)

Through detailed crystallographic and spectroscopic analysis, the research team, which also comprised Assistant Professor Kenichi Kitanishi from TUS, Dr. Arshak Tsaturyan from Southern Federal University, and Professor Masaki Unno from Ibaraki University, among others, confirmed the formation of the hybrid protein CuST@lysozyme, and elucidated its structure. (tus.ac.jp)

If you plot these points at the imidazole ring of muscle cells than females. (reflectionsbodysolutions.com)

Knowledge about the complex regulatory processes in biofilm formation can provide more insight into survival strategies of S. Typhimurium in non-host environments and can be the fundament of new eradication methods. (biomedcentral.com)

In order to unravel how this regulator impinges on Salmonella biofilm formation, we aimed at elucidating the S . Typhimurium FabR regulon. (biomedcentral.com)

A tunable microwave-assisted process for the formation of two relevant groups of heterocycles continues to be designed biologically. (bioxorio.com)

Greater detail on image formation in the TEM is also available . (magma.ca)

Theoretical description of 2D-cluster formation of nonionic surfactants at the air/water interface. (mpg.de)

Imidazole is a five-membered planar ring that is solvable in water and other polar diluents. (tsijournals.com)
Imidazole is an extremely polar fragment with an estimated dipole of 3.61D that is entirely solvable in water [ 2 ]. (tsijournals.com)
1-(n-Alkyl)-imidazoles at the air/water interface. (mpg.de)

Imidazole is a component of theophylline, which is present in tea leaves and coffee beans and activates the central nervous system. (tsijournals.com)

Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex. (oregonstate.edu)
We investigated the formation of a hybrid protein composed of lysozyme and a functional SOD-mimetic Cu(II) complex. (tus.ac.jp)

This work expands the scope of stereocontrolled direct bond formation from photoexcited states which was previously limited to [2+2] photocycloadditions. (uni-marburg.de)

The methods may be carried out in a continuous fashion or discontinuously, and with minimum waste formation. (justia.com)

Step 1 and Step 2, the main difference is the formation of the tetrahedral carbon involving Ser195 covalently bonding to Trp252, and serine's hydroxyl hydrogen migrating to the imidazole ring of His57. (openmopac.net)
For the [2 + 2] cycloaddition, the dimerization of pyrrole-imidazole monomers is rate-limiting, whereas for the [4 + 2] cycloaddition, the cyclization is the slowest step. (elsevierpure.com)

This analysis was restricted to women exposures during the first few weeks of pregnancy, which is a continuously enrolled (365 days) for the year under study in critical period for organ formation. (cdc.gov)

It was shown for example that an incomplete LPS fraction does not affect biofilm formation capacity of Salmonella on hydrophobic gallstone surfaces, but highly reduces its biofilm capacity on hydrophilic glass surfaces [ 7 ]. (biomedcentral.com)

Candida species, including the novel opportunistic cans many virulence factors, such as germ tube formation, pathogen Candida dubliniensis , are now emerging as exoenzyme production, and phenotypic switching (10). (cdc.gov)

Anatomy1

Organisms8

Diseases3

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes27

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science3

Health Care1

Antifungal3

Histidine6

Alkaloids1

Triazoles1

Ammonia2

Synthesis4

Heterocyclic4

Derivatives4

Compounds3

Molecule2

Anticancer1

Compound2

Catalyst2

Electron1

Biological1

Biosynthesis3

Fungal cell1

Methanol1

Proteins2

Ligand3

Reaction3

Molecular1

Chemistry1

Molecules3

Carboxylic1

Structures1

Hydrogen bonds3

Organic1

Amino1

Group1

Results1

Chemical2

Found1

Important1

Stability1

Conditions1

Research1

Cells1

Processes1

Order1

Groups1

Greater1

Description1

Water3

Central1

Complex2

Direct1

Minimum1

Step2

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