Silybum marianum in vitro-flavonolignan production" (PDF). (wikipedia.org)
Mature fruits (achenes) of milk thistle (Silybum marianum (L.) Gaertner, Asteraceae) accumulate high amounts of silymarin, a complex mixture of bioactive antioxidant flavonolignans deriving from taxifolin. (intechopen.com)
Silymarin, a flavonolignan from 'milk thistle' (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany alone. (nih.gov)
Large-Scale Isolation of Flavonolignans from Silybum marianum Extract Affords New Minor Cons. (uncg.edu)
Here, we investigated the effect of silibinin (a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk thistle) on the epidermal growth factor (EGF) ligand-induced CD44 expression in human breast cancer cells. (iiarjournals.org)
Silibinin ( Figure 1 ) is a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk thistle, and has a wide range of pharmacologic effects, such as antihepatotoxic and anticarcinogenic in a variety of tumor cells ( 4 , 5 ). (iiarjournals.org)
2020. Single Laboratory Validation of UHPLC-MS/MS Assays for Six Milk ThistleFlavonolignans in Human Serum. . (oregonstate.edu)
Silymarin flavonolignans1
New brominated derivatives of silymarinflavonolignans and related flavonoids were prepared. (cas.cz)
Silibinin1
Silymarin composed of six flavonolignans that Silibinin, with 40-50, is the most one. (ac.ir)
Silybin2
Silymarin consists of four flavonolignan isomers namely--silybin, isosilybin, silydianin and silychristin. (nih.gov)
Silymarin, as well as an isolated form of flavonolignan known as silybin, can support a healthy liver and promote the body's natural ability to combat toxins such as alcohol, environmental toxins and poisons. (holographichealth.com)
Biosynthesis1
This review focuses on recent developments in chemistry, biosynthesis, modern advanced analytical methods, and transformations of flavonolignans specifically reflecting their chirality. (cas.cz)
Antioxidants2
1. Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization. (upol.cz)
Moreover, it is now clear that flavonolignans do not act as antioxidants in vivo, but as specific ligands of biological targets and therefore their chirality is crucial. (cas.cz)
Biological1
A growing number of studies show that the respective diastereomers of flavonolignans have significantly different activities in anisotropic biological systems. (cas.cz)
Active2
The active constituents of milk thistle supplements are believed to be the flavonolignans contained within the extracts. (aspetjournals.org)
Silymarin (the mixture of flavonolignans extracted from Silybum marianum) has potentially beneficial antioxidant properties. (nih.gov)
Silymarin is a flavonolignan that has been introduced fairly recently as a hepatoprotective agent. (medscape.com)
Phytochemistry analysis revealed an abundance of active constituents, particularly silymarin, composed of polyphenols and flavonolignans. (nih.gov)
Silymarin is majorly found in leaves, seeds, and fruits and is comprised of seven flavonolignans. (nih.gov)
The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. (nih.gov)
The plant's healing abilities may come from a mixture of flavonolignans called "silymarin" and its main element, which is called "silybinin. (healthline.com)
Milk thistle products are typically either an extract of milk thistle, termed silymarin, or a phytosome preparation of the two major flavonolignans. (nih.gov)
The benefits of this plant come from its silymarin content-a mixture of chemicals known as flavonolignans. (wholefoodsmagazine.com)
Silymarin contains a group of closely-related flavonolignan compounds including silibinin, and is extracted from Silybum marianum species, also called milk thistle. (nih.gov)
The herb is derived from the hard fruits of the Silybum marianum plant, and contains a substance called Silymarin, which is a group of flavonolignans. (narsto.org)
Silybin and the other silymarinflavonolignans from milk thistle conserve tissue glutathione, are liver-protective, and have anticancer potential. (altmedrev.com)
Silymarin is the key component of S. marianum and includes flavonolignans (silibinin, isosilibinin, silychristin, isosilychristin, and silydianin) and a flavonoid (taxifolin). (genominfo.org)
Silymarin, as well as an isolated form of flavonolignan known as silybin, can support a healthy liver and promote the body's natural ability to combat toxins such as alcohol, environmental toxins and poisons. (drinkliquidvitamins.com)
Silymarin is not a single component but a complex of chemicals known as flavonolignans. (herbhealer.net)
The substance contains silymarin and silibinin, vital flavonolignans that basically help your liver regenerate faster. (madebykatiebug.com)
Silymarin is a mixture of flavonolignans extracted from the seeds of the milk thistle plant (Silybum marianum). (rcd.bio)
The plant's seeds contain fatty acids and proteins, as well as silymarin, a mixture of flavonolignans, which is what makes it so effective. (karpasia-hp.com)
Silibinin, also known as silybin, is the major active constituent of silymarin, a standardized milk thistle seeds standardized extract containing a mixture of flavonolignans consisting of silibinin and isosilibinin. (icliniq.com)
Designed to reduce the toxic load in your body and relieve occasional constipation, CleanseSMART® also contains silymarin, a mixture of flavonolignans isolated from the botanical seed milk thistle, an herbal ingredient traditionally used for liver protection. (durhamnaturals.com)
Milk thistle has a wide safety margin which has led to an array of commercially available milk thistle products with different recommended doses and/or formulations designed to increase systemic concentrations of the major bioactive constituents, flavonolignans. (nih.gov)
Ether1
The flavonolignans tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether and tricin 4'-O-(threo-beta-guaiacylglyceryl) ether can be isolated together with their 7-O-glucosides in the leaves of Hyparrhenia hirta. (wikipedia.org)
Flavonoid1
Flavonolignans are natural phenols composed of a part flavonoid and a part phenylpropane. (wikipedia.org)
Tricin1
Three flavonolignans derived from the flavone tricin have been isolated from the herb Avena sativa. (wikipedia.org)
First, we will characterize the roles of OATPs in milk thistle flavonolignan disposition through in vitro kinetic experiments (study 1.1) and in vivo pharmacokinetic experiments in OATP humanized mice (study 1.2). (nih.gov)