• Western blot analysis on extracts of both embryonic fibroblasts and liver nuclear membranes from homozygous mice confirmed that no detectable protein was expressed from this allele. (jax.org)
  • Mouse embryonic fibroblasts exhibit proliferative and mitotic defects, frequent cytokinesis failure, and loss of genomic stability. (jax.org)
  • One hypothesis is that the PKR mutants inhibit kinase function by forming inactive heterodimers with XL388 manufacture endogenous wild-type PKR (6 46 This also raises a fundamental question concerning the role of dimerization on PKR function. (bio2009.org)
  • The compound does not inhibit the proliferation of normal fibroblasts nor that of hemopoietic progenitor cells. (tripod.com)
  • The data for that publicity in the drug in blood immediately after the 1st oral adminis tration and parasitaemia at day seven had been fitted to a logistic function to predict the exposure needed to inhibit para sitaemia at day 7 following infection in compound handled mice by 90% with respect to vehicle handled mice. (faksignaling.com)
  • Accordingly, the cytokines produced by the KSiNP-treated macrophages were capable of inducing fibroblast proliferation and subsequent secretion of extracellular matrix (ECM). (megazyme.com)
  • Alan Hall showed the specificity of Rho in the stimulation of focal adhesions and stress fibres formation in fibroblasts in the presence of extracellular factors in 1992. (wikipedia.org)
  • Just recently, Ltp1 was shown to inactivate (dephosphorylate) the tyrosine kinase Ptk1, which in turn was shown to control levels of exopolysaccharide production in both strain 33277 and W83 (24), showing that this tyrosine kinase modulates production and export of extracellular polysaccharide in from a plasmid or deletion of the 77bpIR element alters the synthesis of surface. (oscars2019info.com)
  • He used strains of E. Coli with mutated B-lactamase, an antibiotic resistance enzyme, and assayed their activity in the presence of Benzylpenicillin and Cephalosporin C. Direct selection on these mutants allowed catalytic properties of B-lactamase to be identified and allowed structure-function relationships of the enzyme to be further researched. (wikipedia.org)
  • λKH54 as well as the Escherichia coli strains AG1688 and JH372 (34) had been kindly supplied by J. C. Hu (Tx A&M College or university). (bio2009.org)
  • My dissertation is focused on understanding how a fraction of E . coli mutants grow with a repeating pattern of high and low cell density when on soft agar plates. (tamu.edu)
  • Using an E. coli strain deficient with ALKB, we found that ALKBH6 complements ALKB deficiency and increases resistance after alkylating agent treatment. (frontiersin.org)
  • Immunofluorescence and antibody techniques were used to localise the mutant V12rac1 protein after being microinjected into the cytoplasm of confluent serum-starved Swiss 3T3 cells. (wikipedia.org)
  • smoke, there was little mRNA despite robust COX-2 protein expression, a finding that correlates with almost exclusive cytoplasmic HuR within the lungs of mice. (cancerhugs.com)
  • Despite this increase in mRNA, there is little COX-2 protein expression [4], suggesting that the AhR suppress Mouse monoclonal to FGR COX-2 protein by post-transcriptional regulatory mechanisms. (cancerhugs.com)
  • Tissue extracts of Mouse Testis (Lane 6) and Mouse Kidney (Lane 7) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). (thermofisher.com)
  • The CaMKIIα-tTA transgene inserted on chromosome 12, resulting in a 508 kb deletion that affects five mouse genes: Vipr2 (vasoactive intestinal peptide receptor 2), Wdr60 (WD repeat-containing protein 60), Esyt2 (extended synaptotagmin-like protein 2), Ncapg2 (non-SMC condensin II complex, subunit G2), and Ptprn2 (protein tyrosine phosphatase, receptor type, N polypeptide 2). (alzforum.org)
  • Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
  • Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
  • This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
  • Tissue homogenates from paralyzed G93A expressing mice induced MND in 6 of 10 mice expressing low levels of G85R-SOD1 fused to yellow fluorescent protein (G85R-YFP mice) by 3- 11 months, and produced widespread spinal inclusion pathology. (docksci.com)
  • In zebrafish mutants in which a particular BMP protein is functionally reduced, there was a resulting increase in Lim1+ interneurons (medial interneurons) post-mitotically (Nguyen et al. (bartleby.com)
  • BACKGROUND: Fibroblast activiation protein alpha (FAP) is considered a diagnostic and prognostic biomarker for various types of cancer. (inra.fr)
  • An in vitro gene mutation assay was conducted with sodium arsenite in the supF gene of pZ189 shuttle vector system in DNA repair proficient GM0637 human fibroblasts to determine whether arsenic alone induces mutation and whether the combination of arsenic and UV irradiation leads to a yield of mutants greater than the sum of the arsenic or UV treatments alone. (europa.eu)
  • Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without metabolic activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535 and TA 1537 (OECD TG 471) (Hüls AG, 1998a). (europa.eu)
  • 0. The pharmacokinetics of compounds just after oral admin istration was established concurrently from the same mice utilized for the therapeutic efficacy assay. (faksignaling.com)
  • These data are consistent with in vivo results: an avirulent RV mutant bearing the same double mutation is not able to infect sensory neurons or motoneurons (P. Coulon, J.-P. Ternaux, A. Flamand, and C. Tuffereau, J. Virol. (harvard.edu)
  • Examples of a novel series of phenanthrolinones are shown to be potent competitive inhibitors of avian prolyl 4-hydroxylase, and of collagen hydroxylation, in embryonic chick tendon cells and human foreskin fibroblasts in vitro and in the oestradiol-stimulated rat uterus in vivo. (embl.de)
  • United kingdom 112,214 is usually a dual platelet activating component receptorhista mine H1 receptor antagonist and was chosen for in vivo scientific studies from the P. falciparum mouse model. (faksignaling.com)
  • Compared to the wild type strain, the growth of Δ gh5-7 and Δ gh5- 7Δ gh2-4 mutants, but not Δ gh2-1 , Δ gh2-4 , and Δ gh2- 1Δ gh2-4 mutants, was poor in the cultures containing glucomannan or galactomannan as the sole carbon source, suggesting that GH5-7 plays a critical role in the utilization of heteromannans in vivo . (megazyme.com)
  • The mutants are also more Mouse monoclonal to SCGB2A2 susceptible to killing by the complement system, indicating a role of A-LPS synthesis in the serum resistance of (14, 15). (oscars2019info.com)
  • Xpc −/− mice displayed a significant increase in lung tumors and a trend toward increased liver tumors compared with Xpa -deficient or wild-type mice. (aacrjournals.org)
  • Additionally, Xpc -deficient mice exhibited a strong increase in mutant frequency in lung compared with Xpa −/− mice, whereas in both models mutant frequency is increased in liver. (aacrjournals.org)
  • Lung fibroblasts were also generated from a novel lineage of mice harboring a mutant AhR that is incapable of binding to DNA (referred to hereafter as mice. (cancerhugs.com)
  • Human retinal-pigment epithelial cells were infected with Pg, and its isogenic mutant strains and genes were analyzed by quantitative polymerase chain reaction (qPCR). (dentistrytoday.com)
  • To create T2 mice, a targeted insertion strategy was used to place the MAPT P301L transgene in a location in the mouse genome where no endogenous mouse genes would be disrupted. (alzforum.org)
  • In addition, shrinkage of the dentate gyrus occurs in the CaMKIIα-tTA activator line, although it is not yet known whether this is due to the expression of tTA or to the disruption of one or more endogenous mouse genes. (alzforum.org)
  • Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
  • I compared the expression between bat and mouse limb development and found a subset of genes and receptors that were expressed exclusively in each the bat and mouse limbs. (tamu.edu)
  • I have focused on identifying band forming mutant strains, and using whole genome sequencing to find genes that are important for this pattern formation. (tamu.edu)
  • After finding the genes involved in this pattern formation I will use that information to identify conditions that the band forming mutants have an advantage over wild type cells. (tamu.edu)
  • 2017). Furthermore, CRISPR/Cas9 mutants in the genes (GT14 family), which encode GlcA transferase activity for AGPs, produced plants having reduced yields due to the intine and exine defects in the mature pollen grains (Zhang et al. (exposed-skin-care.net)
  • Similarly, treated heterozygous mice maintained elevated levels of beta-glucuronidase and did not develop antibodies. (mcmaster.ca)
  • We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)
  • It was isolated as one of several proteins that became phosphorylated on tyrosine residues in chicken embryo fibroblasts transformed with the v-Src oncogene [ 4 ]. (biomedcentral.com)
  • TMR-001, a proprietary bulk drug substance solution of ranpirnase, was evaluated against rabies virus in three cell types: mouse neuroblastoma, BSR (baby hamster kidney cells), and bat primary fibroblast cells. (cdc.gov)
  • After injection into mice, tumors started to form in as little as 10 days. (wikipedia.org)
  • Xpa −/− mice showed a significant elevation in liver tumors. (aacrjournals.org)
  • 3) p53 null mice develop tumors with 100% penetrance. (nature.com)
  • The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. (tripod.com)
  • These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
  • The empirical difference between programed and nonprogramed senescence becomes evident when comparing the stereotypical steps leading to death in salmon contrasted with the lack of such stereotypy in most organisms such as humans and mice. (fightaging.org)
  • Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
  • or each of these agents, carcinogenicity in rats and/or mice, els, differences in exposure con- there was sufficient evidence of car- for example for the liver (aflatoxins, ditions between studies in animals cinogenicity from studies in rats and/ trichloroethylene [TCE], and vinyl and in humans, or limitations in Part 1 · Chapter 1. (who.int)
  • 2021). Here we used various microscopic and immunological techniques to provide deeper insight into the male gametophytic defects in the mutant. (exposed-skin-care.net)
  • To evaluate the importance of p62 in the lens defects caused by a connexin50 mutant, we also examined the effect of deleting p62 in homozygous Cx50D47A mice. (molvis.org)
  • To elucidate differences in the functions of these two proteins, comprehensive survival studies with Xpa −/− , Xpc −/− and wild-type control female mice in a pure C57BL/6J background were done. (aacrjournals.org)
  • overexpression of the cellular PKR inhibitor causes a transformed phenotype and rapid tumor formation in nude mice (3). (bio2009.org)
  • 7 Technology and Development Team for Mouse Phenotype Analysis: Japan Mouse Clinic, RIKEN BioResource Center, Tsukuba, Japan. (jci.org)
  • We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. (umassmed.edu)
  • Importantly, a capsule null mutant strain was shown to be a more potent inducer of cytokine synthesis by human gingival fibroblasts than the corresponding parent strain, indicating a role for capsule in cloaking against innate immune responses (3). (oscars2019info.com)
  • Its anti-mutagenic effects were examined using Salmonella typhimurium TA98 and TA100 strains. (tripod.com)
  • The number of mutant colonies of Salmonella typhimurium strain TA98 upon exposure to AF-2 (0.2 microg/plate) decreased in a concentration-dependent manner in the presence of different DEHP concentrations (decreasing to 90.4, 83.9, 75.4, 69.6 and 46.9%, respectively, for DEHP concentrations of 100, 50, 10, 5 and 1 microg/plate). (tripod.com)
  • Deletion mutants in (PG1138) and (PG2119) lack A-LPS and have less gingipain activity, indicating an involvement of these loci in A-LPS biosynthesis (13, 14). (oscars2019info.com)
  • As mentioned above, PG1138 is essential for A-LPS biosynthesis and therefore contributes to resistance to complement killing, which may explain the high conservation in various strains. (oscars2019info.com)
  • No particle-bound catalase was found in cultured fibroblasts, and ether glycerolipid (plasmalogen) biosynthesis was markedly reduced. (lookformedical.com)
  • Spodoptera frugiperda (Sf21) cells expressing G of the RV strain CVS (Gcvs-Sf21 cells) bind specifically to neuroblastoma cells of different species but not to any other cell type (fibroblast, myoblast, epithelial, or glioma). (harvard.edu)
  • To elucidate the mechanisms by which connexin mutations lead to cataracts, we have been studying mouse models that mimic the mutations identified in human pedigrees with inherited congenital cataracts. (molvis.org)
  • All catalase mutants are viable under standard culture conditions and recessive lethal mutations within the 75Cl-F1 interval have been shown not to affect catalase activity. (lookformedical.com)
  • The mechanism(s) by which the functionally defective PKR mutants or wild-type P58IPK induce malignant transformation is not known. (bio2009.org)
  • Our study was designed with an objective to interrogate the role of Pg and its fimbriae-mediated infection of human retinal-pigment epithelial cells and retro-orbitally injected mice retina, thus revealing possible molecular links between CP and AMD," said Hyun Hong, a predoctoral dental student. (dentistrytoday.com)
  • In contrast, nonencapsulated strains adhere more to cultured primary gingival epithelial cells and cause a severe localized abscess (6). (oscars2019info.com)
  • In Chinese hamster cells, arsenite did not induce ouabain-resistant mutants or thioguanine-resistant mutants. (europa.eu)
  • METHODS and materials Bacterial strains bacteriophage and media. (bio2009.org)
  • While studying the biology of these mutant strains, I have been working with an undergraduate computer science major to create a software suite that will adapt the current programs to handle circular bacterial DNA. (tamu.edu)
  • Sodium arsenite was tested at the concentrations of 1, 2.5 and 5.0 µM in GM 637 human fibroblasts for 72 hours and plasmid was irradiated with 320 J/m2. (europa.eu)
  • rTg4510 mice express a repressible form of human tau containing the P301L mutation that has been linked with familial frontotemporal dementia. (alzforum.org)
  • this mouse has become a popular model, as it phenocopies the tau pathology and pronounced neurodegeneration observed in human tauopathies, in addition to providing researchers with temporal control over mutant tau transgene expression. (alzforum.org)
  • rTg4510 mice ("r" for regulatable) are produced by crossing the 4510 responder line, carrying a human MAPT P301L cDNA downstream of a tetracycline operon-responsive element (TRE), to an activator line expressing a tetracycline-controlled transactivator (tTA) under control of the CaMKIIα promoter. (alzforum.org)
  • We investigated prion-like propagation of pathological a-syn in Tg(SNCA)1Nbm/J mice that do not express mouse but low levels of human wt a-syn and do not naturally develop any pathology or neurodegenerative disease. (docksci.com)
  • Intriguingly, brain homogenate from aged control subjects without neurological disorder equally induced synucleinopathy in brains of Tg(SNCA)1Nbm/J mice suggesting that aged human brains can contain pathological a-syn. (docksci.com)
  • Examining these mice from many angles, their disease looks very much like human vitiligo. (umassmed.edu)
  • Second, we are developing humanized mouse models of vitiligo, where we transfer human T cells, or both T cells and skin, from vitiligo patients to immunosuppressed mice that permit the growth of human tissues. (umassmed.edu)
  • Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. (umassmed.edu)
  • Embryonic catalase protects against endogenous and phenytoin-enhanced DNA oxidation and embryopathies in acatalasemic and human catalase-expressing mice. (lookformedical.com)
  • We report here that cultured XP cell strains are also markedly deficient in the catalase activity with about only 25% of the activity measured in normal human cells. (lookformedical.com)
  • 293T cells and chicken fibroblast DF-1 cells were maintained in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal calf serum (FCS). (cdc.gov)
  • However, implanted mutant MPS VII mice developed antibodies against the murine beta-glucuronidase, demonstrating a potential obstacle in patients with a null mutation who react against the replaced enzyme as a foreign antigen. (mcmaster.ca)
  • Strains that produce K-antigen capsule are more resistant to phagocytosis (4) and cause a spreading type of infection in a murine lesion model (5). (oscars2019info.com)
  • GTPase activity of different mutant forms of p21, one cloned from a patient with myeloblastic leukaemia and one derived from in vitro mutagenesis, was measured. (wikipedia.org)
  • In an in vitro mammalian cell gene mutation test performed similarly to OECD guideline 476, L5178Y/ TK+/- mouse lymphoma cells were exposed to sodium arsenate at concentrations of 26, 34, 46, 61 and 81 μg/mL in the absence of metabolic activation and the exposure duration was 3 hours. (europa.eu)
  • To survey the ease with which motor neuron disease (MND) can be transmitted, we injected spinal cord homogenates prepared from paralyzed mice expressing mutant superoxide dismutase 1 (SOD1-G93A and G37R) into the spinal cords of genetically vulnerable SOD1 transgenic mice. (docksci.com)
  • Attachment to mouse neuroblastoma NG108-15 cells is abolished by previous treatment of Gcvs-Sf2 cells with anti-G antibody. (harvard.edu)
  • The inhibition of endogenous Rac function by mutants N17rac and V12rac1 prevented growth factor-induced membrane ruffling. (wikipedia.org)
  • The integration site of the MAPT P301L transgene is within the Fgf14 (fibroblast growth factor 14) gene on chromosome 14, resulting in a 244 Kb deletion that includes exon 1. (alzforum.org)
  • During my Master's degree I worked in the lab of Dr. Chris Cretekos, and helped characterize the expression of several fibroblast growth factors (FGFs) and their receptors in the developing short-tailed fruit bat ( Carollia perspicillata ) limb. (tamu.edu)
  • In this study, we investigated the role of type-II AGs of AGPs in male sporophytic and gametophytic development, pollen grains, and pollen tube growth by using the mutant. (exposed-skin-care.net)
  • On the other hand, all the mutants showed significantly slow growth when grown in the medium containing linear β-mannan. (megazyme.com)
  • However, deletion of p62 did not affect the sizes of the lenses or the severity of their cataracts in homozygous Cx50D47A mice. (molvis.org)
  • Moreover, deletion of p62 did not change the levels of crystallins, histone H3, the mitochondrial import receptor subunit TOM20 homolog, or the abundance of nuclei and nuclear fragments in the lenses of homozygous Cx50D47A mice. (molvis.org)
  • These findings indicate that disruption of Fgf14 contributes to the neuropathological and neurodegenerative phenotypes observed in rTg4510 mice. (alzforum.org)
  • Keeping in mind the caveat that not all phenotypes in rTg4510 mice are necessarily due to tau P301L overexpression, the following summarizes the extensive literature describing rTg4510 mice. (alzforum.org)
  • Moreover, substitution with autophosphorylation-deficient PINK1 fails to rescue pink1 null mutant phenotypes. (sdbonline.org)
  • The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. (nih.gov)
  • Mice homozygous for a gene-trapped allele exhibit perinatal lethality associated with a developmental delay and respiratory failure. (jax.org)
  • The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants. (lookformedical.com)
  • All plants (WT, mutant plants were viable, Alexander staining was performed as previously described a-Apo-oxytetracycline by Peterson et al. (exposed-skin-care.net)
  • We have used the beta-glucuronidase-deficient mouse model of mucopolysaccharidosis type VII (MPS VII) to develop an alternative approach to therapy. (mcmaster.ca)
  • No direct correlation between catalatic activity and excision repair ability has been found, since a XP variant line is as deficient as an XP-C strain. (lookformedical.com)
  • 2021). Additionally, CRISPR/Cas9 mutants also revealed aborted pollen grains to be responsible for reduced seed set in a previous study (Zhang et al. (exposed-skin-care.net)
  • Researchers are thus urged to be cautious in ascribing findings in these mice to the expression of transgenic tau P301L . (alzforum.org)
  • T2 mice were then crossed with the CaMKIIα-tTA activator line to create bi-transgenic mice (designated rT2/T2 when homozygous for the MAPT P301L transgene). (alzforum.org)
  • The bi-transgenic mice accumulate an early burden of tau pathology in the form of argyrophilic tangle-like inclusions. (alzforum.org)
  • Homogenates from paralyzed mice expressing the G37R variant were among those that transmitted poorly regardless of the strain of recipient transgenic animal injected, a finding suggestive of strain-like properties that manifest as differing abilities to transmit MND. (docksci.com)
  • Experimental infection of mice. (cdc.gov)
  • Using a full-thickness excision model in either diabetic mice or healthy mice, the wounds treated with KSiNPs displayed a dramatically increased closure rate and collagen production, along with decreased inflammation and increased angiogenesis in the regenerating tissues. (megazyme.com)
  • Results showed no correlation between the wild-type or mutant N-ras p21's GTPase activity and transforming potential. (wikipedia.org)
  • Levels of total p62 were increased in the lenses of homozygous Cx50D47A mice compared to those of the wild-type animals. (molvis.org)
  • Briefly, eight RNA polymerase I plasmids (for the synthesis of the eight influenza A viral RNAs) together with plasmids for the expression of the PB2, PB1, PA, and NP proteins derived from the influenza A virus strain A/WSN/33 (H1N1) were transfected into 293T cells. (cdc.gov)
  • Clinical isolates of P. gingivalis strains with high dipeptidyl peptidase 4 (DPP4) expression also had a high capacity for biofilm formation and were more infective. (inra.fr)
  • Gray triangles = other expression annotations only (e.g. absence of expression or data from mutants). (jax.org)
  • The keystone oral-pathobiont and one of the major causative organisms of CP, Porphyromonas gingivalis (Pg), has been identified with the ability to invade epithelial tissue, fibroblasts, and dendritic cells. (dentistrytoday.com)
  • Under the test conditions, sodium arsenate is not considered as mutagenic in mouse lymphoma L5178Y cells. (europa.eu)
  • Overexpression of PKR in mouse (46) insect (4) and candida (14) cells leads to serious inhibition of development due to improved eIF-2α phosphorylation. (bio2009.org)
  • Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. (cnrs.fr)
  • branching in 3D cultures, an occasion that correlated with enhanced pulmonary outgrowth of breast cancer cells in mice. (microrna1.com)
  • The benefit of this approach is that we can study the key cells that participate in vitiligo directly from patients, without variables that may change them, including their transfer into mice. (umassmed.edu)
  • This study reports the isolation of a stable deficiency, Df(3L)CatDH104(75C1-2;75F1), that uncovers the catalase locus and the subsequent isolation of six acatalasemic mutants. (lookformedical.com)
  • In adult Swiss Webster female mice fed technical captan in their diet at levels ranging from 4 000 to 16 000 ppm for up to 35 days, soluble thiol levels in the duodenum from the proximal end were elevated throughout the feeding period. (inchem.org)
  • Results from this experiment were confirmed by those of a second test with groups of female mice of the same strain fed dietary levels of captan ranging from 500 to 16 000 ppm for up to 213 days. (inchem.org)
  • Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis. (lookformedical.com)
  • The latter include long-term/carcinogenicity studies in mice and rats, a three-generation reproduction in rats and teratology studies in rabbits, dogs and monkeys. (inchem.org)
  • Importantly, second passage of homogenates from G93A!G85R-YFP mice back into newborn G85R-YFP mice, induced disease in 4 of 4 mice by 3 months of age. (docksci.com)
  • No significant increases in mutant frequency were observed following treatment of sodium arsenate in the absence of metabolic activation. (europa.eu)
  • Sodium arsenite alone produced significant increases in the pZ189 mutant frequency at the concentration of 5.0 µM, whereas 1 and 2.5 µM arsenite were not mutagenic. (europa.eu)
  • We investigated whether levels of p62 and its phosphorylation were altered in the lenses of Cx50D47A mice, which express a mutant of connexin50 (Cx50) that leads to cataracts and impaired lens differentiation. (molvis.org)
  • Description: RNA profiling data sets generated by the Mouse ENCODE project. (nih.gov)
  • During this time I worked on a project focusing on optic cup formation in the mouse eye. (tamu.edu)
  • Extra over, each D2 HAN derivatives displayed enhanced actin strain fi ber formation in response to TGF 1 stimulation. (microrna1.com)
  • Nucleotide sequence of 21·8 kbp of variola major virus strain Harvey and comparison with vaccinia virus. (microbiologyresearch.org)
  • TOXICOLOGICAL STUDIES Special Studies on Reproduction Groups of 15 male and 30 female rats (Charles River COBS CD strain, 31 days old) were fed technical captan in their diet at the equivalent of 0, 25, 100, 250 or 500 mg/kg body weight/day for 102 days and then mated to initiate a three-generation reproduction study. (inchem.org)
  • The ratio of p62 phosphorylated at threonine-269/serine-272 (T269/S272) to total p62 was significantly decreased, whereas the ratio of p62 phosphorylated at serine-349 (S349) to total p62 was significantly increased in lenses of homozygous Cx50D47A mice. (molvis.org)