AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
FibrinogenThrombinReceptors, ThrombinThrombin TimeFibrinAfibrinogenemiaFibrin Fibrinogen Degradation ProductsFibrinopeptide ABlood PlateletsFibrinopeptide BBlood CoagulationHirudinsPlatelet AggregationReceptor, PAR-1AntithrombinsAntithrombin IIIPlatelet ActivationHemostaticsPlatelet Membrane GlycoproteinsProthrombinBlood Coagulation TestsFibrinolysisHemostasisFibrinolysinBlood Coagulation DisordersPlatelet Glycoprotein GPIIb-IIIa ComplexBlood Coagulation FactorsProtein CAncrodBatroxobinHeparin Cofactor IIReceptors, FibrinogenPartial Thromboplastin TimePlatelet AdhesivenessHeparinFactor XIIIFactor XaProthrombin TimeThrombomodulinKineticsPeptide FragmentsAmino Acid SequenceThrombosisAdenosine DiphosphateMolecular Sequence DataOligopeptidesClot RetractionCoagulantsThromboplastinPipecolic AcidsDisseminated Intravascular CoagulationFactor VIIIBinding SitesProtein Bindingvon Willebrand FactorFactor VReceptors, Cell SurfaceAnticoagulantsFactor VIIPlasminogenElectrophoresis, Polyacrylamide GelRecombinant ProteinsPlatelet Glycoprotein GPIb-IX ComplexCells, CulturedBlood ViscosityPlatelet Aggregation InhibitorsThrombastheniaBleeding TimeCalciumEndothelium, VascularBlood ProteinsFactor XHemorrhagic Disordersalpha-2-AntiplasminTissue Plasminogen ActivatorPlatelet CountFibrinolytic AgentsHirudin TherapyReceptors, Proteinase-ActivatedC-Reactive ProteinCattleBlood Platelet DisordersFactor XIIIaAntibodies, MonoclonalCell AdhesionCarboxypeptidase UFactor XICrotalid VenomsBiological MarkersMolecular WeightTime FactorsDose-Response Relationship, DrugEnzyme ActivationMacromolecular SubstancesPlasmaFibronectinsPeptidesProtein ConformationP-SelectinSerine Proteinase Inhibitors
Converts fibrinogen to fibrinPlateletsAnother clotting protein calledProthrombin to thrombinPlateletAPTTAbsence of fibrinogenCleaved to form fibrinAntithrombinActivated to fibrinHeparinPeptideSolubleConversion of fibrinogenPlasminActivatesClot formationProteinComplexesFibrin clotCongenitalEnzyme calledVIIaHypofibrinogenemiaInhibitsDeficiencyHirudinProteaseProteinsQuantitativelyConcentrationsChainsVesselHereditaryBlood serumInvolvesSevereCalciumConcentrationHemostaticProtofibrilBloodstreamAcuteHumanFlowPlasmaComponentsFactor
Converts fibrinogen to fibrin3
Platelets14
  • Download Citation on ResearchGate \textbar Arachidonate induced fibrinogen binding to thrombin degranulated platelets is independent of released ADP \textbar When human or rabbit platelets are stimulated with ADP, fibrinogen (Fbg) binding sites are revealed, the platelets bind Fbg and aggregate. (mcmaster.ca)
  • Platelets were activated with ADP, thrombin, or the thrombin receptor agonist peptide SFLLRN (TRAP 1-6 ). (nature.com)
  • During thrombus formation, circulating prothrombin is activated to the active clotting factor, thrombin, by activated platelets. (medscape.com)
  • Further recruitment of activated platelets, which expose phosphatidylserine on their membranes, allows the assembly of the intrinsic tenase (FIXa/FVIIIa) and prothrombinase (FXa/FVa) complexes, resulting in additional FX activation and conversion of prothrombin to thrombin, respectively (3). (scielo.br)
  • This provokes the release of thromboxane A 2 and the secretion of granular contents including ADP and, via these autocrine agents, the subsequent recruitment of additional flowing platelets, which assemble into a growing thrombus via α IIb β 3 -fibrinogen interactions (aggregating platelet population) ( 1 ). (frontiersin.org)
  • To determine if dogs with neoplasia produce more coated platelets, a subpopulation of activated platelets generated by dual stimulation with thrombin and convulxin, a glycoprotein VI agonist, than healthy control dogs. (avma.org)
  • Platelets were stimulated ex vivo with thrombin and convulxin. (avma.org)
  • Flow cytometry was used to quantify the percentage of coated platelets based on high levels of surface fibrinogen. (avma.org)
  • Naturally rich in fibrinogen and platelets and, originally liquid PRP jellifies upon thrombin and calcium-chloride activation. (aofoundation.org)
  • Platelets were analyzed by flow cytometry for relative size, shape, aggregation, fibrinogen binding, P-selectin, and lysosomal-associated membrane protein-1 (LAMP-1) expression. (cdc.gov)
  • Flow cytometric analysis of unstimulated platelets from CAPs-exposed mice indicated size and shape changes, and platelets from CAPs-exposed animals had a 54% increase in fibrinogen binding indicative of platelet priming. (cdc.gov)
  • Stimulation of platelets by thrombin resulted in up-regulation of LAMP-1 expression in CAPs-exposed animals and an increased microparticle population relative to control animals. (cdc.gov)
  • Fibrinogen binds to the glycoprotein IIb/IIIa complexes of adjacent platelets, connecting them into aggregates. (msdmanuals.com)
  • Thrombin converts fibrinogen into fibrin monomers, and the fibrin monomers polymerize into fibrin polymers that bind aggregated platelets into platelet-fibrin hemostatic plugs. (msdmanuals.com)
Another clotting protein called1
  • They added this solution to a tiny, double-barreled syringe that contained a separate solution of another clotting protein called thrombin. (scienceblog.com)
Prothrombin to thrombin3
Platelet2
  • Thrombin, which is generated at these phosphatidylserine sites, triggers the formation of fibrin fibers, which consolidate the platelet thrombus into a stable clot sealing the breach in a vessel wall ( 2 ). (frontiersin.org)
  • Fibrinogen is an essential blood-clotting factor and is involved in a range of other functions, including platelet aggregation and smooth muscle proliferation. (cdc.gov)
APTT1
Absence of fibrinogen2
  • In the absence of fibrinogen/thrombin for clot formation, much of the injected material was extruded to the outside of the gland. (nih.gov)
  • Mutations in the FGG gene can lead to congenital afibrinogenemia, a condition that causes excessive bleeding due to the absence of fibrinogen protein in the blood. (medlineplus.gov)
Cleaved to form fibrin1
Antithrombin1
  • Therapy with heparin usually lowers the level of the coagulation components fibrinogen, fibrin, thrombin/antithrombin complexes, fragment 1+2 and Factor II activity. (google.com)
Activated to fibrin1
Heparin1
Peptide1
Soluble4
  • The remainder of the fibrinogen molecule, a monomer , is soluble and stable at pH values less than 6 (i.e., in acid solutions). (britannica.com)
  • During plasma coagulation, soluble fibrin is generated by the influence of thrombin on fibrinogen. (horiba.com)
  • Developed in the blood from a soluble protein, fibrinogen , fibrin is laid down at the site of a wound in the form of a mesh, which then dries and hardens so that the bleeding stops. (daviddarling.info)
  • Fibrinogen is a soluble protein, a coagulation factor, synthesized by the liver and released into the bloodstream (Figure 2). (daviddarling.info)
Conversion of fibrinogen2
Plasmin2
Activates3
  • Thrombin also activates factor XIII from the human body to factor XIIIa, which then cross-links the fibrin monomers to form a stable clot. (wikipedia.org)
  • The last to to activate is factor 10a which in turn activates thrombin. (bartleby.com)
  • We studied FVII gene poly- then activates factors IX and X leading to morphisms in healthy Tunisians with the the generation of thrombin [ 2 ]. (who.int)
Clot formation1
  • Thrombin, generated by reactions initiated by activated tissue factor VII/factor IX pathways, leads to clot formation. (medscape.com)
Protein13
  • These findings demonstrate that, in fully hydrated conditions, thrombin and fibrinogen γ' have dramatic effects on protofibril content and that protein density within fibers correlates with strength of the fibrin network. (whiterose.ac.uk)
  • Fibrinogen, the protein of the blood plasma, is converted into the insoluble protein fibrin during the clotting process. (britannica.com)
  • The researchers mixed exosomes from mesenchymal stem cells with fibrinogen, a protein involved in blood clotting. (scienceblog.com)
  • Fibrinogen, which is a plasma protein, is activated by thrombin and polymerized into a filament, the so-called protofibril. (aps.org)
  • Fibrinogen is a protein made by the liver . (wikipedia.org)
  • The FGG gene provides instructions for making the fibrinogen gamma (γ) chain, one piece (subunit) of the fibrinogen protein. (medlineplus.gov)
  • Two sets of this three-protein complex combine to form functional fibrinogen. (medlineplus.gov)
  • For coagulation to occur, another protein called thrombin removes a piece from the Aα and the Bβ subunits of the functional fibrinogen protein (the pieces are called the A and B fibrinopeptides). (medlineplus.gov)
  • Without the γ subunit, the fibrinogen protein is not assembled, which results in the absence of fibrin. (medlineplus.gov)
  • Dysfibrinogenemia is a condition characterized by abnormally functioning fibrinogen, although the protein is present at normal levels. (medlineplus.gov)
  • This condition is usually caused by mutations that change a single protein building block (amino acid) in the fibrinogen γ chain. (medlineplus.gov)
  • These mutations alter the function of the fibrinogen protein and, depending on the functional change, can lead to excessive bleeding or abnormal blood clotting (thrombosis). (medlineplus.gov)
  • Hypodysfibrinogenemia is a condition characterized by low levels of abnormally functioning fibrinogen protein in the blood. (medlineplus.gov)
Complexes1
Fibrin clot2
  • We conclude that regulation of protofibril content of fibers is an important mechanism by which thrombin and fibrinogen γ' modulate fibrin clot structure and strength. (whiterose.ac.uk)
  • According to previous studies, the network structure varies depending on aggregation conditions, e.g., concentrations of fibrinogen and solvent flow, and alters the mechanical and chemical characteristics of the fibrin clot. (aps.org)
Congenital1
  • Molecular analysis of the fibrinogen gene cluster in 16 patients with congenital afibrinogenemia: novel truncating mutations in the FGA and FGG genes. (medlineplus.gov)
Enzyme called1
VIIa1
  • 7 There was an association between OSA and increased levels of factors XIIa, VIIa, thrombin, PAI-1, fibrinogen, and tissue factor. (acc.org)
Hypofibrinogenemia1
Inhibits1
Deficiency1
Hirudin1
  • Hirudin is a potent thrombin-specific protease inhibitor. (rcsb.org)
Protease1
  • In this regard, much effort by the Center for the Study of Venoms and Venomous Animals (CEVAP) has been made to produce a new fibrin sealant that uses a serine protease from a Brazilian snake ( Crotalus durissus terrificus ) with thrombin-like activity. (hindawi.com)
Proteins1
  • Fibrimex uses fibrinogen and thrombin proteins, which company representative Christiaan Penning said was "designed by nature … but used in a more intelligent way. (latimes.com)
Quantitatively1
  • On the STA-Compact, the Clauss clotting method determined the fibrinogen concentration in plasma quantitatively. (cdc.gov)
Concentrations2
Chains1
Vessel1
Hereditary1
  • A shortened thrombin time is rare and is observed in patients treated with dextran or hydroxyethyl starch or in individuals with certain forms of hereditary dysfibrinogenemia. (medscape.com)
Blood serum2
  • Also, in order to avoid human blood, bubaline-derived blood serum cryoprecipitate has been used as the fibrinogen source. (hindawi.com)
  • The fibrinogen-free fluid obtained after removal of the clot, called blood serum, is blood plasma minus fibrinogen. (britannica.com)
Involves2
Severe1
Calcium1
  • Factors that influence dimensional structure of fibrin gel giving rise to fine or coarse gel: Changing concentration of fibrinogen Changing concentration of thrombin - increased concentration increases ultimate tensile strength and Young modulus of gel Changing concentration of calcium pH Temperature A formulation with human thrombin was approved for medical use in the United States in March 2003, and in the European Union in October 2008. (wikipedia.org)
Concentration5
  • Since under these conditions the fibrinogen content was rate limiting, the clotting time can be used as a measure of the concentration of the fibrinogen and in fact, the clotting time is inversely proportional to the level of fibrinogen in the plasma. (cdc.gov)
  • The time was translated into fibrinogen concentration from a fibrinogen standard curve, stored on the STA Compact. (cdc.gov)
  • RÉSUMÉ Les polymorphismes du gène du facteur VII peuvent contribuer à l'élévation de la concentration en activité coagulante du facteur VII (FVIIc) qui a été associée au risque cardio-vasculaire. (who.int)
  • Les sujets ayant un génotype R/R avaient une concentration en FVIIc significativement plus élevée que les sujets hétérozy- gotes et homozygotes porteurs de l'allèle Q353 (96,36 vs 59,52). (who.int)
  • La concentration en FVIIc avec le polymor- phisme d'insertion de 10 pb n'était pas significativement différente. (who.int)
Hemostatic1
  • The technique of grafting with hemostatic self-adhesive fleece of collagen-fibrinogen-thrombin has been popularized in Europe (single surgeon, single institution) with potential advantages (shorter surgery duration, less technically demanding procedure and relatively cheaper than other graft materials). (auanet.org)
Protofibril2
  • Increased thrombin induced a pronounced decrease in average protofibril content per fiber, with a relatively minor decrease in fiber size, leading to the formation of less compact fiber structures. (whiterose.ac.uk)
  • Decreased protofibril content of the fibers produced by high thrombin resulted in weakened clot architecture as analyzed by magnetic tweezers in purified systems and by thromboelastometry in plasma and whole blood. (whiterose.ac.uk)
Bloodstream1
Acute1
Human3
Flow2
  • Fibrinogen solutions are highly viscous and show strong flow birefringence. (britannica.com)
  • Of particular importance in NHANES, the data can be used to study the relationship between fibrinogen levels and clinically measured lower extremity arterial blood flow as assessed by the Ankle-Brachial Index in the Lower Extremity Disease component. (cdc.gov)
Plasma6
Components1
Factor1
  • A growing body of evidence has identified fibrinogen as an important risk factor for cardiovascular disease, the major cause of death in the U.S. The objective of including this measure was to provide data on laboratory, clinical, and socio-demographic correlates of fibrinogen levels. (cdc.gov)