• Researchers may accept and/or use human fetal tissue for transplantation into a relative of the donor or other individual designated by the donor (i.e., donor-designated recipient) only if the tissue is obtained from a spontaneous abortion or stillbirth. (umn.edu)
  • Laboratory-made "biosynthetic" corneas can spur damaged tissue and broken nerves to regenerate, restoring vision in human eyes just as well as donor corneas, according to a two-year study of 10 patients reported in Science Translational Medicine. (aaas.org)
  • Delayed graft transplantation also led to an increase in donor-derived blood vessels, resulting in a transient improvement of graft vascularization at 4 d after transplantation. (jneurosci.org)
  • Patients are more likely to die waiting for a human donor heart than in the first 2 years after transplantation. (cdc.gov)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • The lack of donor availability is a major limitation to the widespread use of allogeneic hematopoietic stem cell transplantation, and therefore it would be beneficial to identify less immunogenic HLA mismatches. (elsevierpure.com)
  • Foetal tissues have also been used in liver and thymus transplantations (1968). (wikipedia.org)
  • Between 1960 and 1990, numerous attempts were made to transplant fetal liver and thymus for various conditions. (lozierinstitute.org)
  • do not donate blood, organs, tissues, or cells for transplantation after you receive betibeglogene autotemcel injection. (medlineplus.gov)
  • Transplantation of human organs and tissues1 saves many lives and restores essential functions in circumstances when no medical alternative of comparable effectiveness exists. (who.int)
  • The transplantation of solid organs, such as kidney, liver, heart or lung, is increasingly a regular component of health care in all countries, and is no longer a feature of health care in high-income countries alone. (who.int)
  • Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
  • The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
  • Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. (nih.gov)
  • if the foetal neurons are not completely functionally integrated in the host, it may cause various side effects, which are the risks and limitations associated with this procedure. (wikipedia.org)
  • Graft transplantation of embryonic cortical neurons may thus hold therapeutic potential and warrants further detailed analysis of its translational value. (jneurosci.org)
  • sought to identify the optimal time for transplantation by comparing the effect of immediate and delayed transplantation of E14 motor cortical neurons on graft vascularization, survival, and contribution to long-term motor outcome. (jneurosci.org)
  • This involves transplantation of developing midbrain cells from aborted fetuses, (the part that form mesDA neurons), into the striatum of a PD patient. (lu.se)
  • Previously, it was thought that transplanted neurons could not extend axons over long distances rendering transplantation into the SN a non-viable approach. (lu.se)
  • However, the success of fetal tissue transplants has been meager at best, and ethically-derived alternatives exist and are coming to dominate the field. (lozierinstitute.org)
  • The first recorded fetal tissue transplants were in 1921 in the UK, in a failed attempt to treat Addison's disease, [1] and in 1928 in Italy, in a failed attempt to treat cancer. (lozierinstitute.org)
  • That attempt also failed, as did subsequent similar fetal tissue transplants in 1959. (lozierinstitute.org)
  • Between 1970 and 1991 approximately 1,500 people received fetal pancreatic tissue transplants in attempts to treat diabetes, mostly in the former Soviet Union and the People's Republic of China. (lozierinstitute.org)
  • [8] Subsequent reports showed that severe problems developed from fetal tissue transplants. (lozierinstitute.org)
  • A second large, controlled study published in 2003 showed similar results (funded by NIH), with over half of the patients developing potentially disabling tremors caused by the fetal brain tissue transplants. (lozierinstitute.org)
  • [12] The results of these two large studies led to a moratorium on fetal tissue transplants for Parkinson's. (lozierinstitute.org)
  • The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
  • In Europe, hundreds of thousands of tissue transplants are performed each year, and in 1999 an estimated 750 000 people in the United States of America received human tissue, twice as many as in 1990. (who.int)
  • Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
  • Composite transplants (composite vascular allografts) involve multiple tissues, usually including skin and soft tissues and sometimes musculoskeletal structures. (msdmanuals.com)
  • We have examined the maturation of tectal tissue transplanted from fetal rats to the midbrain of newborns and have characterized the distribution of host retinal and cortical afferents within the transplants. (edu.au)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • It maintains a critical balance between maternal and fetal homeostasis. (nature.com)
  • The maternal and fetal antigens that are transmitted through the bidirectional transplacental passage during pregnancy may induce tolerance to noninherited maternal antigens (NIMAs) in offspring and to inherited paternal antigens (IPAs) in the mother. (elsevierpure.com)
  • PERTINENT ISSUES: The morality of organ transplantation. (christianliferesources.com)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
  • Disappearance of exocrine elements, with only ducts and fibrous tissue remaining, resulted in a pure endocrine organ. (diabetesjournals.org)
  • The placenta is a heterogeneous organ whose development involves complex interactions of trophoblasts with decidual, vascular, and immune cells at the fetal-maternal interface. (nature.com)
  • By providing temporary heart, kidney, or liver support as a bridge-to-transplantation, these biological devices may allow patients to recover end-organ function and await allograft transplantation in a more stable clinical state, thus improving their chances of survival. (cdc.gov)
  • However, if one views bridging strategies as a first feasibility test, then cross-species transplantation does offer the possibility of eventual long-term organ replacement. (cdc.gov)
  • The ideal treatment option for terminally ill patients is organ transplantation. (frontiersin.org)
  • To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
  • Organ transplantation is the ultimate treatment option for patients suffering from refractory diseases. (frontiersin.org)
  • Depending on the patient's medical condition, a refractory disease patient also requires an on-time selective option, such as less invasive cellular therapy options or curative organ transplantation that can function immediately after transplantation. (frontiersin.org)
  • There is a theoretical concern that transmission could occur through organ or tissue transplantation, and although Zika virus RNA has been detected in breast milk, transmission through breastfeeding has not been documented ( 5 ). (cdc.gov)
  • Foetal brain cell graft is a surgical procedure that can be used as a regenerative treatment for various neurological conditions, but was mainly explored and used specifically for treating Parkinson's disease (PD). (wikipedia.org)
  • Until now, no other vascular graft engineered from human tissue has tolerated simple storage. (aaas.org)
  • This phase might provide an optimal therapeutic window for transplantation because it may increase functional integration of the graft into the host tissue. (jneurosci.org)
  • In a pilot study, transplanting the graft 4, 7, or 30 d after lesion induction indicated that a delay of 7 d was the optimal time for transplantation. (jneurosci.org)
  • The results thus demonstrated that delaying transplantation within a specific time window increased graft survival and integration into host brain tissue. (jneurosci.org)
  • It would be valuable for future studies to investigate the molecular mechanisms underlying the enhanced graft survival rate after delayed transplantation. (jneurosci.org)
  • Their results showed that delaying transplantation increased cell proliferation, without increasing apoptosis, consequently leading to increased graft size in the delayed condition. (jneurosci.org)
  • Recent research has shown that pieces of fetal nigral tissue placed in the striatum of 6-OHDA lesioned rats offer greater cell survival and predictability of graft function (in comparison to dissociated nigral cells) in the animal model of Parkinson's disease [ 20 ]. (hindawi.com)
  • Firstly, while a PN graft is used to bridge two brain areas, an intracerebral embryonic tissue graft is meant to restore the function of the damaged area. (org.es)
  • Secondly, while all elements in PN grafting are at the same age, the intracerebral embryonic tissue graft is heterochronic with respect to the host tissue. (org.es)
  • Furthermore, the fetal graft may produce trophic factors or signaling cues, which are present in the brain only at early developmental stages, and should reactivate neurotropic processes in a 'dormant' host neuron populations. (org.es)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • Similarly, corneal transplantation can successfully relieve corneal blindness in many cases. (who.int)
  • Corneal Transplantation Corneal transplantations are done for several reasons: To reconstruct the cornea (eg, replacing a perforated cornea) To relieve intractable pain (eg, severe foreign body sensation due to recurrent. (msdmanuals.com)
  • Experimental mice, i.e., wild-type, Col5a1 f/f and Kera-Cre/Col5a1 f/f ( Col5a1 ∆st/∆st , collagen V null in the corneal stroma) mice in a C57BL/6J genetic background, were subjected to a lamellar keratectomy, and treated with or without UMSC (10 4 cells/cornea) transplantation via an intrastromal injection or a fibrin plug. (molvis.org)
  • UMSC transplantation was successful in recovering some corneal transparency in injured corneas of wild-type, Col5a1 f/f and Col5a1 ∆st/∆st mice. (molvis.org)
  • Specifically, 9 patients received systemic infusion of mesenchymal stem cells derived from adipose tissue and followed up for a 12-month follow-up period. (sscb-stembiotech.com)
  • As reported by the researchers, allogeneic transplantation of mesenchymal stem cells from adipose tissue was shown to be safe and able to reduce proteinuria and disease activity. (sscb-stembiotech.com)
  • For this reason, multiple infusions of adipose tissue mesenchymal stem cells over time are necessary to maintain long-term remission of refractory lupus nephritis. (sscb-stembiotech.com)
  • (1) IN GENERAL - The Secretary may conduct or support research on the transplantation of human fetal tissue for therapeutic purposes. (hhs.gov)
  • (2) SOURCE OF TISSUE - Human fetal tissue may be used in research carried out under paragraph (1) regardless of whether the tissue is obtained pursuant to a spontaneous or induced abortion or pursuant to a stillbirth. (hhs.gov)
  • (1) IN GENERAL - In research carried out under subsection (a), human fetal tissue may be used only if the head of the agency or other entity conducting the research involved certifies to the Secretary that the statements required under subsections (b)(2) and (c) will be available for audit by the Secretary. (hhs.gov)
  • (2) CONFIDENTIALITY OF AUDIT - Any audit conducted by the Secretary pursuant to paragraph (1) shall be conducted in a confidential manner to protect the privacy rights of the individuals and entities involved in such research, including such individuals and entities involved in the donation, transfer, receipt, or transplantation of human fetal tissue. (hhs.gov)
  • Human fetal tissue transplantation research : report of the Advisory Committee to the Director, National Institutes of Health, December 14, 1988, Bethesda, Maryland. (who.int)
  • University researchers ("researchers") may conduct research on the transplantation of human fetal tissue or cell lines derived from human fetal tissue ("human fetal tissue") for therapeutic purposes only in accordance with applicable federal and state laws and regulations and University policies and procedures. (umn.edu)
  • notify ABP when the research is complete to arrange for disposition of any remaining human fetal tissue. (umn.edu)
  • buy or sell human fetal tissue, except reasonable payments are permitted associated with the transportation, implantation, processing, preservation, quality control or storage of human fetal tissue. (umn.edu)
  • Researchers must apply for approval from the FTR for the use of human fetal tissue and apply for approval from the IRB to conduct human fetal tissue transplantation research. (umn.edu)
  • If the proposed research involves aborted fetal tissue, the application to FTR will include a written explanation of the need for human fetal tissue from induced abortions. (umn.edu)
  • FTR will assess whether alternatives, including non-aborted human fetal tissue, can be used for the research, and share that assessment with the IRB before the IRB makes its decision. (umn.edu)
  • Personnel must contact the Anatomy Bequest Program (ABP) prior to obtaining human fetal tissue from any source. (umn.edu)
  • Researchers must either: 1) obtain the human fetal tissue through ABP or 2) obtain approval from ABP for the source of human fetal tissue supplied by a research sponsor, collaborator or other source. (umn.edu)
  • ABP will procure human fetal tissue from tissue procurement organizations or clinics outside Minnesota that operate in compliance with federal law and applicable state laws and certify they do not obtain tissue from abortions performed in Minnesota. (umn.edu)
  • ABP also may accept donations of human fetal tissue obtained from a stillborn infant, or an embryo or fetus that died of natural causes in utero as authorized under applicable state laws. (umn.edu)
  • ABP will dispose of the human fetal tissue in a culturally-sensitive, dignified manner through cremation, burial or other lawful disposition method. (umn.edu)
  • Personnel must contact the ABP if the intended use of the human fetal tissue changes or if the study will take longer than anticipated. (umn.edu)
  • Human foetal tissues have been widely used in transplantations to treat various conditions, which is mainly due to its unique properties, containing a rich source of primordial stem cells. (wikipedia.org)
  • Researchers participating in a AAAS Annual Meeting news briefing discuss how the use of brain tissue from living donors has prompted a paradigm shift in the study and understanding of the human brain. (aaas.org)
  • Specifically, according to HHS's own documents, 'Section 498A of the Public Health Service Act [42 USC 289g-1] requires the annual submission to Congress of a report describing research involving therapeutic transplantation of human fetal tissue supported or conducted by the NIH. (lifenews.com)
  • Ultimately, the only documents turned over were the redacted emails and several letters from HHS to Congress stating that the National Institute of Health (another part of HHS) had no required reports to give Congress about research on transplanting human fetal tissue for therapeutic purposes because NIH hadn't been involved with any such work. (lifenews.com)
  • After that, "The NIH did not provide any financial support for human fetal tissue transplantation research. (lifenews.com)
  • Human fetal tissue research has gone on for decades. (lozierinstitute.org)
  • 1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
  • No one knew whether human ovarian tissue could survive the process--after all, that kind of deep freeze normally kills mature eggs. (discovermagazine.com)
  • It has been estimated that approximately 45,000 Americans under age 65 could benefit each year from heart transplantation, yet only 2,000 human hearts are available annually. (cdc.gov)
  • Since the introduction of the mouse small intestinal organoid model in 2009, 1 there has been an avalanche of developments in this field, including development of culture conditions for human organoids derived from primary colonic tissue, 2 as well as from human pluripotent stem cells (hPSCs). (stemcell.com)
  • and single cell RNA-seq technology helped us to gain a global recognition of the heterogeneous populations in the murine bone marrow (BM), however, the cell census of human fetal BM remains underestimated owing to material limitations. (bjmu.edu.cn)
  • Recently, the team published a research paper titled 'Characteristics of Dental Stem Cells in Human Fetal Bone Marrow by Single Cell Transcriptive and Functional Analysis' in the 'Signal Transmission and Targeted Therapy (STTT)', we reported the expression landscape of human fetal BM nucleated cells (BMNCs) based on the single-cell transcriptomic analysis. (bjmu.edu.cn)
  • Human glioma tissue microarrays indicated the positive expression rates of CDC2/CyclinB1 with a positive correlation with pathologic grades (r = 0.982, r = 0.959, respectively). (biomedcentral.com)
  • Establishment of a cell line from a human fetal liver and its xenotransplantation to nude mice. (jax.org)
  • Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)
  • Between 1988 and 1994, roughly 140 Parkinson's disease patients received fetal tissue (up to six fetuses per patient), with varying results. (lozierinstitute.org)
  • Methods: This article examines different emotional, cognitive and discursive strategies used by neurobiologists in a foetal cell transplantation trial in Parkinson's disease research, using cells harvested from aborted embryos. (lu.se)
  • I'm part of one European study called TRANSEURO , which is now at the stage of transplanting fetal cells into patients with Parkinson's disease as part of a new clinical trial. (eurostemcell.org)
  • Determination of the optimal therapeutic window for transplantation is of paramount importance for allowing effective translation to the clinic, in part because a delay between injury and transplantation is inevitable in a clinical setting. (jneurosci.org)
  • Alternatives to allograft donors, such as baboon or pig xenografts, require serious investigation if clinical transplantation is ever to meet the current demand and continue the explosive growth pattern it has established over the past quarter century. (cdc.gov)
  • Tissue microarrays (TMAs) including I-IV grade clinical glioma samples was used to determine the prognostic effect of the CDC2/Cyclin B1 expression in gliomas on different grades. (biomedcentral.com)
  • Neonatal hemochromatosis is a syndrome in which severe liver disease of fetal or perinatal onset is associated with deposition of stainable iron in extrahepatic sites. (medscape.com)
  • Liver tissue of affected infants displays severe injury with marked loss of hepatocytes. (medscape.com)
  • To access the ventral midbrain for tissue dissection, cover tissues are removed from the aborted foetus. (wikipedia.org)
  • Foetal tissue transplantation is a foetal allograft procedure, using tissues from an aborted foetus and implanting it into a diseased patient's body to improve defective tissue functioning. (wikipedia.org)
  • citation needed] Stem cells found in the foetal tissues can differentiate into any cell type. (wikipedia.org)
  • Foetal cells are differentiated stem cells from pluripotent embryonic stem cells. (wikipedia.org)
  • In comparison to adult (mature) stem cells, foetal stem cells' proliferation rate is much faster and have greater plasticity in differential potential. (wikipedia.org)
  • [5] Conditions such as anemias and immunodeficiencies, for which fetal tissue attempts largely failed, are now treated routinely with adult stem cells, including umbilical cord blood stem cells, [6] even while the patient is still in the womb. (lozierinstitute.org)
  • Tissue-specific stem cells (also known as Somatic Stem Cells) that appear during fetal development and remain in the body throughout life. (bvsalud.org)
  • The key functions of adult stem cells are to maintain and repair the specific tissues where they reside (e.g. skin or blood). (bvsalud.org)
  • Note that fetal tissue has been taken in a number of cases from fetuses at developmental ages where fetal surgery is now used to correct problems and save lives, and at stages where science now demonstrates that the unborn fetus can feel pain. (lozierinstitute.org)
  • Since the placenta co-exists with the fetus, it also encounters various intra-uterine exposures, and experiences certain detrimental effects, which in turn could negatively impact maintenance of a pregnancy or fetal health 2 . (nature.com)
  • Fetal Tissue Transplantation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • UMSC transplantation with a fibrin plug improves the healing of injured corneas and regeneration of transparent corneas, as determined with in vivo HRT II confocal microscopy. (molvis.org)
  • Since the seventies, numerous investigations have focused on trying to restore lost function by replacement of injured brain structures with homologous allogeneic embryonic neural tissue. (org.es)
  • Since the early fetal-cell studies in the 1980s and 90s there hadn't been much advance, and also some dissapointments in the field. (eurostemcell.org)
  • Transplantation of tectal tissue in rats. (edu.au)
  • Dive into the research topics of 'Transplantation of tectal tissue in rats. (edu.au)
  • One version of the approach he envisions involves giving a woman back some of her ovarian tissue if she has been somehow sterilized. (discovermagazine.com)
  • Results: The findings indicate that the labour performed by the researchers in the trial work involves transforming the foetal material practically, as well as culturally, from trash to treasure. (lu.se)
  • If this is accurate, what about all the harvesting of fetal body parts that Planned Parenthood itself categorizes as research? (lifenews.com)
  • One patient who received transplant of fetal brain tissue (from a total of 3 fetuses) died subsequently, and at autopsy was found to have various non-brain tissues ( e.g, skin-like tissue, hair, cartilage, and other tissue nodules) growing in his brain. (lozierinstitute.org)
  • Innovative therapies, such as progenitor and mesenchymal stem cell transplantation, targeting the specific altered pathway rather than the symptoms, are in the process of development. (smw.ch)
  • Researchers say they can grow large amounts of the transplantable tissue using cells from a small number of donors. (aaas.org)
  • The transformation process contains different phases, and in the interview material we observed that the foetal material or cells were considered objects, subjects or rejected as abject by the researchers handling them, depending on what phase of process or practice they referred to or had experience of. (lu.se)
  • Focusing on how practical as well as emotional and cultural strategies and rationalizations of the researchers emerge in interview accounts, this study adds insights on the rationale of practically procuring, transforming and utilizing the foetal material to the already existing studies focused on the donations. (lu.se)
  • Foetal brain cells are unique as they are multi-potent and proliferate faster. (wikipedia.org)
  • The widespread success of foetal tissue transplantation led to the use of foetal brain cells to treat neurological diseases. (wikipedia.org)
  • The dissection is targeted to isolate homogenous cell types from group of tissues in the brain. (wikipedia.org)
  • Fetal cell/tissue transplantation has been arduously studied as a potential way to repair the injured brain. (jneurosci.org)
  • performed additional studies to compare the effect of 7 d delay and immediate transplantation on survival and integration of grafted cells into host brain tissue at 4, 7, and 14 d after transplantation. (jneurosci.org)
  • By "laying out" (instead of forcibly expelling) the implantable material from a thin walled glass capillary, this technology has the potential to enhance neural transplantation procedures by reducing trauma to the host brain during implantation and allowing for the implantation of engineered/dissected tissues or constructs in such a way that their orientation and integrity are maintained in the host. (hindawi.com)
  • Transplantation of immature cells has been considered a potential therapeutic strategy for the damaged adult brain and spinal cord, and there is currently sustained interest in the generation of stem cell lines that could be used to treat certain CNS injuries or disorders. (hindawi.com)
  • Past studies have shown that some fetal nigral cells transplanted in this way can grow a limited number of axonal projections towards the striatum, but most are generally incapable of growing over the distance required to establish functional connections in the striatum in the adult brain [ 8 - 10 ]. (hindawi.com)
  • Putting fetal brain tissue grafts in the mature central nervous system (CNS) differs from peripheral nerve (PN) grafting in at least the following two ways. (org.es)
  • The fetal grafted tissue must develop its own set of connections with the right structures in the host brain, and these connections must be orderly arranged. (org.es)
  • For a short period post-implantation, grafted tissue behaves as an immature piece of brain. (org.es)
  • Unfortunately, there is abundant literature suggesting that environmental constraints from the mature host brain alter the restorative capacities of fetal grafts in various ways. (org.es)
  • A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. (lookformedical.com)
  • Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. (lookformedical.com)
  • The aim of this thesis was to understand how particular factors such as neuronal content, placement and cell source, affect functional outcome after transplantation into the rodent brain. (lu.se)
  • Lastly, the cells can survive in lower oxygen conditions, and tend to be more resistant to ischemic environments during transplantation or in vitro conditions. (wikipedia.org)
  • Intestinal organoids are three-dimensional (3D) in vitro tissue cultures that model the in vivo intestine. (stemcell.com)
  • Conclusions: The marginal and ambiguous status of the embryo that emerges in the accounts turns the scientists handling foetal cells into liminal characters in modern medicine. (lu.se)
  • In vivo transplantation demonstrated that LIFR+PDGFRB+CD45-CD31-CD235a- MSCs could form bone tissues and reconstitute the hematopoietic microenvironment (HME) effectively in vivo. (bjmu.edu.cn)
  • Downregulated adipose tissue expression of browning genes with increased environmental temperatures. (medscape.com)
  • Ethical questions about face transplantation are even more prominent than those about extremity transplantation because the surgical procedure is extremely demanding and the immunosuppression required puts the recipient at considerable risk of opportunistic infections. (msdmanuals.com)
  • Tissues, including the placenta, are comprised of diverse cell types with distinguishable developmental or functional origin that form a complex niche 1 . (nature.com)
  • Due to the presence of low levels of histocompatibility antigens in foetal cells, the chances of the recipient rejecting the transplanted foetal cell is very low. (wikipedia.org)
  • These strategies range from cell transplantation to the administration of growth factors. (jneurosci.org)
  • Immunotherapy has become an important part of hematopoietic stem cell (HSC) transplantation and cancer therapy. (nih.gov)
  • Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)
  • Tissue microarrays were utilized to investigate the expression of genes in a large number of tumor samples and to identify overexpressed genes which could be potentially causing tumorigenesis. (biomedcentral.com)
  • Together, their data suggest the existence of a temporal window after injury induction, when there is an optimal balance between inflammation and prorepair factors, which improve transplantation outcome. (jneurosci.org)
  • ii) any known medical risks to the woman or risks to her privacy that might be associated with the donation of the tissue and that are in addition to risks of such type that are associated with the woman's medical care. (hhs.gov)
  • A standardised procedure is followed: the cells are usually obtained from a 7-8 weeks old foetus and the collected cells undergo testing to examine whether they are free from infectious agents and safe for transplantation. (wikipedia.org)
  • Grafting is a surgical procedure involving the replacement of damaged or missing body tissues from a healthy body, in which blood supply of the surgical area integrates with the neighbouring cells in the body. (wikipedia.org)
  • Also, foetal cells differentiate in response to their surrounding environment, and their location plays a key role, for instance, the functional connections they establish, their growth, elongation and migration are facilitated by the location and environmental cues. (wikipedia.org)
  • It is also found that foetal cells can produce high levels of angiogenic and neurotrophic factors, which increases their growth rate after transplantation. (wikipedia.org)
  • As foetal cells have short extensions and weak intercellular connections, they survive better after grafting. (wikipedia.org)
  • Another critical question about the MSC-based bone tissue engineering is the necessity to expand the cells prior to use. (bjmu.edu.cn)
  • We still do not know what specific factors contribute to the success in transplantation i.e. what cells are responsible for motor recovery? (lu.se)
  • Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity of the constructs during and after their transplantation. (hindawi.com)
  • Here, novel technology has been developed that allows for the implantation of neural constructs or intact pieces of neural tissue into the CNS with low trauma. (hindawi.com)
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
  • Scholars@Duke publication: Topical Review: Use of Fetal Tissue in Foot and Ankle Surgery. (duke.edu)
  • With improved methods of sterilization, processing, and storage, surgeons need to be informed about the potential benefits of fetal tissue in foot and ankle surgery. (duke.edu)
  • UNLABELLED: Fetal tissues are well known for their therapeutic potential. (duke.edu)
  • Officials say they are unsure if the specific fetal tissue sold to the Obama administration came from babies aborted at Planned Parenthood. (lifenews.com)
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)