AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
FerritinsApoferritinsIronHemosiderinTransferrinAnemia, Iron-DeficiencyIron Metabolism DisordersIron-Regulatory ProteinsIron OverloadReceptors, TransferrinIron RadioisotopesDeferoxamineHemochromatosisSiderosisHemoglobinsAnemia, HypochromicIron Chelating AgentsFerrous CompoundsFerric CompoundsIron Regulatory Protein 1CeruloplasminErythrocyte IndicesFerrozineIron-Binding ProteinsPhlebotomyHorsesIron Regulatory Protein 2BloodlettingIron-Dextran ComplexLiverbeta-ThalassemiaHepcidinsHemosiderosisEncyclopedias as Topic
Serum ferritin levelConcentrationsRole of ferritinIncrease your ferritin levelsLevelsPolyclonal AntibodyLiverSubunitAssociated with several neurodegenerative diseasesFunctional ferritinHuman ferritinSpleenAssayBiomarkersELISAProteinsBone MarrowSolubleSynthesisBullfrogCorrelatesAccumulationPlasmaFerricGeneLevelDeficiencyImmunoassayApoferritin1000IntracellularProtein that stores ironBindsCorrelationVariesChronicHemoglobinDiagnostic4500GenesHemosiderinVitroBloodstreamCellsTissuesMoleculesDeficientDiseasesChainsAcuteBufferMeasurementComplexesIron is storedBlood testInflammation
Serum ferritin level2
  • The amount of ferritin in the blood (serum ferritin level) is directly related to the amount of iron stored in your body. (mountsinai.org)
  • A high serum ferritin level is also an indication for liver biopsy. (medscape.com)
Concentrations9
  • No association between ferritin concentrations and finger clubbing has been found in any of the diseases studied. (bmj.com)
  • Pulmonary artery and pulmonary vein ferritin concentrations were similar to systemic venous concentrations. (bmj.com)
  • Serum ferritin concentrations were also increased in a variety of chronic lung diseases but were normal in subjects with asbestosis. (bmj.com)
  • Plasma ferritin concentrations: their clinical significance and relevance to patient care. (edu.pl)
  • Having observed an increased serum FGF-23 in three subjects with low circulating ferritin concentrations we investigated the association between low ferritin and raised serum FGF-23. (uea.ac.uk)
  • Conclusion: The measurement of FGF-23 by both Immutopics assays is altered in the presence of low circulating concentrations of serum ferritin whereas with the Kainos intact assay this effect was not demonstrated. (uea.ac.uk)
  • It is present in small concentrations in blood, and the serum ferritin concentration normally correlates well with total-body iron stores, making its measurement important in the diagnosis of disorders of iron metabolism. (medscape.com)
  • Ferritin is present in small concentrations in blood. (medscape.com)
  • Ferritin concentrations were significantly higher in men and in individuals over 40 years of age. (bvsalud.org)
Role of ferritin1
Increase your ferritin levels3
  • Certain medicines can decrease or increase your ferritin levels. (medlineplus.gov)
  • It still helps to eat broccoli, spinach, and baked potatoes to increase your ferritin levels. (newhealthadvisor.org)
  • Vitamin C can improve absorption of nonheme iron and help you increase your ferritin levels by eating vegetables. (newhealthadvisor.org)
Levels41
  • A lower-than-normal level of ferritin occurs if you have anemia caused by low iron levels in the body. (mountsinai.org)
  • A ferritin blood test is used to help check your iron levels. (medlineplus.gov)
  • Lower than normal ferritin levels may mean you have iron deficiency anemia, or another condition related to low iron levels. (medlineplus.gov)
  • Higher than normal ferritin levels can mean you have too much iron in your body. (medlineplus.gov)
  • A ferritin test is used to measure iron levels in the body, and investigates whether the body's iron store is adequate to keep healthy. (theonlineclinic.co.uk)
  • A ferritin test may also be done to monitor a long-term condition that could alter iron levels, including autoimmune diseases (e.g., rheumatoid arthritis), kidney diseases, and cancer, or to see if a treatment for an iron deficiency is working. (theonlineclinic.co.uk)
  • The ferritin test may be done if you have symptoms indicating that your iron levels are abnormal. (theonlineclinic.co.uk)
  • The ferritin test may also be needed if your routine blood test shows that your haemoglobin levels or haematocrit is low. (theonlineclinic.co.uk)
  • If the results show that your ferritin levels are abnormal, other tests may be conducted to find the cause. (theonlineclinic.co.uk)
  • Too low or too high ferritin levels are not always caused by a medical condition. (theonlineclinic.co.uk)
  • Ferritin levels were significantly raised in the subjects with bronchial carcinoma, but were not useful in monitoring recurrence of the tumour. (bmj.com)
  • Ferritin levels were raised in patients with acute pneumonias but did not correlate with the total white cell count or erythrocyte sedimentation rate. (bmj.com)
  • Our clinical studies have shown that plant-based ferritin iron can effectively increase and maintain healthy iron levels. (florahealth.com)
  • In the blood donor study discussed earlier, those who developed cancer had ferritin levels around 127.1 ng/mL. (nutritionfacts.org)
  • Thus, iron deficiency may exist when ferritin levels decline to less than about 12 ng/mL, whereas ferrotoxic disease may occur with levels greater than about 50 ng/mL. (nutritionfacts.org)
  • Harvard recently looked at blood donations and colorectal cancer, and found no connection, but the range of ferritin levels the researchers looking at was roughly 100 to less than 200 ng/mL, as you can see at 2:28 in my video . (nutritionfacts.org)
  • Hematological tests in two affected individuals showed very high levels of serum ferritin without iron overload leading to the diagnosis of hyperferritinemia-cataract syndrome. (nih.gov)
  • Although UVB increased accumulation of newly synthesized ferritin chains, total ferritin levels were unaltered. (bioone.org)
  • Ferritin is low in those with iron deficiency anemia and high when levels of iron are raised. (anylabtestnow.com)
  • Liver dysfunction can cause elevated ferritin levels because the liver is unable to clear it from the body. (anylabtestnow.com)
  • I have lower Ferritin - good iron levels but Ferritin (Storage) is low. (qvc.com)
  • My ferritin was 4 at one point, but eating iron rich foods and taking Blood Builder iron supplement daily (as well a stopping my regular blood donations through the Red Cross) helped my levels stay on the low end of the acceptable range. (qvc.com)
  • There is no other way for me, or my wife, to get Ferritin back to safe levels. (qvc.com)
  • There was no correlation between serum ferritin levels and either the number of transfusions or the amount of iron deposited in the liver. (bmj.com)
  • However, for a given level of iron stores, ferritin levels were higher in patients with chronic hepatitis (including chronic aggressive and chronic persistent forms) than in those with hepatic siderosis only. (bmj.com)
  • On the other hand, ferritin levels that are above the reference range can be indicative of conditions such as iron overload, infections, inflammations, collagen diseases, liver diseases, neoplastic diseases, and chronic renal failure. (biorag.org)
  • Hypothyroidism or underactive thyroid can lead to poor iron absorption which is why it's important to check your iron and ferritin levels. (thyroiduk.org)
  • Patients are baffled when their serum iron levels come back elevated and their ferritin levels come back low even though they have all of the symptoms of iron depletion. (drwholeness.com)
  • Levels of ferritin can help doctors understand how much iron is in the body's stores. (medicalnewstoday.com)
  • Low ferritin levels indicate low iron stores and iron deficiency. (medicalnewstoday.com)
  • We aimed to determine the clinical significance of ferritin levels ≥ 1000 ng/mL in adults hospitalized in the general medical service. (edu.pl)
  • 6] Lee MH, Means RT, Jr. Extremely elevated serum ferritin levels in a university hospital: associated diseases and clinical significance. (edu.pl)
  • however, plasma ferritin levels are markedly increased in persons with excess iron. (medscape.com)
  • Serum ferritin levels can be measured with a sensitive and specific immunoassay, serving as an index of body iron stores. (medscape.com)
  • If your ferritin levels are lower than normal, you can try certain remedies for it. (newhealthadvisor.org)
  • Fortunately‚ Ferritin Bioavailable Iron 5 mg by Ecological Formulas can help bring the amount of ferritin up to optimal levels. (hamamall.com)
  • In an attempt to understand why ferritin levels correlate with prognosis, studies have focused on the ability of ferritin to inhibit host immune responses and thereby enhance tumor growth. (grantome.com)
  • Thirty-five per cent (35 %) of the children and 21 % of the mothers had low serum ferritin levels, while 30 % of the mothers had low serum 25-hydroxyvitamin D with 28 % of mothers having a low serum folate status. (who.int)
  • Serum ferritin and transferrin saturation levels in ß° and ß(+) thalassemia patients. (bvsalud.org)
  • Ferritin levels and transferrin saturation were similar in beta-thalassemics with and without mutations in the HFE gene . (bvsalud.org)
  • Our conclusion is that ferritin levels are variable in the beta-thalassemia , trait regardless of the type of beta-globin mutation . (bvsalud.org)
Polyclonal Antibody4
  • The following product was used in this experiment: Ferritin Heavy Chain Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-27500, RRID AB_2544976. (thermofisher.com)
  • Western blot was performed using Anti-Ferritin Heavy Chain Rabbit Polyclonal Antibody (Product # PA5-27500) and a 20kDa band corresponding to Ferritin Heavy Chain was observed across cell lines and tissues tested. (thermofisher.com)
  • Sandwich ELISA analysis of recombinant human ferritin light polypeptide (FTL) standards ranging from 1.6-1000ng/ml (A) or 100ul of diluted normal human serum or diluted normal human plasma (B) using GTX15746 Ferritin antibody [101] (capture antibody) at 1 μg/mL and biotin-conjugated ferritin rabbit polyclonal antibody (detection antibody) at 1 μg/mL. (genetex.com)
  • Sandwich ELISA analysis of recombinant human ferritin light polypeptide (FTL) standards ranging from 1.6-1000ng/ml using GTX15746 Ferritin antibody [101] (detection antibody) at 1 μg/mL and Ferritin duck polyclonal antibody (capture antibody). (genetex.com)
Liver7
  • Liver diseases (much of the ferritin in your body is stored in your liver. (medlineplus.gov)
  • Ferritin and iron are also found in other tissues of the body, including bone marrow, spleen, liver, and muscles, and are needed for normal development of the brain and immune system. (theonlineclinic.co.uk)
  • One method of controlling iron deficiency in the body is to stimulate the liver to synthesize ferritin, the protein that stores iron in order to maintain the correct balance. (hairloss-reversible.com)
  • Serum ferritin, liver iron stores, and liver histology in children with thalassaemia. (bmj.com)
  • Serum ferritin, liver iron stores, and liver histology were studied in 38 children with thalassaemia major who were being treated by regular blood transfusions. (bmj.com)
  • Rat liver siderosome ferritin. (medscape.com)
  • Found in skeletal muscles, bone marrow, spleen, and the liver, ferritin is a protein that naturally binds to iron and is present in the blood in a very small amount. (newhealthadvisor.org)
Subunit5
  • In the pearl oyster Pinctada fucata, an additional subunit resembling Lymnaea soma ferritin is associated with shell formation. (wikipedia.org)
  • FTH1 is the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. (thermofisher.com)
  • Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. (thermofisher.com)
  • This gene encodes the light subunit of the ferritin protein. (genetex.com)
  • J. Harned , A. M. Grimes , and M. C. McGahan "The Effect of UVB Irradiation on Ferritin Subunit Synthesis, Ferritin Assembly and Fe Metabolism in Cultured Canine Lens Epithelial Cells," Photochemistry and Photobiology 77(4), 440-445, (1 April 2003). (bioone.org)
Associated with several neurodegenerative diseases2
  • Defects in ferritin proteins are associated with several neurodegenerative diseases. (thermofisher.com)
  • Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. (genetex.com)
Functional ferritin2
  • When a mitochondrion takes it up, it processes it into a mature protein similar to the ferritins found in the cytoplasm, which it assembles to form functional ferritin shells. (wikipedia.org)
  • however, this study provides a cautionary note regarding the conclusions of such studies in the absence of data indicating assembly of functional ferritin molecules. (bioone.org)
Human ferritin2
  • ELISA analysis of human Ferritin or BSA diluted in carbonate/bicarbonate buffer (1 μg/ml, 100μl/well) using GTX15746 Ferritin antibody [101] at 2 - 1000 μg/mL (serial diluted). (genetex.com)
  • The Human Ferritin ELISA Kit is a highly sensitive two-site enzyme linked immunoassay (ELISA) for measuring Ferritin in Human biological fluids. (innov-research.com)
Spleen2
  • Native Ferritin, Spleen (Cat. (scrippslabs.com)
  • The ferritin in this exclusive formula is a natural derivative of bovine spleen. (hamamall.com)
Assay5
  • The serum ferritin concentration has been determined by an immunoradiometric assay in 90 subjects with a variety of pulmonary diseases. (bmj.com)
  • In this assay the Ferritin present in samples reacts with the anti-Ferritin antibodies which have been adsorbed to the surface of polystyrene microtiter wells. (innov-research.com)
  • Serum ferritin should be measured when an elevated FGF-23 is obtained using the Immutopics C-terminal or intact FGF-23 assay to prevent misdiagnosis of the cause of this abnormality. (uea.ac.uk)
  • Ferritin, folic acid and TSH were measured in serum by immunoradiometric assay (IRMA), charcoal boil and double antibody assay kit (DPC, Los Angeles, California), respectively. (who.int)
  • Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. (who.int)
Biomarkers1
  • We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. (haematologica.org)
ELISA1
  • C-reactive protein and ferritin were centrally quantified by ELISA from cryopreserved plasma whereas each center provided pre-transplant albumin. (haematologica.org)
Proteins1
  • After the removal of unbound proteins by washing, anti-Ferritin antibodies conjugated with horseradish peroxidase (HRP), are added. (innov-research.com)
Bone Marrow1
  • Hair follicles are known to contain ferritin, and when the circulating stores of ferritin decline then these stores are called upon to ensure support for more essential cells, such as bone marrow. (hairloss-reversible.com)
Soluble2
Synthesis2
  • Because the lens is constantly exposed to UV irradiation, we studied its effects on ferritin synthesis and Fe metabolism in cultured lens epithelial cells with and without ascorbic acid (Asc). (bioone.org)
  • Koorts AM, Viljoen M. Ferritin and ferritin isoforms I: Structure-function relationships, synthesis, degradation and secretion. (medscape.com)
Bullfrog1
  • In this study, we detect the allosteric networks in Pseudomonas aeruginosa bacterioferritin (BfrB), bacterial ferritin (FtnA), and bullfrog M and L ferritins (Ftns) by a network-weaving algorithm (NWA) that passes threads of an allosteric network through highly correlated residues using hierarchical clustering. (ku.edu)
Correlates1
Accumulation2
  • In contrast, Asc, which induced a quantitatively similar increase in accumulation of newly synthesized ferritin chains, doubled the total amount of ferritin. (bioone.org)
  • Ferritin accumulation was greatly increased proximal to the nanoceria, forming core-shell-like structures in C57BL/6 but even distribution in BALB/c mice. (cdc.gov)
Plasma1
  • Plasma ferritin determination as a diagnostic tool. (edu.pl)
Ferric1
  • It is postulated that in addition to these effects, ferritin or the ferric ions that it carries may function as a growth factor for neuroblastoma and directly contribute to tumor growth. (grantome.com)
Gene2
  • Some ferritin complexes in vertebrates are hetero-oligomers of two highly related gene products with slightly different physiological properties. (wikipedia.org)
  • Haplotype analysis placed the cataract locus to a 5.0 cM region between D19S902 and D19S867, in close proximity to the L-ferritin light chain gene (FTL) on chromosome 19q13.3. (nih.gov)
Level10
  • The ferritin blood test measures the level of ferritin in the blood. (mountsinai.org)
  • The lower the ferritin level, even within the "normal" range, the more likely it is that the person does not have enough iron. (mountsinai.org)
  • The ferritin level in the blood is therefore used to indicate the amount of iron currently stored in the body. (theonlineclinic.co.uk)
  • Who should have their Ferritin level tested? (theonlineclinic.co.uk)
  • Testing your ferritin level requires a small blood sample, which is collected by you at home. (theonlineclinic.co.uk)
  • What's the Best Ferritin Level to Lower Cancer Risk? (nutritionfacts.org)
  • The Ferritin Test measures the level of ferritin molecules in the blood. (anylabtestnow.com)
  • A low ferritin level in the blood indicates iron deficiency. (theepochtimes.com)
  • Ferritin level increases with age, and the level is higher in men than women. (medscape.com)
  • However, it is also bad to have too much of iron in your body, and that is why having a level within ferritin normal range is essential, as this indicates the right balance of iron in your body. (newhealthadvisor.org)
Deficiency7
  • hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia. (wikipedia.org)
  • One of the most common causes of hair loss in pre-menopausal women is not hormones, but a nutritional deficiency, with depleted iron stores [serum ferritin] being the most important factor. (hairloss-reversible.com)
  • Ferritin is also a surrogate marker of the total amount of iron stored in the body, so serum ferritin is used as a diagnostic test for iron deficiency anaemia. (biorag.org)
  • Recent studies suggest that ferritin provides a more sensitive, specific and reliable measure to determine iron deficiency at an early stage. (biorag.org)
  • A ferritin below 30 is generally considered iron deficiency. (drwholeness.com)
  • The most reliable method of assessing iron deficiency is with a blood test to check serum ferritin status. (drwholeness.com)
  • H. pylori infection was determined by urea breath test and iron deficiency using serum ferritin. (cdc.gov)
Immunoassay1
  • The Ferritin Fluorescence Immunoassay (FIA) test is a lateral flow chromatographic fluorescence immunoassay for the quantitative detection of ferritin in human serum using the RaFIA system. (biorag.org)
Apoferritin1
10001
  • We scanned the hospital laboratory database for ferritin values ≥ 1000 ng/mL, and evaluated the medical history, diagnoses, and survival of patients hospitalized in the general medical service. (edu.pl)
Intracellular3
  • Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. (wikipedia.org)
  • Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. (genetex.com)
  • Ferritin is an intracellular protein that stores iron and releases it in a controlled manner. (biorag.org)
Protein that stores iron1
Binds1
Correlation2
  • A high degree of correlation was demonstrated between serum ferritin concentration and storage iron measured by quantitative phlebotomy. (bmj.com)
  • A serial concentration of ferritin reference materials from 2.0 to 1000.0 ng/mL was tested and the correlation coefficient (R) is ≥0.9900. (biorag.org)
Varies2
  • The function and structure of the expressed ferritin protein varies in different cell types. (wikipedia.org)
  • The reference (normal) range for ferritin varies across different laboratories, serves as a guide only, and doesn't preclude a ferritin value outside of the normal range being considered normal for an individual person. (theonlineclinic.co.uk)
Chronic1
  • Infection (58.7%), chronic kidney disease (22.0%), and solid or hematological malignancies (21.6% and 17.1%, respectively) were the leading conditions associated with elevated ferritin. (edu.pl)
Hemoglobin1
  • Why do African Americans have higher serum ferritin than European Americans, despite lower hemoglobin? (umd.edu)
Diagnostic1
  • The diagnostic and prognostic utility of extremely elevated ferritin values in hospitalized medical patients is lacking. (edu.pl)
45001
Genes2
  • citation needed] Ferritin genes are highly conserved between species. (wikipedia.org)
  • All vertebrate ferritin genes have three introns and four exons. (wikipedia.org)
Hemosiderin6
Vitro1
  • Preliminary data suggest that desferoxamine, a high affinity iron chelator which can extract iron from ferritin, kills growing neuroblastoma cells in vitro. (grantome.com)
Bloodstream2
Cells6
  • Ferritin is a protein inside your cells that stores iron. (mountsinai.org)
  • ICC/IF analysis of HepG2 cells using GTX15746 Ferritin antibody [101]. (genetex.com)
  • Ferritin is a multimeric protein consisting of heavy and light chains assembled in different tissue-specific ratios, which can protect cells from oxidative stress by storing reactive iron (Fe). (bioone.org)
  • Ferritin is found in virtually all cells of the body and in tissue fluids. (medscape.com)
  • Indirect evidence suggests that ferritin in these patients may be synthesized by their tumor cells. (grantome.com)
  • and to study the ability of neuroblastoma cells to bind ferritin in the manner of known growth factors. (grantome.com)
Tissues1
  • Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. (wikipedia.org)
Molecules2
  • Ferritin-like molecules show a remarkable combination of the evolutionary conserved activity of iron uptake and release that engage different pores in the conserved ferritin shell. (ku.edu)
  • Applying NWA revealed that each of the molecules has an extended allosteric network mostly buried inside the ferritin shell. (ku.edu)
Deficient1
Diseases1
  • Further elucidation is needed about how ferritin regulation is perturbed in diseases, and whether increased stored iron plays a role in different clinical outcomes and drug response. (umd.edu)
Chains2
  • It is composed of 24 subunits of the heavy and light ferritin chains. (thermofisher.com)
  • Because UVB did not change Fe storage in ferritin or the size of the labile Fe pool, it was hypothesized and then determined that these newly synthesized chains did not assemble into functional holoferritin. (bioone.org)
Acute1
  • Ferritin is an acute-phase reactant that coordinates cellular defense against oxidative stress and inflammation along with transferrin and its receptor. (medscape.com)
Buffer1
  • Ferritin Dilution Buffer is a Tris buffered solution and is provided in a ready-to-use format. (scrippslabs.com)
Measurement3
  • The method for measurement of Ferritin on the Roche Elecsys-170 is a sandwich principle with a total duration time of 18 minutes. (cdc.gov)
  • The ferritin measurement in ng/mL was converted to µg/L by multiplying by 1.0. (cdc.gov)
  • Design-- In this community-based cluster survey, capillary blood was obtained from 680 children (aged 6-35 mo) for measurement of iron status by using ferritin, TfR, and ZP. (cdc.gov)
Complexes1
  • These enzyme-labeled antibodies form complexes with the previously bound Ferritin. (innov-research.com)
Iron is stored2
Blood test5
Inflammation2
  • You doctor may wish to look for signs of inflammation as an elevated serum ferritin is an indication of inflammation. (healthtap.com)
  • Conclusion-- TfR better estimates the prevalence of ID in preschoolers than do ferritin, ZP, and the TfR/ferritin index on the basis of multiple indexes in a high inflammation, resource-poor setting. (cdc.gov)