Fas fasl fas ligand protein. Medical search. Frequent questions

Apoptosis is most often mediated by extrinsic pathway via FAS or CD95 or apoptosis antigen 1 (APO-1) or tumor necrosis factor receptor superfamily 6 (TNFRSF6), a cell surface death receptor. (medscape.com)
Mice homozygous for FAS mutations develop hypergammaglobulinemia, glomerulonephritis, massive lymphadenopathy, and expansion of an otherwise rare population of T-cell receptor (TCR) α/β cells that lack expression of both CD4 and CD8 (double-negative T [DNT] cells). (medscape.com)
It plays an important role in immune homeostasis and cell -mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS . (online-medical-dictionary.org)
As we reviewed possible hits, the 'aha moment' came when we saw Fas ligand on the list of affected proteins, because we know Fas is an integral receptor for controlling cell death," said Lathem. (medindia.net)
The extrinsic pathway is mediated by a variety of death receptor ligands, including tumor necrosis factor (TNF) and Fas ligand (FaSL), that trigger apoptosis by binding to cell surface receptors. (cdc.gov)
Necroptosis is a programmed form of necrotic cell death that is dependent on activation of receptor interacting protein kinase-3 (RIPK3) and occurs when caspase activation is insufficient or blocked. (bioradiations.com)
1. FAS & TNF1 receptor families with death domain. (howmed.net)
FasL ,TNF receptor →caspase 8→ exec caspase. (howmed.net)
Colon & lung cancer cells produce blocking protein for Fas receptor CTL cannot kill these tumor cells. (howmed.net)
While preventing interaction of its own Fas receptor with FasL from self-destruction. (howmed.net)
whereas the other, death receptor pathway, involves the binding of a death ligand, such as Fas ligand (FasL), to Fas resulting in activation of caspase-8. (ac.ir)
Fas/APO-1/CD95, member of the tumor necrosis factor (TNF) receptor superfamily, is a widely expressed cell surface receptor that can initiate apoptosis when activated by its ligand (FasL). (ac.ir)
Lately research connected to mechanisms of leukemia cell resistance to Fas FasL mediated apoptosis selleck chemical such as Fas and FasL mutation and expression abnormality, Fas signaling transduction pathway abnormality, and regulatory have an impact on of apoptotic regulatory genes on Fas FasL process, as well as tactics replying to antiapoptosis of leukemia cells including NF kappa B, XIAP, membrane receptor CD28 and matrix metalloproteinase 7 obtained some pro gresses. (microrna21.com)
Including the function from the p75 neurotrophin receptor (p75) and Fas continues to be intensively examined in the anxious system during advancement and in degeneration and regeneration [4]. (healthyconnectionsinc.com)
The inhibitory effect of oestradiol on FasL expression was mediated through binding to its receptor, as co-treatment of tamoxifen, an oestrogen receptor inhibitor, completely nullified the oestradiol-induced decrease in FasL mRNA expression. (elsevierpure.com)
FAS is a type I transmembrane protein and belongs to the TNF receptor superfamily. (biolegend.com)
CONCLUSIONS: Signal transduction through the Fas receptor plays no essential role in the induction of tolerance using anti-CD4 and anti-CD8 monoclonal antibodies or its maintenance by active regulation. (ox.ac.uk)
In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used. (antibodies-online.cn)
Cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. (lu.se)
It is most often associated with heterozygous mutations in the gene that encodes the Fas protein tumor necrosis factor receptor superfamily 6 ( TNFRSF6 ) and other related effector proteins that regulate lymphocyte survival. (medscape.com)

Additionally, FOXO1 trans-activate Bim protein, which a member of the Bcl-2 family that promotes apoptosis and plays a role in the intrinsic mitochondrial apoptotic pathway. (wikipedia.org)
Most cases of ALPS are caused by loss-of-function mutations in components of the FAS apoptotic pathway or extrinsic pathway. (medscape.com)
NFAT2, as an important transcriptional promoter, regulates expression of TNF-α, myc proto-oncogene protein (c-myc), cyclooxygenase-2 (COX-2), Fas ligand (FasL) and also generates crosstalks with ERK/MAPK pathway and AKT/GSK3b signaling, which achieves its control of the cell fate [7-12]. (researchsquare.com)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
Therefore, it was hypothesized that the Fas/FasL pathway and apoptosis may be associated with the course of granulomatous inflammation in sarcoidosis. (ersjournals.com)
It has been shown that the Fas pathway is functional in cardiac myocytes and plays a critical role in myocardial death due to ischemia-reperfusion in vivo [ 4 ]. (ac.ir)
In lpr mice, a naturally occurring mutant deficient in Fas, there is marked reduction in infarct size and abundance of apoptotic cardiac myocytes following ischemia and reperfusion that also signifies the importance of Fas pathway in ischemia-reperfusion injury [ 5 ]. (ac.ir)
However, BF + GCV only induced apoptosis via Fas/FasL signal pathway accompanied with increased P53 expression. (biomedcentral.com)
The Fas FasL technique as an essential pathway inducing cell apoptosis participates in occurrence and improvement of leukemia. (microrna21.com)

Also, FOXO1 regulates TNF-related apoptosis-inducing ligand (TRAIL), which caused FOXO1-induced apoptosis in the human prostate cancer cell line LAPC4 when FOXO1 adenovirus-mediated overexpression was used. (wikipedia.org)
TNF , TNF-related apoptosis-inducing ligand ( TRAIL ), and Fas ligand ( FasL ). (massgenomics.org)

FOXO1 upregulates Fas ligand (FasL) transcriptionally resulting in apoptotic cell death. (wikipedia.org)
This is the first time anyone has shown how bacteria can subvert apoptotic cell death by directly destroying Fas ligand," said Lathem, a member of the Center for Genetic Medicine and Interdepartmental Immunobiology Center. (medindia.net)
ED 50 = 10 - 50 ng/ml, corresponding to a specific activity of 0.02 - 0.1 x 10 6 units/mg, as determined by inhibition of apoptotic cell death induced by FASL on Jurkat cells. (biolegend.com)

The activator shuts down a molecule, Fas ligand (FasL), which stimulates a form of programmed cell death known as apoptosis. (medindia.net)
For instance Fas-associated death domains (FADD) proteins an adaptor molecule for Fas signaling includes both a DD and a DED. (healthyconnectionsinc.com)
Thus, in addition to DcR1, DcR2 and OPG, DcR3 is another TNFR family molecule which modulates ligands that induce apoptosis. (bio-techne.com)
deletion of an exon encoding the transmembrane domain results in a soluble FAS molecule that blocks apoptosis. (biolegend.com)

this results in cytoplasmic recruitment of a protein known as the FAS-associated death domain (FADD), followed by recruitment of procaspase 8 and procaspase 10 and resultant cellular apoptosis. (medscape.com)
Under conditions that sensitize the cell to death, a cell death-inducing complex of RIPK1, Fas-associated protein via death domain (FADD), caspase-8, and cellular FLICE-like inhibitory protein (cFLIP) is formed. (bioradiations.com)
Fas-associated death domain (DD) adaptor (FADD) an associate from the DD superfamily contains both a DD and a death effector domain (DED) that are essential in mediating FAS ligand-induced apoptotic signaling. (healthyconnectionsinc.com)
Pursuing Fas Ligand (FasL) engagement FADD is normally recruited to bind Fas (Compact disc95/Apo-1) through a DD-DD connections. (healthyconnectionsinc.com)
The binding of FASL to FAS induces conformational changes in FAS, leading to the recruitment of FADD and procaspase-8 and the assembly of the death-inducing signaling complex (DISC). (biolegend.com)

Mutations have been identified in each of the genes that code for Fas, FasL, caspase 8 and caspase 10 (see the image below). (medscape.com)
Mutations have been identified in each of the genes coding for Fas, Fas-ligand (FasL), caspase-8, and caspase-10. (medscape.com)

FCM analysis found that human NP cells with increased FasL expression resulted in significantly increased apoptosis ratio of macrophages and CD8 + T cells. (medsci.org)
In contrast, testosterone increased FasL expression dose-dependently in SLE T cells stimulated with PMA plus ionomycin. (elsevierpure.com)

Fas (APO-1/CD95) and its ligand (FasL) are cell surface proteins whose interaction activates apoptosis of Fas-expressing targets. (unifg.it)

Inhibition of Fas expression prevents I/R induced apoptosis. (ac.ir)
Inhibition of cytotoxic effect of FASL on Jurkat cells in the presence of recombinant human FAS. (biolegend.com)

Thrombospondins (TSP) are secreted proteins with the ability to inhibit angiogenesis. (dadamo.com)
Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. (bio-techne.com)

Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. (wikipedia.org)
The first genetic defect was described in 1995 by the discovery of the FAS gene mutation. (medscape.com)
Real-time PCR and Western blot analyses were used to evaluate gene and protein expression levels. (wjgnet.com)
Additionally, BRDs contain several catalytic domains that enable them to act as methyltransferases, ATP-dependent re-modellers or histone acetyltransferases and helicases ( 8 ) Bromodomain and extra-terminal domain (BET) proteins are a family of transcriptional mediators that regulate gene expression ( 8 , 9 ). (frontiersin.org)
FASLG, the protein encoded by this gene would be the ligand for FAS. (microrna21.com)
In this study we describe the effect of hyperthermia on activation of the fas-L gene in T lymphocytes. (unifg.it)
Numerous cellular proteins detect DNA damage and induce senescence , a permanent change of state characterized by morphological and gene expression changes. (massgenomics.org)
[ 1 ] In 1995, defective lymphocyte apoptosis secondary to mutations in the FAS gene was identified as a molecular basis for ALPS. (medscape.com)

We aimed for addressing the role of FasL expression in human intervertebral disc degeneration (IDD) and immune privilege in terms of the interaction between NP cells and immunocytes via the FasL-Fas machinery. (medsci.org)
Interaction of FAS with this ligand is important in triggering apoptosis of some styles of cells this kind of as lymphocytes. (microrna21.com)
The interaction of FAS/FASL in immature dendritic cells (DCs) induces functional maturation. (biolegend.com)
In addition, FAS/FASL interaction increases the production of chemokines in NK-T cells, and FASL acts as a survival factor for human CD34 + cells and increases their colony formation. (biolegend.com)
Subsequent investigation of this isoform revealed its novel interaction with B23 [2], a multifunctional nucleolar protein involved in ribosome biogenesis, rRNA transcription, mitosis, cell growth control, and apoptosis [3]. (oncotarget.com)
Subsequent investigation, elucidated NSP 5a3a's potential involvement in cellular processes such as ribosome biogenesis and rRNA processing by validating NSP 5a3a's novel interaction with B23 and ribonuclear protein hnRNP-L possibly implicating NSP 5a3a's involvement in cellular activities such as RNA metabolism and processing [4]. (oncotarget.com)

Its ligand (FasL), a member of the tumor necrosis factor (TNF) family, which includes two forms of a membrane-bound form and a soluble one, induces apoptosis of Fas-bearing cells through cytotoxic activity. (iomcworld.com)
Phosphorylation of RIPK3 leads to recruitment and subsequent phosphorylation of mixed lineage kinase domain-like protein (MLKL), which translocates to intracellular and plasma membranes and induces membrane permeabilization and rupture, either through calcium or sodium influx through ion channels or direct binding to membrane phosphatidylinositol phosphates (this is still controversial among experts). (bioradiations.com)

NFAT2 overexpression induced the expression of Egr2 and FasL and suppressed the phosphorylation of AKT and ERK. (researchsquare.com)
Moreover, we found that heat shock factor-1 is a transactivator of fas-L promoter in activated T cells, and the overexpression of a dominant negative form of heat shock factor-1 may attenuate the effect of hyperthermia on fas-L promoter activity. (unifg.it)
Furthermore, overexpression of dominant negative mutants of protein kinase Cε (PKCε) and PKCθ partially inhibited the promoter activation and, more importantly, could significantly reduce the enhancement mediated by hyperthermia, indicating that modulation of PKC activity may play an important role in this regulation. (unifg.it)

Because transduced normal B cells expressed only low levels of FasL and did not kill Fas-expressing Jurkat or A20 B lymphoma cells in vitro, these data suggest that gld B cells are not tolerogenic due to unique characteristics of these B cells rather than the lack of functional FasL expression. (usuhs.edu)

A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS . (online-medical-dictionary.org)
FasL mRNA was expressed in BAL lymphocytes from 15 of 20 patients with sarcoidosis, but from only one of 10 patients with normal lung parenchyma. (ersjournals.com)
FasL protein was expressed in lymphocytes surrounding and within the granuloma. (ersjournals.com)

We show that hyperthermic treatment enhances Fas-L-mediated cytotoxicity, fas-L mRNA expression, and fas-L promoter activity in activated T cell lines. (unifg.it)

[ 6 ] Some patients may have a compound heterozygous mutation or more than one mutation, such as FAS mutation and CASP10 mutation. (medscape.com)

Immunohistochemistry was also performed to detect Fas and FasL protein, and reverse transcriptase polymerase chain reaction (RT-PCR) and RT in situ PCR to detect FasL messenger ribonucleic acid (mRNA). (ersjournals.com)
To detect the expression of Fas in the cardiomyocytes, immunohistochemistry method was used. (ac.ir)
Endoscopic duodenal biopsy specimens from 12 patients with untreated and 12 with treated CD and 12 control subjects were evaluated for enterocyte apoptosis by the terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine triphosphate nick-end labeling assay and for Fas and FasL expression by immunohistochemistry. (nih.gov)

In T cells, the Fas-Fas-L system regulates activation-induced cell death, is implicated in diseases in which lymphocyte homeostasis is compromised, and plays an important role during cytotoxic and regulatory actions mediated by these cells. (unifg.it)

This could be a common feature, where we see other bacteria manipulating cell death pathways by altering Fas signaling. (medindia.net)
The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)

Inhibitory peptides and fragments of TSP1 bind to CD36, leading to the expression of FAS ligand (FasL), which activates the expression of Fas. (dadamo.com)

In contrast, inflammatory pathologies, such as multiple sclerosis, myocardial ischemia-reperfusion injury, inflammatory bowel disease, and chronic obstructive pulmonary disease, are associated with elevated expression of necroptotic signaling proteins. (bioradiations.com)
Upregulation of Fas expression in myocardial ischemia-reperfusion can induce cardiomyocyte apoptosis, and atorvastatin can significantly inhibit cardiomyocyte apoptosis by inhibiting Fas expression. (ac.ir)

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (bio-techne.com)
BioLegend carrier-free recombinant proteins provided in liquid format are shipped on blue-ice. (biolegend.com)

Their function is regulated by the activation of a number of activating and inhibitory receptors that bind to specific ligands expressed on the surface of target cells. (frontiersin.org)

The essential role of FAS plays in maintaining lymphocyte homeostasis and peripheral immune tolerance to prevent autoimmunity was first demonstrated by studying FAS-deficient MRL/lpr-/- mice. (medscape.com)

BF-rTK + GCV induced tumor apoptosis mediated by FasL and TNFR2 through the mitochondrial control of apoptosis via Bid and Bim without inducing necroptosis and autophagy. (biomedcentral.com)

Membrane rupture leads to the spilling of intracellular content into the organ and the release of damage-associated molecular patterns (DAMPs), such as interleukin (IL)-1α, IL-β, IL-33, and high-mobility group protein 1, into the extracellular space. (bioradiations.com)
Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
The extracellular region of FAS possesses three cystein-rich domains characteristic of the TNF superfamily, and the intracellular region which includes a death domain (DD). (biolegend.com)

METHODS: Tolerance to transplanted skin and bone marrow, mismatched for multiple minor histocompatibility antigens, was induced in Fas mutant and control mice using anti-CD4 and anti-CD8 monoclonal antibodies. (ox.ac.uk)
Additionally, tolerant Fas mutant mice accepted grafts bearing tolerated and third party antigens. (ox.ac.uk)

Bromodomains are proteins that contain modules of ~110 amino acids that recognize and bind acetylated lysine residues in histones and other proteins. (frontiersin.org)
Among TNF family members, DcR3 was shown to bind with Fas ligand (FasL) and LIGHT and inhibit FasL- and LIGHT-induced apoptosis. (bio-techne.com)

Human FAS, amino acids (Arg17-Asn173) (Accession# NM_000043), was expressed in 293E cells. (biolegend.com)

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells. (umassmed.edu)

FasL expression was detected by qRT-PCR, western blotting and flow cytometry (FCM). (medsci.org)

P45 attenuates FasL-induced caspase activation. (healthyconnectionsinc.com)

A coculture of isolated enterocytes (targets) and purified lamina propria mononuclear cells (LPMCs) (effectors) was performed in the absence or presence of an antagonistic ZB4 anti-Fas antibody. (nih.gov)
Moreover, pre-treatment of FasL-transfected L5178Y cells with either oestradiol or anti-FasL antibody inhibited significantly the apoptosis of Fas-sensitive Hela cells when two types of cells were co-cultured. (elsevierpure.com)
Fas-mediated apoptosis has been characterized as an important mechanism of peripheral self-tolerance and we here examine whether it has any role in anti-CD4 monoclonal antibody-induced dominant tolerance. (ox.ac.uk)
RESULTS: Monoclonal antibody therapy rendered Fas mutant mice tolerant of minor disparate skin and bone marrow. (ox.ac.uk)

Fas is type I membrane protein, expressed on various tissue including hematopoietic cell. (iomcworld.com)
Apoptosis, on the other hand, is characterized by cell shrinkage, membrane blebbing, condensation, margination of nuclear chromatin, packaging of apoptotic bodies, and engulfment of the immunogenic intracellular proteins by phagocytes and macrophages. (bioradiations.com)
Fas-activated DCs increase the expression of MHC II, B7 co-stimulatory molecules, and DC-lysosome-associated membrane proteins (DC-LAMP), and secrete proinflammatory cytokines such as IL-1β and TNF-α. (biolegend.com)
Type II membrane protein. (lu.se)

In addition, although protective functions are well documented for AMP-activated protein kinase (AMPK), paradoxically, disease-promoting effects have also been demonstrated for this enzyme. (mdpi.com)
Using two different methods it was possible to detect constitutive activity of p38 mitogen-activated protein kinase (p38) in newly isolated neutrophils. (lu.se)
During the transient loss of p38 activity there was a temporary Fas-induced increase in phosphatidylinositol 3-kinase (PI3K) activity, which also had a pro-apoptotic impact on the neutrophils. (lu.se)

Administration of G-CSF under a large quantity of soluble FasL might play an important role in the pathogenesis of BMN through apoptosis of hematopoietic cells in the bone marrow. (iomcworld.com)

Using a chemo-genetic approach, we identify BET bromodomain containing proteins BRD2 and BRD4 as central regulators of NK cell functions, including direct cytokine secretion, NK cell contact-dependent inflammatory cytokine secretion from monocytes as well as NK cell cytolytic functions. (frontiersin.org)
In concern with a relation to cytokine, his serum FasL was examined and found to be extremely elevated. (iomcworld.com)

In the presence of divalent cations, the secreted protein binds to the surface of the activated platelets and is responsible for the endogenous lectin-like activity associated with activated platelets. (dadamo.com)
HPV produces protein E6 which binds & inactivates apoptosis promoter p53. (howmed.net)

Like osteoprotegerin (OPG), DcR3 lacks a transmembrane sequence and is a secreted protein. (bio-techne.com)

Splenocytes from these and control tolerant animals when transferred into partially immunocompromised Fas mutant or control recipients, induced antigen-specific suppression of graft rejection. (ox.ac.uk)

Unlike necrosis, an unregulated form of cell death caused by external physicochemical stress, necroptosis is highly regulated and acts as a defense mechanism or escape route for cells infected with viruses that inhibit apoptosis signaling proteins (examples of these viruses include the murine cytomegalovirus, West Nile virus, human immunodeficiency virus-1 (HIV-1), and herpes simplex virus). (bioradiations.com)

It was shown that functional Fas system contributes to apoptotic myocardial cell death in response to ischemia/reperfusion injury [ 4 , 5 ]. (ac.ir)

The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. (aacrjournals.org)
A cellular DNA-repair protein, namely O 6 -methylguanine-DNA methyltransferase (MGMT) protein, reverses alkylation at the O 6 position of guanine, thereby inhibiting the lethal cross-linking and bringing about resistance to alkylating agents ( 2, 3 ). (aacrjournals.org)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)

Furthermore, because MGMT protein loss may be a result of promoter hypermethylation, it was reported that methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness to alkylating agents ( 7 ). (aacrjournals.org)

Fas expression was significantly higher in the ischemia-reperfusion group as compared to sham-operated group, but was decreased significantly in atorvastatin treated group as compared with I/R group. (ac.ir)

We show that ApoBDs generated from IAV-infected monocytes contained IAV mRNA, protein and virions and consequently, could facilitate viral propagation in vitro and in vivo, and induce a robust antiviral immune response. (nature.com)
ApoBDs generated by IAV-infected monocytes contained a series of IAV components, including IAV mRNA, proteins, and infectious virions. (nature.com)

In the immune system, Fas antigen (Fas) and Fas ligand (FasL) are involved in the down regulation of immune reactions by inducing apoptosis. (ersjournals.com)

In keeping with these results p45 inhibits FasL-induced cell loss of life markedly. (healthyconnectionsinc.com)
These data suggest that oestrogen inhibits activation-induced apoptosis of SLE T cells by down-regulating the expression of FasL. (elsevierpure.com)

They will also be looking at different bacterial infections to see if any manipulate cell death by altering Fas signaling in a similar manner. (medindia.net)
Require activations signal →protein cleavage within cell causing cell death. (howmed.net)
Apoptosis is a genetically programmed form of cell death that is mediated by the activation of the caspase cascade and results in the cleavage of protein substrates and oligonucleosomal fragmentation of DNA. (ac.ir)
Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)

The expression of Egr2 and FasL, and the phosphorylation of AKT and ERK, after ionomycin and PMA co-stimulation, was detected, while the Ca 2+ mobilization stimulated by K + solution was determined. (researchsquare.com)
The results in this dissertation also demonstrate that the protein phosphatase type 2A (PP2A) can directly and independently decrease the phosphorylation levels of both p38 and caspase 3. (lu.se)

Dominant tolerance and linked suppression induced by therapeutic antibodies do not depend on Fas-FasL interactions. (ox.ac.uk)

FLIP, Fas-associated death domain-like interleukin-1β converting enzyme-like inhibitory protein. (cdc.gov)

Neutrophil apoptosis can be modulated by several factors in the local environment, such as the Fas ligand (FasL), but the molecular mechanisms involved are poorly understood. (lu.se)
The 397 amino acid recombinant protein has a predicted molecular mass of approximately 44.7 kD. (biolegend.com)

Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (bio-techne.com)

Some cancer cell produce FasL which kill CTL directed against these tumor cells. (howmed.net)

TNFRFSF6/Fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T cells, or both. (lu.se)

antibodies-online offers a wide range of antibodies, proteins, arrays and kits for cytokines. (antibodies-online.cn)

Further studies are needed to determine the role of Fas, FasL and other regulatory factors in apoptosis in the granulomatous inflammation in pulmonary sarcoidosis. (ersjournals.com)

Additional markers of apoptosis such as Fas, Fas ligand (FasL), and Bax, as well as anti-apoptotic molecules such as bcl2/BAG-1, are reported to be relevant to prognosis in a smaller number of publications. (biomedcentral.com)

Organisms1

Chemicals and Drugs7

Phenomena and Processes2

RECEPTOR20

Pathway9

Apoptosis-induci2

Apoptotic cell3

Molecule4

FADD5

Genes2

Increased FasL expression2

CD951

Inhibition2

Ability to inhibit2

Gene8

Interaction6

Induces2

Overexpression3

Jurkat1

Lymphocytes3

MRNA expression1

Mutation1

Immunohistochemistry3

Cytotoxic1

Pathways2

Activates1

Myocardial ischemia-reperfusion2

Recombinant proteins2

Receptors1

Lymphocyte1

Mitochondrial1

Extracellular3

Antigens2

Bind2

Amino acids1

Perforin1

Expression was detected1

Caspase activation1

Antibody4

Membrane4

Kinase3

Soluble1

Cytokine2

Binds2

Transmembrane1

Antigen specific1

Inhibit apoptosis1

Functional1

Cellular3

Promoter1

Significantly1

Monocytes2

Immune system1

Inhibits2

Cell death4

Phosphorylation2

Dominant1

Inhibitory protein1

Molecular2

Enhances1

Tumor cells1

Role in the induction1

Antibodies1

Regulatory1

Markers1