• Heart failure among South Asians: a narrative review of risk, nature, outcomes and management. (ox.ac.uk)
  • Reviewed literature showed that South Asians with HF were more likely to be younger and have diabetes and hypertension. (ox.ac.uk)
  • These papers also implied that outcomes for South Asians with HF were similar or even better than for Caucasians. (ox.ac.uk)
  • The review highlighted the under-representation of South Asians in HF trials, meaning that evidence-based recommendations tailored to this specific population are limited. (ox.ac.uk)
  • The population frequency of the indel (rs66698963) is remarkably different among human populations with the insertion being far more frequent in South Asians, Africans and some East Asian populations, and far less common in European and other East Asian populations. (fatsoflife.com)
  • Independent effect of ethnicity on glycemia in South Asians and white Europeans. (ox.ac.uk)
  • This comparison has not been performed between South Asians (SAs) and WEs. (ox.ac.uk)
  • We present age-specific incidence rates of MS from two ongoing prospective cohort studies of US women-the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHS II)-and compare them by ancestry and geographic region. (neurology.org)
  • The mask is ill-suited for non-European populations, especially sub-Saharan Africans and East Asians. (femininebeauty.info)
  • From a genomic perspective, we are all Africans," he said with clear assurance-his work has also helped to show that all humans can trace their ancestry far back to a small population of Africans who later expanded and spread out across the globe. (popular-archaeology.com)
  • The African continent is home to 1.2 billion people, 17% of the world's population, and a large proportion of human genetic diversity and yet African populations are relatively under-studied with only 3% of Genome-Wide Association Study (GWAS) samples coming from African ancestries (1), mostly African Americans. (madcapnetwork.org)
  • There is a history buried deep within our living genes, a history that could possibly take us back to glimpse the primordial soup of our human ancestry, perhaps even as far back as the ancient proto-humans who walked the world long before modern humans. (popular-archaeology.com)
  • Little is known, however, about the association in China where many have lower body mass index (BMI) or about the relevance of young adulthood adiposity for pancreatic cancer in both Western and East Asian populations. (ox.ac.uk)
  • CONCLUSIONS: In both East Asian and Western populations, adiposity was positively associated with risk of pancreatic cancer, with a somewhat stronger association for young than late-life adiposity. (ox.ac.uk)
  • These migrations resulted in gene flow across vast areas, ultimately linking pastoralist populations in Scandinavia with groups that expanded into Siberia. (mpg.de)
  • At the Tokyo meeting, for example, it was noted that even among the Japanese researchers, there was no unitary understanding of what populations should be considered "Asian. (mixedracestudies.org)
  • For example, the incidence rate of liver cancer has been shown with substantial disparity between Hispanic, Asian and non-Hispanic white populations. (omicsdi.org)
  • RESULTS:In this study we designed an unique AIM panel that infers 3-way genetic admixture from three distinct and selective continental populations (African (AFR), European (EUR), and East Asian (EAS)) within evolutionarily conserved exonic regions. (omicsdi.org)
  • Polygenic Risk Scores for prostate cancer have been developed by European and Asian studies but they do not work as well in African populations for several reasons. (madcapnetwork.org)
  • For example, European and Asian studies miss many alleles that are present in African populations due to the much greater genetic diversity in Africa. (madcapnetwork.org)
  • However, as of this writing, you won't get this type of information, but rather a simple 4-group global admixture estimate, as well as a measure of your similarity to the Human Genome Diversity Panel populations. (blogspot.com)
  • Because of extensive admixture among these various groups, the Brazilian population shows great variability in terms of Populations on different continents vary considerably in their skin pigmentation, phenotypic features, and genomic structure [2]. (cdc.gov)
  • Subjects identified themselves as belonging to one of four major racial/ethnic groups (white, African American, East Asian, and Hispanic) and were recruited from 15 different geographic locales within the United States and Taiwan. (blogspot.com)
  • An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data. (omicsdi.org)
  • Within stable angina and ACS cohorts, 7% of patients were black, 2% were Hispanic, 0.3% were Native American, 1% were Asian, and 90% were white, respectively. (elsevierpure.com)
  • It was anticipated that collating existing studies in this manner would be useful for guiding professionals in managing HF within this ethnic group, given that to achieve optimal care, regimens need to take into account cultural differences that may impact on adherence. (ox.ac.uk)
  • it cannot be assumed that treatments shown to work for Caucasians will be efficacious for those from minority ethnic groups. (ox.ac.uk)
  • A higher incidence of MS has been found in northern areas compared with southern areas of the United States and other countries, but the attenuation of this gradient in Europe in the last few decades and the consideration of ethnic factors have led some authors to question the existence of a strong association between MS and latitude. (neurology.org)
  • OBJECTIVE: HbA(1c) levels are higher in most ethnic groups compared with white Europeans (WEs) independent of glycemic control. (ox.ac.uk)
  • To evaluate the possibility that such differences are accompanied by differences in brain structure, we conducted a large comparative study on cognitively matched young and old adults from two cultural/ethnic groups - Chinese Singaporeans and non-Asian Americans - that involved a total of 140 persons. (illinois.edu)
  • Although the observed differences in gray matter may be rooted in strategic differences in cognition arising from ethnic/cultural differences, alternative explanations involving genetic heritage and environmental factors are also considered. (illinois.edu)
  • This lack of association was not influenced by adjustment for sex, diastolic blood pressure, history of coronary disease, or ethnicity (Asian or non-Asian). (ox.ac.uk)
  • On the other hand, we detected only modest genetic differentiation between different current geographic locales within each race/ethnicity group. (blogspot.com)
  • Thus, ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity-as opposed to current residence-is the major determinant of genetic structure in the U.S. population. (blogspot.com)
  • We analyzed the independent effect of ethnicity on HbA(1c) and fasting and 2-h plasma glucose (FPG and 2 hrPG, respectively) between these groups. (ox.ac.uk)
  • When comparing between continental ethnicity, meaning sorting African from European from Asian from Native American, these tests are relatively accurate, meaning there is sometimes a little bit of overlap, but not much. (dna-explained.com)
  • The importance of the distinction between race and ethnicity cannot be overemphasized as the latter pays close attention to (presumably) shared cultural factors such as language, diet, and religion. (mixedracestudies.org)
  • BACKGROUND:Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. These ancestral groups have markedly different incidence rates and outcomes in many types of cancers. (omicsdi.org)
  • Prostate cancer is an excellent example of the research opportunity in Africa: it is the leading cause of cancer-related deaths in African men and, globally, has higher prevalence and worse outcomes in men of African ancestry. (madcapnetwork.org)
  • Some islanders, especially in St David's, still trace their ancestry to Native Americans, and many more are ignorant of having such ancestry. (wikipedia.org)
  • The mask appears to trace best the outline of an individual with European ancestry. (femininebeauty.info)
  • Most Indo-Guyanese trace their ancestry to the mid-1800s, when (East) Indian indentured servants were brought to Guyana, an English-speaking, continental West Indian country formerly known as British Guiana (1). (cdc.gov)
  • Therefore, a literature review relating to the nature, outcome and treatment of HF in South Asian patients compared to Caucasians was conducted. (ox.ac.uk)
  • The relationship between treatment response and genotype was assessed separately for Caucasians and Asians. (york.ac.uk)
  • Individuals of South Asian descent have a high prevalence of comorbidities that are risk factors for the development of heart failure (HF), including diabetes mellitus and metabolic syndrome. (ox.ac.uk)
  • In the older European group the most strongly associated marker was downstream of the neurexin-1 (NRXN1) gene (rs1401327, P = 3.92E-8). (ox.ac.uk)
  • No other region reached genome-wide significance, and association signals were lower for the younger European group and Asian group. (ox.ac.uk)
  • Another example of the challenges associated with the use of population descriptors can be found in the frequent use of the terms European, African, and Asian. (mixedracestudies.org)
  • Although we should not overlook the correlation between "race" and socio-economic inequality involving factors such as health care and medical care, such discussion has usually arisen within the context of some North American and European societies. (mixedracestudies.org)
  • When the actual samples in the name of "European", "African", and "Asian" are taken from certain limited groups, without taking into account significant diversity within each region, it is unlikely that such broad terms have any scientific meaning, at least from the perspective of genetics on the global level. (mixedracestudies.org)
  • Using continental reference ancestry, African (AFR), non-Finnish European (EUR), East Asian (EAS), Indigenous American (IAM), South Asian (SAS), we obtain accurate and precise estimates (within 0.1%) for all simulation scenarios. (omicsdi.org)
  • Conclusions: Our results indicate that European ancestry is a risk factor for cutaneous melanoma. (cdc.gov)
  • The NHANES II sample was selected so that certain population groups thought to be at high risk of malnutrition (persons with low incomes, preschool children and the elderly) were oversampled. (cdc.gov)
  • RESEARCH DESIGN AND METHODS: Analysis of the ADDITION-Leicester study, in which 4,688 WEs and 1,352 SAs underwent oral glucose tolerance testing, HbA(1c), and other risk factor measurements. (ox.ac.uk)
  • Although several methods exist to estimate ancestry in individual-level data, methods to estimate ancestry proportions in summary data are lacking. (omicsdi.org)
  • The patients were divided into 4 groups (Table): 1) pa- and Brazil ( 1 - 3 ). (cdc.gov)
  • Currently, ancestry informative marker (AIM) panels have been widely utilized with up to a few hundred ancestry-informative single nucleotide polymorphisms (SNPs) to infer ancestry admixture. (omicsdi.org)
  • After attributing a regional and/or continental ancestry to each individual using genome-wide polymorphism data, we are able to capture the effect of different environmental exposures on gene expression and health-related traits, while simultaneously controlling for genetic relatedness and migration. (nature.com)
  • The polymorphism was present as an insertion in cells derived from a group of Japanese individuals, but was completely absent (a deletion) in others, albeit with a lower frequency (hence called the minor allele). (fatsoflife.com)
  • Univariable and multivariable (with covariates that included risk factors, symptoms, and comorbidities) logistic regression models were used to estimate significant CAD, defined as ≥70% stenosis, and in-hospital mortality. (elsevierpure.com)
  • The 22-base pair sequence (named rs66698963) is likely to affect the activity of a nearby sterol response element (a binding site for sterol response element binding protein, which is a class of DNA-binding transcription factors involved in sterol and fatty acid homeostasis). (fatsoflife.com)
  • Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)
  • Future research should include trials commencing preconception and provide results disaggregated by a priori defined participant characteristics including social and environmental factors, clinical traits, and other novel risk factors to predict GDM prevention through interventions. (cdc.gov)
  • Studies were assessed for blinding (for the clinical course of depression or genotype) and evaluation of confounding factors (differences at baseline, or confounders adjusted for in the analysis). (york.ac.uk)
  • Significant baseline risk factors for DSS included a history of vomiting, higher temperature, a palpable liver, and a lower platelet count. (ox.ac.uk)
  • S cone ratios (0.143:1 ± 0.002) had significant genetic variance with a heritability estimate of 43% but did not differ between sexes or age groups. (bvsalud.org)
  • There is an emergent literature suggesting that East Asians and Westerners differ in cognitive processes because of cultural biases to process information holistically (East Asians) or analytically (Westerners). (illinois.edu)
  • Tobit conditional regression and ordinal logistic regression were used to investigate the association of alcohol consumption with aortic calcification after adjusting for cardiovascular risk factors and potential confounders. (elsevierpure.com)
  • and 4) patients who did not parasite genetic factors or differences in exposure rate ( 5 , 6 ). (cdc.gov)
  • When considering the contribution of environmental as well as genetic factors to diversity within each continental region, the scientific validity of the use of such broad terms to describe samples becomes even more questionable. (mixedracestudies.org)
  • Intriguingly, we found differences in the antiproliferative response between gastric cancer cells tested derived from Brazilian patients as compared to those from Asian patients, the latter being largely resistant to BET inhibition. (ox.ac.uk)
  • However, group differences were evident when high-performing old were compared. (illinois.edu)
  • Pre-op maximum Cobb angle and corrected angle were found to be risk factors on self-image, as well as satisfaction with management, in male and female patients. (biomedcentral.com)
  • Conclusions Our findings suggest that heavy alcohol consumption may be an independent risk factor for atherosclerosis. (elsevierpure.com)
  • The impact of any given disease risk factor will vary from person-to-person depending on their background, diabetes-related propensity, and environmental exposures. (cdc.gov)
  • Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. (wakehealth.edu)
  • Drawing from this founding population of individuals with largely French ancestry, we selected 1007 individuals to determine mechanisms by which genomes, the environment, and their interactions contribute to phenotypic variation. (nature.com)
  • From ∼ 1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. (nature.com)
  • This pseudoscience is technically not the same as racism , which is the belief that one or more of these various groups is "superior" or "inferior" to one or more others, usually in some vague, undefined way. (rationalwiki.org)
  • DISCUSSION: These findings provide further evidence that MD is a factor that differentiates treatment-seeking from nontreatment-seeking individuals with CP. (ox.ac.uk)
  • CONCLUSIONS: HbA(1c), FPG, and 2 hrPG levels were higher in SAs independent of factors affecting glycemic control. (ox.ac.uk)
  • From settlement until the nineteenth century, the largest demographic group remained what in the United States is referred to as white-Anglo (or white Anglo-Saxon Protestant). (wikipedia.org)
  • During the course of the eighteenth century, Bermuda's population was boiled down to two demographic groups: White and Coloured. (wikipedia.org)
  • A very important new article by a group of Greek and Chinese researchers provides the first quantitative assessment of mental processing in two groups of students, aged 8 to 14, belonging to the Caucasoid and Mongoloid races. (blogspot.com)
  • The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. (cdc.gov)
  • Every 2 years, follow-up questionnaires are mailed to the participants of both studies to update information on potential risk factors for chronic diseases and to ascertain whether major medical events have occurred. (neurology.org)
  • http://www.partnershipfortomorrow.ca ) is a cohort comprising over 315,000 Canadians, and captures over 700 variables, ranging from longitudinal health information to environmental exposures, to determine genetic and environmental factors contributing to chronic disease. (nature.com)
  • Cox proportional hazards regression model was used to calculate hazard ratio (HR) and 95% confidence interval (CI) for the association after adjusting for diabetes risk factors. (ox.ac.uk)