• Associate Professor of Pathology, UNC Blood Research Center, for recently being appointed to chair the 2022 Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis. (unc.edu)
  • Slack, B.E. and Wurtman, R.J. (2007) Regulation of Synthesis and Metabolism of the Amyloid Precursor Protein by Extracellular Signals. (bu.edu)
  • This is accompanied by increased, VAMP3-dependent secretion of MT1-MMP, enhanced degradation of extracellular matrix, and increased cell invasion. (nature.com)
  • During the whole period of woman life there are many processes which involve degradation of extracellular matrix (tissue morphogenesis, angiogenesis, bone remodelling, wound healing, trophoblast implantation, involution of postpartum uterus or involution of postlactation mammary gland). (ispub.com)
  • These results suggest that IL-6 stimulated PA activity through an enhancement of tPA gene expression and may be involved in extracellular matrix degradation through the stimulation of the PA-plasmin system of human dental pulp (HDP) cells ( 7 ). (ispub.com)
  • The intact proteolysis domain is resistant to MMP cleavage, but structurally-disruptive muscular dystrophy-related mutations sensitize dystroglycan to proteolysis. (biorxiv.org)
  • Cell surface Notch receptor is thought to be a heterodimer consisting of the ligand binding extracellular region associated with the remaining transmembrane protein, as a result of post-translational proteolytic cleavage by a furin-like enzyme. (novusbio.com)
  • The Notch-1 receptor undergoes post-translational furin-type proteolytic cleavage, generating a heterodimer through the interaction of a hydrophobic area C-terminal to the LNR on the extracellular region with the transmembrane/cytoplasmic portion (8, 9). (rndsystems.com)
  • Self cleavage within the aGPCR auto-proteolysis-inducing (GAIN) domain produces two protomers-N-terminal and C-terminal fragments-that remain non-covalently attached after receptors reach the cell surface1. (stanford.edu)
  • Matrix metalloproteinases (MMPs) are a large family of extracellular enzymes, which function to remodel the pericellular environment, primarily through the cleavage of extracellular matrix proteins [ 16 , 17 , 18 ]. (biomedcentral.com)
  • ADAMs cleave a number of transmembrane proteins within their extracellular domains, resulting in the release (shedding) of their ectodomains. (bu.edu)
  • The molecule is synthesized as a 2472 amino acid (aa) precursor that contains a putative 27 aa signal sequence, a 1650 aa extracellular region, a 23 aa transmembrane (TM) segment and a 772 aa cytoplasmic domain (2). (novusbio.com)
  • Mouse Notch-1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGF-like repeats and three Lin-12/notch repeats (LNR), a 21 aa transmembrane (TM) segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain and a PEST sequence. (rndsystems.com)
  • Low-resolution maps of the receptors in their N-terminal fragment-bound state indicate that the GAIN domain projects flexibly towards the extracellular space, keeping the encrypted TA peptide away from the seven-transmembrane domain. (stanford.edu)
  • High-resolution structures of GPR56 and LPHN3 in their active, G-protein-coupled states, reveal that after dissociation of the extracellular region, the decrypted TA peptides engage the seven-transmembrane domain core with a notable conservation of interactions that also involve extracellular loop 2. (stanford.edu)
  • In macrophages, cathepsin S can be replaced by cathepsin F. Secreted cathepsin S cleaves some extracellular matrix (ECM) proteins. (wikipedia.org)
  • Oxidation works in concert with proteolysis, improving N liberation from proteins in SOM. (lu.se)
  • Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (cancerindex.org)
  • Selective compounds have been developed that target either the extracellular ligand-binding region of the EGFR (including a number of monoclonal antibodies [MAbs], immunotoxins, and ligand-binding cytotoxic agents) or the intracellular tyrosine kinase region (including various small-molecule inhibitors). (medscape.com)
  • The extracellular region of FAS possesses three cystein-rich domains characteristic of the TNF superfamily, and the intracellular region which includes a death domain (DD). (biolegend.com)
  • Upon ligand binding, additional proteolysis events result in the release of the Notch intracellular domain (NICD). (novusbio.com)
  • Upon ligand binding, additional sequential proteolysis by TNF-converting enzyme (ADAM17) and the presenilin-dependent gamma -secretase results in the release of the Notch intracellular domain (NICD) which translocates into the nucleus, activating transcription of Notch-responsive genes (10). (rndsystems.com)
  • Defining the cells and proteinases responsible for destruction of lung extracellular matrix associated with cigarette smoking will be required for development of appropriate proteinase inhibitors for application in COPD. (atsjournals.org)
  • Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. (bio-rad-antibodies.com)
  • Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. (joplink.net)
  • Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. (wikidoc.org)
  • Adhesion G-protein-coupled receptors (aGPCRs) are characterized by the presence of auto-proteolysing extracellular regions that are involved in cell-cell and cell-extracellular matrix interactions1. (stanford.edu)
  • Many mechanisms of protein function contribute to amyloidogenesis, including "nonphysiologic proteolysis, defective or absent physiologic proteolysis, mutations involving changes in thermodynamic or kinetic properties, and pathways that are yet to be defined. (medscape.com)
  • Intriguingly, previously uncharacterized cancer-associated mutations that map to the proteolysis domain similarly lead to increases in proteolysis and rates of cell migration, potentially revealing a new pathogenic mechanism in cancer. (biorxiv.org)
  • Amyloidosis is a clinical disorder caused by extracellular and/or intracellular deposition of insoluble abnormal amyloid fibrils that alter the normal function of tissues. (medscape.com)
  • Cancer cells secrete matrix metalloproteinases to remodel the extracellular matrix, which enables them to overcome tissue barriers and form metastases. (nature.com)
  • One of the most life-threatening aspects of cancer is the ability of transformed cells to invade into the extracellular matrix (ECM) and neighboring tissue to form metastases 1 , 2 . (nature.com)
  • LTP-associated MMP proteolysis is probably then terminated by an increase in the activity of endogenous inhibitors called tissue inhibitors of metalloproteinases. (nature.com)
  • APP proteolysis by beta- and gamma-secretases generates amyloidogenic, neurotoxic Abeta peptides, which form insoluble deposits in the brain in AD. (bu.edu)
  • The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
  • We propose that the production of˙OH and extracellular proteolytic enzymes are regulated by similar nutritional signals. (lu.se)
  • We are also interested in the signaling pathways that regulate limited proteolysis catalyzed by the ADAM (a disintegrin and metalloprotease) family of proteases. (bu.edu)
  • MMPs and TIMPs have pivotal roles in extracellular matrix turnover and homeostasis in the outflow pathways of the eye. (avma.org)
  • Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) are the central molecules for uPA/uPAR/plasmin-dependent proteolysis, which is thought to play a significant role in the development of pregnancy, as well as its many complications during pregnancy. (ispub.com)
  • The adhesion receptor dystroglycan provides a critical mechanical link between the extracellular matrix (ECM) and the actin cytoskeleton to help muscle cells withstand contraction and neural cells maintain the blood brain barrier. (biorxiv.org)
  • Through the recognition of H3K27me1 mark, MMP-9 localizes and generates H3NT proteolysis at the genes encoding osteoclast differentiation factors. (biomedcentral.com)
  • Located in extracellular space. (jax.org)
  • However, recent studies show that rapid and focal MMP-mediated proteolysis proactively drives synaptic structural and functional remodelling that is crucial for ongoing cognitive processes. (nature.com)
  • Proteolysis of dystroglycan by Matrix Metalloproteases (MMPs) also breaks the mechanical anchor and is amplified in several pathogenic states. (biorxiv.org)
  • We also examine some substrate truncation GANT61 small molecule kinase inhibitor mutants and discover that -secretase can cleave substrates that absence the complete extracellular site, so long as such substrates include a free of charge N-terminal amine also. (mingsheng88.org)
  • Intercellular adhesion molecule 5, which binds to and activates integrins, may be a direct target of perisynaptic MMP proteolysis during LTP. (nature.com)
  • Extracellular proteolytic activity was initiated shortly after the oxidation. (lu.se)
  • For the reason that record, we demonstrated that NCT recruits substrates which have got their huge extracellular domains 1st eliminated by an upstream protease in an activity termed ectodomain dropping. (mingsheng88.org)
  • Our data establish new functions for G9a-mediated H3K27me1 in MMP-9-dependent H3NT proteolysis and demonstrate how histone modification can be exploited to regulate osteoclastogenic gene expression at the molecular level. (biomedcentral.com)
  • The large Notch extracellular domain has 36 EGF-like repeats followed by three notch/Lin-12 repeats (LNR). (novusbio.com)
  • Carey, R.M., Blusztajn, J.K., and Slack, B.E. (2011) Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. (bu.edu)
  • By using RNAi and small molecule inhibitor approaches, we also confirmed that G9a is the major methyltransferase to catalyze H3K27me1 for MMP-9-dependent H3NT proteolysis and trigger the expression of osteoclast-specific genes. (biomedcentral.com)
  • This process produces a new, brief extracellular stub with a free of charge N terminus, which is necessary for proteolysis by -secretase. (mingsheng88.org)
  • According to a common concept of thrombosis and hemostasis, damage or injury of a vessel wall and ensuing exposure of extracellular matrix components to the blood stream triggers platelets from the circulation to become adherent and to assemble into a thrombus, thus limiting the extravasation of blood ( 1 , 2 ). (frontiersin.org)
  • and ( 3 ) ineffective repair of elastic fibers and perhaps other extracellular matrix components. (atsjournals.org)
  • We use a combination of biochemical and cell-based assays to show that dystroglycan proteolysis is conformationally regulated by an extracellular, juxtamembrane "proteolysis domain", comprised of tandem Ig-like and SEA-like domains. (biorxiv.org)
  • Also, proteolysis is found in pathological conditions such as tumor growth, metastasis, arthritis and autoimmune diseases ( 1 ). (ispub.com)
  • We show that H3 monomethylation at lysine 27 (H3K27me1) is essential for MMP-9-dependent H3NT proteolysis during RANKL-induced osteoclast differentiation. (biomedcentral.com)
  • We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations. (frontiersin.org)
  • Lipoproteins are complex molecular assemblies that are key participants in the intricate cascade of extracellular lipid metabolism with important consequences in the formation of atherosclerotic lesions and the development of cardiovascular disease. (cdc.gov)
  • Although, to our knowledge, TIMPs have not previously been evaluated in the context of cPACG, the markedly higher concentration of TIMPs in eyes with cPACG suggested that inhibition of proteolysis and extracellular matrix turnover might be a factor in the development of glaucoma in susceptible individuals. (avma.org)