Expression extracellular matrix. Medical search. Frequent questions

Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. (nih.gov)
In this review we discuss the current understanding of the signaling mechanisms used by TGF-beta to elicit its effects on target genes, focusing primarily on Smad proteins and their role in the transcriptional regulation of ECM gene expression. (nih.gov)
In the current study, we investigated the role of different extracellular matrix proteins in stellate cell proliferation, activation (alpha smooth muscle actin expression and retinoic acid uptake) and cytoglobin expression. (biomedcentral.com)
The research themes rank around molecular mechanisms matrix proteins and fibers exert in disorders affecting blood vessels, bone, skin and adipose tissue. (mcgill.ca)
We are interested how extracellular matrix proteins instruct cells to differentiate, migrate, and proliferate, and how cells sense normal and pathologically altered extracellular matrix. (mcgill.ca)
Second, altering the MSC state by inducing differentiation into multiple lineages did not affect the exosomal properties or endocytosis but triggered the expression of lineage-specific genes and proteins in vitro and in vivo respectively. (frontiersin.org)
Extracellular matrix is a fibrillar network composed of structural (collagens) and adhesion (fibronectin) proteins crucial for tissue architecture and biological pathway Histol Histopathol 27:1515-1528, 2012 . (springer.com)
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. (taconic.com)
Immunohistochemical staining was performed to confirm the expression of related proteins in OA and non‑OA tissue samples. (spandidos-publications.com)
Fibronectin (FN) was the only of the tested matrix proteins that induced an increase of VEGF secretion. (uni-marburg.de)
[ 8 , 9 ] Therefore, the pathogenesis appears to involve the concomitant increase in the expression of genes for TGF-beta and extracellular matrix proteins in fibroblasts in the affected tissues. (medscape.com)

The aim of the present study was to use a novel, droplet-based, microfluidic platform to evaluate the prognostic value of a panel of thirty-four genes that regulate the composition of extracellular matrices in colorectal carcinoma. (ul.ie)
We identified a panel of relevant extracellular matrix genes whose expression levels were measured by real-time quantitative polymerase chain reaction using Taqman VR reagents in twenty-four pairs of matched colorectal cancer tumour and associated normal tissue. (ul.ie)
In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
This study aims at integrating two gene expression profile datasets and verifying hub genes and pathways involved in TAD as well as exploring potential molecular mechanisms. (hindawi.com)
The two expression profile datasets were integrated and we found out coexpression of differentially expressed genes (DEGs) using bioinformatics methods. (hindawi.com)
With the development of the gene expression profile, comparisons of differentially expressed genes that participate in the regulation of pathophysiological conditions in pathological tissue and normal tissue were available and convenient, and mRNAs gene expression profiles have been carried out in many diseases including TAD [ 6 ]. (hindawi.com)
Although high-throughput sequencing technologies have provided many diverse expressed genes, different expression profiles in TAD provided various results and no reliable results have been identified up to now [ 6 - 8 ]. (hindawi.com)
Sun X, Zhang J, Li Y, Ren W and Wang L: Etomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes. (spandidos-publications.com)
A gain of function screen for genes that enable proliferation independently of matrix anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. (elifesciences.org)
explored which genes enable epithelial cells from the human mammary gland to grow without being attached to the extracellular matrix. (elifesciences.org)
The gene expression of Ppargc1a varied during scleral growth from week 1 to 2, week 2 to 3, week 3 to 6, and week 6 to 8 and was found to interact with a different set of genes at different scleral growth stages. (molvis.org)

Dysregulated extracellular matrix (ECM) protein like elastin and collagen and depletion of vascular smooth muscle cells (VSMCs) of the aortic wall are believed as the main histopathological findings [ 3 - 5 ]. (hindawi.com)
Fibrosis is a physiological response to cellular injury in the liver and is mediated by the activation of hepatic stellate cells resulting in the replacement of hepatocytes with extracellular matrix comprised principally of collagen 1 to form a hepatic scar. (biomedcentral.com)
HSCs express numerous cell surface receptors including both discoidin domain receptors (DDRs)-which are receptors for collagen I and many of the integrin subunits, which are a major family of cell surface receptors for extracellular molecules and play a critical role in many biological functions [ 7 , 10 ]. (biomedcentral.com)
Western blot analysis was used to detect protein expression levels of MMP‑9, MMP‑13, TIMP‑1, TIMP‑3 and type II collagen in cartilage tissue and chondrocytes. (spandidos-publications.com)
Furthermore, silencing of lncRNA GAS5 expression in IL‑1β‑treated chondrocytes downregulated the protein expression of MMP-9 and MMP-13 whilst upregulating the expression of tissue inhibitor matrix metalloproteinase (TIMP)-1, TIMP-3 and type II collagen. (spandidos-publications.com)
It was suggested that Tgfβ1 could possibly act as a signaling molecule in controlling collagen gene expression and modulate ECM during ocular growth. (molvis.org)
LHX2 regulated the expression of extracellular matrices, such as laminin and collagen, in iPS-HSCs. (ca.gov)
These collagen-dependent regulatory influences also correlated with alterations in either the expression or the DNA binding of the transcription factors Sp1/Sp3, NFI and AP-1 that ensure basal transcription of the α5 gene. (nih.gov)
Primary cultures of human corneal epithelial cells cultivated on BSA (number of replicates: 2), Collagen type I (number of replicates: 2) and Collagen type IV (number of replicates: 2) matrix. (nih.gov)
CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I surface in intestinal epithelial cells. (lu.se)

To conclude, the present study provides evidence that ABPS can inhibit the expression of lncRNA GAS5 in chondrocytes to regulate the homeostasis of ECM, which in turn may delay the occurrence of cartilage degeneration during OA. (spandidos-publications.com)
PGs bind growth factors, regulate proteolytic activity and act as matrix receptors. (lu.se)
Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)

Our results demonstrate that cytoglobin expression is correlated with a more quiescent phenotype of stellate cells in culture and that cytoglobin is regulated by the extracellular matrix through integrin signalling dependent on activation of focal adhesion kinase. (biomedcentral.com)
PVRL4 promotes anchorage-independence by driving cell-to-cell attachment and matrix-independent integrin β4/SHP-2/c-Src activation. (elifesciences.org)
Moreover, PVRL4 triggers a form of signaling between the cells called integrin β4 signaling that allows them to survive without being anchored to the extracellular matrix. (elifesciences.org)
In this study, we examined whether expression of the gene encoding the α5 subunit from the FN binding integrin α5β1 changes as corneal epithelial cells (CECs) are cultured in the presence of collagens. (nih.gov)
Collagens considerably suppressed expression of the α5 gene in CECs at confluence suggesting that the sustained staining for CI and CIV after corneal injury may play a role in controlling adhesion to the temporary FN matrix and further differentiation of CECs into suprabasal epithelial cells through a mechanism involving the α5β1 integrin. (nih.gov)
It is assured that the spectrum and the extent of the integrin expression of cancer cells correlate with their abilities of proliferation and invasion. (uni-marburg.de)
This change of their integrin expression has radical effects on their biological properties. (uni-marburg.de)
The incubation of the two cancer cell lines (XTC, HTC+) without matrix components with a choice of the best examined and available integrin antibodies at this time had no effect on the VEGF secretion. (uni-marburg.de)
There was shown no change of the integrin expression by VEGF. (uni-marburg.de)
The importance of growth factors on the integrin expression is demonstrated in the literature. (uni-marburg.de)
The examination of the influence of VEGF on the integrin expression of the XTC cells in the sense of an "Inside-out" control loop could not prove an autocrine control loop in spite of the well known close interaction of integrins and VEGF receptors. (uni-marburg.de)

The corneal stroma and sclera consist of few fibroblasts and large amounts of extracellular matrix (ECM). (molvis.org)
Moreover, electron microscopy and immunological studies of the skin fibroblasts from the patients confirmed impairment of the extracellular matrix. (nih.gov)
In general, the pathophysiology underlying eosinophilic fasciitis is postulated to involve an inflammatory response resulting in an activated inflammatory cell infiltrate of affected tissues and subsequent dysregulation of extracellular matrix production by lesional fibroblasts. (medscape.com)

It was further possible to sub-classify colorectal cancer based on extracellular matrix protein expressing groups which in turn correlated with prognosis. (ul.ie)

For example proteoglycans sequester biomolecules such as growth factors (TGF-β, VEGF, FGF etc.) and MMPs (Matrix Metalloproteinases). (springer.com)
The underlying mechanisms of matrix destruction in TB remain poorly understood but consideration of the lung extracellular matrix predicts that matrix metalloproteinases (MMPs) will play a central role, owing to their unique ability to degrade fibrillar collagens and other matrix components. (ersjournals.com)
Since we proposed the concept of a matrix degrading phenotype in TB a decade ago, diverse data implicating MMPs as key mediators in TB pathology have accumulated. (ersjournals.com)
Matrix metalloproteinases (MMPs) are enzymes degrading ECM. (lu.se)
Matrix metalloproteases (MMPs) are zinc-dependent proteinases that participate in extracellular matrix degradation 1-3 and favor the invasion and proliferation of tumor cells 4 . (bvsalud.org)

The phenotype of iPS-HSCs, including gene and protein expression profiles and vitamin A storage, resembled that of hepatic stellate cells. (ca.gov)

In the present study, we use mRNA microarray to acquire differential expression profiles in human TAD tissues and non-TAD tissues. (hindawi.com)
The enhanced levels of MMP-7 and -9 mRNA expressions and increased cell invasion into matrigel were observed in colon cancer cells upon stimulation with TAM-conditioned medium. (lu.se)

CONCLUSIONS: The altered expression patterns of glypican and syndecan-1 and -4 in chronic ulcers reflect their possible roles during inflammation and cell proliferation. (lu.se)
Functional analysis showed that the muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways. (cdc.gov)
To examine whether there are associations between gene expression, lipidomics, extracellular matrix, and inflammation in human atherosclerotic plaques. (lu.se)

Its broad activities include, among others, context-specific inhibition or stimulation of cell proliferation, control of extracellular matrix (ECM) synthesis and degradation, control of mesenchymal-epithelial interactions during embryogenesis, mediation of cell and tissue responses to injury, control of carcinogenesis, and modulation of immune functions. (nih.gov)
The results indicated that ABPS delayed the degradation of the ECM by chondrocytes in addition to reducing lncRNA GAS5 expression both in vivo and in vitro . (spandidos-publications.com)

Matrix Biol. (wikipedia.org)
Matrix Biol 110: 106-128. (mcgill.ca)

This gene encodes an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding "double-loop" domains of the albumin protein family. (wikipedia.org)
Congenital corneal stromal dystrophy is a very rare autosomal dominant dystrophy that is caused by a mutation in the DCN gene that encodes decorin (a proteoglycan of the extracellular matrix). (bvsalud.org)

Transforming growth factor-beta (TGF-beta) plays a critical role in the regulation of extracellular matrix gene expression. (nih.gov)
Therefore, the present study aimed to investigate the potential mechanism of ABPS by focusing on its effects on the regulation of chondrocyte extracellular matrix (ECM) homeostasis, with particular emphasis on lncRNA GAS5. (spandidos-publications.com)
For this reason, mitochondrial carrier gene expression needs tight regulation. (cancerindex.org)

OThe molecules of the extracellular matrix play an important role during cell development and morphogenesis. (bvsalud.org)

Henry, M. D. & Campbell, K. P. Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton. (nature.com)
They found that the gene that codes for a protein called poliovirus receptor-like 4 (PVRL4) allows attachment-free cell growth and also makes cells cluster together once detached from the matrix. (elifesciences.org)

Evidence suggests that metalloprotease expression may affect the biological behavior of odontogenic lesions. (bvsalud.org)

Together, our results uncover a new inducer of mammalian heart regeneration and highlight fundamental roles of the extracellular matrix in cardiac repair. (nature.com)

Here, we report null mutations in a member of the extracellular matrix protease family, the gene encoding ADAMTS10, a disintegrin and metalloprotease with thrombospondin motifs. (nih.gov)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Once implanted at the apex, Mtb must engage the host immune response to drive matrix destruction, resulting in cavities within which it proliferates exponentially. (ersjournals.com)

The proliferation and differentiation of satellite cells are regulated by a number of extracellular signals ( Wang & Rudnicki, 2012 Wang YX, Rudnicki MA. (scielo.br)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)

When activated by injury, satellite cells reenter the cell cycle and proliferate in response to extracellular growth factors ( Relaix & Zammit, 2012 Relaix F, Zammit PS. (scielo.br)

We will combine our mRNAs expression profile (6 TAD tissues versus 6 non-TAD tissues) and GSE52093 downloaded from the Gene Expression Omnibus (GEO) database. (hindawi.com)
The two mRNAs expression profiles contained 13 TAD aortic tissues and 11 non-TAD tissues. (hindawi.com)
A single-cell layer of epithelium is separated from the tissues beneath it by a supporting substance called the extracellular matrix. (elifesciences.org)
To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)

Differential expression patterns occurred between the normal and malignant tissue and correlated with histopathological parameters and overall surgical staging. (ul.ie)
Moreover, the relative expression level of lncRNA GAS5 in cartilage tissue and chondrocytes was detected using reverse transcription‑quantitative PCR. (spandidos-publications.com)
It is estimated that up to 90% of cancers in humans originate in epithelial tissue, and the cells within such tumors are known to survive and divide even when they are no longer attached to the extracellular matrix. (elifesciences.org)
Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
The extracellular matrix is essential for the architecture of the tissue and a myriad of associated biological functions. (springer.com)
Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue. (lu.se)

Identification of disease mechanisms in heritable diseases originating in the extracellular matrix. (mcgill.ca)
The extracellular matrix metalloproteinase-2 (MMP-2) is associated with several important disease processes. (mdpi.com)
Gene expression of eye diseases should be studied as early as postnatal weeks 1-2 to ensure that any changes in gene expression pattern during disease development are detected. (molvis.org)

Here we show that changes in the composition of the extracellular matrix during this week can affect cardiomyocyte growth and differentiation in mice. (nature.com)

Multi-walled carbon nanotube s elicit concordant changes in DNA methylation and gene expression following long-term pulmonary exposure in mice. (cdc.gov)

Extracellular matrix and vascular dynamics in the kidney of a murine model for Marfan syndrome. (mcgill.ca)

There are numerous downstream signalling targets of FAK with many of the effects ultimately mediated by changes in gene expression [ 11 - 13 ]. (biomedcentral.com)
Our previous work has shown that industrially produced MWCNTs trigger specific changes in gene expression in the lungs of exposed animals. (cdc.gov)
Integrated analysis of transcriptomics data and DNA methylation data revealed concordant changes in gene expression. (cdc.gov)

The VEGF-synthesis of thyroid cancers seems thus to be influenced by the extra cellular matrix (FN) via integrins. (uni-marburg.de)

Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)

During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order to evade growth constraints associated with the loss of matrix attachment. (elifesciences.org)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Organic extracellular matrix production as a means of cell-cell and cell-substrate adhesion has been extensively studied. (nature.com)

Biofilms are multicellular communities that were so far thought to be held together solely by a self-produced organic extracellular matrix. (nature.com)

Important remodeling of the extracellular matrix is a hallmark of corneal wound healing. (nih.gov)

The mechanism whereby Mtb targets the lung apices is unknown, but once it reaches the lung interstititum, breakdown of the extracellular matrix must occur for the pathogen to disseminate via the airways. (ersjournals.com)

The dynamics of cell-extracellular matrix interactions in normal and pathological situations. (mcgill.ca)
The Reinhardt laboratory is interested in components and mechanisms involved in the biogenesis, function and pathological aspects of the extracellular matrix and its interactions with cells. (mcgill.ca)

Taken together, the present study revealed that MWCNTs exert epigenetic effects in the lungs of exposed animals, potentially driving the subsequent gene expression changes. (cdc.gov)

Methylation reprogramming was correlated with increased gene expression variability. (jneurosci.org)
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
To elucidate whether epigenetic effects play a role for these gene expression changes, we performed whole genome bisulphite sequencing to assess DNA methylation patterns in the lungs 56 days after exposure to MWCNTs. (cdc.gov)

Here, we show that pericytes produce multiple components of the mouse pancreatic and islet interstitial and BM matrices. (nature.com)
The specific expression and distribution of the different BM components in the islets were yet to be fully characterized. (nature.com)
They are found either as integral membrane components or constituents of the extracellular matrix. (lu.se)
Two cancer cell lines (XTC, HTC+) were incubated on different matrix components and the VEGF expression was examined via ELISA. (uni-marburg.de)

The lab also focuses on how the extracellular matrix regulates key growth factors of the TGF-beta superfamily, and on deciphering regulatory mechanisms mediated by microRNAs. (mcgill.ca)

Upon increasing culture times in chicken´s primary skeletal muscle satellite cells, SULF1 and SULF2 expression in 1-week-old chickens was significantly higher than in 2-week-old chickens, suggesting that sulfatases play a key role in satellite cell development. (scielo.br)

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. (nih.gov)

HSCs undergo phenotypic changes from quiescent vitamin A storing cells, involved in maintenance of the normal basement matrix, into proliferative myofibroblast-like cells, expressing myogenic markers such as alpha smooth muscle actin (αSMA). (biomedcentral.com)
We demonstrate that a mature 3D structure of mineral scaffolds holds the extracellular matrix and the bacterial cells together. (nature.com)
The individual cells within a single-cell layer are physically attached to the matrix, and when displaced from it, they promptly undergo programmed cell death. (elifesciences.org)
Moreover, cancerous cells tend to cluster together when they are detached from the extracellular matrix. (elifesciences.org)
Whereas the expression of syndecan-4 and glypican in intact skin was mostly in the pericellular regions of keratinocytes, the epidermal cells from the wound edge contained mostly intracellular PGs. (lu.se)
IL-8 and LTD4 could induce CD47 expression in CRC cells. (lu.se)

Extracellular matrix protein 1 is a protein that in humans is encoded by the ECM1 gene. (wikipedia.org)

Several aspects of MSC function have been attributed to the paracrine effects of MSC derived extracellular vesicles (EVs). (frontiersin.org)

OBJECTIVES: The expression patterns of various cell-associated heparan and chondroitin/dermatan-sulphate PGs in human skin and chronic venous ulcers were investigated. (lu.se)

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