Expression pre b cell receptors. Medical search. Frequent questions

Mas1 receptor agonists and blockers induced HTR8/Svneo cells and BeWo cells , and the effects of the Mas1 receptor on the proliferation and migration of trophoblast cells were detected by the CCK8 proliferation test and scratch test. (bvsalud.org)
Activation/inhibition of the Mas1 receptor had no significant effect on the proliferation of HTR8/Svneo cells and BeWo cells . (bvsalud.org)
At the onset of decidualisation, local proliferation of tissue resident natural killer cells occurs with little involvement from circulating natural killer cells. (wikipedia.org)
Uterine natural killer cells accumulate during pregnancy, and this is thought to be the result of a two-wave process, beginning with proliferation of tissue resident natural killer cells in the decidua basalis, with minimal contribution to this pool from circulating natural killer cells from the blood stream. (wikipedia.org)
Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Its best-known actions in β-cells are to augment meal-related insulin secretion and over the long-term to increase proinsulin synthesis and β-cell proliferation and survival ( 3 , 4 ). (diabetesjournals.org)
IL-10 stimulates the antigen mediated cytotoxicity, survival and proliferation of intra-tumoral CD8+ T cells and simultaneously dampens chronic inflammation. (aacrjournals.org)
IL-10 activates with STAT3 an essential survival and proliferation signal in antigen activated CD8 T cells. (aacrjournals.org)
that critically influences cell proliferation, differentiation and apoptosis ( Miele and Osborne, 1999 ). (elifesciences.org)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
Sex steroid receptors (SSRs), which are involved in BC etiology and progression, promote BCSC proliferation, dedifferentiation and migration. (wjgnet.com)
The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. (embl.de)
Combined treatment with selumetinib and a dose of palbociclib sufficient to reinforce G1 arrest in selumetinib-sensitive cells, but not to impair proliferation of resistant cells, delays the emergence of resistant colonies, meaning that escape from G1 arrest is critical in the formation of resistant clones. (babraham.ac.uk)
TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
Overexpression of TRIM13 in NCI-H1975 and SPC-A-1 cells hampered cell proliferation. (cancerindex.org)
In preparation to apply various toxicants to the developed in vitro human neuronal stem cells, the team has characterized a number of PCB's and PAH compounds for their ability to (a) induce various signal transduction mechanisms and (b) inhibit gap junctional intercellular communication regulating cell proliferation, differentiation, and apoptosis. (nih.gov)
In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)
T cells stimulate B cells to undergo further proliferation and Ig class switching, leading to the expression of the various isotypes IgG, IgA, or immunoglobulin E (IgE). (medscape.com)

The number increases after ovulation by the migration of circulating natural killer cells, as well as differentiation of haematopoietic stem cells. (wikipedia.org)
The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. (nih.gov)
This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
The precise levels and timing of NR0B1 gene expression are critical for gonadal differentiation and sex determination during embryogenesis [ 1 ]. (oncotarget.com)
CD14+ monocytes from IBD patients had significantly decreased cleaved H3T22, suggesting they were epigenetically primed for macrophage differentiation.We describe the first systems-level quantification of histone modifications across immune cells from IBD patients at a single-cell resolution revealing the increased epigenetic heterogeneity that is not possible with traditional ChIP-seq profiling. (stanford.edu)
Early stages of B-cell differentiation can be identified by the status of the immunoglobulin genes and by the cell surface markers CD34, CD19, and surface immunoglobulin (sIg). (medscape.com)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
the gene expression profile during B lymphoid differentiation. (lu.se)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

In fact, cellular PSMA expression is regulated by the androgen receptor (AR), which is frequently targeted during prostate cancer treatments and can therefore confound interpretation. (snmjournals.org)

As with circulating natural killer cells, uterine natural killer cells also express immunoglobulin-like transcripts and natural cytotoxicity receptors. (wikipedia.org)
Expanded natural killer cells killed both allogeneic and autologous primary myeloma cells avidly via a perforin-mediated mechanism in which the activating receptor NKG2D, natural cytotoxicity receptors, and DNAX-accessory molecule-1 played a central role. (haematologica.org)

VK5211, the company's lead program for muscle and bone disorders, is an orally available, non-steroidal selective androgen receptor modulator (SARM) being developed for the treatment of patients recovering from non-elective hip fracture surgery. (prnewswire.com)
VK5211 is an orally available, non-steroidal selective androgen receptor modulator (SARM) entering Phase 2 development for the treatment of patients recovering from non-elective hip fracture surgery. (prnewswire.com)
The purpose of this work was to evaluate the effect of androgen receptor (AR) inhibition on prostate-specific membrane antigen (PSMA) uptake imaged using 68 Ga-PSMA-11 PET in a mouse xenograft model and in a patient with castration-sensitive prostate cancer. (snmjournals.org)
The objective of this study was to determine the gene expression profiles of the androgen/androgen receptor (AR) and anti-Müllerian hormone (AMH)/ Sry-related high-mobility group box 9 (SOX9) pathways in granulosa-luteal cells from patients undergoing standard in vitro fertilization (IVF) with or without recombinant luteinizing hormone (rLH) therapy. (biomedcentral.com)

Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. (nature.com)
One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric antigen receptor (CAR) for cancer treatment. (uni-wuerzburg.de)

Human uterine natural killer cells share many of the surface receptors and proteins of circulating natural killer cells, exhibiting high levels of CD94 and CD56. (wikipedia.org)
The surface expression of CD44 and Toll-like receptor 2, surface receptors for hyaluronan, was determined by flow cytometry. (nel.edu)

Based on the promising results achieved from antibody-mediated PD-1 blockade in the treatment of hematological and solid tumors, we are confident that PD-1 knockout CAR T cells enhance the potency of CAR T cell therapies for treatment of cancers without the side effects of antibody-based therapies. (uni-wuerzburg.de)
The lab showed that, while the AhR in these cancers could be hyper-activated with environmental chemicals, the receptor was already in the "on" position, even in the absence of such chemicals. (bu.edu)
Using novel AhR inhibitors that the laboratory developed, and state-of-the-art molecular technologies including CRISPR/Cas9 gene editing, the lab demonstrated that pre-cancers and cancers were exploiting this receptor/signaling protein to up-regulate expression of genes that drive cancer invasion, metastasis, and longevity. (bu.edu)
In contrast, in a fraction of breast cancers cells that express the estrogen receptor proliferate significantly. (unibas.ch)
These breast cancers are called estrogen receptor-positive breast cancers and comprise about 75% of all breast cancer cases. (unibas.ch)
Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. (lu.se)

Mechanistic analyses revealed that Res activated the oxidant/antioxidant-activated receptor Nrf2 to induce cytoprotective genes. (cdc.gov)
The expression of HIF-1 downstream genes, cancer colony formation, and Matrigel invasion of glioblastoma cells were stimulated by conditioned medium from astrocytes pre-exposed to hypoxia. (cancerindex.org)
This was associated with increased islet Regenerating (Reg) genes expression, and elevated IL-22-producing Th17 T-cells in the pancreas. (bepress.com)
We conclude that IL-22 may contribute to the regeneration of β-cells by up-regulating Regenerating Reg1 and Reg2 genes in the islets. (bepress.com)
Hill T, Krougly O, Nikoopour E, Bellemore S, Lee-Chan E, Fouser LA, Hill DJ and Singh B. The involvement of Interleukin-22 in the expression of Pancreatic Beta cell Regenerating REG genes. (bepress.com)
This is followed by showing that the same inter-cellular communication mechanism can change the collective behavior of oscillatory gene expression (involving so-called ``clock genes'') thereby reproducing all the empirically observed dynamical transitions in somitogenesis, a fundamental developmental process in all vertebrates. (imsc.res.in)
In the first part of the study, we engineered CAR T cells through non-viral Sleeping Beauty (SB) transposition of CAR genes from minimalistic DNA vectors called minicircles rather than conventional SB plasmids. (uni-wuerzburg.de)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)
Other genes affecting coloration are involved in pigment production or development (i.e. regulating the development and migration of pigment cells during embryogenesis). (creation.com)
Genes required for B cell development. (medscape.com)
These cells develop into late pro-B cells in which rearrangement of the heavy chain genes occurs. (medscape.com)
Progression from this late pro-B-cell to the pre-B-cell stage involves the rearrangement and joining of the various segments of the heavy chain genes. (medscape.com)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
At each maturation stage, expression of proteins affects the commitment to move to the next stage and cellular functions, such as rearrangement and expression of Ig genes. (lu.se)
Defects in genes and proteins important for B cell maturation cause primary immunodeficiencies (see IDbase ). (lu.se)

Several coactivator proteins have been shown to bind steroid receptors and enhance their interaction with basal transcription factors, thereby amplifying the transcriptional activation potential of the receptor. (biomedcentral.com)

Unlike 18 F-FDG, PSMA expression does not correlate positively with disease progression. (snmjournals.org)
Njainday's research focuses on WNT5A, and its role in tumour cell progression and plasticity. (lu.se)

These cells are attracted to the uterus during pregnancy independent of chemokine receptors CCR-2 and CCR-5 in spite of these being important in recruitment of other inflammatory responses, and the exact method of their homing is yet to be understood. (wikipedia.org)
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. (thermofisher.com)
CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. (thermofisher.com)

Activation of macrophages was determined based on nitric oxide and tumour necrosis factor alpha production, inducible nitric oxide synthase expression, and the activation of the nuclear factor kappa B transcriptional factor. (nel.edu)
Both macrophage cell lines expressed CD44 and Toll-like receptor 2, which were significantly increased by the pre-treatment of macrophages with bacterial lipopolysaccharide. (nel.edu)
Similarly, hyaluronan of any molecular weight neither exerted stimulatory nor inhibitory effects on macrophages pre-treated by lipopolysaccharide. (nel.edu)
Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)
However, the cellular origin for this gene expression is controversial as it is also known to be expressed in intestinal macrophages. (stanford.edu)
The S. sonnei rough strain invades with APCs, including human dendritic cells (DCs) and mouse macrophages. (cdc.gov)

Treatment also improved the angiogenic balance and proteinuria in the transgenic model, and it reduced angiotensin receptor activating antibodies in both. (jci.org)
Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
Regardless of the need for Th2 cells and their connected cytokines in the pathogenesis of sensitive respiratory disease, research of antigens regarded as causes of T-cell reactions have up to now been mostly limited by those recognized to bind IgE antibodies (7, 8) and induce IgE-mediated instant hypersensitivity reactions (9). (enmd-2076.com)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

Levels of reproductive hormones in the pre-ovulatory follicular fluid and the expression levels of LHR (luteinizing hormone receptor), AR, SOX9, AMH, AR-associated protein 54(ARA54)and ARA70 were determined in granulosa-luteal cells by real-time reverse-transcription PCR. (biomedcentral.com)

The cells were then stained with APC Rat Anti-Mouse CD4 antibody (Cat. (bdbiosciences.com)
The cells were then stained with either BD Horizon BV786 Rat IgG2b, κ Isotype Control (dashed line histogram) or BD Horizon BV786 Rat Anti-Mouse CD25 antibody (solid line histogram). (bdbiosciences.com)
The problem of whether T-cell reputation can be always necessarily associated with antibody recognition offers broader significance with regards to the classic idea of linked reputation of the antigen by both T helper cells and antigen-specific B cells. (enmd-2076.com)
Applications Tested: This 12G5 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Defective antibody production and low circulating numbers of B cells were described in some female infants and in males in whom no Btk abnormalities were detected. (medscape.com)
One vial containing 420 mg of trastuzumab, a humanised IgG1 monoclonal antibody produced by mammalian (Chinese hamster ovary) cell suspension culture and purified by chromatography including specific viral inactivation and removal procedures. (who.int)

Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)

This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
A review on therapeutic targeting of cancer via death receptors dissects this topic comprehensively and is therefore subtly discussed in this minireview which focuses on ROS cancer therapeutics [ 22 ]. (degruyter.com)
Depletion of recipient T cells before 7 × 19 CAR-T cell administration dampened the therapeutic effects of 7 × 19 CAR-T cell treatment, suggesting that CAR-T cells and recipient immune cells collaborated to exert anti-tumor activity. (nature.com)
This therapeutic approach has shown remarkable results against B-cell malignancies in pilot clinical trials. (uni-wuerzburg.de)
This novel approach dramatically increased stable gene transfer rate and cell viability and resulted in higher yield of CAR+ T cells without the need of long ex vivo expansion to generate therapeutic doses of CAR+ T cells. (uni-wuerzburg.de)
In the second part of the study, we ablated expression of PD-1, a checkpoint and negative regulator of T cell function to improve the therapeutic index of CAR T cells. (uni-wuerzburg.de)

Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
Previous studies have suggested that by using the LPS core, Gram-negative bacteria can interact with several C-type lectin receptors that are expressed on antigen-presenting cells (APCs).Hypothesis/Gap Statement. (cdc.gov)

Furthermore, dual in situ hybridization detected positive signals for itr1 and cox2 at the same site, implying that ITR1 may regulate cox2 gene expression. (frontiersin.org)
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. (nature.com)
another ER chaperone), and becomes available to regulate inositol trisphosphate (IP3) receptor-mediated Ca 2+ release to maintain mitochondrial Ca 2+ homeostasis. (molvis.org)
Development of an organism from the embryonic stage involves a number of precisely timed events that arise as a result of interactions between several components including (i) morphogens which set up concentration gradients, (ii) cell-cycle oscillators which regulate mitosis and (iii) inter-cellular communication. (imsc.res.in)

High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
Several downstream signaling pathways from the β-cell GIP-R have been characterized. (diabetesjournals.org)
With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells. (nih.gov)
T cell receptor mediated activation of CD8 T cells induces the expression of IL-10 receptors on these cells. (aacrjournals.org)

Mas1 receptors in normal placental villi tissue were mainly expressed in human trophoblast stem cell membranes and cytoplasm , and the expression of Mas1 receptor mRNA in villi tissue was significantly higher in late pregnancy than in mid- pregnancy . (bvsalud.org)
Nrf2 was required for normal defense against PQ toxicity and fibrogenic reactions as loss of Nrf2 significantly increased PQ toxicity, myofibroblast transformation, and cytokine expression. (cdc.gov)
These results demonstrate a mixed unbiased transcriptomic, proteomic, and immunomic strategy identifies a significantly broadened repertoire of proteins antigens targeted by T cells involved with allergy pathogenesis. (enmd-2076.com)
The clinical outcomes were similar in patients who received rLH therapy and those who did not, though the pre-ovulatory follicular fluid levels of androstenedione, testosterone, and estradiol were significantly higher and progesterone was lower in the rLH supplementation group. (biomedcentral.com)
Moreover, granulosa-luteal cell mRNA levels of LHR, AR, AMH, and SOX9 were significantly higher in the rLH supplementation group relative to the group that did not receive rLH supplementation. (biomedcentral.com)
CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. (who.int)
Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was more marked in cases of severe pre-eclampsia. (who.int)

Signaling is induced through binding of five independent ligands, Delta-like ligands (DLL)-1, 3, 4 and Jagged (Jag)-1 and -2 ( Kopan and Ilagan, 2009 ), to four isoforms of cognate Notch receptors, Notch1 to Notch4, on surface of adjacent cells. (elifesciences.org)
The hormone estrogen acts as a signaling molecule in cells by binding to its cognate receptor, the estrogen receptor, thereby inducing a range of biological effects. (unibas.ch)

Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. (nature.com)

How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)

The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
4 It encodes a receptor tyrosine kinase involved in the development and homeostasis of several cell lines including melanocytic (pigment), hematologic (blood), mast, and germ cells. (creation.com)

Our initial idea was to induce estrogen receptor expression in order to convert triple-negative breast cancer into estrogen-receptor positive breast cancer because of more effective treatment options available for this subtype," says the study's lead author Dr. Milica Vulin. (unibas.ch)

The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
PQ dose-dependently caused toxicity in normal human bronchial epithelium BEAS-2B cells including increased cell death, oxidative stress, and loss of mitochondrial inner membrane potential. (cdc.gov)
We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
ADAMDEC1 protein was mainly released from PDGFRalpha+ cells and accumulated in the mucosal layer lamina propria space near the epithelial basement membrane. (stanford.edu)
The receptor makes a single pass through the cell membrane and contains an intracellular kinase catalytic region divided by a hydrophilic insert. (creation.com)
Higher expression of membrane and soluble CD163 in active tuberculosis patients might provide insights regarding the pathogenesis of tuberculosis, and sCD163 may be a novel biomarker to distinguish TBP from MPE and to predict disease severity. (biomedcentral.com)

We will provide viable cells that proliferate on revival. (abcam.com)
In the normal breast, cells that express the estrogen receptor are mature specialized breast cells and do not proliferate. (unibas.ch)
In the fetal bone marrow, the first committed cell in B-cell development is the early pro-B cell, identified by its ability to proliferate in the presence of interleukin-7 (IL-7). (medscape.com)

This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. (nih.gov)

Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)
DLL-4, in turn, instigated neighbouring platelets to switch to 'activated' phenotype through cleavage of Notch receptor and release of its intracellular domain (NICD), which was averted by inhibition of γ-secretase and phosphatidylinositol-3-kinase (PI3K). (elifesciences.org)
B Cell Development and Its Deregulation to Transformed States at the Pre-B Cell Receptor-Expressing Pre-BII Cell Stage -- Gene Expression Patterns in Human and Mouse B Cell Development -- New Insights into the Phenotype and Cell Derivation of B Cell Chronic Lymphocytic Leukemia -- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models -- What Do Somatic Hypermutation and Class Switch Recombination Teach Us About Chronic Lymphocytic Leukaemia Pathogenesis? (epa.gov)
CD163, a scavenger receptor that serves as an M2 macrophage phenotype marker, is also expressed on monocytes, and binds to haptoglobin-hemoglobin complexes, mediating their endocytosis [ 11 ]. (biomedcentral.com)

In vitro studies of INS-1 cells confirmed that PPAR-γ binds to the putative PPRE sequence and regulates GIP-R transcription. (diabetesjournals.org)
and 5) an increased islet β- cell DNA synthesis in vitro in the presence of IL-22. (bepress.com)
Importantly, CD19-CAR T cells modified by MC-based SB transposition were equally effective as LV transduced CD19-CAR T cells in vitro and in a murine xenograft model (NSG/Raji-ffLuc), where a single administration of CD8+ and CD4+ CAR T cells led to complete eradication of lymphoma and memory formation of CAR T cells after lymphoma clearance. (uni-wuerzburg.de)
This was accomplished using non-viral CRISPR/Cas9 via pre-assemble Cas9 protein and in vitro-transcribed sgRNA (Cas9 RNP). (uni-wuerzburg.de)
The effects of androgen and rLH treatments on AR and AMH expression levels were also tested in vitro using HO23 cells. (biomedcentral.com)

It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. (epa.gov)

We therefore quantified the Reg1, Reg2, and Reg3δ (INGAP) mRNA expression in isolated pre-diabetic NOD islets treated with IL-22. (bepress.com)
We measured IL-22, and IL-22 receptor(R)-α mRNA expression in the pancreas and spleen of pre-diabetic and diabetic NOD mice. (bepress.com)
Our aim was to assess whether, in the United states, with the predominant hepatitis C viral (HCV) genotypes 1a/I and 1b/II, hepatic interferon-α receptor (IFNAR) mRNA expression correlated with response to IFN therapy, levels of HCV RNA, or histologic activity index (HAI). (elsevierpure.com)
As with Japanese HCV patients with genotypes 1b/II-2b/IV, higher hepatic IFNAR mRNA expression in the United States with predominant genotypes 1a/I and 1b/II appears to correlate with response to IFN therapy and a low HCV RNA titer but not with the total HAI or its components. (elsevierpure.com)
In addition, we observed significant correlations between LHR and AR mRNA expression and among AR, AMH, and SOX9 mRNA expression in granulosa-luteal cells from patients undergoing standard IVF treatment. (biomedcentral.com)

Invasion assays and inhibition assays were used to examine the ability of S. sonnei WT and its rough strain to invade APCs and investigate whether CD209 and CD207 are receptors for phagocytosis of rough S. sonnei. (cdc.gov)
This work demonstrated that S. sonnei rough strains - by losing the virulence plasmid - invaded APCs through interactions with CD209 and CD207 receptors. (cdc.gov)

Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
Under prolonged cellular stresses, the σR1 translocates to the extended ER network, whereby it interacts with and regulates the function of a variety of ion channels, receptors, or kinases. (molvis.org)
Understanding the cellular and molecular mechanisms that define cancer and how these mechanisms differ from normal cells is crucial for developing new innovative therapies," says Bentires-Alj. (unibas.ch)

The completion of rearrangement of the light and heavy chains and the presence of surface IgM results in the immature B cell, which then leaves the bone marrow. (medscape.com)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. (thermofisher.com)

However, the regulatory mechanisms controlling NR0B1 expression are not well understood. (oncotarget.com)
Dr. Gubatan's research is focused on translational studies using single-cell genomics to understand mechanisms of biologic therapy failure, elucidate the role of host immune and gut microbiome interactions in the pathogenesis of inflammatory bowel disease (IBD), and develop precision medicine strategies to improve outcomes in patients with IBD. (stanford.edu)
While the Sherr laboratory has historically been oriented towards understanding the biologic effects of environmental chemicals to prevent cancer and to understand the basic molecular mechanisms behind cancer aggression and immunosuppression, it has most recently begun investigating how to detect the changes in cells that precede cancer formation and how to intercept cancer at these inflection points before it develops. (bu.edu)
Figure 4: Mechanisms why infiltrating pre-adipocytes could suppress PCa AR expression to promote PCa cell invasion. (oncotarget.com)
Purusottams current research is to study the mechanisms of novel WNT5A derived antagonistic-peptides in pre-Clinical models of malignant melanoma. (lu.se)

In the present study, ovoviviparous guppies ( Poecilia reticulata ) were used to study the effect of AVT on delivery mediated by the activation of prostaglandin (PG) biosynthesis via isotocin (IT) receptors (ITRs). (frontiersin.org)
Background: The success of and the durability of immune therapy of cancer is thought to depend on the activation and expansion of tumor reactive and infiltrating CD8+ T cells. (aacrjournals.org)
In conclusion, this study shows that CpG methylation within the NR0B1 promoter is not involved in the in vivo regulation of NR0B1 expression, whereas the hyperacetylation of histone H4 and the unmethylation of histones H3K9 and H3K27, and their binding to the NR0B1 promoter results in decondensed euchromatin for NR0B1 activation. (oncotarget.com)
Further, B cell antigen receptor (BCR) activation induced proteome profiles were studied in anti-IgM stimulated Ramos cells in a time series. (lu.se)

The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). (cancerindex.org)
The effects of highly purified pharmacological grade hyaluronan of defined molecular weights 11, 52, 87, 250 and 970 kilodaltons were tested on mouse macrophage cell lines RAW 264.7 and MHS. (nel.edu)
Hyaluronan of any molecular weight did not activate production of nitric oxide or tumour necrosis factor alpha in any mouse macrophage cell lines. (nel.edu)

Surface expression of CD14, CD16, and CD163 on monocytes was detected using flow cytometry. (biomedcentral.com)

The sigma-1 receptor (σR1), a ligand-operated chaperone, has been inferred to be neuroprotective in previous studies using σR1 ligands. (molvis.org)
In particular, the Notch receptor-Delta ligand communication between neighboring cells is shown to play a hitherto unexpected role in the ``French Flag'' paradigm, which describes how a morphogen concentration gradient can dictate different cell fates in a position-dependent manner. (imsc.res.in)
We demonstrate expression of Notch1, its ligand DLL-4 and their respective transcripts in human platelets. (elifesciences.org)

On the other hand, the "exosome vesicle " is an extracellular particle released from the endosomal compartment of most eukaryotic cells. (frontiersin.org)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)

In this characteristic, they resemble stem cells or cells in an early stage of maturation. (unibas.ch)
Although defects may occur in many steps in B-cell development and maturation resulting in the lack of Ig production, the most common and well-described defect is the one at the stage of pro-B-cell to pre-B-cell maturation (see the image below). (medscape.com)
Two-dimensional differential gel electrophoresis (2D-DIGE) and mass spectrometry (MS) based quantitative proteomics were used to study differential protein abundance in various B cell types during B cell maturation. (lu.se)
Differential protein expression was studied in eight human cell lines representing various maturation stages from early pre-B cell until terminally differentiated plasma cell (see Supplementary Table 1 ). (lu.se)
To view our previous 2DE proteomic results, click on Proteome analysis of B cell maturation. (lu.se)
To view the latest results, click on 2D-DIGE analysis of B cell maturation. (lu.se)
Here you can compare interactive 2D-DIGE images representing B cell proteomes for different maturation stages. (lu.se)

Islet GIP-R expression and immunohistochemistry studies were performed in pancreas-specific PPARγ knockout mice (PANC PPARγ −/− ), normoglycemic 60% pancreatectomy rats (Px), normoglycemic and hyperglycemic Zucker fatty (ZF) rats, and mouse islets incubated with troglitazone. (diabetesjournals.org)
Effectiveness of photodynamic therapy in the treatment of lichen sclerosus: cell changes in immunohistochemistry. (nel.edu)

The gene is preferentially expressed by immature dendritic cells and memory T cells. (cancerindex.org)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
In a subset of peri-vascularly located immature neural crest-like neuroblastoma cells, aggressiveness and growth promoting charasteristics have been reported to be instigated by HIF-2α, a key element of the oxygen-sensing machinery. (lu.se)

The study demonstrated that Res prevents PQ-induced ROS production, inflammation, and fibrogenic reactions in cultured cells by activating Nrf2 signaling. (cdc.gov)
Immunoblotting, reporter assays, quantitative RT-PCR, and chromatin immunoprecipitation were performed to evaluate HIF-1 signaling in glioblastoma cells. (cancerindex.org)
Our studies have shown physiologic and pharmacologic regulation of GIP-R expression in β-cells by PPARγ signaling. (diabetesjournals.org)
Also disruption of this signaling pathway may account for the lowered β-cell GIP-R expression and resulting GIP resistance in type 2 diabetes. (diabetesjournals.org)
While the role of morphogens has received enormous attention in developmental contexts, it is now becoming clear that juxtacrine signaling, which occurs between cells in physical proximity, can also play a key role in shaping the outcomes of such processes. (imsc.res.in)
The aim of the PhD thesis, for which this is a pre-synopsis submission talk, is to investigate the precise mechanism by which contact-mediated signaling affects specific developmental phenomena. (imsc.res.in)
Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. (elifesciences.org)
Figure 3: Recruited pre-adipocytes enhanced PCa cell invasion via alteration of AR/TGF-β1/Smad/MMP9 signaling. (oncotarget.com)
WNT5A belongs to the non-transforming class of WNTs, and upon binding to different receptors or co-receptor complexes (Frizzled, RYK, ROR1/2, LRP5/6 and CD146), it elicits non-canonical (β-catenin-independent) signaling. (lu.se)
Zdenka is investigating the role of WNT5A signaling in Oral Squamous cell Carcinoma. (lu.se)

in mice bearing PSMA-expressing xenografts demonstrated that PSMA expression is increased with both orchiectomy and enzalutamide ( 11 ), a finding that has recently been reproduced in multiple prostate cancer cell lines and circulating tumor cells ( 13 , 14 ). (snmjournals.org)
Specifically, the AhR was shown to enforce the development of cancer stem cells, a small but critical subset of tumor cells that are highly resistant to chemotherapy and radiotherapy and are prone to metastasize. (bu.edu)

In contrast, WNT5A expression is associated with increased metastasis and reduced survival in melanoma patients. (lu.se)

Uterine natural killer cells make up approximately 70% of maternal lymphocytes during pregnancy, occupying both the decidua basalis of the endometrium at the implantation site and the mesometrial lymphoid aggregate of pregnancy (MLAp) that surrounds the blood vessels supplying the placenta. (wikipedia.org)
We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 × 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs. (nature.com)
Distinct lymphoid, myeloid, and stromal cell types in the TME exert opposing influences on PDAC tumor trajectory, suggesting a more complex organization than the classical "hot" versus "cold" tumor distinction. (stanford.edu)
The mature B cells circulate between secondary lymphoid organs and migrate into lymphoid follicles of the spleen and lymph nodes in response to further stimuli and various chemokines. (medscape.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
In vivo verification was shown by a 70% reduction in GIP-R protein expression in islets from PANC PPARγ −/− mice and a twofold increase in islets of 14-day post-60% Px Sprague-Dawley rats that hyperexpress β-cell PPARγ. (diabetesjournals.org)
The aim was to investigate the efficacy of PDT in women with LS and the analysis of protein expression before and after PDT. (nel.edu)
We found that TRIM13 mRNA and protein expression was reduced in NSCLC tissues and cell lines in comparison to paired non-cancerous tissues and a human normal bronchial epithelial cell line, respectively. (cancerindex.org)

Monocytes are the predominant innate immune cells at the early stage of Mycobacterium tuberculosis ( M. tb ) infection as the host defense against intracellular pathogens. (biomedcentral.com)

However, unlike natural killer cells, Uterine natural killer cells do not have a fundamental role in the innate immune system and therefore, are not cytotoxic. (wikipedia.org)
Figure 1: 7 × 19 CAR-T cells show improved immune function. (nature.com)
The response to immune checkpoint blockade, depends on a pre-existing, CD8 T cell-rich tumor microenvironment. (aacrjournals.org)
Mass-cytometry-based quantitation of global histone post-translational modifications at single-cell resolution across peripheral immune cells in IBD. (stanford.edu)
Current understanding of histone post-translational modifications (histone modifications) across immune cell types in patients with inflammatory bowel disease (IBD) during remission and flare is limited. (stanford.edu)
We used epigenetic profiling by time-of-flight (EpiTOF) to investigate changes in histone modifications within peripheral blood mononuclear cells from IBD patients.We discovered substantial heterogeneity in histone modifications across multiple immune cell types in IBD patients. (stanford.edu)
While earlier work characterized PDAC as an immunologically privileged tumor poorly recognized by the immune system, recent studies revealed the important and nuanced roles of immune cells in the pathogenesis of PDAC. (stanford.edu)
Especially in the era of immunotherapies, it has been suggested that "normal-like" cells can be cleared by the immune system while "cancerous" cells evade killing by immune cells. (unibas.ch)

We have optimized human small intestinal organoid (hSIO) culturing, constitutively generating all differentiated cell types while maintaining an active stem cell compartment. (amolf.nl)
1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers the only curative modality for many hematological disorders. (hindawi.com)
KIT has also gone by several other names including c-kit , v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, stem cell factor receptor, mast cell growth factor receptor, and CD117 . (creation.com)

Ovarian androgens are produced by thecal cells and exert their action in a paracrine fashion on granulosa cells. (biomedcentral.com)

Finally, Nrf2 mediated the protective response to PQ by Res because protection was lost in Nrf2-deficient cells. (cdc.gov)
Design and Methods OPM2 and high-risk primary myeloma tumors were grown in human fetal bone implanted into non-obese diabetic severe combined immunodeficiency mice with a deficient interleukin-2 receptor gamma chain. (haematologica.org)

However, they possess a unique expression profile of certain proteins, specifically CD9, CD103 (an integrin) and killer immunoglobulin-like receptors. (wikipedia.org)
Notably, mouse models suggest that they lack CD16 and L-selectin, proteins that are prominent on pNKs (peripheral NK cells). (wikipedia.org)
Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple myeloma. (cancerindex.org)
The finding of proteins that creates Th2 cells but aren't IgE reactive may permit the advancement EI1 of safer immunotherapeutic strategies. (enmd-2076.com)
Although occasionally it's been demonstrated that T cells can only just or preferentially offer help B cells particular for the same proteins (17, 18), in additional systems this limitation was not the situation (19, 20). (enmd-2076.com)
It had been discovered that two protein that can be found on a single particle could function collectively which T cells particular for one proteins could offer help for B cells particular for the next proteins (20). (enmd-2076.com)

Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. (haematologica.org)

[ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
Go to Imaging of Nasopharyngeal and Laryngeal Squamous Cell Carcinoma and Head and Neck Squamous Cell Carcinoma for complete information on these topics. (medscape.com)

The population of natural killer cells in the uterine tissue will only persist if pregnancy occurs. (wikipedia.org)
Our findings demonstrate that acquisition of MEK inhibitor resistance often occurs through gene amplification and can be suppressed by impeding cell cycle entry in drug. (babraham.ac.uk)
Gastrointestinal toxicity occurs during the neutropenic (pre-engraftment) period. (hindawi.com)
Cancer occurs when cells grow uncontrollably and spread to other organs in the body. (unibas.ch)
This type of carcinoma occurs mainly in pre-menopausal women and often lacks effective treatment options. (unibas.ch)
Pre-eclampsia, which occurs in Sample feraserisingtoabove70IU/L),signsof about5%ofpregnanciesandresults A sampleof 60 pregnantwomenin clonus,HELLPsyndrome[haemolytic insubstantialmaternalandneonatal thethirdtrimesterofpregnancywere anaemia/elevatedliverenzymes/low morbidity and mortality, is a preg- recruitedfromtheoutpatientclinics plateletcount]andpapilloedema. (who.int)

Human trophoblast stem cells were isolated and cultured from early pregnancy villous tissues . (bvsalud.org)
Histopathological analyses showed increased infiltration of dendritic cells (DC) and T cells into tumor tissues following 7 × 19 CAR-T cell therapy. (nature.com)
Figure 3: Infiltration of tumor tissues treated with 7 × 19 CAR-T cells by both T cells and DCs. (nature.com)
Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid incretin hormone that binds to a seven-transmembrane G-protein-coupled receptor (GIP-R) that is expressed in numerous tissues including islet β-cells and α-cells ( 1 , 2 ). (diabetesjournals.org)
Similar histone occupancies were confirmed in a comparison of cancerous tissues with strong, moderate and negative NR0B1 expression. (oncotarget.com)
Nuclear receptor subfamily 0 group B member 1 ( NR0B1 ), which is located on the X chromosome, is abundantly expressed in normal reproductive testicular and ovarian tissues. (oncotarget.com)

Inhibition of paraquat-induced oxidative stress, proinflammatory cytokine expression, and fibroblast-tomyofibroblast transformation by resveratrol via the Nrf2 pathway. (cdc.gov)
Inhibition of the AR can increase PSMA expression in prostate cancer metastases and increase the number of lesions visualized using PSMA PET. (snmjournals.org)
As opposed to prostate-specific antigen levels, PSMA expression on the cell surface increases with AR inhibition ( 10 - 12 ). (snmjournals.org)
ERKi treatment of cells drives the poly-ubiquitylation and proteasome-dependent turnover of ERK2 and pharmacological or genetic inhibition of Cullin-RING E3 ligases prevents this. (babraham.ac.uk)

Fry, T.J. & Mackall, C.L. Interleukin-7: master regulator of peripheral T-cell homeostasis? (nature.com)
The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)
Interleukin-6 drives melanoma cell motility through p38α-MAPK-dependent up-regulation of WNT5A expression. (lu.se)

When the heavy chain is produced, it is transported to the cell surface by the Ig-α (CD79a) and Ig-β (CD82) heterodimers or by the surrogate light chain. (medscape.com)

Mas1 receptors are expressed in placental villous tissue and their expression varies with gestation . (bvsalud.org)

Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)
Given that cancer cells and astrocytes in glioblastomas coexist in a hypoxic microenvironment, we examined whether astrocytes affect the adaptation of glioblastoma cells to hypoxia. (cancerindex.org)

We establish that IGF-II-induced HIF2A/EPAS1 expression during hypoxia is due to de novo transcription and further present the estrogen-related receptor alpha (ERRα) transcription factor as a positive regulator of HIF2A. (lu.se)
WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism. (lu.se)

Anatomy36

Organisms10

Diseases8

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes66

Information Science3

Proliferation20

Differentiation10

Regulated by the androgen receptor1

Natural cytotoxicity receptors2

Androgen receptor4

Chimeric antigen receptor2

Surface receptors2

Cancers6

Genes16

Steroid receptors1

Progression2

Chemokine4

Macrophages6

Antibodies5

Luteinizing hormone1

Antibody7

Apoptosis2

Therapeutic6

Antigen-prese2

Regulate4

Pathways5

Induces2

Significantly7

Cognate2

Dendritic cell1

Biomarkers2

Tyrosine2

Induce1

Membrane6

Proliferate3

Encodes1

Phenotype4

Vitro5

Malignancies1

MRNA expression5

APCs2

Cellular3

Bone marrow2

Endothelial cells2

Mechanisms5

Activation4

Macrophage3

Flow cytometry1

Ligand3

Extracellular2

Maturation7

Immunohistochemistry2

Immature3

Signaling10

Tumor cells2

Metastasis1

Lymphoid4

Protein expression4

Intracellular1

Immune8

Stem cell5

Granulosa cells1

Deficient2

Proteins6

Gene Expression Profiling1

Squamous Cell Carc2

Occurs6

Tissues6

Inhibition4

Interleukin4

Surrogate light1

Placental1

Microenvironment2

Regulator2