• Immunohistochemistry-Paraffin: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • 2005). The aim of this study was to investigate the expression of VEGF in dogs with lymphoma by means of immunohistochemistry and its relationship to biological behavior of canine lymphomas. (vin.com)
  • Immunohistochemistry was performed to identify T or B cell origin, using anti-CD3 polyclonal antibody (Dako) and anti-CD79a monoclonal antibody (Dako), respectively. (vin.com)
  • Using immunohistochemistry, radiobinding, and indirect immunofluorescence assays, seven distinct cell surface antigens, detected by monoclonal antibodies, were analyzed for the degree of homogeneity or heterogeneity of antigen expression on A Panel of human small cell lung cancers. (elsevierpure.com)
  • 4,5 The immunohistochemistry (IHC)-based detection of CK5 with anti-Cytokeratin 5/6 (D5/16B4) antibody can be used to aid in the distinction between pulmonary SCCA and pulmonary adenocarcinoma (ADC). (roche.com)
  • Finally, the application of monoclonal antibodies to immunohistochemistry and radionuclide imaging also may provide new areas of diagnostic application for monoclonal antibodies in gynecologic oncology. (duke.edu)
  • The immunohistochemistry technique was performed by the streptavidin-biotin method using the antibody anti-MMP9. (bvsalud.org)
  • Materials and Methods: The expression of COM-1 mRNA was examined using a quantitative polymerase chain reaction (PCR) technique together with immunohistochemistry to examine expression and distribution of the COM-1 protein in human colorectal carcinoma and matched normal colorectal mucosa. (iiarjournals.org)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA254759(CD24 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (cusabio.com)
  • The tissue and development restricted expression makes SOX11 a potentially important diagnostic tool in immunohistochemistry (IHC). (nordiqc.org)
  • With all assays, considerable heterogeneity of antigen expression between tumors from different Patients was observed. (elsevierpure.com)
  • The objective of this study was to evaluate PCNA immunohistochemical expression of sebaceous tumors in dogs. (uff.br)
  • Most of the tumors were neoplasms (67.27%), and 75.67% of those were benign. (uff.br)
  • No previous studies were found using PCNA antibody in sebaceous tumors of dogs. (uff.br)
  • Somatostatin receptor type 2 (SSTR2) and thyroid-stimulating hormone receptor (TSHR) display variable expression in primary thyroid tumors and have been implicated as theranostic targets. (bvsalud.org)
  • p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
  • Interestingly, tumors with both negative mdm-2 and p21 expression, irrespective of p53 status, had a high response rate to docetaxel but no response to MF. (lu.se)
  • The expression of PD-L1 and Ki67 in the tumors decreased and an increase in granzyme B levels was found in CAR T cells. (oncotarget.com)
  • These armed second-generation CAR T cells empowered to secrete human anti-PD-L1 antibodies in the ccRCC milieu to combat T cell exhaustion is an innovation in this field that should provide renewed potential for CAR T cell immunotherapy of solid tumors where limited efficacy is currently seen. (oncotarget.com)
  • As an evasion mechanism, many tumors are able to stimulate the expression of immune checkpoint molecules, resulting in an exhausted phenotype of T cells that cannot restrain tumor progression [ 1 ]. (oncotarget.com)
  • High expression in tumors is generally a poor prognostic marker. (enquirebio.com)
  • However, most of these strategies used in-house-developed antibodies and were focused on lung tumors. (interleukinreceptor.com)
  • Desmoid tumors are benign neoplasms, but are often unresectable because of their aggressive and local infiltration, compression of surrounding structures and massive involvement of adjacent vital structures. (ommegaonline.org)
  • We could validate these findings by immunofluorescence analyses in patient tumors and by increased expression in the hypoxic core of GBM spheroids. (lu.se)
  • Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
  • The availability of unlimited quantities of several pure monoclonal antibodies directed against novel epitopes on tumor-associated antigens has permitted development of highly sensitive assays for serum markers. (duke.edu)
  • AIMS: To develop monoclonal antibodies that recognise antigens or immature crypt base cells, on the assumption that in a neoplasm undifferentiated but not the terminally differentiated cells will be responsible for tumour progression. (maastrichtuniversity.nl)
  • By stepwise harvesting, crypt base cell enriched fractions were obtained, and after incubation with antibodies against dominant antigens, used as immunogens. (maastrichtuniversity.nl)
  • CAR-expression on T or NK cells allows them to specifically target cancer cells via recognition of tumor associated antigens. (nature.com)
  • Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)
  • In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
  • Antibodies blocking the immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and programmed death-1-ligand 1 (PD-L1) antigens have been tested in several gastrointestinal malignancies. (medscape.com)
  • Here, we describe a new method (immuno-SILAC) for the absolute quantification of proteins in complex samples based on polyclonal antibodies and stable isotope-labeled recombinant protein fragments to allow affinity enrichment prior to mass spectrometry analysis and accurate quantification. (nih.gov)
  • Here, we show that we were able to use small amounts of antibodies (50 ng per target) in this manner for efficient multiplex analysis of quantitative levels of proteins in a human HeLa cell lysate. (nih.gov)
  • Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. (duke.edu)
  • We were also able to define immunogenic membrane proteins from lung (squamous and adenoCa) as well as prostate neoplasms. (jcancer.org)
  • The availability of tools to interrogate the transcriptome and proteome, such as expression profiling, have identified a substantial library of products that could aid in distinguishing a well-differentiated pancreatic carcinoma from a benign pancreatic lesion.2 Many of these proteins can be detected immunohistochemically and are thus available to the practicing pathologist (Table 2).3 Some of these markers have been validated on biopsy specimens as well. (coek.info)
  • Other factors have been suggested to correlate with response to immunotherapy based on clinical and preclinical studies, including elevated type 1 helper T cell (Th1) tumoral gene signature, [ 11 ] and IFN-γ expression, possibly attributable to its ties to other proteins and cytokines within the tumor microenvironment. (medscape.com)
  • This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
  • Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)
  • In addition, when cell lines or Patient samples expressing antigen Positive and antigen negative tumor cells were cloned, heterogeneity of antigenic expression was still Present in the clonal lines. (elsevierpure.com)
  • This suggests that either the expression of the antigen was not heritable and/or the ability to regenerate antigenic heterogeneity is an intrinsic Property of the tumor cells. (elsevierpure.com)
  • The heterogeneity of antigen expression on lung cancer cells has significant implications for the use of these and other monoclonal antibodies in the study and therapy of lung cancer. (elsevierpure.com)
  • Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
  • Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)
  • Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. (enquirebio.com)
  • Background: Expression studies of somatostatin receptor type 2A (SSTR2A) in neuroendocrine neoplasms (NENs) led to the development of clinically relevant diagnostic and therapeutic strategies. (interleukinreceptor.com)
  • Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. (enquirebio.com)
  • Some markers may emerge through a more fundamental knowledge of the biology of gynecologic neoplasms, including the expression of growth factors and their receptors. (duke.edu)
  • The antibody clone D5/16B4, raised for the detection of CK5, is also reactive to CK6, another type II CK (60 kDa) that shares 86% sequence homology to CK5. (roche.com)
  • One 5 mL dispenser of anti-Cytokeratin 5/6 (D5/16B4) antibody contains approximately 52 μg of a mouse monoclonal antibody. (roche.com)
  • Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Anti-Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody (anti-Cytokeratin 5/6 (D5/16B4) antibody) is a mouse monoclonal antibody raised for the detection of cytokeratin (CK) 5. (roche.com)
  • Anti-Cytokeratin 5/6 (D5/16B4) antibody is a monoclonal antibody produced as cell culture supernatant. (roche.com)
  • 200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. (novusbio.com)
  • We took advantage of the antibody resources publicly available from the Human Protein Atlas project covering more than 80% of all human protein-coding genes. (nih.gov)
  • Epitope mapping revealed that a majority of the polyclonal antibodies recognized multiple linear epitopes, and based on these results, a semi-automated method was developed for peptide enrichment using polyclonal antibodies immobilized on protein A-coated magnetic beads. (nih.gov)
  • A protocol based on the simultaneous multiplex capture of more than 40 protein targets showed that approximately half of the antibodies enriched at least one functional peptide detected in the subsequent mass spectrometry analysis. (nih.gov)
  • The results suggest that polyclonal antibodies generated via immunization of recombinant protein fragments could be used for the enrichment of target peptides to allow for rapid mass spectrometry analysis taking advantage of a substantial reduction in sample complexity. (nih.gov)
  • Description: The monoclonal antibody SolA15 recognizes mouse and rat Ki-67, a 300 kDa nuclear protein. (thermofisher.com)
  • We have obtained monoclonal antibodies to the human neu protein by immunizing a Balb/c mouse with a Balb/c cell line expressing the human neu gene by transfection. (prinsesmaximacentrum.nl)
  • The monoclonal antibodies reacted with neu protein on intact cells by immunofluorescence and immunoprecipitated neu in metabolically labeled cells, also in the presence of tunicamycin. (prinsesmaximacentrum.nl)
  • We tested possible down-modulating effects of these monoclonal antibodies on SKBR-3 mammary tumor cells, which express high levels of wild-type human neu protein. (prinsesmaximacentrum.nl)
  • In contrast, the antibodies induced 50-65% down-modulation in NIH3T3 cells expressing the mutated human neu protein and could inhibit these cells to form colonies in soft agar. (prinsesmaximacentrum.nl)
  • The antibody is diluted in a phosphate buffered saline containing carrier protein and 0.10% ProClin 300, a preservative. (roche.com)
  • In prostate tissues, we have shown that cancer tissues have significantly reduced expression of COM-1 protein compared to normal prostate tissue whereas prostate cancer cell lines widely expressed COM-1. (iiarjournals.org)
  • We have observed that no studies have examined the expression of COM-1 in tumours of the lower gastrointestinal tract and as such have set out to examine quantitatively the expression of COM-1 in carcinomas and matched normal tissues of the colon and rectum and to examine the localisation of COM-1 protein within the tissues. (iiarjournals.org)
  • The era of immune checkpoint blockers (ICB), which started in 2011 with the approval of an antibody targeting cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells (namely, ipilimumab) for the treatment of metastatic melanoma ( 1 ), has brought a new paradigm to cancer therapy whereby the immune system is being harnessed to cure the cancer. (aacrjournals.org)
  • Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms. (ucsf.edu)
  • High expression of GRB2 associated binding protein 3 mRNA predicts positive prognosis in melanoma. (cdc.gov)
  • Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
  • T his is a state-of-the-art review of the molecular genetics of pancreatic neoplasms. (coek.info)
  • Although understanding of the molecular features underlying pancreatic neoplasms is still in its infancy, a strong emphasis on the relevance of these findings for the practicing surgical pathologist is provided. (coek.info)
  • INTRODUCTION Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States.1 There have been significant advances in our understanding of the genetics of pancreatic neoplasms in the past 2 decades, as well as an explosion of information over the past 3 years, largely because of the availability of whole genome and exome sequencing technologies. (coek.info)
  • This article provides a state-of-the-art review of the molecular genetics of pancreatic neoplasms with a strong emphasis on the relevance of these findings for the practicing surgical pathologist. (coek.info)
  • Frameshift and nonsense mutations occur frequently in CMML, acute myeloid leukemia ( 3 ), and myeloproliferative neoplasm (MPN) cases ( 4 ). (aacrjournals.org)
  • In thyroid cancers, COM-1 has been found to be overexpressed in papillary and follicular tumours but to a much lower degree in anaplastic tumours, this is together with a change in location of COM-1 expression on immunohistochemical (IHC) staining from nuclear (found in normal tissue and follicular tumours) to cytoplasmic (in papillary and anaplastic tumours) locations ( 9 ). (iiarjournals.org)
  • The expression was mixed nuclear/cytoplasmic. (ox.ac.uk)
  • Before incubation with the primary antibody, sections were heated in steamer (95°C), for 30 minutes. (vin.com)
  • Sections were incubated with primary antibody overnight at 4°C, following the two-step horseradish peroxidase technique and using Envision Dual-link Kit (Dako). (vin.com)
  • Negative controls were performed using non-specific IgG as the primary antibody. (vin.com)
  • ProductData": { "ID": "RTD000669", "ProductType": "Others", "BrandName": "anti-Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody", "ProductNameAddition": "", "RegulatoryDisclaimer1": "For in vitro diagnostic use. (roche.com)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Anti-Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody is intended for laboratory use in the qualitative immunohistochemical detection of cytokeratin 5 by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument. (roche.com)
  • Chronic myeloid neoplasms are malignant clonal hematopoietic stem cell disorders driven by recurrent genetic events, with an inherent risk of transformation to acute myeloid leukemia (AML) 1 , 2 . (nature.com)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
  • In this work, MMP-9 was used as an immunohistochemical marker in order to correlate its expression with histological grading of 28 cases of oral squamous cell carcinoma (OSCC) obtained from the Laboratory of Oral Pathology, School of Dentistry of Pernambuco (FOP / UPE). (bvsalud.org)
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • Using the recently described MeLiM miniature pig model of heritable cutaneous malignant melanoma, we studied the expression of two ECM glycoproteins, the tenascin-C (TN-C) and tenascin-X (TN-X), in normal skin and melanoma. (nih.gov)
  • At the time, ICBs had just entered clinical testing, an endeavor that culminated in 2011 with the approval of the first anti-CTLA-4 antibody for use in metastatic melanoma patients (ipilimumab). (aacrjournals.org)
  • Multiple Myeloma Oncogene-1 (MUM1), also known as Interferon Regulatory Factor 4 (IRF4), is a transcription factor present in a variety of hematolymphoid neoplasms and in malignant melanoma, but is absent from other human tumours. (genomeme.ca)
  • In situ hybridization shows expression throughout the central nervous system (CNS) from earliest stage studied (3.5 weeks) to older fetuses (19 weeks). (nordiqc.org)
  • 9,10 Thus, detection of CK5 in prostatic basal cells with anti-Cytokeratin 5/6 (D5/16B4) antibody may be used to aid in the differentiation of benign and malignant prostate lesions. (roche.com)
  • The local antibody delivery led to marked immune checkpoint blockade. (oncotarget.com)
  • However, only nuclear TP (TPnuc) expression by tumor cells was correlated with increased angiogenic activity. (ox.ac.uk)
  • This study was designed to explore the differential expression of SSTR2 and TSHR in oncocytic (Hurthle cell) carcinoma (OC) vs oncocytic adenoma (OA). (bvsalud.org)
  • CONCLUSION: A mucin associated maturation epitope was identified in colonic crypt base cells, the expression of which in Dukes' stage B3 colorectal carcinoma may be associated with poor prognosis. (maastrichtuniversity.nl)
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
  • Cluster of differentiation 5 (CD5) is expressed in high levels on the surface of T cells, while controversy surrounds the expression levels and role of CD5 in B cells. (abeomics.com)
  • Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. (cusabio.com)
  • Loss of TET2 has been shown to lead to aberrant gene expression that can disrupt normal differentiation processes. (aacrjournals.org)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • Flow Cytometry: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Flow Cytometric Analysis of Human Raji cells using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • In translocations that result in partial trisomy or in cases of mosaic trisomy 18, clinical expression is less severe, and survival is usually longer. (medscape.com)
  • PANCREATIC DUCTAL ADENOCARCINOMA CLINICAL FEATURES Ductal adenocarcinoma of the pancreas is the most common malignant neoplasm of the pancreas. (coek.info)
  • Nordström L, Andréasson U, Jerkeman M, Dictor M, Borrebaeck C, Ek S. Expanded clinical and experimental use of SOX11 - using a monoclonal antibody. (nordiqc.org)
  • Myeloid neoplasms are clonal hematopoietic stem cell disorders driven by the sequential acquisition of recurrent genetic lesions. (nature.com)
  • In addition, CK5 is expressed in mesothelial cells of the pulmonary pleura and is overexpressed in epithelioid malignant mesothelioma (MM). 6 CK5 is consistently absent in pulmonary ADC that confounds the diagnosis of epithelioid MM. 6,7 Thus, detection of CK5 with anti-Cytokeratin 5/6 (D5/16B4) antibody can be used to aid in the differential diagnosis of epithelioid MM from lung ADC. (roche.com)
  • The antibody mouse anti-VEGF monoclonal (Dako) was used at a 1:25 dilution. (vin.com)
  • PAX-5: a valuable immunohistochemical marker in the differential diagnosis of lymphoid neoplasms. (cellmarque.com)
  • The expression of thymidine phosphorylase (TP), a potent chemotactic factor for endothelial cells, was studied in 60 adenocarcinomas of the gallbladder, by use of immunohistochemical techniques. (ox.ac.uk)
  • Immunohistochemical analysis revealed that there were significant differences in the expression of KIN17 between cancer tissues and adjacent tissues. (spandidos-publications.com)
  • The possibility of building up a proteome-wide resource for immuno-SILAC assays based on publicly available antibody resources is discussed. (nih.gov)
  • The advent of monoclonal technology has increased the potential utility of antibody-dependent tumor marker assays in gynecologic oncology. (duke.edu)
  • Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases. (enquirebio.com)
  • Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. (nordiqc.org)
  • Yilmaz & Deshpande occasionally, they are cystic and thus can mimic primary cystic neoplasms of the pancreas. (coek.info)
  • Investigating the relationship between KIN17 and neoplasms will provide a vital theoretical basis for KIN17 to serve as a diagnostic and prognostic biomarker for cancer patients and as a potential target for cancer therapy. (spandidos-publications.com)
  • The present review was the first, to the best of our knowledge, to systematically summarize and clarify the relevance between KIN17 and tumor development from different aspects ( Table I ), including the structure, function, expression level and regulatory mechanisms of KIN17, so as to explore the potential of KIN17 as a tumor diagnostic and prognostic biomarker and as a potential therapeutic target. (spandidos-publications.com)
  • Conclusions: This study indicates that low (0-30%) p53 expression is a favourable prognostic factor in patients with resected DBDC. (johnshopkins.edu)
  • In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
  • Results: COM-1 was expressed in 22.8% of normal colorectal mucosa samples and the expression in these tissues was 54.9 copies of COM-1 transcript per sample. (iiarjournals.org)
  • Expression is seen in fetal tissues (18-25 weeks) mainly in the brain. (nordiqc.org)
  • Specific antibody concentration is approximately 10.4 μg/mL. (roche.com)
  • An isotype control should be used at the same concentration as the antibody of interest. (bdbiosciences.com)
  • CMML shares the typical repertoire of genetic driver lesions with other myeloid neoplasms and is particularly enriched in truncating mutations involving ASXL1 (prevalence ~40%) 3 . (nature.com)
  • Western Blot: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Western Blot Analysis of Ramos cell lysate using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. (novusbio.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
  • Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. (thermofisher.com)
  • Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. (thermofisher.com)
  • and 177 Lu-lilotomab, a CD37 antibody for the treatment of B-cell lymphomas, are being highlighted. (snmjournals.org)
  • Antigenic expression was not cell cycle dependent. (elsevierpure.com)
  • To explore this in peripheral samples, we characterized CD8+ T cell gene expression across a cohort of patients with MM receiving anti-PD-1 alone (sICB) or in combination with anti-CTLA-4 (cICB). (ox.ac.uk)
  • however, Cell Marque™, Sigma-Aldrich Co. LLC, its shareholders, its officers, its employees, and its business associates assume no liability for any reliance on any of the contents of this information including but not limited to any of the antibody panels. (cellmarque.com)
  • The antibody panels were constructed based on the internal investigations of Cell Marque™ with scores based on the percentage of positivity represented as follows: "-" for 0-40%, "-/+" for 40-50%, "+/-" for 50-60%, "+" for 60-100%, and blank for no available data. (cellmarque.com)
  • In addition to this there is evidence that some tumour inhibitory agents (1,25-dihydroxycholecalciferol and transforming growth factor (TGF)-β) may up-regulate the expression of COM-1 and result in cell growth arrest ( 11 , 12 ). (iiarjournals.org)
  • Since then, several antibodies targeting another coinhibitory receptor, the programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1), have been approved for the treatment of multiple cancers ( 2 ). (aacrjournals.org)
  • As a part of a diagnostic panel, its utility lies predominantly as a marker for T cells, with over 70% of T cell neoplasms expressing CD5. (abeomics.com)
  • RESULTS: Of one crypt base cell specific antibody (5E9), the reactive epitope appeared to be a non-terminal carbohydrate in the mucin O-glycans of the colon. (maastrichtuniversity.nl)
  • MUM1 expression has been indicated in both pediatric and adult diffuse large B-cell lymphoma (DLBCL), and, when the immunostaining status of CD10 and Bcl6 is also considered, Anti-MUM1 can be used to sub-distinguish germinal center type DLBCL from the non-germinal center type. (genomeme.ca)
  • Classical " CARs consist of an extracellular binding domain mostly derived from a monoclonal antibody fragment (single-chain variable fragment-scFv), which is linked to intracellular binding domains of the T-cell receptor complex. (nature.com)
  • SOX11 over-expression is reported in over 90% of mantle cell lymphomas (MCL), including the rare cyclin D1 negative cases. (nordiqc.org)
  • Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. (nordiqc.org)
  • Ek S, Dictor M, Jerkeman M, Jirström K, Borrebaeck C a K. Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. (nordiqc.org)
  • Utility and Diagnostic Pitfalls of SOX11 Monoclonal Antibodies in Mantle Cell Lymphoma and other Lymphoproliferative Disorders. (nordiqc.org)
  • SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. (nordiqc.org)
  • These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
  • Thymidine phosphorylase expression in gallbladder adenocarcinomas. (ox.ac.uk)
  • Paraffin wax sections of 70 surgically resected colorectal adenocarcinomas were examined for the overexpression of HER2/c-erbB-2 oncoprotein using three different specific antibodies and the avidin-biotin immunoperoxidase technique. (ox.ac.uk)
  • There is no known nonspecific antibody reactivity observed in this product. (roche.com)
  • Applications Reported: This SolA15 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. (thermofisher.com)
  • Applications Tested: This SolA15 antibody has been tested by intracellular staining followed by flow cytometric analysis of mouse splenocytes using the Foxp3/Transcription Factor Staining Buffer Set (Product # 00-5523-00) and protocol. (thermofisher.com)
  • Flow cytometric analysis of Notch1 expression on stimulated human peripheral blood lymphocytes. (bdbiosciences.com)
  • If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)
  • report a case of a patient with metastatic gastric cancer with a meaningful response to the anti-programmed death-ligand 1 (PD-L1) antibody avelumab. (medscape.com)
  • We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1 MT in chronic myelomonocytic leukemia (CMML). (nature.com)
  • Within myeloid neoplasms, chronic myelomonocytic leukemia (CMML) represents an attractive disease model since it is characterized by both myelodysplastic and myeloproliferative features, while retaining a relatively simple clonal composition 3 . (nature.com)
  • CD5 demonstrates positive expression in thymic carcinomas, and is not as sensitive as CD3. (abeomics.com)
  • Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
  • Whereas pig normal skin displayed a discrete TN-C signal at the dermo-epidermal junction, around blood vessels and hair bulbs, the swine tumour showed enhanced expression of TN-C in these areas and around stromal and tumour cells. (nih.gov)
  • Cathepsin K antibodies are marketed for research into expression of this enzyme by various cells. (wikipedia.org)
  • Cells were then surface-stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and stained intracellularly, using the Foxp3/Transcription Factor Staining Buffer Set (Product # 00-5523-00) and protocol, with 1.0 µg of Ki-67 Monoclonal Antibody, Brilliant Ultra Violet 615. (thermofisher.com)
  • CK5 is expressed in prostatic basal cells and the loss of CK5 expression is indicative of neoplasms that have breached the basal membrane. (roche.com)
  • PAX-5 antibody has a strong nuclear expression for Reed-Sternberg cells and B-lymphocytes in Hodgkin lymphoma. (cellmarque.com)
  • Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. (enquirebio.com)
  • Expression of a marker for colonic crypt base cells is correlated with poor prognosis in human colorectal cancer. (maastrichtuniversity.nl)
  • We evaluated commercially available SSTR2A antibodies in NENs of the colorectum to observe their subcellular localization and distribution within the resected tumor. (interleukinreceptor.com)
  • Chromatin remodeling of promoters and enhancers is strongly associated with gene expression and heterogenous among overexpressed genes. (nature.com)
  • The SolA15 antibody also recognizes human, non-human primate and canine Ki-67. (thermofisher.com)
  • dashed line histogram) or Alexa Fluor® 647 Mouse Anti-Human Notch1 antibody (Cat. (bdbiosciences.com)
  • Competition for PRPF8 availability alters the transcription-coupled splicing of RNAs in which weak 5′ splice sites predominate, enabling diversification of human gene expression during biological processes like mitosis. (biomedcentral.com)
  • SOX11 expression is critical for embryonic neurogenesis and tissue remodeling, is normally expressed during the developing nervous system of human embryos and is required for neurite growth and neuron survival. (nordiqc.org)
  • The human SOX11 gene: cloning, chromosomal assignment and tissue expression. (nordiqc.org)
  • These in vitro, and their expression in these human tumour virus. (who.int)
  • Antibodies against a presynaptic structure, the voltage-gated potassium channels of peripheral nerves, have been detected in patients with neuromyotonia with or without thymoma. (medscape.com)