The genome of VHSV is composed of approximately 11-kb of single stranded RNA, which contains six genes that are located along the genome in the 3′-5′ order: 3′-N-P-M-G-NV-L-5′, nucleocapsid protein (N), polymerase-associated phosphoprotein (P), matrix protein (M), surface glycoprotein (G), a unique non-virion protein (NV), and virus polymerase (L). VHSV enters the host cell through either fusion or endocytosis. (wikipedia.org)
The researchers say this heralds the application of these molecules as chemical probes to explore viral biology and produce specific antivirals targeting RNA regions of the coronavirus genome. (news-medical.net)
Virions are composed of a 25 nm icoshedral capsid encompassing a 4.9 kb single-stranded DNA genome with two open reading frames: rep and cap. (justia.com)
This was possible in the lab because the molecular biology of replication is well characterised and that measles virus is polyploid allowing the engineering of a tri-segmented genome that can replicate and be packaged into virions. (virology.ws)
The virion consists of single-stranded positive-sense RNA genome of approximately 8500 nucleotides in length and icosahedron capsid protein [ 5 , 6 ]. (biomedcentral.com)
The replication of HBV involves the production of covalently closed circular DNA (cccDNA) from the HBV genome through the repair of virion relaxed circular DNA (rcDNA) in the virion. (biomedcentral.com)
Maturation2
Gag is subsequently cleaved into its component domains, causing structural maturation to repurpose the virion for cell entry. (rcsb.org)
Rotavirus nonstructural protein 4 (NSP4), a trans-ER glycoprotein, mediates the maturation of intermediate vial particles to infectious virions within the infected cells. (auckland.ac.nz)
Proteins6
Small molecules that behave like drugs can be used to explore the function of various proteins and large molecules, acting as chemical probes. (news-medical.net)
Education Corner Explores the Structure-Function Relationship with Digital and Physical 3D Models of Proteins. (sdsc.edu)
I want to explore in more detail the idea that the structural proteins of viruses likely originated from cell proteins ( link to paper ). (virology.ws)
An analysis of the sequence an structure of major virion proteins has identified likely ancestors in cellular proteins. (virology.ws)
The pathogenesis of severe dengue has not been fully elucidated, and the role of host proteins associated with viral particles has received little exploration. (gabriel-network.org)
A novel technique of virion-enrichment from plasma has allowed to identify two host proteins that have prognostic value for classifying patients with acute dengue who are more likely to develop a severe dengue. (gabriel-network.org)
Viral4
This system allows the investigators to explore the functional properties of individual viral genes of VHSV in detail. (wikipedia.org)
The 'VirION' (Viral, long-read metagenomics via MinION sequencing) approach was first validated using mock communities where it was found to be as relatively quantitative as short-read methods and provided significant improvements in recovery of viral genomes. (peerj.com)
We then then applied VirION to the first metagenome from a natural viral community from the Western English Channel. (peerj.com)
Together, these findings suggest that VirION provides a high throughput and cost-effective alternative to fosmid and single-virus genomic approaches to more comprehensively explore viral communities in nature. (peerj.com)
Infectivity2
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. (justia.com)
It utilizes a monoclonal antibody against HSV glycoprotein D which is present on the HSV virion and required for infectivity. (chop.edu)
Replicate1
She encounters the X Parasites, virions that can replicate their hosts' physical appearances and memories, killing them afterward. (alchetron.com)
Vitro4
In vitro reconstitution of virion transport in infected cell extracts reveals that IMV and IEV move toward microtubule plus-ends with respective velocities of 0.66 and 0.56 µm/s. (figshare.com)
In the absence of kinesin-1 there is a near-complete loss of in vitro motility and reduction in the intracellular spread of both types of virion. (figshare.com)
Likewise, 1A4B-6 inhibited virus growth in vitro at a pre-attachment step after virions were incubated at 37C and inhibited virus-mediated cell fusion. (cdc.gov)
The potential to elicit broadly cross-reactive MAbs with limited virus neutralizing activity in vitro but that can inhibit virus entry and protect animals from infection merits further exploration for vaccine and therapeutic developmental research. (cdc.gov)
Infectious2
Check out this Emerging Infectious Diseases issue exploring influenza A viruses through art and art that arose from great pandemics of the virus . (cdc.gov)
Later, as the virus matures, it is clipped into functional pieces that build the infectious structures of the virion. (hivecenter.net)
Genomes1
I see +ssRNA, -ssRNA and dsRNA genomes as all part of the same process of RNA replication, just depends which has evolved to be put in the virion. (virology.ws)
Vaccine1
However, the acid stability of virus capsid is greatly required for the maintenance of intact virion during the process of virus culture and vaccine production. (biomedcentral.com)
Methods1
The present study aimed to explore and analyze international publications on monkeypox through scientometric methods. (bvsalud.org)
Molecule2
Click molecule labels to explore molecular sequence information. (nih.gov)
The study of pH stability of FMDV not only contributes to the exploration of molecule and mechanism information for FMDV uncoating, but also enlightens the development of FMDV vaccines, including the traditionally inactivated vaccines and the new VLP (virus-like particle) vaccines. (biomedcentral.com)
Molecules1
The Education Corner Explores the Molecules of Biological Warfare in Virtual Reality. (sdsc.edu)
Infection1
Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection. (figshare.com)
Hosts1
A research estimates that the sum of all SARS-CoV-2 virions present in human hosts may weigh between a hundred grams and 10 kilograms. (baixargratismovel.com)
Breakthroughs2
Explore the timeline of discovery and major breakthroughs in our understanding of the influenza virus. (cdc.gov)
They explored the concept scientific breakthroughs and improvements occur when info is mixed from disparate fields. (baixargratismovel.com)
Virus4
Explore the swine flu virus up close with a transmission electron microscope image. (cdc.gov)
However, the biological and evolutionary consequences of giving measles virus a tri-segmented have not really been explored but would shed light on this process. (virology.ws)
Resistance to white spot syndrome virus in the European shore crab is associated with suppressed virion trafficking and heightened immune responses. (exeter.ac.uk)
Electron microscopy of human immunodeficiency virus (HIV)-1 virions. (medscape.com)
Gene2
This system was immediately utilized to characterize the non-virion (NV) gene of novirhabdoviruses. (wikipedia.org)
There are various ways to achieve genetic variation and gene expression, and viruses explore all aspects of this space. (virology.ws)
Structures1
This issue reviews 2018 milestones and publications, improved support for XFEL/SFX structures, new PDB-101 resources for exploring Molecular Evolution and Antimicrobial Resistance, and more. (sdsc.edu)
Cell1
When it is newly made and still a polyprotein, it orchestrates the budding of new virions from the cell surface. (hivecenter.net)
Immune1
Aims: This research aims to explore the potential interactions of NSP4 with host's innate immune system, and to identify the receptors of NSP4 on innate immune cells. (auckland.ac.nz)
Functional1
The structure reveals that these functional dimers form very early during the formation of new HIV-1 virions, indicating that it may not need to extricate itself from Pol before it starts work in cleaving other sites in Gag and Pol. (hivecenter.net)
Target5
Mary Jane De Belen & Viron De Belen created a baby registry at Target. (thebump.com)
Surfen interferes with the binding of SEVI to both target cells and HIV-1 virions but does not cause the SEVI fibrils to break up. (medicalxpress.com)
They further demonstrated that surfen interferes with the binding of SEVI to both target cells and HIV-1 virions. (medicalxpress.com)
The impact of PCR recombination towards the amplification of this cccDNA specific target was explored by mixing three marked, yet overlapping HBV DNA fragments. (biomedcentral.com)
As the virion contains uniquely rcDNA, amplification of the cccDNA target resulted from PCR recombination. (biomedcentral.com)
Sign1
Once you arrive you will be sure by the deep red storefront and the huge gold "VIRON" sign. (deepjapan.org)
Human1
Information designer Giorgia Lupi, RAND's inaugural artist-in-residence, produced a inventive piece that explores questions about how the human body-and society on the whole-may be reworked by way of Internet of Bodies technology. (baixargratismovel.com)
Surface1
Bounty hunter Samus Aran, the protagonist, explores the surface of the planet SR388 with a survey crew from Biologic Space Laboratories (BSL). (alchetron.com)
Study1
That's what researchers Jean Dickey and Steven Marcus of NASA's Jet Propulsion Laboratory, Pasadena, Calif., and colleague Olivier de Viron of the Universite Paris Diderot and Institut de Physique du Globe de Paris in France, set out to discover in a first-of-its-kind study. (nasa.gov)
Order2
This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid stability of vaccines. (biomedcentral.com)
In order to explore the uncoating activity of FMDV and enhance the acid stability of vaccines, we summarized the available works about the pH stability of FMDV. (biomedcentral.com)
Find1
Explore a back street of Shibuya, and you'll find secret restaurants. (deepjapan.org)
Transmission1
Descriptive analyses were performed to explore the method used to detect the index case and the mode of early transmission, according to cluster category. (who.int)