• Studies utilize in vitro measurements of mRNA, protein, enzymatic activity, enzyme kinetics, and cell signaling as well as in vivo measurements of hormone levels, blood flow, blood pressure, and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. (augusta.edu)
  • Our experimental models include various strains of inbred and genetically manipulated rats and mice. (augusta.edu)
  • Rodents (mice or rats) are placed in the center compartment and allowed to explore the arms in search of this reward. (noldus.com)
  • However, lesions to the amygdala and frontal cortex caused deleterious effects on performance only in the C57 strain, indicating that perhaps the enhanced learning seen in these mice is due to participation from these brain regions in addition to the normally recruited hippocampal activity. (noldus.com)
  • Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
  • Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
  • In mice and rats, females require mating stimulation for the maintenance of pregnancy. (nature.com)
  • The production of female mice with pseudopregnancy induced using sonic vibration was as efficient as rats. (nature.com)
  • The L-arginine doses used in rats did not cause pancreatitis in mice. (pancreapedia.org)
  • In this Methods entry, we describe protocols for the induction of L-arginine induced acute pancreatitis in rats and mice. (pancreapedia.org)
  • This important part of their business includes research animal models such as inbred, outbred, disease and immunodeficiency models, including mice, rats, hamsters, guinea pigs and rabbits to name a few examples. (citeab.com)
  • C57BL/6J is an inbred strain, commonly used as a genetic background when genetically modified mice are utilised as models for human disease. (citeab.com)
  • The complex regulation of Na v s, together with the anatomical rostral shift of the DRG harboring injured fibers in C57BL/6 J mice, emphasize that caution is necessary and preliminary anatomical experiments should be carried out for gene and protein expression studies after SNI in mouse strains. (biomedcentral.com)
  • In addition, MHC and Vra4 congenic strains on these backgrounds were studied to give information on MHC and non-MHC gene contribution. (nih.gov)
  • This suggestion was confirmed by the detection of significant difference in blood pressure between SHR and SHR.1N congenic strains. (mcw.edu)
  • Cervical thymuses were detected in 12-21% of rats from these inbred and congenic strains. (shengsci.com)
  • To prove the existence of an epistatic interaction we have analyzed congenic strains for chromosome 1 and 10 carrying high blood pressure QTL alleles from the spontaneously hypertensive rat on a normotensive background of the Wistar-Kyoto (WKY) rat. (mcw.edu)
  • This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj. (mcw.edu)
  • The LEXF: a new set of rat recombinant inbred strains between LE/Stm and F344. (mcw.edu)
  • Rats, Inbred F344. (bvsalud.org)
  • Genetic contributions were assessed using three strains of male rats with different genetic backgrounds [Fischer-344 (F344), Sprague-Dawley (SD), Brown-Norway (BN)] maintained on a standard or high fat (HF) diet for 24 wk. (cdc.gov)
  • Generally, the exposome components of diet and WF exposure had the greater influence on the parameters measured compared to the changes associated with rat strain except for the body weight changes observed with the HF diet that were more pronounced in the inbred F344 and BN strains. (cdc.gov)
  • An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains. (mcw.edu)
  • Resistant to experimental allergic encephalomyelitis and the induction of autoimmune thyroiditis. (ozgene.com)
  • Control Sprague-Dawley (SD) rats showed consistent alterations in mRNAs that are modulated by GC, such as type II GC receptor (GR) and metallothionein-1 (MT-1). (elsevierpure.com)
  • Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)
  • Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
  • Genome scan for trabecular bone density, from a cross between strains C57BL/6J and C3H. (jax.org)
  • 1987. The influence of physical activity in 1 ,2dimethylhydrazine induced colon carcinogenesis in the rat. (cdc.gov)
  • 2007. Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. . (oregonstate.edu)
  • For example, in livestock breeding, breeders may use inbreeding when trying to establish a new and desirable trait in the stock and for producing distinct families within a breed, but will need to watch for undesirable characteristics in offspring, which can then be eliminated through further selective breeding or culling. (wikipedia.org)
  • Inbreeding also helps to ascertain the type of gene action affecting a trait. (wikipedia.org)
  • Such differences in emotionality responses in the 10th generation of selected rats further indicate a possible use of this model to study correlations between trait anxiety and defen- sive reactions. (bvsalud.org)
  • Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. (mcw.edu)
  • Natural infections in other Equidae, transmitted brain homogenates from infected ruminants, rabbits, cats, and ostriches have also horses to experimental animals. (cdc.gov)
  • A lesion to the commonly known location of memory function, the hippocampus [5], causes significant deficits in performance in either the C57 strain or the DBA strain of mouse. (noldus.com)
  • The MPDt systematically characterizes biochemical and behavioral phenotypes of 40 commonly used and genetically diverse inbred mouse strains. (jax.org)
  • The mode of blood pressure inheritance and some genetic markers of spontaneous hypertension were evaluated in a new set of recombinant inbred (RI) strains obtained by crossing of normotensive (BN.lx) and hypertensive (SHR) progenitor strains. (mcw.edu)
  • Blood pressure values of RI strains were continuously distributed between both progenitor strains, although normotensive strains slightly prevailed. (mcw.edu)
  • The present study assessed the effect of prolonged betamethasone use in ligature-induced periodontitis in adult Fischer-344 rats. (bvsalud.org)
  • Inbred Fischer rats have greater HPA activation. (bvsalud.org)
  • Inbred Fischer rats produce greater amounts of the abovementioned substances, which has a direct effect on the nervous, connective, and epithelial tissues of the periodontium, facilitating the progression of ligatureinduced periodontitis 7-9 . (bvsalud.org)
  • Majority of rodents are bred under strictly inbred conditions. (org.in)
  • The avoidance of expression of such deleterious recessive alleles caused by inbreeding, via inbreeding avoidance mechanisms, is the main selective reason for outcrossing. (wikipedia.org)
  • Conversely, we postulate that the deficit in escape avoidance behavior exhibited by the LH strain may be associated with an alteration in GC-mediated gene expression in the brain. (elsevierpure.com)
  • The Experimental Animal Facility is located in an exclusive and specially designed building with over 10,000 sq.ft area spread over two floors. (org.in)
  • The main activity of Experimental Animal facility (EAF) is to bread, maintain and supply quality animals to n-house researchers, as per the sanctions from Institutional Animal ethics Committee (IAEC). (org.in)
  • All activities of the Experimental Animal Facility are carried out as per the standard Operating Procedures (SOPs). (org.in)
  • Animal Resource Centre (ARC), Western Australia received stock strain from Murdoch University, Perth, Australia as F12 (1981). (ozgene.com)
  • The closed Dongtinghu population of Microtus fortis (S: DTMF) cultivated by Shanghai Laboratory Animal Research Center was recognized as a Chinese laboratory animal resource by the Experimental Animal Resources and Evaluation Working Committee of the Chinese Association for Laboratory Animal Sciences in 2021. (slarc.org.cn)
  • This paper reviews the development of experimental animal management in Shanghai in the past ten years, reflects the evolution of national experimental animal management in recent years, points out the weak links in the development process, and puts forward suggestions for the innovation and development of experimental animal work. (slarc.org.cn)
  • Embryo transfer (ET) is an essential reproductive technology for the production of new animal strains and maintenance of genetic resources. (nature.com)
  • When the use of laboratory animal is obligatory, the most appropriate specie, breed, and strain with the closest homology to humans must be chosen. (ommegaonline.org)
  • The weekly sampling schedule is devised such a way that every 12 weeks representative animal from all the strains are covered under the conventional microbiology testing. (actrec.gov.in)
  • Different animal models of experimental acute pancreatitis induced by caerulein, choline deficient ethionine supplemented (CDE) diet, or sodium taurocholate have been developed. (pancreapedia.org)
  • Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)
  • Effect of diet and occupational exposure in different rat strains on serum biomarkers and peripheral blood mononuclear cell telomere length: development of an animal model to examine the exposome. (cdc.gov)
  • The goal was to develop an experimental model of the exposome by collecting biological samples during critical life stages of an exposed animal that are applicable to worker populations. (cdc.gov)
  • Offspring of biologically related persons are subject to the possible effects of inbreeding, such as congenital birth defects. (wikipedia.org)
  • For instance, using a rat model of depression known as congenital helplessness (cLH), researchers have shown that rats with depression-like symptomatology perform poorly in this task [6]. (noldus.com)
  • The increased role of QTL mapping and favored status of the inbred mouse in that role, are due to the improvement and development of genetic research tools (many of them pioneered by The Jackson Laboratory) to manipulate the mouse genome. (jax.org)
  • It was the first mouse strain to have its genome sequenced, back in 2003. (citeab.com)
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • Shimada S, Abais-Battad JM, Alsheikh AJ, Yang C, Stumpf M, Kurth T, Mattson DL , Cowley, AW Jr. Renal perfusion pressure determines infiltration of leukocytes in the kidney of rats with angiotensin II induced hypertension. (augusta.edu)
  • Splenocyte transfer exacerbates salt-sensitive hypertension in rats. (augusta.edu)
  • Using the inbred mouse as a model organism, QTL mapping has become a very important tool for finding the genes that regulate complex human diseases, including atherosclerosis, diabetes, obesity, asthma and hypertension. (jax.org)
  • This phenomenon was first revealed between laboratory rat and human hypertension QTL. (jax.org)
  • She and co-researchers found significant concordance among mouse, human and rat hypertension QTL, 4 between mouse and human HDL cholesterol QTL, 6 between rat and human kidney disease QTL, 7 between mouse and human atherosclerosis QTL, 8 and among various species for osteoporosis, inflammatory bowel disease, type II diabetes and asthma QTL. (jax.org)
  • We have used inbred and congenic rat strains in F(2) segregation studies to discover epistasis in a polygenic model of hypertension. (mcw.edu)
  • Hypertension-Associated Genes in the Mesenteric Artery of Three Spontaneously Hypertensive Rat Substrains Identified Using a DNA Array Method. (kyoto-u.ac.jp)
  • Most QTL have been mapped in model organisms such as the mouse and the rat. (jax.org)
  • This study was designed to determine whether tissue engineering could be used to reduce ventricular remodeling in a rat model of non-transmural, non-ST-elevation myocardial infarction. (pharmaceuticalintelligence.com)
  • Based upon this observation, Tani et al (27) reported an L-arginine induced rat model of necrotizing acute pancreatitis. (pancreapedia.org)
  • Since these observations, the model of L-arginine induced acute pancreatitis in rat has been used in different laboratories. (pancreapedia.org)
  • Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)
  • even Na v 1.3, known to be upregulated in rat neuropathic pain models, was lower in the SNI mouse model. (biomedcentral.com)
  • The L5 spinal nerve ligation (SNL) is an experimental neuropathic pain model which displays a clear separation between injured and non-injured cell bodies [ 31 ]. (biomedcentral.com)
  • These studies were designed to determine if the acute alcohol-induced decreases in luteinizing hormone (LH) seen in previous studies using rats could be due to an inhibitory effect of ethanol (ETOH) on hypothalamic LHRH release. (tamu.edu)
  • The experimental animals without clinical disorders were selected regardless of sex. (go.jp)
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
  • however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
  • In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)
  • Listing of the strains of these animals can be viewed by clicking here- "Strains" . (actrec.gov.in)
  • 20 mg/m3 x 3 hr/d x 4 d/wk x 5 wk) or filtered air until wk 12 at which time some animals from each strain were euthanized. (cdc.gov)
  • Finally, in terms of outcome, the EAE susceptible DA strain displayed a significantly smaller resulting lesion volume than the resistant PVG-RT1(av1) strain. (nih.gov)
  • Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits. (mcw.edu)
  • however, because the increased proportion of deleterious homozygotes exposes the allele to natural selection, in the long run its frequency decreases more rapidly in inbred populations. (wikipedia.org)
  • Strain is transferred to Ozgene ARC in 2023. (ozgene.com)
  • We have investigated gelsolin modulation in rat aortic SMC by immunohistochemistry, Western blotting and Northern hybridization using three models which are known to show modulation of actin isoform expression: development, aortic intimal thickening after experimental endothelial injury, and growth in culture. (unige.ch)
  • Nature Communications 7:10464 [Best reference on the BXD family of strains and the wide range of phenotypes that have been generated over the past 40 years. (genenetwork.org)
  • Inbreeding is a technique used in selective breeding. (wikipedia.org)
  • The advantages of inbreeding may be the result of a tendency to preserve the structures of alleles interacting at different loci that have been adapted together by a common selective history. (wikipedia.org)
  • A strong genetic component underlies the development of learned helplessness as shown by the emergence of a line of highly vulnerable rats (LH strain) through selective inbreeding. (elsevierpure.com)
  • However, under the same experimental conditions, LH rats showed more selective hormone induced changes since GC had no effect on hypothalamic and hippocampal GR mRNA whereas a significant increase in MT-1 mRNA was observed. (elsevierpure.com)
  • Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats. (kyoto-u.ac.jp)
  • The present results provide evidence that direct infusion of MPP+ into the medial forebrain bundle of the rat can lead to a complete loss of dopamine neurons in the pars compacta of the substantia nigra with ensuing behavioural, neurochemical and biochemical changes characteristic of the lesion. (unboundmedicine.com)
  • The data support the hypothesis that the increased vulnerability exhibited by LH rats is correlated with alterations in GC-mediated gene expression in limbic structures. (elsevierpure.com)
  • Inbreeding can significantly influence gene expression which can prevent inbreeding depression. (wikipedia.org)
  • The PVG-RT1(av1) strain had significantly more T-cell influx than both DA and PVG, suggesting regulation both by MHC and non-MHC genes. (nih.gov)
  • Under our experimental conditions, both GR and MT-1 mRNA are significantly increased in the hippocampus of hormone-treated SD rats. (elsevierpure.com)
  • Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats. (kyoto-u.ac.jp)
  • Inbreeding results in homozygosity, which can increase the chances of offspring being affected by recessive traits. (wikipedia.org)
  • Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of manpower in the field of toxicology. (inchem.org)
  • Interestingly, researchers have noted significant differences in performance in the radial arm maze between different strains of mouse, specifically regarding which areas of the brain are used in completing the task. (noldus.com)
  • SAMPs (senescence-accelerated mouse prones) are inbred mouse lines showing accelerated aging. (biomedcentral.com)
  • Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)
  • Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)
  • The Mouse Phenome Database (MPD) is particularly useful for helping investigators select the most appropriate strains to cross in a QTL mapping project. (jax.org)
  • The rat Downunder (Du) coat color mutation is associated with eye anomalies and embryonic lethality and maps to a 3.9-Mb region on chromosome 3. (kyoto-u.ac.jp)
  • Effects of ethanol on hypothalamic luteinizing hormone-releasing hormone (LHRH) in the male rat. (tamu.edu)
  • To test this hypothesis, basal extracellular concentrations of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens as well as the effects of repeated ethanol pretreatment on the basal release of these transmitters were examined in alcohol-preferring (P), alcohol-nonpreferring (NP), and genetically heterogeneous Wistar rats. (aspetjournals.org)
  • 1-Methyl-4-phenylpyridinium ion (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, has been chronically infused (10 micrograms/24 h for 7 days) via osmotic minipumps into the left median forebrain bundle of the rat in order to determine whether it can induce permanent damage to the nigrostriatal dopamine system. (unboundmedicine.com)
  • P and NP rats also show distinct differences with regard to brain DA transmission. (aspetjournals.org)
  • There are currently nine independent strains from SAMP1 to SAMP11, which show distinct features of the aging phenomenon. (biomedcentral.com)
  • Inbreeding can result in purging of deleterious alleles from a population through purifying selection. (wikipedia.org)
  • Inbreeding is also used to reveal deleterious recessive alleles, which can then be eliminated through assortative breeding or through culling. (wikipedia.org)
  • When deleterious recessive alleles are unmasked due to the increased homozygosity generated by inbreeding, this can cause inbreeding depression. (wikipedia.org)
  • Additionally, a double congenic strain was developed with both chromosome 1 and 10 high blood pressure QTL alleles on the WKY background. (mcw.edu)
  • In extreme cases, this usually leads to at least temporarily decreased biological fitness of a population (called inbreeding depression), which is its ability to survive and reproduce. (wikipedia.org)
  • We developed a method, named Easy-ET, to induce pseudopregnancy in female rats by artificial stimulation using sonic vibration instead of mating with vasectomized males. (nature.com)
  • Male and female rats from the 10th generation were used to assess anxiety-like reactions in the elevated plus maze (EPM), depressive-like behavior in the forced swim test (FST), and aversive memory in the contextual fear conditioning paradigm. (bvsalud.org)
  • Thus, effects of multiple injections of ETOH on the relative amount of immunoreactive LHRH fibers in the hypothalamus and median eminence (ME) of castrate and intact male rats were determined immunocytochemically. (tamu.edu)
  • Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. (kyoto-u.ac.jp)
  • 2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
  • Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)