• rats
  • Nerve growth factor (NGF) infusion significantly reduces spatial recent memory deficits in aged rats, an effect that has great relevance to the treatment of memory impairments characteristic of patients with Alzheimer's disease. (jneurosci.org)
  • Although NGF did not affect overall sensorimotor skills during infusion in either age group, sensorimotor skills were significantly improved both 2 and 4 weeks after discontinuation of infusion in 22-month-old rats. (jneurosci.org)
  • However, published studies on the effects of NGF in aged rats have tested memory only during NGF administration, and therefore, it is unknown whether NGF-induced improvements are transient or persistent. (jneurosci.org)
  • The full relationship of GDF11 to aging-and any possible differences in the action of GDF11 in mice, rats, and humans-is unclear and continues to be researched. (wikipedia.org)
  • One limitation of the experiments is that outbred rats cannot be used because it can lead to a significant loss of pairs due to intoxication of the blood supply from a dissimilar rat. (wikipedia.org)
  • The rats were killed with ether and weighed at the conclusion of the experiment and the amount of fat in each animal was quantified. (wikipedia.org)
  • diseases
  • The effects of systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) on the risk of cardiovascular diseases (CVD) have been established in epidemiological studies, but consistent estimates of effect sizes by age and sex are not available. (plos.org)
  • Although the major metabolic risk factors for these diseases have been characterized in epidemiological studies, consistent measurements of their effects by age, sex and region are not available. (plos.org)
  • That's why aging-related diseases tend to occur in very specific organs like the brain(Alzheimer's, Parkinson's), blood vessels(Cardiovascular disease), pancreas(Tye 2 diabetes), and bones(Osteoporosis). (hackyourgut.com)
  • Of course many of these diseases can be kept at bay with lifestyle factors, but that's because lifestyle affects time in the biological sense by affecting cellular replication. (hackyourgut.com)
  • 2 Consequently, effective strategies are needed to prevent age-related diseases and to improve the quality of longer lives. (pubmedcentralcanada.ca)
  • 7 , 8 Capitalizing on this perspective, this study tested the contribution of adverse psychosocial experiences in childhood to 3 adult conditions that are known to predict age-related diseases: depression, inflammation, and the clustering of metabolic risk markers, hereinafter referred to as age-related-disease risks. (pubmedcentralcanada.ca)
  • In later years, the free radical theory was expanded to include not only aging per se, but also age-related diseases. (wikipedia.org)
  • Alzheimer's
  • These findings demonstrate that the beneficial effects of NGF on spatial recent memory can persist for up to 1 month after discontinuation of infusion and suggest that NGF can be used intermittently for the treatment of age-associated memory dysfunction and Alzheimer's disease. (jneurosci.org)
  • Because simple synaptic interventions to stimulate remaining cholinergic neurons in Alzheimer's brains have met with limited success ( Thal, 1994 ), treatments with compounds such as trophic factors, which promote the growth and survival of specific neuronal populations, recently have become promising alternatives. (jneurosci.org)
  • Research with women and men undertaking HRT has shown that taking sex hormones that are biologically identical to human hormones delays the onset, decreases the incidence of, and can reverse the course of age related illnesses such as heart disease, Alzheimer's disease, osteoporosis, and some types of cancer. (wikipedia.org)
  • differences
  • Still, their results concerning the effect of maternal age do not translate to humans but illustrate the kind of ways in which differences between genetically identical individuals might arise. (eurekalert.org)
  • These age differences may speak to the age differences in incidence of anorexia nervosa. (wlu.ca)
  • A study looking at age differences in which children can remember episodic memories (e.g. their first day of school, attending a friend's birthday party), elementary and preschool students were questioned about delay interval in past experiences and found significant differences in what children recall. (wikipedia.org)
  • effects
  • The complex interactive effects of environmental and biological factors must be taken into account for studies of vector competence and epidemiology, especially when laboratory studies are used to generalize to natural transmission dynamics where the extent of variation is largely unknown. (ajtmh.org)
  • The authors are fully grateful to the anonymous users for publicly providing its data, and to Mr. Lucio Amelio, student of the Faculty of Medicine and Surgery, University of Bologna, Italy, for the helpful discussions about the biological effects of the human factors. (springer.com)
  • We pooled all data to estimate relative risks (RRs) for each risk factor and examined effect modification by age or other factors, using random effects models. (plos.org)
  • For all risk factors, proportional effects declined with age, were generally consistent by sex, and differed by region in only a few age groups for certain risk factor-disease pairs. (plos.org)
  • Our results provide robust, comparable and precise estimates of the effects of major metabolic risk factors on CVD and diabetes by age group. (plos.org)
  • Understanding the effects of metabolic risk factors on CVD mortality and burden of disease are important inputs for policy and priority setting related to disease prevention. (plos.org)
  • Population-based risk assessment requires data on population exposure to risk factors and on the magnitude of their effects on different disease outcomes , . (plos.org)
  • These experiments have been repeatedly confirmed since, and the effects are pretty powerful. (hackyourgut.com)
  • You may have heard of the age rejuvenating effects of young blood and that silicon valley billionaire venture capitalists are champing at the bit to get their hands on the blood of young people. (hackyourgut.com)
  • Thus, age seems to be an important factor in wheel running effects on feeding and weight. (wlu.ca)
  • The effects of adverse childhood experiences on age-related-disease risks in adulthood were nonredundant, cumulative, and independent of the influence of established developmental and concurrent risk factors. (pubmedcentralcanada.ca)
  • Adverse effects depend on two main factors: i) routes of exposure (oral, inhalation, or dermal) and ii) dose (duration and concentration of exposure). (wikipedia.org)
  • Because of the randomized controlled design, the study was able to isolate the effects of insurance from confounding factors such as the initial health status of participants. (wikipedia.org)
  • Models and experiments test or determine the effects that the independent variables have on the dependent variables. (wikipedia.org)
  • These effects suggest an "anti-hypertrophic effect", aiding in the reversal process of age-related hypertrophy, on the cardiomyocytes. (wikipedia.org)
  • These previous findings have been disputed since another publication has demonstrated the contrary, concluding that GDF11 increases with age and has deleterious effects on skeletal muscle regeneration, being a pro-aging factor, with very high levels in some aged individuals. (wikipedia.org)
  • The effects are mediated by the insulin-like growth factor (IGF) system, which is upregulated in response to BST or rBST administration in well-fed cows. (wikipedia.org)
  • Theory
  • An Experiment with Time is a book by the British soldier, aeronautical engineer and philosopher J. W. Dunne (1875-1949) on the subjects of precognitive dreams and a theory of time which he later called Serialism. (wikipedia.org)
  • That in theory cuts down on some of the forms of stochastic damage that lead to degenerative aging. (fightaging.org)
  • Rather than seeing aging as a loss of functionality as we get older, this theory defines aging as any change in an organism over time, as evidenced by the fact that if all chemical reactions in the body were stopped, no change, and thus no aging, would occur. (wikipedia.org)
  • Evidence supporting this theory comes from disease studies showing that women who reach menopause later have less heart disease and stroke, less dementia, and less osteoporosis, supporting the theory that the longer the HPG axis is in balance, the less likely one is to develop age-related diseases. (wikipedia.org)
  • Depending on the context, an independent variable is sometimes called a "predictor variable", "regressor", "controlled variable", "manipulated variable", "explanatory variable", "exposure variable" (see reliability theory), "risk factor" (see medical statistics), "feature" (in machine learning and pattern recognition) or "input variable. (wikipedia.org)
  • The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time. (wikipedia.org)
  • Denham Harman first proposed the free radical theory of aging in the 1950s, and in the 1970s extended the idea to implicate mitochondrial production of reactive oxygen species. (wikipedia.org)
  • The free radical theory of aging was conceived by Denham Harman in the 1950s, when prevailing scientific opinion held that free radicals were too unstable to exist in biological systems. (wikipedia.org)
  • In 1972, Harman modified his original theory to what became known as the mitochondrial theory of aging. (wikipedia.org)
  • This mitochondrial theory has been more widely accepted that it could play a major role in contributing to the aging process. (wikipedia.org)
  • Since Harman first proposed the free radical theory of aging, there have been continual modifications and extensions to his original theory. (wikipedia.org)
  • This experiment was to support the theory that damage to the hypothalamus, particularly the ventromedial hypothalamus, leads to obesity caused by the overconsumption of food. (wikipedia.org)
  • humans
  • Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is encoded by the GDF11 gene. (wikipedia.org)
  • adult
  • The effect of larval rearing conditions and adult age on the susceptibility of Culex tritaeniorhynchus to infection with West Nile virus. (ajtmh.org)
  • Science shows that with age we lose synaptic connections, but the adult brain also continues to create neurons in the regions dedicated to learning. (conversationagent.com)
  • Seven in 10 girls ages 13 to 16 (71 percent), for instance, watch what we called in this survey 'adult dramas' - shows such as 'CSI' and 'Law and Order' - compared with just 57 percent of boys in that age group. (washingtontimes.com)
  • Interventions targeting modifiable risk factors (eg, smoking, inactivity, and poor diet) in adult life have only limited efficacy in preventing age-related disease. (pubmedcentralcanada.ca)
  • The size of a newborn brain is approximately 400g and continues to grow to 1100g at the age of three, which is close to the size of an adult brain (1300-1400g). (wikipedia.org)
  • dysfunction
  • When the HPG axis becomes unbalanced, cellular growth and development is dysregulated, and cell death and dysfunction can occur, both of which can initiate senescence, the accumulated damage to cells, tissues, and organs that occurs with the passage of time and that is associated with functional loss during aging. (wikipedia.org)
  • biological factors
  • Complex interactions between environmental and biological factors influence the susceptibility of Culex pipiens quinquefasciatus to St. Louis encephalitis virus and could affect the epidemiology of virus transmission. (ajtmh.org)
  • Enrico Ferri, a student of Lombroso, believed social as well as biological factors played a role, and believed criminals should not be held responsible when factors causing their criminality were beyond their control. (wikipedia.org)
  • males
  • The vast majority (85 percent) of males ages 13 to 16 say they watch 'youth comedies,' such as 'Malcolm in the Middle' and '8 Simple Rules for Dating My Teenage Daughter. (washingtontimes.com)
  • decreases
  • The volume of white matter starts its linear increase from age four to 20, but cortical gray matter is decreases in the parietal, occipital and temporal regions starting from age four, continually changing until after age 12. (wikipedia.org)
  • disease
  • Help to end age-related disease. (fightaging.org)
  • To understand why children exposed to adverse psychosocial experiences are at elevated risk for age-related disease, such as cardiovascular disease, by testing whether adverse childhood experiences predict enduring abnormalities in stress-sensitive biological systems, namely, the nervous, immune, and endocrine/metabolic systems. (pubmedcentralcanada.ca)
  • Children exposed to adverse psychosocial experiences have enduring emotional, immune, and metabolic abnormalities that contribute to explaining their elevated risk for age-related disease. (pubmedcentralcanada.ca)
  • 1 As the population ages, the public health impact of age-related conditions, such as cardiovascular disease, type 2 diabetes mellitus, and dementia, increases. (pubmedcentralcanada.ca)
  • 3 , 4 Because of the increasing recognition that preventable risk exposures in early life may contribute to pathophysiological processes leading to age-related disease, 5 , 6 the science of aging has turned to a life-course perspective. (pubmedcentralcanada.ca)
  • Endocrinology of reproduction The Laboratory of Aging, Endocrinology and Disease Bowen RL, Atwood CS (2011). (wikipedia.org)
  • increases
  • Research in the Journal of Law and Human Behaviour found that the ability for child eyewitnesses to accurately recall details of events increases with age, as did the ability to answer specific questions, identify the confederate and resist suggestion. (wikipedia.org)
  • Thus
  • Thus, a situation allowing for a randomized experiment occurred, with a control group of individuals not selected by the lottery and a treatment group of individuals selected by the lottery and thus eligible to apply for Medicaid. (wikipedia.org)
  • species
  • In both species, mutations in targets of TOR, such as ribosomal S6 kinase (an enzyme involved in protein translation), several translation-initiation factors and multiple ribosomal proteins, increase lifespan8. (natap.org)
  • Factors that influence chemical toxicity include the dosage (and whether it is acute or chronic), route of exposure, species, age, sex, and environment. (wikipedia.org)
  • stem
  • GDF11 activates the TGF-β pathway in cardiomyocytes derived from pluripotent hematopoietic stem cells and suppresses the phosphorylation of Forkhead (FOX proteins) transcription factors. (wikipedia.org)
  • growth
  • Collected data including demographic factors and response time is subjected to association rule mining, using the FP-Growth algorithm for extracting the association rules. (springer.com)
  • GDF11 belongs to the transforming growth factor beta superfamily that controls anterior-posterior patterning by regulating the expression of Hox genes. (wikipedia.org)
  • organ
  • Studies completed more than 40 years ago identified that what's in your blood regulates organ function to a large extent, primarily by regulating how organs age. (hackyourgut.com)
  • known
  • But over the long haul all that really matters is progress in medicine: building new classes of therapy to repair and reverse the known root causes of aging. (fightaging.org)
  • neuronal
  • implicates this neuronal population in age-associated memory decline and provides a target for pharmacological treatment of memory loss. (jneurosci.org)
  • In particular, these studies indicate the importance of circulating factors in regulating the maintenance of neuronal (Villeda et al. (wikipedia.org)
  • effect
  • Effect estimates in prior global comparative risk assessment (CRA) analyses of metabolic risk factors including systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) were based on the Asia Pacific Cohort Studies Collaboration (APCSC) and selected other cohort pooling studies - . (plos.org)
  • environmental factors
  • Here, we connect leaf-level full range spectral data (400-2400 nm) of leaves to the hierarchical organization of plant diversity within the oak genus ( Quercus ) using field and greenhouse experiments in which environmental factors and plant age are controlled. (mdpi.com)
  • Culture and environmental factors may discourage or prevent much of it, but we're wired to keep learning. (conversationagent.com)
  • levels
  • Sociological positivism suggests societal factors such as poverty, membership of subcultures, or low levels of education predispose people to crime. (wikipedia.org)
  • Reliability
  • This method ages all IC's building blocks to allow relevant failure modes to be triggered and implemented in a short reliability experiment. (wikipedia.org)
  • Reliability engineers must understand the power distribution on the chip and align the aging so that it is similar for all elements of an IC. (wikipedia.org)
  • Reliability engineering aims to age all I/Os in the same way as the other IC elements. (wikipedia.org)
  • influence
  • Experiments comparing the proposed method with the earlier studies of the CAPTCHA usability show the novelty of the method for the understanding of usability of CAPTCHA interfaces, which is based on the cognitive factors that influence the response time. (springer.com)
  • Factors that influence chemical toxicity: Dosage Both large single exposures (acute) and continuous small exposures (chronic) are studied. (wikipedia.org)
  • studies
  • After our literature search methodology, we discuss the main theoretical standpoints of the studies and the methods used, before summarizing the work across 16 categories of proposed causative factors. (royalsocietypublishing.org)
  • individuals
  • Across all risk factors, an average of 123 cohorts provided data on 1.4 million individuals and 52,000 CVD events. (plos.org)
  • While it's true that over time we age, time isn't constant across individuals. (hackyourgut.com)
  • study
  • The aim is to study the cognitive factors influencing the Internet users in finding a solution to these four CAPTCHA types. (springer.com)
  • Adolphe Quetelet used data and statistical analysis to study the relationship between crime and sociological factors. (wikipedia.org)
  • The control and study groups were statistically similar in many dimensions such as age and ethnicity. (wikipedia.org)
  • show
  • We also show that the probability of a body or leg infection interacted in complex ways between colonies, ages, EITs, and doses. (ajtmh.org)
  • They show the dependence of the response time on the co-occurrence of the demographic factors. (springer.com)
  • test
  • Experiment two was a dialysis test showing positive and negative reactions for specific substances. (freeonlineresearchpapers.com)
  • Experiment two was a dialysis test, procedures are the following, One: Tie off one end of a piece of dialysis tubing that has been soaking in distilled water (Couch and Burger 2004). (freeonlineresearchpapers.com)
  • The digital toggling factor (DTF) represents the number of transistors that change their state during the stress test, relative to the total number of gates in the digital portion of the IC. (wikipedia.org)
  • However
  • There is, however, no systematic evaluation and comparison of these sources for new global and national risk assessments, including potential heterogeneity by age, sex, or region. (plos.org)
  • Although our ancestors revered the wisdom that came with age, an open question in modern times is how we can keep our intellectual engine going well past our prime, however we define it. (conversationagent.com)
  • However, external factors are important to consider when deciding on which type of team to compose for completing any certain objective. (wikipedia.org)
  • years
  • The main aim of the HTOL is to age the device such that a short experiment will allow the lifetime of the IC to be predicted (e.g. 1,000 HTOL hours shall predict a minimum of "X" years of operation). (wikipedia.org)
  • gender
  • Furthermore, homogeneous organizational teams in terms of age, race and gender are hypothesized to report less conflict as compared to heterogeneous organizational teams. (wikipedia.org)
  • causes
  • Noting that radiation causes "mutation, cancer and aging", Harman argued that oxygen free radicals produced during normal respiration would cause cumulative damage which would eventually lead to organismal loss of functionality, and ultimately death. (wikipedia.org)