• This sequence is associated with proteins that have a short intracellular half-life. (wikipedia.org)
  • Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. (bdbiosciences.com)
  • In addition, we show that position-weighted matrices (PWM) compiled from SPOT assays can be used for binding motif screening in potential binding partners and present cases where motifs are either conserved or lost among homologous SH3 interacting proteins. (upf.edu)
  • In contrast to the signal sequences of exported proteins, the bacterial SRP signal sequences are more hydrophobic and are mostly "uncleaved signal sequences" present in membrane proteins that remain in the final protein-chain as transmembrane anchor sequences. (nature.com)
  • The increase of the hydrophobicity in the signal sequences of E. coli presecretory proteins makes it possible to re-route the SecA dependent preproteins into the SRP targeting cycle 17 . (nature.com)
  • Architectural proteins, although minimally conserved in terms of structure and sequence among kingdoms, act upon DNA using conserved mechanisms (Luijsterburg et al. (universiteitleiden.nl)
  • It is remodeled actively in eukaryotes by motor enzymes that can move or displace nucleosomes, in addition to remodeling mechanisms more ubiquitous in bacteria and archaea that are based on the interplay between multiple architectural proteins. (universiteitleiden.nl)
  • IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence. (lookformedical.com)
  • Known as "destabilising motifs", these sequences attract the attention of a group of proteins called Ccr4-Not. (elifesciences.org)
  • The interaction between rapidly evolving centromere sequences and conserved kinetochore machinery appears to be mediated by centromere-binding proteins. (shengsci.com)
  • A recent theory proposes that the independent evolution of centromere-binding proteins in isolated populations may be a universal cause of speciation among eukaryotes. (shengsci.com)
  • Although most of the work was done on budding yeast, because of the relative ease of genetic and biochemical studies in this organism, it is safe to assume that most of the observations also apply to higher eukaryotes, as nearly all the proteins involved in ribosome assembly are conserved between yeast and human. (biomedcentral.com)
  • Furthermore, SNPs mining was carried out for the ABC proteins sequences, revealing pivotal genomic information. (biomedcentral.com)
  • It is possible to divide ABC transporters into the following two groups: those present only in prokaryotes and which require substrate-binding proteins for transport, and those found only in eukaryotes and that bind directly to the substrate from the interior of the cell [ 15 ]. (biomedcentral.com)
  • The detection of remotely conserved proteins oftentimes involves sophisticated manual intervention that is difficult to automate. (biomedcentral.com)
  • Though the VCP and their binding partners are conserved in eukaryotes, the sequences that mediate their interactions are significantly different across organisms showing that evolution has established more than one way for these proteins to interact. (eu.org)
  • In addition to the absence of significant hits observed by BLAST analysis, no significant sequence homology was observed with known rhabdovirus proteins in pairwise alignments. (cdc.gov)
  • The amino acid sequence of the G protein consisted of 669 aa and contained an N terminal signal peptide (1-MYHLIVLLVMLGQRAVA-17), a noncytoplasmic domain (aa 18-646), a transmembrane domain (647-ITAILMPLLSLAVVVGIIMCC-667), and a cytoplasmic tail of 2 aa, similar to other rhabdovirus G proteins as predicted by using Phobius and TMHMM ( http://www.cbs.dtu.dk/services/TMHMM ) ( 6 , 7 ). (cdc.gov)
  • Despite an evolutionary distance of at least 1.5 to 2.0 billion years, the deduced Gau proteins share some conserved amino acid signatures and structure, which suggests a possible conserved function. (biomedcentral.com)
  • In humans there exist five isoforms of the B56 type regulatory subunit and they bind to their interacting proteins through a conserved LxxIxE motif. (eu.org)
  • The motif is conserved in essential proteins throughout the eukaryotic domain of life and also in human viruses, suggesting that the motifs are required for basic cellular function. (eu.org)
  • Most of the B56 binding proteins contain a conserved motif LxxIxE which acts as a docking site for B56. (eu.org)
  • Certain G-quadraplexes appear to be evolutionarily conserved across mammalian species, suggesting they play common critical roles. (anti-agingfirewalls.com)
  • Through structural analysis, we identified an evolutionarily conserved acidic patch of Rad51. (woofahs.com)
  • 2018). The Rad51 paralogs Rad55-Rad57 are another group of evolutionarily conserved auxiliary factors. (woofahs.com)
  • There is a conserved HLR sequence motif. (embl.de)
  • This analysis revealed a striking example of binding motif divergence in a C. albicans Rvs167 paralog, which cannot be explained by overall SH3 sequence or interface residue divergence, and we validated this specificity change with a yeast two-hybrid (Y2H) assay. (upf.edu)
  • Within this sequence a Walker A motif is present at residues 30-38. (nature.com)
  • In this "SRP pathway", an open question is how a signal sequence is recognized since no consensus motif exists and is relevant for SRP binding. (nature.com)
  • The C-terminal domain contains the conserved PTP motif of the catalytic site, whereas the N-terminal domain, which shares no sequence similarity with other DSPs, contributes to substrate specificity, and lacks catalytic activity. (rcsb.org)
  • Our analyses revealed a deeply conserved cis-acting element, termed the 'GYM motif' (paired G, paired pyrimidine and mismatched C or A), near the cleavage site. (bvsalud.org)
  • The NBD is a highly conserved sequence that presents characteristic sites such as Q-look, the H-motif, and the LSGGQ-motif [ 14 , 15 ]. (biomedcentral.com)
  • Structural studies of Derlin1-VCP ( 5GLF ) and UFD1-VCP ( 5C1B ) complexes show that the motif is bound to three highly conserved binding pockets in VCPNc. (eu.org)
  • The motif binds to a well conserved and surface-exposed binding groove formed between the B56 HEAT repeats 3 and 4. (eu.org)
  • The motif is found throughout eukaryotes and and in some viruses, which emphasises the general mechanism of B56 binding and its pivotal role in many cellular functions. (eu.org)
  • The sequence information was used to identify putative paralogs, characterize salmon Kozak motifs, polyadenylation signal variation and to identify motifs likely to be involved in the regulation of particular genes. (biomedcentral.com)
  • There are many superfamilies of Znf motifs, varying in both sequence and structure. (embl.de)
  • Furthermore, no conserved motifs were detected in N, P, and M genes of RFFRV that are commonly observed in rhabdoviruses. (cdc.gov)
  • However, intergenic regions between all major ORFs contained relatively conserved motifs that could be transcription termination/polyadenylation sequences (A/U) CU 7 , similar to other rhabdoviruses ( 5 ). (cdc.gov)
  • PAS motifs appear in archaea, eubacteria and eukarya. (embl-heidelberg.de)
  • The results suggest that the roles for the two factors in DNA methylation maintenance pathways can be traced back to the last eukaryotic common ancestor and that the CDC7A-HELLS-DNMT axis shaped the evolutionary retention of DNA methylation in eukaryotes. (elifesciences.org)
  • Transcription in eukaryotes is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary RNA replica. (stemcelldaily.com)
  • A positionally conserved ORF has been found on the complementary strand of the cox1 genes of both eukaryotic mitochondria (protist, plant, fungal and animal) and alpha-proteobacteria. (biomedcentral.com)
  • This search has led to the observation of an unknown, positionally conserved open reading frame (ORF) on the complementary strand of eukaryotic cox1 genes. (biomedcentral.com)
  • There are two completely conserved residues (W and H) that may be functionally important. (embl.de)
  • Furthermore, it is suggested that the binding of SRP to the signal sequence is promoted by the presence of basic amino acid residues through electrostatic interactions 18 . (nature.com)
  • The second is a relatively poorly conserved leucine zipper region characterised by leucine in the last position of every seven amino acids, and hydrophobic residues at positions 3 and 4. (biomedcentral.com)
  • It is characterized by a short hydrophobic sequence stretch with two invariant Gly residues. (eu.org)
  • The CCHHC-type zinc finger contains five absolutely conserved cysteine and histidine residues (rather than the more usual four) with the sequence C-P-x-P-G-C-x-G-x-G-H-x(7)-H-R-x(4)-C. The second histidine has been shown to coordinate Zn(II) along with the three cysteines residues. (embl.de)
  • As such, our results are important for future studies aimed at unraveling complex specificity networks of peptide recognition domains in higher eukaryotes, including mammals. (upf.edu)
  • In eukaryotes, a polycistronic 35S pre-rRNA is transcribed in the nucleolus and cleaved into precursors (pre-rRNAs) of mature 18S and 5.8S rRNAs, as well as 25S or 28S rRNAs in yeast and higher eukaryotes, respectively [ 3 ]. (biomedcentral.com)
  • Pre-mRNA splicing is a nuclear process that is conserved across eukaryotes [ 1 ]. (ijbs.com)
  • Shortening or removal of mRNA poly(A) tails (deadenylation) represses gene expression in eukaryotes. (elifesciences.org)
  • We propose that codon usage differences encoded into mRNA sequences might be a conserved strategy in eukaryotes to regulate small RNA biogenesis and Argonaute targeting. (pasteur.fr)
  • Gene expression also relies on extensive C-to-U (and sometimes U-to-C) RNA editing, in which substitution of specific pyrimidines in the mRNA sequence restores phylogenetically conserved codons [ 8 ]. (biomedcentral.com)
  • Editing involves changing some nucleotides in the pre-mRNA to alter its sequence and function. (stemcelldaily.com)
  • We built a set T of flanking regions of genes with 1-3 introns from 21st and 22nd chromosomes extracted from GenBank to define positions having conserved properties, namely hydrophobicity, that are potentially essential for recognition by spliceosome. (ijbs.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • What Is the Size Distribution of snRNA Genes and Related Sequences in the Genome? (cshlpress.com)
  • The genome contains the fewest genes of any angiosperm mitochondrial genome sequenced to date, with intact copies of only 25 of the 41 protein genes inferred to be present in the common ancestor of angiosperms. (biomedcentral.com)
  • In addition, genes encoding 18S and, especially, 5S rRNA exhibit exceptional sequence divergence relative to other plants. (biomedcentral.com)
  • Unlike prokaryotes, eukaryotes do not have specific termination sequences on their genes. (stemcelldaily.com)
  • Transcription in eukaryotes is a complex and highly regulated process that ensures accurate and timely expression of genes. (stemcelldaily.com)
  • All SPOT readouts were hierarchically clustered and we observed that the organization of the SH3 specificity landscape in three distinct profile classes remains conserved across these four yeast species. (upf.edu)
  • We find that the fission yeast homologues of Tristetraprolin/TTP and Pumilio/Puf (Zfs1 and Puf3) interact with Ccr4-Not via multiple regions within low-complexity sequences, suggestive of a multipartite interface that extends beyond previously defined interactions. (elifesciences.org)
  • 2006). These factors are mostly conserved in the budding yeast despite the large evolutionary distance separating the two yeasts, although it should be 6-Bnz-cAMP sodium salt noted that this homolog of Swi5-Sfr1 (Mei5-Sae3) is only involved in 6-Bnz-cAMP sodium salt meiotic HR (San Filippo et al. (woofahs.com)
  • Using a two-color assay to simultaneously monitor poly(A) tail removal from different RNAs, we demonstrate that Puf3 can distinguish between RNAs of very similar sequence. (elifesciences.org)
  • Micro RNAs (MiRNAs) are endogenous, small RNA molecules that were identified in a wide range of eukaryotes. (usda.gov)
  • Background: MicroRNAs (miRNA) are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition. (usda.gov)
  • Here, we show that CSR-1 slicer activity is primarily involved in triggering the synthesis of small RNAs on the coding sequences of germline mRNAs and post-transcriptionally regulates a fraction of targets. (pasteur.fr)
  • RNA interference (RNAi) is a biological process conserved in most eukaryotes and characterized by the sequence-specific degradation of target RNA by complementary small RNAs (sRNAs) [ 1 ] . (encyclopedia.pub)
  • Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. (lookformedical.com)
  • SRP is universally conserved in its core region that consists of a ribonucleoprotein particle, the SRP RNA (4.5S RNA in E. coli ) and the protein component SRP54 (Ffh in E. coli for "fifty-four-homolog") that binds to the conserved RNA domain IV 4 . (nature.com)
  • Sequence variation in two regions of the mitochondrial ND1 gene, encompassing 710 base pairs, is described for 168 salmon from 11 rivers. (shengsci.com)
  • In this study, we report the first complete mitochondrial genome sequence from a member of this family, Silene latifolia . (biomedcentral.com)
  • The mitochondrial genomes of flowering plants exhibit a number of characteristics that distinguish them from the mitochondrial genomes of other eukaryotes [ 1 ]. (biomedcentral.com)
  • The mitochondrial gene content is highly variable across eukaryotes. (biomedcentral.com)
  • With the advent of fully sequenced genomes, the computational study of orthologous protein relationships in evolution, comparative genomics, but also for substantiating the evolutionary conservation of fundamental cellular processes increased exponentially. (biomedcentral.com)
  • A comparison of the nucleotide genetic relatedness for the newly emerged Mubende variant indicated that it was most closely related to the Nakisamata SUDV sequence from 2011, represented a likely new zoonotic spillover event, and exhibited an inter- and intra-outbreak substitution rate consistent with previous outbreaks. (cdc.gov)
  • Five major and 3 minor open reading frames (ORFs) were identified that had a genome organization similar to that of other rhabdoviruses ( Figure , panel A). No significant hits were obtained by BLAST analysis ( http://blast.ncbi.nlm.gov/Blast.cgi ) of N, P, M, and G nucleotide and amino acid sequences, which was reported previously for novel divergent rhabdoviruses ( 4 ). (cdc.gov)
  • Based on their nucleotide sequences, the 10 cDNAs were classified into four subfamilies. (huji.ac.il)
  • The overall similarity in the predicted secondary structure between analogous U2 and U12-type snRNAs suggests that the spliceosome rearrangements during catalysis are conserved between the two spliceosomes [ 3 - 4 ]. (ijbs.com)
  • The Mubende variant glycoprotein amino acid sequences exhibited 99.7% similarity altogether and a maximum of 96.1% glycoprotein similarity compared to historical SUDV strains from 1976. (cdc.gov)
  • The Mubende variant exhibited 96% amino acid similarity with historic SUDV sequences from the 1970s and a high degree of conservation throughout the outbreak, which was important for ongoing diagnostics and highly promising for future therapy development. (cdc.gov)
  • Programs like BLAST or the orthology search engine Inparanoid can be used to find orthologs when the similarity between two sequences is sufficiently high. (biomedcentral.com)
  • Based on relaxed sequence similarity searches, morFeus selects sequences based on the similarity of their alignments to the query, tests for orthology by iterative reciprocal BLAST searches and calculates a network score for the resulting network of orthologs that is a measure of orthology independent of the E-value. (biomedcentral.com)
  • Yet, reciprocal sequence similarity is thus far one of the main established methods for defining orthology computationally and is ubiquitously used on a small- as well as a large-scale. (biomedcentral.com)
  • These families share poor sequence similarity. (genesilico.pl)
  • The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. (eu.org)
  • DNA methylation, particularly 5-methylcytosine (5mC) at CpG sequences, is widely conserved in eukaryotes. (elifesciences.org)
  • It is widely distributed and highly conserved in animals, plants, and microorganisms. (biomedcentral.com)
  • 2008). In addition to being widely conserved among eukaryotes, the mechanisms through which Swi5-Sfr1 promotes HR appear to be highly comparable in yeasts and mammals (Tsai et al. (woofahs.com)
  • Manual comparison of sequence alignments is oftentimes used to detect remotely conserved orthologs in the twilight zone. (biomedcentral.com)
  • MiRNAs are most often identified through computational prediction from genome sequences. (usda.gov)
  • From the 142 confirmed cases, we performed unbiased (Illumina) and SUDV-amplicon-specific (Minion) high-throughput sequencing to obtain 120 SUDV genome-and coding-complete sequences, representing 95.4% (104/109) of SVD-confirmed individuals within a sequence-able range (Ct 30) and 10 genome sequences outside of this range and 6 duplicate genome sequences. (cdc.gov)
  • abstract = "Calmodulin is a ubiquitous transducer of calcium signals in eukaryotes. (huji.ac.il)
  • In addition, a third conserved intronic sequence that is known to be functionally important in splicing is the so-called branch point site (BPS) which is usually located very close to the end of the intron, at most 40 nucleotides before the terminal dinucleotide. (ijbs.com)
  • Adjacent to this termination signal was a stretch of conserved nucleotides that might function as a transcription initiation signal Technical Appendix Table 1). (cdc.gov)
  • The Cdc14 family of dual-specificity protein phosphatases (DSPs) is conserved within eukaryotes and functions to down-regulate mitotic Cdk activities, promoting cytokinesis and mitotic exit. (rcsb.org)
  • Finally, by comparing pairwise SH3 sequence identity to binding profile correlation we show that for 75% of all analyzed families the SH3 specificity profile was remarkably conserved over a large evolutionary distance. (upf.edu)
  • This domain is found in eukaryotes, and is approximately 70 amino acids in length. (embl.de)
  • The bZIP protein sequence contains 2 conserved bZIP domains with a total length of ~ 60-80 amino acids. (biomedcentral.com)
  • From the transcriptome database of C. rogercresseyi , 57 putative members of ABC protein sequences were identified and phylogenetically classified into the eight subfamilies described for ABC transporters in arthropods. (biomedcentral.com)
  • This is the list of transcription factor binding sites that bind transcription factors: ZF02 (C2H2 zinc finger transcription factors 2) Cart1 Sequence-specific DNA-binding transcription factor HTLV-I U5 repressive element-binding protein 1 NKX homeodomain factors AARE binding factors PREB core-binding element DUF4688 is a large region found within C1orf94 protein sequence and in both isoforms a and b. (wikipedia.org)
  • Fascinatingly, one core protein, the D-serine transporter as been shown to be one of the most commonly found sequences in nature. (ukri.org)
  • G-quadruplexes are secondary semi-stable folded structures found in our DNA and RNA which tend to assemble around guanine-rich sequences in the presence of cation molecules like potassium. (anti-agingfirewalls.com)
  • However, the composition of SRP varies among the different organisms with the most evolved version found in eukaryotes 5 . (nature.com)
  • In some yeasts, such as in Saccharomyces cerevisiae (gene URA1), it is a cytosolic protein while in other eukaryotes it is found in the mitochondria [ 1 ]. (expasy.org)
  • Here we found evidence pointing to an additional sequence-dependent determinant beyond these structural properties. (bvsalud.org)
  • Ubiquitin protein has a conserved amino acid sequence, found in all eukaryotes and it is important in many of cellular functions .The increase or decrease in the ubiquitin level lead to causing many diseases including cancer .The aim of this study is to measure the concentration of ubiquitin c protein in blood serum of lung cancer patients and healthy control subjects by using ELISA technique. (edu.iq)
  • This entry represents the CysCysHisHisCys (CCHHC) type zinc finger domain found in eukaryotes. (embl.de)
  • The most-extensively studied core promoter element in eukaryotes is a short DNA sequence known as a TATA box, found 25-30 base pairs upstream from the start site of transcription. (stemcelldaily.com)
  • High frequency intra- and intermolecular recombination among large repeated sequences is the rule, generating a heterogeneous pool of genome configurations within a single individual [ 12 - 14 ]. (biomedcentral.com)
  • DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. (lookformedical.com)
  • While DNMT3, the maintenance DNA methyltransferase DNMT1, HELLS, and CDCA7 are all highly conserved in vertebrates and green plants, they are frequently co-lost in other evolutionary clades. (elifesciences.org)
  • The splice-site sequences of U2-type introns are highly degenerate, so many different sequences can function as U2-type splice sites. (ijbs.com)
  • A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. (ensembl.org)
  • Finally, conserved 7-mers in the 3'UTRs were identified, of which some were identical to miRNA target sequences. (biomedcentral.com)
  • Identity between some of these 7-mers and miRNA target sequences suggests that they are miRNA targets in Salmo salar transcripts as well. (biomedcentral.com)
  • The rainbow trout genome sequence is not available yet, which does not allow miRNA prediction for this species which is of great economic interest for aquaculture and sport fisheries, and is a model research organism for studies related to carcinogenesis, toxicology, comparative immunology, disease ecology, physiology and nutrition. (usda.gov)
  • Identification of sequence variations in the miRNA -target interactions may be particularly useful for rainbow trout breeding programs. (usda.gov)
  • AmiRNAs are produced in planta by expressing amiRNA transgenes containing a functional plant MIRNA precursor in which the endogenous miRNA guide/miRNA star sequences are substituted by the amiRNA guide/amiRNA star sequences (Figure 1a) [ 5 ] [ 6 ] . (encyclopedia.pub)
  • This is the only residue that is absolutely conserved in all the Y-synthases. (genesilico.pl)
  • The mRNAs can carry short sequences of genetic letters that can trigger their own destruction. (elifesciences.org)
  • Fitch defined the terms orthology and paralogy as early as 1970, when only very few protein sequences were known [ 1 ]. (biomedcentral.com)
  • Integrating the genetic sequence and epidemiological data into the response activities generated a broad overview of the outbreak, allowing for quick fact-checking of epidemiological connections between the identified patients. (cdc.gov)
  • Rad55 and Rad57 were identified in based on sequence homology and genetic screening, respectively (Khasanov et al. (woofahs.com)
  • almost all CDCA7 harboring eukaryote species also have HELLS and DNMT1 (or another maintenance methyltransferase, DNMT5). (elifesciences.org)
  • In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. (wellnessresources.com)
  • Full-length sequenced inserts from cDNAs (FLIcs) are an important tool for correct annotation and clustering of the genomic sequence in any species. (biomedcentral.com)
  • One would expect that the large number of almost identical ohnologous sequences would make such gene transcript predictions particularly challenging in salmonid species. (biomedcentral.com)
  • With cross-linking studies, it could be shown that the hydrophobicity of the signal sequence is crucial for SRP binding, since lowering the hydrophobicity resulted in less efficient cross-linking 15 , 16 . (nature.com)
  • Using genomic library enrichment, the efficiency of SSR marker development was 14.4% from sequencing data to operationally useful loci. (shengsci.com)
  • In eukaryotes, the synthesis of the oligosaccharide core is mediated by a lipid carrier called dolichol-phosphate (Dol-P) which is located in the membranes of the endoplasmic reticulum (ER, Fig. 1a ). (biomedcentral.com)
  • Thus, a high sequence identity within an SH3 domain family predicts conserved binding specificity, whereas divergence in sequence identity often coincided with a change in binding specificity within this family. (upf.edu)
  • The spliceosome recognizes conserved sequences at the exon-intron boundaries, namely the 5' splice site (5'ss) and the 3' splice site (3'ss). (ijbs.com)
  • However, these reconstructions are prone to error caused by low quality of single-pass sequences, alternative splice forms, expressed pseudogenes and sequence similarities between transcripts within gene families. (biomedcentral.com)
  • What Are the Sequences at Splice Junctions? (cshlpress.com)
  • As a result, the origin of eukaryotes from former organisms is one of the most intriguing questions in biology. (biomedcentral.com)
  • We provide an example of remotely conserved orthologs, which were experimentally shown to be functionally equivalent in the respective organisms and therefore meet the criteria of the orthology-function conjecture. (biomedcentral.com)
  • Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. (wellnessresources.com)
  • After running SAPS on a group of orthologs (Gorilla, Rat, Dog, and Bat), the protein's composition only shows minor variations compared to the human sequence: Proline is still the most abundant amino acid followed by leucine and tryptophan remains the least abundant. (wikipedia.org)
  • This methodology should be used to better integrate discrete epidemiological and sequence data for future viral outbreaks. (cdc.gov)
  • In plants, RNAi tools based on the expression of dsRNAs of viral sequence have been extensively used to confer antiviral resistance, despite their lack of high specificity. (encyclopedia.pub)
  • This suggests that the requirement for a diverse array of auxiliary factors to promote recombinational DNA repair has been conserved throughout evolution, highlighting its importance. (woofahs.com)
  • High quality full-length insert sequences from 560 pre-smolt white muscle tissue specific cDNAs were generated, accession numbers [GenBank: BT043497 - BT044056]. (biomedcentral.com)
  • In eukaryotes, this family has a characteristic organization marked by two transmembrane domains (TMD) that are formed by five or six helixes which determine the specificity of the transporter [ 13 , 14 ]. (biomedcentral.com)
  • We detected transmembrane domains in the amino acid sequences of all 3 additional ORFs, suggesting they might act as viroporin ( 8 , 9 ). (cdc.gov)
  • Studies of the salmon genome might therefore contribute important biological knowledge on the evolution of ohnologs (duplicate sequences that originate from a whole genome duplication) [ 15 ]. (biomedcentral.com)
  • In contrast to the large number of ESTs available, including the ESTs from 23 developmental and tissue specific cDNA libraries contributed by the Salmon Genome Project (SGP), the number of sequences where the full-length of the cDNA insert has been determined has been small. (biomedcentral.com)
  • The sequence of DHOdease is rather well conserved and we have developed two signature patterns specific to this enzyme. (expasy.org)
  • Based on our results, we conclude that morFeus is a powerful and specific search method for detecting remotely conserved orthologs. (biomedcentral.com)
  • The obtained sequence of RFFRV was partially confirmed by specific primers and Sanger sequencing of PCR amplicons. (cdc.gov)
  • The B56 docking site has a consensus sequence ([LMFYWIC]. (eu.org)
  • These clusters of tentative consensus sequences (TCs) serve as a valuable resource for putative gene products. (biomedcentral.com)