Epigenetic promoter regions genetic. Medical search. Frequent questions

We observed that the majority of non-photoreceptor genes had promoters in a repressive chromatin state, but these promoters were in unmethylated or low-methylated regions. (nih.gov)
Meanwhile, the majority of promoters for photoreceptor genes were found in a permissive chromatin state, but were highly-methylated. (nih.gov)
However, promoters of these genes were demethylated and activated during retinal development. (nih.gov)
2) highly-methylated promoters of photoreceptor-related genes. (nih.gov)
Epigenetics of anxiety and stress-related disorders is the field studying the relationship between epigenetic modifications of genes and anxiety and stress-related disorders, including mental health disorders such as generalized anxiety disorder (GAD), post-traumatic stress disorder, obsessive-compulsive disorder (OCD), and more. (wikipedia.org)
Stress-induced epigenetic changes, particularly to genes that effect the hypothalamic-pituitary-adrenal (HPA) axis, persist into future generations, negatively impacting the capacity of offspring to adapt to stress. (wikipedia.org)
These heritable epigenetic modifications include DNA methylation of the promoter regions of genes that affect sensitivity to stress. (wikipedia.org)
Epigenetic modification in response to stress results in molecular and genetic alterations that in turn results in mis-regulated or silenced genes. (wikipedia.org)
Maternal separation and postnatal maternal abuse also increases DNA methylation at regulatory regions of BDNF genes in the prefrontal cortex and hippocampus, leading to potential stress vulnerability in future generations. (wikipedia.org)
Stress can also result in inheritable changes DNA methylation in the promoter regions of the estrogen receptor alpha (ERα), glucocorticoid receptor (GR), and mineralocorticoid receptor (MR). These changes lead to altered expression of these genes in offspring that in turn leads to decreased stress tolerance. (wikipedia.org)
Genomic imprinting is an epigenetic phenomenon that causes genes to be expressed or not, depending on whether they are inherited from the mother or the father. (wikipedia.org)
Previous studies have implicated allelic loss at chromosome 17q in the development of non-small cell lung carcinoma (NSCLC), and a number of known and putative tumour-suppressor genes reside within this region. (edgehill.ac.uk)
Genetic variations that lie outside of any known genes can lead to disease. (nih.gov)
To gain insights into these non-coding regions, a team of scientists partly supported by NIH's National Human Genome Research Institute (NHGRI) carried out a genome-wide survey of epigenetic marks - factors that change the way genes are read, or expressed, without changing the DNA sequence itself. (nih.gov)
Three chromatin states were associated with regulatory regions known as promoters, which sit close to genes and allow them to be read. (nih.gov)
Four chromatin states were associated with regions known as enhancers, which act at a distance and are not always easy to tie to particular genes. (nih.gov)
For example, active promoter states in skeletal muscle were associated with extracellular structure genes, while active promoter states in lymphoblastoid cells were associated with immune response genes. (nih.gov)
Promoters active in both cells types were associated with general metabolism genes. (nih.gov)
To connect enhancer regions to likely target genes, the researchers compared patterns of chromatin activity with gene expression across the 9 cell types. (nih.gov)
These domestication traits likely consisted of a few major genes controlling dramatic changes in crop physiology, as is suggested by genetic studies comparing maize to its ancestor teosinte (Doebley et al. (springer.com)
100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions of ~81% of human genes, as calculated following gene enrichment analysis. (mdpi.com)
Additionally, we found that 68.2% of intragenic sequences exhibiting tissue-specific DNA methylation identified from a genome-wide screen harbored features of promoters more commonly associated with the 5'-end of genes. (escholarship.org)
It is commonly known that inactivation of certain tumor-suppressor genes occurs as a consequence of hypermethylation within the promoter regions and a numerous studies have demonstrated a broad range of genes silenced by DNA methylation in different cancer types. (nih.gov)
This important work substantially advances our understanding of the interplay between genetic variation, chromatin, and genes within topologically associated domains and how this interplay regulates gene expression. (elifesciences.org)
By maintaining the balance between cell growth and inhibition, these genes prevent the accumulation of genetic errors and the uncontrolled proliferation of cells. (mearticles.com)
DNA methylation, a common epigenetic modification, can alter the expression of tumor suppressor genes. (mearticles.com)
Hypermethylation of promoter regions can lead to the silencing of these genes, promoting tumor growth. (mearticles.com)
For tumor suppressor genes, the insertion of genetic material encoding proteins such as p53 has shown promising results in reducing tumor growth and proliferation. (mearticles.com)
It is the the dream of every molecular geneticist: an easy-to-use program that compares data sets from different cellular conditions, identifies enhancer regions and then assigns them to their target genes. (technologynetworks.com)
They serve as regulators of genomic regions that are responsible for the activation and deactivation of genes, such as promoters and enhancers. (technologynetworks.com)
In many complex diseases, the epigenetic control of genes does not work correctly and is of great interest for scientists. (technologynetworks.com)
The PWS imprinting control region is the promoter for a one megabase paternal transcript encoding the ubiquitous protein-coding Snrpn gene and multiple neuron-specific noncoding RNAs, including the PWS-related Snord116 repetitive locus of small nucleolar RNAs and host genes, and the antisense transcript to AS-causing ubiquitin ligase encoding Ube3a (Ube3a-ATS). (fpwr.org)
Alterations in the epigenetic signature of genes involved in stress responsivity may represent one of the neurobiological mechanisms. (biomedcentral.com)
However, epigenetic changes in other candidate genes such as brain-derived neurotrophic factor ( BDNF ) and serotonin transporter are also implicated in early life stress (ELS) and susceptibility to adult psychiatric disorders. (biomedcentral.com)
Further, these epigenetic changes are cell/tissue-specific in regulating expression of genes, providing potential biomarkers for understanding the trajectory of early stress-induced susceptibility to adult psychiatric disorders. (biomedcentral.com)
Detection of methylation of the promoter region of the MAL and CADM1 genes by pyrosequencing in cervical carcinoma. (nel.edu)
Mersakova S, Visnovsky J, Holubekova V, Nachajova M, Kudela E, Danko J, Lasabova Z. Detection of methylation of the promoter region of the MAL and CADM1 genes by pyrosequencing in cervical carcinoma. (nel.edu)
A number of genetic studies led to the identification of genes and/or copy number variants whose alterations are associated with autism, but no specific factor has been found so far to be responsible for a substantial proportion of cases. (biomedcentral.com)
Epigenetic modifications may also play a role, as demonstrated by the occurrence of autism in genetic conditions caused by mutations in imprinted genes or regions. (biomedcentral.com)
The nature of this epigenetic dysregulation is unknown but, if proved to be true, might explain the failure to identify sequence alterations in a host of candidate genes. (biomedcentral.com)
Distally, it preferentially targets active promoters and regulates expression of neural differentiation genes, in part through physical association with the POU3F3 protein. (ox.ac.uk)
It is believed that the occurrence of leukemia is the result of genetic and epigenetic changes in protooncogene and tumor suppressor genes [ 8 ]. (hindawi.com)
These dCas9-activator fusions targeted to the promoter region of endogenous genes can then modulate gene expression 7 - 11 . (cdc.gov)
We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)

Apart from DNA methylation alterations in promoter regions and repetitive DNA sequences, this phenomenon is associated also with regulation of expression of noncoding RNAs such as microRNAs that may play role in tumor suppression. (nih.gov)
Moreover, unlike genetic alterations, DNA methylation is reversible what makes it extremely interesting for therapy approaches. (nih.gov)
It has been increasingly recognized that other types of alterations in the genome, known as epigenetic changes, can modulate its structure and function without affecting the underlying DNA sequence. (ernolaszlo.com)
Epigenetic alterations, acting both independently and together with increasing mutational burden, genomic instability, and stem cell exhaustion, can influence gene expression in ways that promote aging (Saul 2021). (ernolaszlo.com)
Furthermore, epigenetic alterations at the serotonin transporter (SERT) promoter region have been associated with environmental influences such as stressful life experiences. (ox.ac.uk)
We first present a brief overview of the stress response pathways followed by a detailed review of evidence demonstrating epigenetic alterations following ELS in animal models and humans. (biomedcentral.com)
published this month in BMC Medicine , reports on genomic and epigenetic alterations of OXTR , the gene encoding the receptor for oxytocin. (biomedcentral.com)

Epigenetic modifications play a role in the development and heritability of these disorders and related symptoms. (wikipedia.org)
Early life experiences, even when generations removed, can cause permanent epigenetic modifications of DNA resulting in changes in gene expression, endocrine function and metabolism. (wikipedia.org)
For example, epigenetic modifications to the gene BDNF (brain derived neurotrophic factor), as well as dATF-2, as a result of stress can be passed on to offspring. (wikipedia.org)
Chronic variable stress induces offspring hypothalamic gene expression modifications, including elevated methylation levels of the BDNF promoter in the hippocampus. (wikipedia.org)
Maternal care likewise contributes to HPA-related epigenetic modifications. (wikipedia.org)
Epigenetic modifications as a result of absent maternal care lead to decreased estrogen receptor alpha expression, due to increased methylation at the gene's promoter. (wikipedia.org)
Epigenetic changes are performed by enzymes known as writers, which can add epigenetic modifications, erasers, which erase epigenetic modifications, and readers, which can recognize epigenetic modifications and cause a downstream effect. (wikipedia.org)
Stress-induced modifications of these writers, erasers, and readers result in important epigenetic modifications such as DNA methylation and acetylation. (wikipedia.org)
The scientists assessed chromatin states across 9 different cell types by mapping the locations across the genome of several epigenetic modifications to DNA, such as methylation and acetylation. (nih.gov)
1) L Liu, G Jin*, X Zhou* (2015) ---**[[http://nar.oxfordjournals.org/content/43/8/3873.short Modeling the relationship of epigenetic modifications to transcription factor binding]]**--- //Nucleic acids research// 43 (8), 3873-3885. (aporc.org)
DNA methylation is one of the most intensely studied epigenetic modifications in mammals. (nih.gov)
DNA methylation is associated with histone modifications and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by changing chromatin architecture. (nih.gov)
However, accumulating evidence points to the involvement of epigenetic modifications as foundational in creating ASD pathophysiology. (mdpi.com)
Analysis of the AHR proximal promoter region using chromatin immunoprecipitation confirmed that enhanced expression of AhR in LTEE cells involves changes in histone modifications, notably decreased trimethylation of histone 3, lysine 27. (umn.edu)
DNA methylation is the predominantly studied epigenetic mark followed by histone modifications specifically acetylation and methylation. (biomedcentral.com)
The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. (medlineplus.gov)

In this study, we investigated the epigenetic plasticity of adult murine RPE to identify possible mechanisms that prevent mammalian RPE from regenerating retinal tissue. (nih.gov)
We expect to design a sensitive and high-throughput approach for assessing the relationship between the methylation profile and transcriptional activity for of Nm23-H1 promoter, to analysis the cis-acting regulatory elements, and define the mechanisms of Nm23-H1 transcriptional regulation. (tmu.edu.tw)
Understanding the scope and landscape of these interactions on a genome-wide scale is a vital step towards deciphering the genetic regulation of gene expression and, in turn, the mechanisms of non-coding variation on phenotypic outcomes. (elifesciences.org)
Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are oppositely imprinted autism-spectrum disorders with known genetic bases, but complex epigenetic mechanisms underlie their pathogenesis. (fpwr.org)
Despite extensive genetic and biological research, significant controversy surrounds our understanding of the specific mechanisms of their pathogenesis. (mdpi.com)
Epigenetic mechanisms such as DNA methylation work at the interface between genetic and environmental influences. (ox.ac.uk)
Here, we investigated genetic and epigenetic mechanisms that affect AhR expression. (umn.edu)
These findings address two major points of the current debate on the etiology and pathogenesis of autism: the role of oxytocin, known to be involved in modeling human behavior, and the possible involvement of epigenetic mechanisms. (biomedcentral.com)
The project aims to study the genetic controls and the molecular mechanisms involved in sex regulation in different species belonging to the genus Pseudo-nitzschia, by studying the genome and transcriptome of strains with different MT, also using genetic transformation, protein analysis and epigenetic analysis tools. (szn.it)

Unmethylated THOR repressed TERT promoter activity regardless of TPM status, and hypermethylation of THOR counteracted this repressive function. (jci.org)
Fibulin-5 was silenced by promoter hypermethylation in a majority of lung cancer cell lines and primary tumors. (aacrjournals.org)
The subsequent analysis of a group of unrelated autistic subjects did not show an OXTR deletion, but rather hypermethylation of the gene promoter, with a reduced mRNA expression. (biomedcentral.com)
PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer. (cdc.gov)

It is because of the complexity of transcriptional events, which may be a mixture of epigenetic regulation and genetic control on function regions (e.g., enhancers and promoters). (aporc.org)
To accomplish this, the transcriptional unit is preceded by regulatory elements, such as promoters and enhancers, that modulate production of its protein encoding transcript ( Figure 1.2 ). (ernolaszlo.com)

Transcriptional activity of 5-HT 1A receptor promoter containing rs198585630 C/T allele was determined in vitro . (frontiersin.org)
We demonstrated that transcriptional activity of 5-HT 1A receptor promoter containing rs198585630 C allele was higher than that of 5-HT 1A receptor promoter containing T allele. (frontiersin.org)
The transcriptional activity of 5-HT 1A receptor promoter was stimulated by 30 mW/cm 2 microwave exposure, and rs198585630 C allele was more sensitive to microwave exposure, as it showed stronger transcriptional activation. (frontiersin.org)
My research interest is in the patient-specific analysis by considering the variations from transcriptional, epigentic, and genetic variations. (aporc.org)
Analyses of the human AHR proximal promoter in MCF-7 human breast cancer cells using luciferase assays and electrophoretic mobility shift assays revealed multiple specificity protein (Sp) 1 binding sequences that are transcriptional activators in vitro. (umn.edu)
Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)

Gene silence via methylation of the CpG islands is cancer's most common epigenetic modification. (biomedcentral.com)

Recent data show that these extrinsic environmental factors synergize with intrinsic age-related changes to influence epigenetic regulation of gene expression, ultimately contributing to the visible-and invisible-signs of skin aging (Chevalier 2019). (ernolaszlo.com)
Subsequent sections focus on the epigenetic regulation of gene expression and its relevance to skin aging. (ernolaszlo.com)
Regarding the etiology, it is generally accepted that genetic factors play a major role and it has become clear that, with the exception of a minority of instances (about 1%) in which the phenotype is caused by a single gene alteration, the genetic component leading to autism is complex, being based on interactions of multiple genetic changes and/or epigenetic regulation of gene expression. (biomedcentral.com)

Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. (oregonstate.edu)
Countless such studies across diverse diseases and conditions have implicated specific regions in the genome. (nih.gov)
The identified epigenetic regulation and genetic variation will be validated by CRISPR and TALE-TET1 genome editing techniques. (aporc.org)
Here we undertake a genome-scale analysis of these interactions in a genetically diverse population to systematically identify global genetic-epigenetic interaction, and reveal constraints imposed by chromatin structure. (elifesciences.org)
With 176 samples profiled for genotype, gene expression, and open chromatin, we used regression modeling to infer genetic-epigenetic interactions on a genome-wide scale. (elifesciences.org)
Our results demonstrate that statistical interactions between genetic variants and chromatin accessibility are common throughout the genome. (elifesciences.org)
Yet the interacting effects that genetic and epigenetic factors produce on gene transcription are rarely studied at a genome-wide scale, leaving us without global information on a key step between the genetic code and the phenotype. (elifesciences.org)
Because of this complexity, decades of experimental work, even with the aid of sophisticated molecular genetic tools (such as high resolution total genome quantitative analysis, array expression analysis or high resolution single nucleotide polymorphism (SNP) array platforms) have failed to identify specific causes in any substantial proportion of cases [ 4 , 5 ]. (biomedcentral.com)
Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)

Aberrant DNA methylation has been introduced as a major epigenetic event in tumorigenesis [ 9 , 10 ]. (biomedcentral.com)

These regions attract proteins that attach to promoter sequences which function as a switch for each gene. (technologynetworks.com)

Female offspring with low licking-grooming mothers have decreased promoter methylation and increased histone acetylation, leading to increased glucocorticoid receptor expression. (wikipedia.org)

In this study, we describe the TERT hypermethylated oncological region (THOR), a 433-bp genomic region encompassing 52 CpG sites located immediately upstream of the TERT core promoter, as a cancer-associated epigenetic mechanism of TERT upregulation. (jci.org)
show that there is genomic and epigenetic evidence of a reduced function of the oxytocin receptor in autism. (biomedcentral.com)

Because these approaches will rely on novel data types such as DNA sequences and high-throughput phenotyping images, Breeding 4 will call for analyses that are complementary to traditional quantitative genetic studies, being based on machine learning techniques which make efficient use of sequence and image data. (springer.com)
The recent expansion of repeated HERV sequences has offered a framework for genetic and epigenetic innovation. (mdpi.com)
Because DNA methylation is known to influence the activity of promoter sequences, we searched for genetic and epigenetic evidence of in vivo promoter activity embedded within SHANK3 in mouse and human tissues. (escholarship.org)
Circular dichroism spectroscopy revealed the ability of sequences of this GC-rich region to form guanine-quadruplex structures in vitro. (umn.edu)

DNA methylation is a type of epigenetic modification in which methyl groups are added to cytosines of DNA. (wikipedia.org)
However, few data is available about the regulation of Nm23-H1 expression related with chemotherapy treatment or epigenetic modification. (tmu.edu.tw)
research shows that about 90% of the blood system of malignant tumors with at least the height of single gene methylation is closely related since this is a reversible process of genetic modification can be through to handle to restore the normal expression of gene methylation, to achieve the purpose of prevention and treatment of tumor [ 10 ]. (hindawi.com)

In this study, we explore the regulatory role of mutations occurring in distal regulatory elements related to gene expression and phenotypic variations with adapted long-read ChIA-PET, and construct high-resolution chromatin interaction maps of maize promoter proximal regions and distal regulatory elements associated with RNA polymerase II occupancy and histone mark H3K4me3. (nature.com)
Although TERT promoter mutations (TPMs) are a major cancer-associated genetic mechanism of TERT upregulation, many cancers exhibit TERT upregulation without TPMs. (jci.org)

Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses. (cancerindex.org)
The absence of a distinct methylation pattern implies the importance of other epigenetic processes, which may alter the production of NIS mRNA. (biomedcentral.com)
Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)
Both primary and secondary glioblastomas have distinct genetic characteristics, which can change as the tumors evolve. (msdmanuals.com)

Here, we characterize epigenetic features of active promoter proximal regions and candidate distal regulatory elements to construct high-resolution chromatin interaction maps for maize via long-read chromatin interaction analysis by paired-end tag sequencing (ChIA-PET). (nature.com)

analyzed DNA methylation in the KIAA0319 promoter region to investigate whether epigenetic markers of language lateralization could be identified in nonneuronal tissue [ 7 ]. (biomedcentral.com)

While a full complement of open chromatin, epigenetic, and TF-binding experiments provide information for likely candidate regulatory regions, using TF-binding approaches such as ChIP-seq or DAP-seq can provide additional valuable insight and targets for reverse genetic approaches such as EMS-induced or natural SNP variant screens or CRISPR editing techniques (e.g. promoter bashing). (usda.gov)
Studies are generally limited to examination of individual regions or overlapping single-nucleotide polymorphisms (SNPs) and open chromatin peaks with limited investigation into how these regulatory elements combine to affect gene transcription 1 , 2 . (elifesciences.org)

Identify the minimal promoter region and characterize the cis-acting regulatory elements as well as corresponding transcription factors in ESCC cell models. (tmu.edu.tw)

Many genetic variations outside protein-coding regions are associated with maize phenotypes. (nature.com)
Using this integrated and cross-species approach, we identified two intragenic regions with promoter activity in vitro, are differentially methylated in vivo, and facilitate the tissue-specific transcription of novel and potentially protein-coding SHANK3 transcripts. (escholarship.org)
The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)
The ASXL1 protein may have an additional role in gene regulation by signaling to molecules to add a methyl group (a process called methylation) to an area near a gene called the promoter region, which controls gene activity. (medlineplus.gov)

Genetic analyses are a powerful approach that allow the study of these interactions. (elifesciences.org)
More specifically, this review analyses the epigenetic signatures of postnatal adversity such as childhood abuse or maltreatment and later-life psychopathology in human and animal models of early life stress. (biomedcentral.com)

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Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)

DNA methylation profile was preserved in PDX mice in 97.5% of the promoters (ρ = 0.99). (uzh.ch)
Interestingly, both the ATAC regions, which showed a significant decrease in accessibility in PDXs and the regions hypermethylated in PDXs, were associated with immune response, which might reflect the immune deficiency of the mice and potentially the incomplete interaction between murine cytokines and human receptors. (uzh.ch)

The specific aims of this project will be: 1) Design a sensitive and high-throughput approach (methylation-sensitive high resolution melting curve analyze) to assess the DNA methylation status for Nm23-H1 promoter region in different metastasis/invasion and chemoresistance phenotypes of ESCC cell lines. (tmu.edu.tw)
Dali interacts with the DNMT1 DNA methyltransferase in mouse and human and regulates DNA methylation status of CpG island-associated promoters in trans. (ox.ac.uk)

Other chromatin states correspond to insulators, which also help regulate active and repressed regions. (nih.gov)

This mouse population segregates millions of variants from eight inbred founders, enabling precision genetic mapping with extensive genotypic and phenotypic diversity. (elifesciences.org)
Recent research suggests that some genetic variants may be associated with a more beneficial response to psychological therapy. (ox.ac.uk)
Detecting regions of homozygosity improves the diagnosis of pathogenic variants and uniparental disomy in pediatric patients. (cdc.gov)

Lewis identified epigenetic markers of stress experienced early in life that increased drug intake in an animal model. (asu.edu)

The maps indicate that chromatin loops are formed between regulatory elements, and that gene pairs between promoter proximal regions tend to be co-expressed. (nature.com)
Many promoter proximal regions are involved in chromatin loops with distal regulatory elements, which regulate important agronomic traits. (nature.com)
The resulting maps are analyzed to identify and assess the roles of promoter proximal-proximal interaction (PPI) and proximal-distal interaction (PDI). (nature.com)

Conversely, phenotypic variation in genetically diverse populations is a result of both genetic and epigenetic factors operating in tandem. (elifesciences.org)
These inconsistencies can be explained in part by heterogeneity between studies, possibly due to the different criteria for phenotypic assessment, age, sample size, population genetic background, and environmental factors. (biomedcentral.com)

Genetic pathways to primary and secondary glioblastomas. (who.int)

These findings provide evidence that genetic and epigenetic factors operate within the context of three-dimensional chromatin structure. (elifesciences.org)

MtI of the CYGB promoter was associated with CYGB mRNA expression (linear regression analysis, P=0.009), suggesting a primary role for the epigenetic events in CYGB silencing. (edgehill.ac.uk)
Bioinformatic approaches were employed for checking the expression of C1QBP in HCC patient samples and the association between C1QBP mRNA expression and survival rates of patients with HCC or the promoter methylation of C1QBP . (jcancer.org)

Our results highlight the significance of 3D organization of regulatory elements and suggest that the topology of long-range genetic variations may affect gene expression as well as phenotype variation. (nature.com)
Identifying non-coding regions that control gene expression has become an essential aspect of understanding gene regulatory networks that can play a role in crop improvements such as crop manipulation, stress response, and plant evolution. (usda.gov)
2) Establish ESCC cell models carrying a reporter gene under the control of different 5'-flanking regulatory Nm23-H1 promoter region. (tmu.edu.tw)
The scientists found that regulatory regions vary greatly in activity depending on the cell type. (nih.gov)

2012. MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. . (oregonstate.edu)

Collectively, these results suggest that epigenetic silencing of fibulin-5 promotes lung cancer invasion and metastasis by activating MMP-7 expression through the ERK pathway. (aacrjournals.org)
These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. (cdc.gov)

2016. Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. . (oregonstate.edu)

Viral methods involve the use of viral vectors , such as adenoviral and adeno-associated vectors, to deliver the desired genetic material into tumor cells. (mearticles.com)

These results give researchers a framework for uncovering genetic regulators that could be potential targets for drug development. (nih.gov)

2011. Dietary factors and epigenetic regulation for prostate cancer prevention. . (oregonstate.edu)
Clinical Management of Prostate Cancer in High-Risk Genetic Mutation Carriers. (cdc.gov)
Genetic testing in prostate cancer management: Considerations informing primary care. (cdc.gov)

Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. (oregonstate.edu)

Gene expression is known to be affected by interactions between local genetic variation and DNA accessibility, with the latter organized into three-dimensional chromatin structures. (elifesciences.org)
It is known that genetic variation accounts for 20-80% of the total variation in reading skills, and the genetic variations discovered thus far only explain the "tip of the iceberg" of estimated heritability [ 1 , 2 ]. (biomedcentral.com)

It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. (wikipedia.org)

In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)

furthermore, by studying different biogeographical populations, conservation of the coding region of the MRP3 gene and variability (polymorphism) in its promoter region were found (Russo et al. (szn.it)

These correlative data suggest that the intragenic methylation negatively influences promoter activity. (escholarship.org)
it is also subject to epigenetic influences . (mearticles.com)

Characterization of accessible chromatin regions in cattle rumen epithelial tissue during weaning. (usda.gov)
Comprehensive characterization of the epigenetic landscape in Multiple Myeloma. (cdc.gov)

These methods offer advantages such as cost-effectiveness, reduced immune response, and the ability to deliver larger genetic payloads. (mearticles.com)

This white paper will first provide a brief refresher on the central paradigm of molecular biology, the rigorously controlled process by which genetic information flows within cells and biological systems. (ernolaszlo.com)

First, fMRI was used to identify regions associated with two different stages of language production planning: the posterior superior temporal gyrus (pSTG) for phonological encoding (critical for VWM of nonwords) and the middle temporal gyrus (MTG) for lexical-semantic retrieval (not critical for VWM of nonwords). (mpi.nl)

Next, in the same subjects, these regions were targeted with repetitive transcranial magnetic stimulation (rTMS) during language production and VWM task performance. (mpi.nl)

Anatomy14

Organisms11

Diseases3

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes99

Disciplines and Occupations1

Information Science3

Health Care1

Genes44

Alterations7

Modifications16

Mechanisms9

Hypermethylation4

Enhancers2

Transcriptional6

Common epigenetic modification1

Regulation of gene ex3

Genome9

Major epigenetic1

Proteins1

Glucocorticoid receptor1

Genomic2

Sequences4

Modification3

Mutations2

Distinct4

Active promoter1

Analyzed DNA methylation1

Open chromatin2

Characterize1

Protein4

Analyses2

Genetics1

Transcription1

Mice2

Methylation status2

Insulators1

Variants3

Markers1

Proximal3

Phenotypic2

Primary and secondary glioblastomas1

Findings1

MRNA expression2

Regulatory4

Phytochemicals1

Collectively2

Telomerase1

Tumor1

Framework for uncover1

Prostate cancer3

Demethylation1

Variation2

Sequence1

Pathogenesis1

Polymorphism1

Influences2

Characterization2

Immune response1

Molecular biology1

Identify1

Repetitive1