Eosinophil granule proteins. Medical search. Frequent questions

Toxins released by the eosinophils include eosinophil-derived neurotoxin, cationic protein, major basic protein, reactive oxygen species, and arachidonic acid derivatives. (medscape.com)
[11] Eosinophil cationic protein and eosinophil-derived neurotoxin are ribonucleases with antiviral activity. (wikidoc.org)
The primary granules contain lysophospholipase, associated with eosinophilic infiltrations 14 , and the secondary, or specific granules, contain major basic protein (MBP), eosinophils cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil protein X or eosinophil derived neurotoxin (EPX/EDN) 15,16 . (edu.pk)
Lesional tissue was examined by means of immunofluorescence for neutrophil elastase and lactoferrin and for eosinophil granule MBP, eosinophil-derived neurotoxin (EDN), and eosinophil cationic protein (ECP). (utmb.edu)
Eosinophil-derived neurotoxin can severely damage myelinated neurons. (msdmanuals.com)
Substance P, major basic protein (MBP), and eosinophil peroxidase (EPO), but not eosinophil derived neurotoxin, induced histamine release from human skin MCs through MrgX2. (confex.com)
Constituents of eosinophil secretory granules include a number of highly cytotoxic proteins, including eosinophil cationic protein, major basic protein, and eosinophil-derived neurotoxin. (medscape.com)
The increased urinary concentrations of leukotriene and eosinophil-derived neurotoxin were associated with acute exacerbation in eosinophilic pneumonia patients. (ersjournals.com)
Eosinophil-derived neurotoxin (EDN) is used as an eosinophil degranulation marker in urine. (ersjournals.com)
Eosinophil-specific granule content, including eosinophil cationic protein, eosinophil-derived neurotoxin, and major basic protein (MBP), is deficient in specific granule deficiency (SGD) and have a defect in myelopoiesis. (lu.se)

The staining is concentrated in small granules within the cellular cytoplasm , which contain many chemical mediators, such as histamine and proteins such as eosinophil peroxidase , RNase , DNases , lipase , plasminogen , and Major Basic Protein . (wikidoc.org)
Major basic protein, eosinophil peroxidase , and eosinophil cationic protein are toxic to many tissues. (wikidoc.org)
Eosinophil Peroxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
A 66-kDa peroxidase found in EOSINOPHIL granules. (wakehealth.edu)
Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. (wakehealth.edu)
This graph shows the total number of publications written about "Eosinophil Peroxidase" by people in this website by year, and whether "Eosinophil Peroxidase" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Eosinophil Peroxidase" by people in Profiles. (wakehealth.edu)
Eosinophil peroxidase, which differs significantly from peroxidase of other granulocytes, generates oxidizing radicals in the presence of hydrogen peroxide and a halide. (msdmanuals.com)
IL-6 was found to coelute with eosinophil crystalloid granule marker proteins, including eosinophil peroxidase (EPO), major basic protein (MBP), arylsulfatase B, end β-hexosaminidase. (huji.ac.il)
Role of eosinophil peroxidase in the origins of protein oxidation in asthma. (edu.pk)
Takenaka T, Okuda M, Kawabori S, Kubo K. Extracellular release of peroxidase from eosinophils by interaction with immune complexes. (edu.pk)
The Release Kinetics of Eosinophil Peroxidase and Mitochondrial DNA Is Different in Association with Eosinophil Extracellular Trap Formation. (unil.ch)

The specific types of granulocytes are neutrophils, eosinophils, and basophils. (medlineplus.gov)
Eosinophils are granulocytes (white blood cells that contain granules in their cytoplasm) derived from the same progenitor cells as monocytes-macrophages, neutrophils, and basophils. (msdmanuals.com)
In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. (biomedcentral.com)
Eosinophils are one of three types of granulocytes, along with neutrophils and basophils. (healthmatters.io)
Allergic rhinitis, a type 2 inflammatory sickness, is mediated by immunoglobulin E in nasal mucosa due to airborne allergens and formed inflammatory infiltrates containing of eosinophils, mast cells, basophils, and T-cells, which escorts the secretion of granule proteins, cytokines, and chemokines, thereby inducing the onset of clinical symptoms. (phcog.com)
The former include eosinophils, neutrophils and basophils, to the second - the lymphocytes and monocytes. (netlify.app)
Granulocytes are divided into three groups: Neutrophils, eosinophils and basophils. (netlify.app)
Neutrophils, basophils and eosinophils are often referred to as granulocytes, while lymphocytes and monocytes are considered to be agranulocytes, as they contain fewer and less obvious granules. (3d4medical.com)

Eosinophil granulocytes , usually called eosinophils (or, less commonly, acidophils ), are white blood cells of the immune system that are responsible for combating infection and parasites in vertebrates . (wikidoc.org)
Granulocytes are a type of white blood cell that has small granules inside them. (medlineplus.gov)
White blood cells are divided into granules or granulocytes (their core has a granular structure) and nezernistye (agranulocytes), the core of which has nezernistuyu structure, these types of white blood cells perform different tasks. (netlify.app)

In addition, eosinophils play a role in fighting viral infections, which is evident from the abundance of RNAses they contain within their granules, and in fibrin removal during inflammation . (wikidoc.org)
Eosinophils are known to be an indirect marker of airway inflammation in asthma. (edu.pk)
Airway inflammation is present during an acute exacerbation of asthma, and is characterized by infiltration and activation of both eosinophils and neutrophils 2 . (edu.pk)
Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. (biomedcentral.com)
Therefore, exclusively inhibiting the actions of interleukin-5 can suppress at least one of the alleged causes of asthma, namely tissue damage due to eosinophil accumulation during pulmonary inflammation. (biomedcentral.com)
Eosinophils, prominent cells in asthmatic inflammation, have been shown to synthesize, store, and release an array of up to 18 cytokines and growth factors, including interleukin-6 (IL-6). (huji.ac.il)
Eosinophils are pivotal in the pathophysiology of most forms of chronic respiratory mucosal inflammation. (onlineasthmainhalers.com)
There is strong evidence for the crucial role of eosinophils in ongoing inflammation and tissue damage. (onlineasthmainhalers.com)
Circulating eosinophils move into tissues (especially into subepithelial sites) in reaction to inflammation prompted by antigen-antibody complexes, parasites, or micro-organisms. (felipedia.org)
Dr. Kristin Leiferman, MD has a specialized focus on allergy-related inflammation and autoantibody expression that includes mast cell- and eosinophil-related diseases. (nexeosbio.com)
Eosinophils significantly contribute to inflammation related to allergies, eczema, and asthma. (healthmatters.io)
Eosinophils increase inflammation to help the body fight off infection and disease. (healthmatters.io)
But having too many eosinophils for a long period of time can cause chronic inflammation, which may lead to tissue damage and/or chronic health conditions. (healthmatters.io)
In light of the proteases abundance and their colocalization, it is likely that together they have a very potent degrading activity on almost any protein in the area of neutrophil activation and granule release, including both foreign bacterial or viral proteins as well as various self-proteins in the area of inflammation/infection. (slu.se)

cationic granule proteins and their release by degranulation . (wikidoc.org)
As the Th2 immune response is characterized by eosinophil mobilization to the target organ and release of their cationic granule proteins, it is reasonable to investigate if the degranulation of eosinophils could be associated with the local injury. (bvsalud.org)

Skin status of patients was assessed every 2 weeks by a standardized scoring, and serum eosinophilic cationic protein (ECP) was determined before and after diet. (nih.gov)
ABSTRACT This study evaluated peripheral eosinophil and serum eosinophilic cationic protein (s-ECP) levels as markers of asthma control. (who.int)
Granules of eosinophils contain toxic basic proteins, the major protein being eosinophilic cationic protein (ECP). (onlineasthmainhalers.com)

[ 14 ] Gliech et al reported a dose-dependent cytotoxic effect of the eosinophilic granular proteins, inhibiting multiple enzyme systems. (medscape.com)
Following activation by an immune stimulus, eosinophils degranulate to release an array of cytotoxic granule cationic proteins that are capable of inducing tissue damage and dysfunction. (wikidoc.org)
Experimental studies on eosinophil function have shown cytotoxic effects on airway epithelium resulting in ciliostasis and lysis of the epithelium. (onlineasthmainhalers.com)
Damage and degeneration of mucosal tissues may be due to a proliferation of cytotoxic T cells or toxic products released by degranulating eosinophils. (medscape.com)

Total asthma cases had higher eosinophil counts and s-ECP levels than healthy children and partially controlled asthmatics had significantly higher levels of both markers than controlled asthmatics. (who.int)
A negative correlation was noted between degree of asthma control and both eosinophil counts and s-ECP levels ( r = -0.60 and -0.75 respectively). (who.int)
s-ECP as well as peripheral eosinophil count may be helpful in the assessment of asthma control. (who.int)
Eosinophils are considered the main effector cells in allergic responses and asthma pathogenesis and are associated with disease severity. (wikidoc.org)
Eosinophils are currently regarded as the effector cells responsible for much of the pathology of asthma. (edu.pk)
Eosinophil-mediated damage to the respiratory epithelium is a major pathogenetic mechanism in asthma. (edu.pk)
This article is a review of the latest works about the relationship of eosinophil and eosinophil products with asthma. (edu.pk)
Kokuludag A, Sin A, Terzioglu E, Saydam G, Sebik F. Elevation of serum eosinophil cationic protein, soluble tumor necrosis factor receptors and soluble intercellular adhesion molecule-1 levels in acute bronchial asthma. (edu.pk)
Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. (edu.pk)
Labbe A, Aublet-Cuvelier B, Jouaville L, Beaugeon G, Fiani L, Petit I, Ouchchane L, Doly M. Prospective longitudinal study of urinary eosinophil protein X in children with asthma and chronic cough. (edu.pk)
Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma. (edu.pk)
Eosinophils in asthma. (edu.pk)
Gleich GJ (1990): The eosinophil and bronchial asthma: current understanding. (edu.pk)
Venge P. Serum measurement of eosinophil cationic protein (ECP) in bronchial asthma. (edu.pk)
Eotaxin represents the principal eosinophil chemoattractant in a novel murine asthma model induced by house dust containing cockroach allergens. (edu.pk)
Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. (edu.pk)
Koh YI, Choi S. Blood eosinophil counts for the prediction of the severity of exercise-induced bronchospasm in asthma. (edu.pk)
Horn BR, Robin ED, Theodore J, Van Kessel A. Total eosinophil counts in the management of bronchial asthma. (edu.pk)
In other inflammatory diseases associated with eosinophilia, such as allergic asthma, aspirin-intolerant asthma and nasal polyposis, local eosinophil accumulation closely correlates with tissue cysteinyl LT (CysLT) concentration 9 , 10 . (ersjournals.com)

The intracytoplasmic granular content of activated eosinophils is thought to be responsible for the toxic damage to the heart, as reported by Tai and associates. (medscape.com)
These mediators are released by a process called degranulation following activation of the eosinophil, and are toxic to both parasite and host tissues. (wikidoc.org)
First, the release of highly toxic granule proteins stored preferentially in secondary granules. (edu.pk)
However, although eosinophilia commonly accompanies helminthic infections and eosinophils are toxic to helminths in vitro, there is no direct evidence that they kill parasites in vivo. (msdmanuals.com)
these proteins are toxic to several parasites and to mammalian cells. (msdmanuals.com)
Eosinophil cells contain small sand-like granules that release a toxic protein to destroy and consume invading organisms. (healthmatters.io)

The regulatory mechanisms of activation and degranulation of eosinophils occur in three stages. (edu.pk)

A prominent feature of the eosinophil is the presence of many spherical or ovoid granules in their cytoplasm. (edu.pk)
These categories of lymphocytes characterized by the presence or absence of granules in the cytoplasm. (netlify.app)

NexEos is lucky to have her expertise surrounding the role of eosinophils in human biology, and her passion for individualized, precision care. (nexeosbio.com)

Eosinophils are major effector cells in allergic inflammatory response. (biomedcentral.com)

Lavage fluid from the lumen of the asthmatic airway contains numerous mediators including histamine, prostaglandins (predominantly PGD2 and PGF2), leukotrienes, kinins, kallikrein, and eosinophil derived major basic protein. (edu.pk)
The third step comprises the release of granule proteins, which occurs when eosinophils become exposed to soluble mediators for example PAF 10 , immuncomplexes 11 or solid particles 12 . (edu.pk)
They are also able to secrete additional mediators, which are not performed by their granules such as interleukins (IL) 5 . (bvsalud.org)

The presence of eosinophils in these latter organs is associated with disease. (wikidoc.org)
Since eosinophils are attracted to and phagocytize antigen-antibody complexes, the presence of eosinophils in the EGC indicates that it is an immune-mediated disease. (felipedia.org)

Bronchoscopic biopsies show presence of significantly more active eosinophils in the submucosae of mild and even asymptomatic asthmatics compared to controls. (edu.pk)
Human eosinophil hematopoiesis studied in vitro by means of murine eosinophil differentiation factor (IL5): production of functionally active eosinophils from normal human bone marrow. (edu.pk)

In this report, we show that IL-6 immunofluorescence localizes to the matrix of the crystalloid granule in peripheral blood eosinophils from atopic asthmatics using confocal laser scanning microscopy (CLSM). (huji.ac.il)
Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to a distinct crystalloid-free granule population in mature human eosinophils. (edu.pk)
Eosinophils contain different populations of mediator-storage organelles, including small secretory vesicles as well as crystalloid granules. (biomedcentral.com)
In cytolysis, eosinophil cell membrane loses its integrity and crystalloid granules are released to extracellular space. (biomedcentral.com)
Potential function of crystalloid granules in extracellular space as it relates to inflammatory events remains widely unknown. (biomedcentral.com)
We hypothesized that eosinophil crystalloid granules are equipped to function independently in extracellular space. (biomedcentral.com)
Our findings indicate that both DNA and RNA localize to human and rabbit eosinophil crystalloid granules and that RNA seems to be synthesized in intra-granular space further suggesting the presence of functional transcription machinery inside the granules. (biomedcentral.com)
Furthermore, we show here that crystalloid granules express functional membrane receptors for a cytokine, IFN-gamma, as well as G protein-coupled membrane receptors for a chemokine, eotaxin. (biomedcentral.com)
Taken together our findings define a new potential role for eosinophil crystalloid granules as independent extracellular functional units in inflammatory events and may reveal a novel target in modulating the inflammatory events. (biomedcentral.com)

Four distinct populations of granule (primary granules, secondary or specific granules, small granules, lipid bodies) have been recognized in eosinophil 13 . (edu.pk)
BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. (biovendor.com)

The wall thickening is characterised by submucosal oedema, vasodilatation, with cellular infiltrates, predominantly of lymphocytes and eosinophils. (edu.pk)
When Th2 lymphocytes are activated to produce cytokines, such as IL-5, this increases the production of eosinophils in the bone marrow and promotes release of these cells into the circulation 8 . (edu.pk)
Activated T lymphocytes produce a variety of lymphokines that are involved in eosinophilic maturation and act as eosinophil-chemotactic factors. (medscape.com)

All of these are either important for monocyte-macrophage, neutrophil or eosinophil proliferation, recruitment and activation, suggesting that cytokines/chemokines and proteases may have coevolved to not block the recruitment of monocytes-macrophages, neutrophils and possibly eosinophils during an inflammatory response involving neutrophil activation. (slu.se)
Mast cells are cells that reside in the connective tissue and contain a large number of granules, rich in histamine, heparin, chymase, serotonin, and also cytokines. (bvsalud.org)

After maturation, eosinophils circulate in blood and migrate to inflammatory sites in tissues, or to sites of helminth infection in response to chemokines like CCL11 (eotaxin-1), CCL24 (eotaxin-2), CCL5 ( RANTES ), and certain leukotrienes like leukotriene B4 (LTB4). (wikidoc.org)
The second step is the migration of eosinophils from the circulation to various tissues. (edu.pk)
An essential mediator of eosinophil trafficking into mucosal tissues. (edu.pk)
Eosinophils are a type of white blood cell that lives in your body's tissues. (healthmatters.io)
The primary function of erythrocytes is the transport of oxygen from the lungs to the tissues, this is made possible by the presence of haemoglobin - a red, iron-rich protein that binds oxygen. (3d4medical.com)

Prior studies have shown that extracellular deposition of eosinophil granule major basic protein (MBP) occurs in lesional AD skin, despite a paucity of infiltrating eosinophils, and that deposition of both neutrophil and eosinophil granule proteins occurs in the IgE-mediated late-phase reaction. (utmb.edu)
We evaluated the participation of both eosinophil and neutrophil granule proteins in AD. (utmb.edu)
Marked extracellular deposition of at least one of the eosinophil granule proteins was present in the dermis of 15 of the 22 AD skin specimens, but minimal or no extracellular neutrophil elastase or lactoferrin deposition was observed in any specimens. (utmb.edu)
These results suggest that eosinophil degranulation occurs in AD but that neutrophil degranulation does not. (utmb.edu)
Although eosinophil degranulation is prominent in both the late-phase reaction and in AD, the lack of neutrophil degranulation in AD demonstrates differences in the inflamamtory reactions. (utmb.edu)

[ 13 ] Spry et al reported eosinophilic degranulation of basic proteins causing myocardial damage in tissue cultures in vitro. (medscape.com)
Eosinophils persist in the circulation for 8-12 hours, and can survive in tissue for an additional 8-12 days in the absence of stimulation. (wikidoc.org)
The eosinophil is therefore an ideal target for selectively inhibiting the tissue damage that accompanies allergic diseases, without inducing the immunosuppressive consequences that can arise from systemic use of pleiotropic drugs such as steroids. (biomedcentral.com)
[ 4 ] This observation is in contrast to that of the animal wound-healing model, in which eosinophils that express transforming growth factor are typically recruited to healing tissue sites. (medscape.com)

Eosinophils are a type of white blood cell (leukocytes) that protect your body from parasites, allergens, foreign bacteria and outside organisms. (healthmatters.io)

Eosinophils develop and mature in bone marrow . (wikidoc.org)
Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. (biomedcentral.com)

Exhaled nitric oxide (NO), serum eosinophil cationic protein (ECP), and induced sputum (processed for eosinophil count and ECP level) were related to recent symptoms, lung function, and bronchial responsiveness. (nih.gov)
Sputum eosinophils were inversely related to the dose of methacholine that corresponded to a 20% fall in FEV1 (PC20) (r=-0.57, p=0.02). (nih.gov)
However, Beeh et al observed no significant difference in sputum eosinophils following nasal allergen provocation, although sputum ECP and intercellular adhesion molecule were increased. (onlineasthmainhalers.com)
Our observations expand those from Wilson et al, who showed that despite a significant increase in nasal symptoms and lavage eosinophil counts, a single nasal allergen challenge was not sufficient to elicit a measurable hemopoietic response in circulation, or an increase in sputum eosinophil counts. (onlineasthmainhalers.com)

Although they are phagocytic, eosinophils are less efficient than neutrophils in killing intracellular bacteria. (msdmanuals.com)
Eosinophils are observed commonly on cytologic imprints, but neutrophils and bacteria may prevail if the lesion is secondarily infected. (felipedia.org)
They also release a bunch of proteins which work to damage the bacteria. (kiddle.co)

In 2002, Science published an article that first showed protein C activates protease-activated receptor-1 (PAR-1) and this process accounts for the protein's modulation of the immune system. (wikipedia.org)
Within the RNaseA superfamily there is a group of highly cationic proteins secreted by innate immune cells with anti-infective and immune-regulatory properties. (frontiersin.org)

Eosinophils prevent foreign organisms from growing inside of host cells (parasites). (healthmatters.io)

IL-5, GM-CSF, and IL-3 are important for eosinophil activation as well as maturation. (wikidoc.org)

Antimicrobial proteins and peptides offer a multifaceted mechanism suitable to fight bacterial resistance. (frontiersin.org)

Human eosinophils express, relative to other circulating leukocytes, large amounts of secretory 14-kD phospholipase A2. (edu.pk)

The lumen contains mucus plugs, shed epithelium (Creola bodies) and Charcot-Leyden crystals (crystallised eosinophil derived major basic protein). (edu.pk)
Association of immunoreactive eosinophil major basic protein with placental septa and cysts. (shengsci.com)
A protein that is immunochemically indistinguishable from the major basic protein of the eosinophil granule is present at elevated concentrations in the plasma of pregnant women. (shengsci.com)
Major basic protein has been localized to placental trophoblasts known as X cells. (shengsci.com)

The migration of eosinophils depends on chemoattractants such as eotaxin, which is an eosinophil specific chemokine 9 . (edu.pk)

Neutrophils from these individuals have abnormalities in nuclear morphology and lack primary, specific, and tertiary granule proteins including lactoferrin, collagenase, and defensins. (lu.se)

35 In humans, protein C is encoded by the PROC gene, which is found on chromosome 2. (wikipedia.org)

Although these mice can produce constitutive levels of eosinophils, they do not react to an allergic challenge with blood or lung eosinophilia or hyperreactivity, compared to normal controls. (biomedcentral.com)
Background: Human mast cells (MCs) from anatomical sites show functional heterogeneity due to expression of various G-protein-coupled receptors (GPCRs), and since the function of human MCs is modulated by various GPCR ligands, the GPCRs expressed on MCs may play an important role in allergic diseases and anaphylaxis. (confex.com)
In addition, it has been demonstrated that recruited luminal airway eosinophils are distinct allergic "inflammatory" professional antigen-presenting cells able to activate primary CD4( ) T-cell responses in regional lymph nodes. (onlineasthmainhalers.com)
An increase of eosinophils as well as increased expression of intercellular adhesion molecule-1 was observed in the nasal and bronchial biopsies of allergic rhinitic patients compared with control subjects. (onlineasthmainhalers.com)
An increased number of eosinophils may mean your body is fighting an infection or allergic reaction. (healthmatters.io)

Leukemic blasts with prominent granules, often resembling multiple Auer rods, are a characteristic feature of Acute Myeloid Leukemia (AML). (labtestsguide.com)

Although eosinophils produce cysteinyl leukotrienes (CysLTs) in large quantities, information on the relationship between CysLTs and eosinophilic pneumonia (EP) is lacking. (ersjournals.com)

Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airway disease. (biovendor.com)

It is known since long that the total eosinophil count reflects asthmatic activity and is useful for regulating steroid dosage and for early detection of exacerbations. (edu.pk)
Further trials designed to measure eosinophil accumulation and lung function in asthmatic persons are currently underway, and will help to define the role of interleukin-5 and eosinophils in general in this disease. (biomedcentral.com)

Research into the clinical use of a recombinant form of human Activated Protein C (rhAPC) known as Drotrecogin alfa-activated, branded Xigris by Eli Lilly and Company, has been surrounded by controversy. (wikipedia.org)
Espana A, Sanz ML, Sola J, Gil P. Wells' syndrome (eosinophilic cellulitis): correlation between clinical activity, eosinophil levels, eosinophil cation protein and interleukin-5. (medscape.com)
Familial eosinophilia is an autosomal dominant disorder with a stable eosinophil count and a benign clinical course. (medscape.com)
Phase II clinical trial results failed to demonstrate an effective means to control the negative impacts of eosinophils. (nexeosbio.com)

We observed the proteins internalization within macrophages and their capacity to eradicate the intracellular mycobacterial infection at a low micro-molar range. (frontiersin.org)
Lundahl J, Halldén G, Hed J. Differences in intracellular pool and receptor-dependent mobilization of the adhesion-promoting glycoprotein Mac-1 between eosinophils and neutrophils. (edu.pk)

Mast cell patients sometimes have eosinophil GI disease where eosinophils activate to lots of triggers and damage the GI tract. (mastattack.org)

34 : 3162 Because of the crucial role that protein C plays as an anticoagulant, those with deficiencies in protein C, or some kind of resistance to APC, suffer from a significantly increased risk of forming dangerous blood clots (thrombosis). (wikipedia.org)
Protein C's anticoagulant role in the human body was first noted by Seegers et al. (wikipedia.org)
These proteins bind heparin and neutralize its anticoagulant activity. (msdmanuals.com)

This fusion gene encodes for the FIP1L1-PDGFR alpha protein, the constitutively activated tyrosine kinase activity that induces eosinophilia. (medscape.com)

The primary aim of this study is to evaluate the participation of eosinophils granules proteins in acute appendicitis, both at local and systemic levels and the secondary aim is to evaluate the diagnostic accuracy of eosinophils granules proteins for the detection of acute appendicitis, as well as for distinguishing between complicated and uncomplicated acute appendicitis. (bvsalud.org)

Magnesium sulfate induces translocation of protein kinase C isoenzymes alpha and delta in myometrial cells from pregnant women. (shengsci.com)

Eosinophils , or acidophils , are leukocytes. (kiddle.co)

Eosinophil production appears to be regulated by T cells through the secretion of the hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5). (msdmanuals.com)

4673 The protein C zymogen is activated when it binds to thrombin, another protein heavily involved in coagulation, and protein C's activation is greatly promoted by the presence of thrombomodulin and endothelial protein C receptors (EPCRs). (wikipedia.org)
The cationic eosinophilic proteins bind to the anionic endothelial protein, thrombomodulin. (medscape.com)

The eosinophil count can decrease with stress, with the use of beta-blockers or corticosteroids, and sometimes during bacterial or viral infections. (msdmanuals.com)
however, a propensity of eosinophils suggests that viral infections such as FHV[3] and underlying hypersensitivities such as a food allergy dermatitis, atopy, flea allergy dermatitis or mosquito-bite hypersensitivity have been associated with these lesions. (felipedia.org)

A clot is formed when fibrin, a fibrous protein, forms a mesh that entraps blood cells, primarily platelets and red blood cells, to stop bleeding and seal a wound when there is vascular injury. (labtestsguide.com)

The essential components of eosinophil migration into the lung, such as leukotriene (LT)D 4 , LTB 4 and IL-5, are generally considered chemotactic factors. (ersjournals.com)

Anatomy4

Organisms1

Diseases2

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Information Science1

Neurotoxin10

Peroxidase12

Basophils8

Granulocytes3

Inflammation14

Cationic granule proteins2

Eosinophilic cationic protein3

Cytotoxic4

Asthma19

Toxic6

Degranulation of eosinophils1

Cytoplasm2

Role of eosinophils1

Effector cells1

Mediators3

Presence of eosinophils2

Active eosinophils2

Crystalloid9

Specific granules2

Lymphocytes3

Cytokines2

Tissues5

Neutrophil5

Tissue4

Allergens1

Bone2

Sputum4

Bacteria3

Immune2

Parasites1

Maturation1

Peptides1

Secretory1

Major4

Eotaxin1

Lactoferrin1

Humans1

Allergic5

Prominent1

Leukotrienes1

Airway1

Asthmatic2

Clinical4

Intracellular2

Damage1

Anticoagulant3

Eosinophilia1

Acute1

Induces1

Acidophils1

Secretion1

Endothelial protein2

Viral2

Fibrin1

Migration1