Energetics structures protein conformation. Medical search. Frequent questions

molecular-level understanding of the structure, stability, interactions and dynamics of proteins. (lth.se)
describe the principal physico-chemical properties of proteins, such as structure, stability, interactions and dynamics. (lth.se)
Analysis of structure, interactions and dynamics of proteins in solution. (lth.se)
Theoretical and Experimental Studies of Enzyme Conformation, Energetics and Dynamics of CYP3A4. (ualg.pt)
Y64 is positioned μ Opioid Receptor/MOR Source within the SII region, which undergoes massive changes in structure and conformational dynamics upon nucleotide exchange. (ghsrinhibitor.com)
While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)
We probe the open conformation of human Hsp90α for druggable sites that overlap with these allosteric control elements, and identify three putative natural compound allosteric modulators: Cephalostatin 17, 20(29)-Lupene-3β-isoferulate and 3′-Bromorubrolide F. We assess the allosteric potential of these ligands by examining their effect on the conformational dynamics of the protein. (nature.com)
Its six backbone torsion angles and glycosidic bond between base and ribose provide conformational dynamics not afforded by the peptide bond of proteins and more flexibility than the DNA backbone. (datexis.com)

A systematic study of the energetics involved in structural changes upon association and connectivity in protein interaction networks. (irbbarcelona.org)
The study of protein binding mechanisms is a major topic of research in structural biology. (irbbarcelona.org)
Through the analyses of 2090 unique unbound → bound transitions, from over 12,000 structures, we show that two-thirds of these proteins do not suffer significant structural changes upon binding, and could thus fit the lock-and-key model well. (irbbarcelona.org)
We observe the P + and P - states are highly sensitive on the structural conformation and atomic charge distributions. (acscomp.org)
Some functions are performed by disordered protein structural parts. (alzforum.org)
A essential house of H-Ras is its structural flexibility, allowing it to engage a range of distinct effector proteins applying distinct SII conformations (4). (ghsrinhibitor.com)
Introduction to genomic & Proteomics, Structural genomics and proteomics, Human Genome project and other sequencing projects, Biological databases and data mining, sequence similarity search and sequence alignment, Protein structure predication and structure analysis, use of software package in Bioinformatics. (bits-pilani.ac.in)
But just as it had originally been the case in other fields of synthetic chemistry, such as molecular or solid state chemistry, the outcome of such a deposition with respect to the structure of the individual molecule or the structural arrangement of many molecules is very hard to predict without prior experimental input. (degruyter.com)
2017. Graded Structural Polymorphism in a Bacterial Thermosensor Protein. . (ncbs.res.in)
2017. Identification and structural characterization of the precursor conformation of the prion protein which directly initiates misfolding and oligomerization. . (ncbs.res.in)
Deep Fried is conformational materials by clustering a structural energy with the protein schemes of a addition. (bob-fernsehdienst.de)
Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. (openwetware.org)

With purified recombinant protein production and peptide synthesis to display limited/selected epitopes, intrinsic factors that can affect the functioning of resulting antibodies can be more easily selected for. (preprints.org)
See also David Thirumalai's Emerging Ideas on the Molecular Basis of Protein and Peptide Aggregation ' (.pdf). (alzforum.org)
Correlated ab initio calculations are used to compare the energetics when the CH and NH groups of the model dipeptide CHONHCH 2 CONH 2 are each allowed to form a H-bond with the proton acceptor O of a peptide group. (usu.edu)
During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. (cusabio.com)
the other is the peptide chain which formed the natural structure of protein through the folding process to obtain biological activity and express life information [ 2 ]. (ijpsonline.com)
Our results identify several salt bridges that stabilize outward-facing conformations and we show that, for all the current structures of MFS transporters, the first two helices of each of the four inverted-topology repeat units form half of either the periplasmic or cytoplasmic gate and that these function cooperatively in a scissor-like motion to control access to the peptide binding site during transport. (philipwfowler.me)

The structures indicate that Sec61 inhibitors stabilize the plug domain of Sec61 in a closed state, thereby preventing the protein-translocation pore from opening. (biorxiv.org)
The Sec61/SecY channel has an hourglass-like structure with a pore constriction (termed the pore ring) halfway across the membrane, which is gated by a movement of a plug-like ER-lumenal (or extracellular in SecY) domain of the channel 5 . (biorxiv.org)
Unlike other channels, opening of the pore is due to the repositioning of tethered pore-lining helices within a surrounding protein shell that dramatically widens a neck of the pore through a concertina of amino acid rearrangements. (elifesciences.org)
In bacteria, this comprises SecY, SecE and usually SecG, with the protein-conducting pore running through the centre of SecY. (elifesciences.org)
showing the cavities through the channel, with the protein in grey surface, the pre-protein pore constrictions in red (SecY) or purple (SecA) mesh, and the SecY plug in red helix. (elifesciences.org)
A large pore is formed by transmembrane proteins. (tcdb.org)
Intrinsically disordered regions in Pex13 and Pex5 resemble those found in nuclear pore complex proteins. (tcdb.org)
3407. S.A. Rutherford, M.W. Goldberg, T.D. Allen, 'Three-dimensional visualization of the route of protein import: the role of nuclear pore complex substructures,' Exp. (nanomedicine.com)
3409. V.C. Cordes, H.R. Rackwitz, S. Reidenbach, 'Mediators of nuclear protein import target karyophilic proteins to pore complexes of cytoplasmic annulate lamellae,' Exp. (nanomedicine.com)

A Biophysical Approach to Oxidative Protein Folding in the ER: Relative Importance of Ero1 and Prdx4 alternative pathways. (ualg.pt)
Protein Folding and Neurodegeneration: Biophysics to the Rescue? (alzforum.org)
This does not change our view of protein folding in the least. (alzforum.org)
This paper explores how the protein folding process per se may be exploited to drive protein translocation. (elifesciences.org)
The pathways related to cell protein folding and degradation need to be elucidated because of training was set. (ijpsonline.com)
The results showed that chaperonin containing tailless complex polypeptide the large number of proteins involved, the complex relationship between proteins and the lack of research on the effects of movement and cell protein folding and degradation. (ijpsonline.com)
As the expression vector of life information, the specific spatial structure formed by protein folding is the basis of its biological function. (ijpsonline.com)
Chaperonin Containing Tailless Complex Polypeptide 1 (CCT-1) is one of the important elements of protein folding pathway in cells and proteasome is an important component of Adenosine Triphosphate (ATP) dependent protein degradation pathway in cells. (ijpsonline.com)
They are involved in the formation of protein folding/degradation signalling pathway, maintaining the normal spatial structure and normal biological function of protein [ 3 ]. (ijpsonline.com)
Specific modifications commonly found at the junction of the stems of the cloverleaf structure (Figure 1), referred to as the core, elbow or hinge in the three-dimensional structure of most tRNAs, are often associated with functional folding, allowing tRNAs to fold into the common L-shape form critical to ribosomal protein synthesis. (datexis.com)
Temperature has a direct effect on fundamental biological systems, including enzyme activity and correct folding of proteins. (springer.com)

Broadly used in modern drug design, molecular docking methods explore the ligand conformations adopted within the binding sites of macromolecular targets. (mdpi.com)
Molecular docking is an essential process in scientific drug discovery to predict the binding mode and affinity of a small molecule (ligand) to a target protein. (intuitivetutorial.com)
Molecular docking involves the use of specialized software programs that simulate the interactions between a ligand and a target protein. (intuitivetutorial.com)
The ligand structure is obtained from a database of chemical structures or can be designed using a molecular modeling software. (intuitivetutorial.com)
The docking process starts by positioning the ligand in the binding site of the protein and then optimizing its conformation and orientation to find the most energetically favorable binding mode. (intuitivetutorial.com)
The binding affinity is calculated based on the interaction energy between the ligand and the protein, which is a measure of how strongly they are attracted to each other. (intuitivetutorial.com)
Understand the binding mechanism: Molecular docking can provide insights into the binding mechanism of a ligand to a target protein. (intuitivetutorial.com)
They use a Lamarckian Genetic Algorithm to search for the optimal binding pose of the ligand in the binding site of the protein. (intuitivetutorial.com)
MOE is a comprehensive molecular modeling software that includes a variety of tools for protein-ligand docking, virtual screening, and lead optimization. (intuitivetutorial.com)
DOCK is a molecular docking software that uses a grid-based method to evaluate the energetics of protein-ligand interactions. (intuitivetutorial.com)
The scoring function is a mathematical function that estimates the energy of the protein-ligand complex, and its accuracy can be affected by factors such as the flexibility of the protein and ligand, the solvation effects, and the accuracy of the force field used to describe the molecular interactions. (intuitivetutorial.com)
The choice of the scoring function can affect the accuracy of the docking results, and care should be taken to select a scoring function that has been validated for the specific protein-ligand system being studied. (intuitivetutorial.com)

In addition, the channel has a seam (lateral gate) in the wall that can open laterally in the plane of the membrane to release transmembrane segments (TMs) of membrane protein clients into the lipid phase. (biorxiv.org)
This new approach has been shown to preserve mobility and enzymatic activity of transmembrane proteins in the resulting nSLB. (lu.se)

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum (ER) membrane that is required for secretion of soluble proteins and production of many membrane proteins. (biorxiv.org)
2011) addresses two of these aspects, the translocation of soluble proteins into the peroxisomal matrix and the biogenesis of the peroxisomal membrane. (tcdb.org)

Here, we implement a combination of metrics to systematically assess the cost of backbone conformational changes that protein domains undergo upon association. (irbbarcelona.org)
Intramolecular Backbone···Backbone Hydrogen Bonds in Polypeptide Conformations. (ncbs.res.in)
Ongoing efforts to develop functional peptoids will necessitate improved capability for control of peptoid structure, particularly of the backbone amide conformation. (nextbigfuture.com)
In e.g. lines 116 onward, "chirality" is discussed with respect to protein backbone. (peerj.com)

Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. (cusabio.com)
Finally, the signal sequence is cleaved and the pre-protein is either folded or trafficked onwards. (elifesciences.org)

mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. (cusabio.com)
The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. (cusabio.com)
Transport of proteins across membranes is a fundamental process, achieved in every cell by the 'Sec' translocon. (elifesciences.org)
The encapsulation and compartmentalisation of cells has necessitated the evolution of machineries that conduct proteins across membranes, including for protein secretion and organellar import. (elifesciences.org)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
While high temperatures account for denatured and misfolded proteins, low temperatures may cause damage to membranes. (springer.com)

Most peroxisomal membrane proteins do not have PTS1 or PTS2, and insertion requires several peroxins distinct from those required for import of soluble matrix proteins. (tcdb.org)
3419. M.A. Mancini, D. He, I.I. Ouspenski, B.R. Brinkley, 'Dynamic continuity of nuclear and mitotic matrix proteins in the cell cycle,' J. Cell Biochem. (nanomedicine.com)
3422. J.H. Hughes, M.B. Cohen, 'Nuclear matrix proteins and their potential applications to diagnostic pathology,' Am. J. Clin. (nanomedicine.com)

We utilize two complementary models, HEK293 cells and human iPSC-derived neurons, and delineate RBM12 as a novel repressor of the G protein-coupled receptor/cAMP/PKA (GPCR/cAMP/PKA) signaling axis. (bvsalud.org)
In agreement with its activity as an RNA-binding protein, loss of RBM12 leads to altered gene expression, including that of multiple effectors of established significance within the receptor pathway. (bvsalud.org)
In the budding yeast Saccharomyces cerevisiae , the minimal transport machinery includes the membrane proteins Pex13 and Pex14 and the cargo-protein-binding transport receptor, Pex5. (tcdb.org)
Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. (cusabio.com)
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. (openwetware.org)
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. (openwetware.org)

In prokaryotes, SecYEG associates with the motor ATPase SecA to carry out translocation for pre-protein secretion. (elifesciences.org)
The bulk of protein secretion and membrane protein insertion is conducted by the ubiquitous Sec translocon. (elifesciences.org)

The improved fluorescence exhibited by different isomeric forms of PPV derivatives in optoelectronic devices motivated us to investigate the influence of various conformational distortions of trans and cis nature on the energetics and localization of positive (P + ) and negative (P - ) polarons. (acscomp.org)

Structures of the disease variant bound to peptides derived from two PCNA partner proteins reveal that the binding pocket can adjust conformation to accommodate some ligands, indicating that the binding site is dynamic and pliable. (rcsb.org)
Among the remaining proteins, one-third explores the bound conformation in the unbound state (conformational selection model) and, while most transitions are possible from an energetic perspective, a few do require external help to break the thermodynamic barrier (induced fit model). (irbbarcelona.org)
The membrane bound docking subcomplex includes several Pex proteins, Pex13p, 14p and 17p. (tcdb.org)

This reversal is important as C 5 is nearly equal in stability to C 7 for the dipeptide, and is representative of the commonly observed β-sheet structure in a protein. (usu.edu)
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
Exploiting side-chain diversity offers many ways to increase the predictability and stability of folds, many ways to link folded structures to form larger systems, and many ways to imbue those structures with new functions. (nextbigfuture.com)
Here, we will focus on the impact of specific modified nucleoside chemistries which add to the chemistry of tRNAs and alter their structure and stability. (datexis.com)
Due to the inherent diversity in the underlying mechanisms, protein-based thermosensors affect different cellular processes such as transcription, translation, protein stability, signal transduction as well as proteolytic processes. (springer.com)

When the dipeptide is in its C 7 conformation, the NH··O H-bond energy is found to be 7.4 kcal/mol, as compared to only 2.8 kcal/mol for the CH··O interaction. (usu.edu)
Hsp90's diverse array of clientele implicate the chaperone in several associated biological functions and place it at the intersection of various fundamental cellular pathways, where it acts as a central hub in maintaining numerous protein interaction networks 1 . (nature.com)
In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)

The eukaryotic DNA polymerase sliding clamp, proliferating cell nuclear antigen or PCNA, is a ring-shaped protein complex that surrounds DNA to act as a sliding platform for increasing processivity of cellular replicases and for coordinating various cellular pathways with DNA replication. (rcsb.org)
3411. P.C. Park, U. De Boni, 'A specific conformation of the territory of chromosome 17 locates ERBB-2 sequences to a DNase-hypersensitive domain at the nuclear periphery,' Chromosoma 107(May 1998):87-95. (nanomedicine.com)

We also analyze the relationship between conformational transitions and protein connectivity, finding that, in general, domains interacting with many partners undergo smaller changes upon association, and are less likely to freely explore larger conformational changes. (irbbarcelona.org)
Membrane-induced conformational changes happen to be reported for each H- and N-Ras (15, 17), and membrane-specific conformations on the HVR in full-length H-Ras happen to be predicted by MD simulations (18). (ghsrinhibitor.com)
A combination of molecular simulation with hydrogendeuterium-exchange mass spectrometry and electron paramagnetic resonance spectroscopy reveal an asymmetry across the membrane: ATP-induced conformational changes in the cytosolic cavity promote unfolded pre-protein structure, while the exterior cavity favours its formation. (elifesciences.org)

Completed the Doutoramento in Protein Electrostatics: Theory, Methods and Applications in 2006/06/01 by Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica and Licenciatura in Bioquímica in 1988 by Universidade de Lisboa Faculdade de Ciências. (ualg.pt)

Parts derived from human and yeast proteins are outlined with solid and dashed lines, respectively. (biorxiv.org)
Even modifications as simple as methyl groups can exhibit distinguishable dynamic motions that depend on their location within the RNA structure, for instance the methyl groups of yeast tRNAPhe. (datexis.com)

In general, modified nucleosides impact the overall structure and local chemistry of tRNAs, the ability of macromolecules to recognize tRNAs, or the decoding ability of tRNAs. (datexis.com)

The reason why Peter Lansbury and others used the term 'natively unfolded' for a-synuclein and other proteins, especially peptides, is that they do not exist, to a significant degree, in the same kind of stable structure that larger native proteins like myoglobin do. (alzforum.org)

The Sec61 complex also mediates membrane integration of many proteins, including most cell surface receptors and cell adhesion molecules. (biorxiv.org)

In the following, we refer to pump of halophilic archaebacteria, has become the these as the extracellular (EC) channel and the paradigm of membrane proteins in general and ion cytoplasmic (CP) channel. (lu.se)

Computer simulation of proteins. (lth.se)
One of the challenges of molecular docking is the accuracy of the protein structure used in the docking simulation. (intuitivetutorial.com)
The quality of the protein structure can affect the accuracy of the docking results, and care should be taken to select a high-quality structure for the docking simulation. (intuitivetutorial.com)

Rod cyclic nucleotide-gated (CNG) channels are modulated by changes in tyrosine phosphorylation catalyzed by protein tyrosine kinases (PTKs) and phosphatases (PTPs). (silverchair.com)
These studies suggest that PTKs affects RETα channels in two ways: (1) by catalyzing phosphorylation of the channel protein, and (2) by allosterically regulating channel activation. (silverchair.com)

Cryo-EM structures of the human Sec61 complex inhibited by various small-molecule inhibitors. (biorxiv.org)

This method can help to identify potential drug candidates by virtually screening large chemical libraries and selecting compounds that are most likely to bind to the target protein with high affinity. (intuitivetutorial.com)
Optimize lead compounds: Once a lead compound has been identified, molecular docking can be used to optimize its structure and improve its binding affinity to the target protein. (intuitivetutorial.com)
Predict drug toxicity: Molecular docking can also be used to predict the potential toxicity of a drug candidate by predicting its binding affinity to off-target proteins. (intuitivetutorial.com)

2016). Here, we show that ATP enhances this process by modulating secondary structure formation within the translocating protein. (elifesciences.org)

carry out spectroscopic measurements on proteins. (lth.se)
The QM/MM calculations were further supported by multireference calculations of the MCO spectroscopic properties20 and combined extended X-ray absorption fine- structure EXAFS/QM/MM calculations.21 This has led to the consensus reaction mechanism depicted in Fig. 1. (lu.se)

In this review, we present an overview over the current state of the art regarding the prediction and clarification of structures of biomolecules on surfaces using theoretical and computational methods. (degruyter.com)

The protein must then fold during or after the translocation process. (elifesciences.org)

Long-distance conformational coupling between the Ras C terminus and canonical switch area has been modeled by MD simulations, revealing how side-chain interactions could transmit information across the protein along isoformspecific routes (21). (ghsrinhibitor.com)
An important corollary is that allostery amongst the dimer interface and Y64SII conformations could straight couple H-Ras dimerization to effector interactions. (ghsrinhibitor.com)
Access to novel side-chain functionality will enable peptoid designers to exploit novel binding interactions, including many that have been discovered and exploited in crystal engineering, a field that has extensively explored the self-assembly of small organic molecules to form well-ordered structures. (nextbigfuture.com)

Protein characterization by optical spectroscopy: Physical principles and applications of fluorescence and circular dichroism spectroscopy. (lth.se)

The mutation lies near the binding site for most PCNA-interacting proteins. (rcsb.org)
We show that the mutation markedly alters the binding energetics for some client proteins, while another, p21(CIP1), is only mildly affected. (rcsb.org)

On the other hand, the situation reverses, and the CH··O H-bond becomes stronger than NH··O, when the dipeptide adopts a C 5 structure. (usu.edu)
In the catalytic reaction, Glu35 is thought to act as a general acid catalyst to protonate the glycosidic oxygen, while Asp52 acts as a conjugate base and stabilizes the carbonium ion intermediate that adopts a half-chair conformation with C1 carbon displaying sp 2 hybridization. (frontiersin.org)

It seems to mean a property that would be observed if several sequential residues were to adopt the same conformation. (peerj.com)

When we're taught biochemistry, we see proteins in their physiologically active forms. (alzforum.org)

Otherwise, an ELISA without the use of streptavidin-biotin binding would be more advisable to avoid biotin and targets protein relationship and prevent biotin interference on results. (preprints.org)
In addition, a quantitative structure-property relationship model was constructed to correlate the polymer's essential characteristic to the selectivity under those conditions, which, moving forward, will allow for the predictive screening of many PIM functionalities. (acscomp.org)
Relationship between CYP3A4 gene polymorphisms, protein structure and activity in disease setting. (ualg.pt)
This would fundamentally change our conventional thinking about protein structure-function relationship, no? (alzforum.org)

Human Genome Project has revealed similar genetic themes not only between species, but also between proteins. (wikipedia.org)
The universally conserved heterotrimeric Sec61 complex (SecY in prokaryotes) plays essential roles in biosynthesis of more than one third of proteins in all species (for review, see ref. 1 - 4 ). (biorxiv.org)

The peroxisomal protein import machinery, which shares similarities with chloroplasts, is unique in transporting folded and large (up to 10 nm in diameter) protein complexes into peroxisomes. (tcdb.org)

Protein music (DNA music or genetic music) is a musical technique where music is composed by converting protein sequences or genes to musical notes. (wikipedia.org)
Pink noise (the correlation structure "1/f spectra") have been found in both musical signals and DNA sequences. (wikipedia.org)
Musical renditions of DNA and proteins is not only a music composition method, but also a technique for studying genetic sequences. (wikipedia.org)
C-terminal PTS1 [(SAC)-(KRH)-(LM)] and N-terminal PTS2 [(RK)-(LIV)-X 5 -(HQ)-(LA)] targeting sequences are recognized by Pex5p and Pex7p, respectively, which may shuttle with the substrate protein to the peroxisomal lumen. (tcdb.org)
DNA thermosensors, also referred to as DNA thermometer, are AT-rich sequences that alter the structure and bending of DNA in response to temperature. (springer.com)
The third class of thermosensing is based on the temperature-dependent conformation of specific RNA sequences, which are termed RNA-thermometer (RNAT). (springer.com)

To honor Michael, we invite submissions for this Special Issue of Viruses focusing on Michael's interests: virus structures and assembly mechanisms, conformational transitions and structure-function relationships, and genome packaging and virus infection mechanisms. (mdpi.com)
Its applications are numerous and it has become an essential tool for identifying new drug candidates, optimizing lead compounds, and understanding the binding mechanisms of drugs to their target proteins. (intuitivetutorial.com)
These mechanisms include the ability of lead to inhibit or mimic the action of calcium and to interact with proteins. (cdc.gov)

circular reference] The first published references to protein music in the scientific literature are a paper co-authored by a member of The Shamen in 1996, and a short correspondence by Hayashi and Munakata in Nature in 1984. (wikipedia.org)

However, the riches sources of biotin as egg yolk, leading to high biotin concentrations in samples, harming the accuracy of diagnostic and proteins concentrations tests. (preprints.org)
The rotation could be correlated with the exchange in position of ~relative to the three different3-subunits as each in turn passed through the forex broker liquidity providers conformations and hydrolysed a molecule of ATE At saturating concentrations of ATE the full speed of rotation is estimated as 130 revolutions per second. (forextrading-madeeasy.com)

The protein structure is typically obtained from experimental techniques such as X-ray crystallography or NMR spectroscopy. (intuitivetutorial.com)

We previously showed that deletion of Protein Kinase A (PKA) regulatory subunit BCY1 can decouple growth and metabolism in Saccharomyces cerevisiae engineered for anaerobic xylose fermentation, allowing for robust fermentation in the absence of division. (bvsalud.org)

For several reasons there is a growing interest in the scientific community in immunoglobulin Y as antibiotic alternative and their oral administration in the polyclonal antibody (pAb) format, to maintain animal health and performance, do not require IgY purification for large-scale production, resulting in protein impurities and high concentration of biotin in the samples. (preprints.org)
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. (openwetware.org)
Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields. (openwetware.org)

This ability to exploit structure within a pre-protein is an unexplored area of protein transport, which may apply to other protein transporters, such as those of the endoplasmic reticulum and mitochondria. (elifesciences.org)

Not only does RNA translate the genetic code decoding it into protein, but it also has various catalytic and regulatory functions yet to be completely elucidated. (datexis.com)
These thermosensors are part of a regulatory network, such as the production of heat shock proteins mediated by sigma factor 32 (RpoH) in Escherichia coli or the transcriptional repressor of heat-shock genes HrcA in Bacillus subtilis (Hecker et al. (springer.com)

The conformations and energetics of the protein secondary and tertiary structures at the atomic level. (wikipedia.org)
Here we present near-atomic-resolution structures of the human Sec61 channel inhibited by a comprehensive panel of structurally distinct small molecules- cotransin, decatransin, apratoxin F, ipomoeassin F, mycolactone, cyclotriazadisulfonamide (CADA) and eeyarestatin I (ESI). (biorxiv.org)

Changes in temperature are typically sensed as a result of conformation changes of protein structure as well as misfolded proteins. (springer.com)

One option involves modulation of the protein through allosteric activation/inhibition. (nature.com)

Conformation of replicated segments of chromosome fibres in human S-phase nucleus,' Chromosome Res. (nanomedicine.com)

These results suggest that the structure of the transition state (TS), which connects the pre-open and closed states of the channel, more closely resembles the structure of the pre-open state. (philipwfowler.me)

2011 ) have reviewed the processes by which matrix and membrane proteins are incorporated into the peroxysome. (tcdb.org)

Protein Kinases Promising Targets for Anticancer Drug Researc. (intechopen.com)

Identify novel drug candidates: By screening large chemical libraries, molecular docking can identify compounds that have the potential to bind to a specific protein target and inhibit its activity. (intuitivetutorial.com)

Developing novel materials and device architectures to further enhance the efficiency of polymer solar cells requires a fundamental understanding of the impact of chemical structures on photovoltaic properties. (uni-potsdam.de)

similarly proteins only make sense when they act as chunked units. (wikipedia.org)
Similarly, the powerful global search techniques that have been applied to, and sometimes specifically developed for, the structure prediction of crystals and single molecules in vacuum or solvent can also be employed for the prediction of the structure(s) of molecules on surfaces. (degruyter.com)

This importance is focussed on the target binding site - epitope, where epitope selection as a part of design thinking beyond traditional antigen selection using whole cell or whole protein immunisation can positively impact success. (preprints.org)

The tool kit in hand for peptoid engineering is large and growing, and has already proved adequate for engineering protein-scale macromolecular objects. (nextbigfuture.com)

I agree with you that we also want to examine the earlier, less stable structures. (alzforum.org)
But we are still far away from an unbiased structure prediction of thermodynamically and/or kinetically stable structures of molecules on surfaces. (degruyter.com)
The solubilized protein was found to be stable in the dark for at least eight months at 277 K. (lu.se)

Anatomy9

Organisms11

Diseases1

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes93

Disciplines and Occupations8

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture2

Information Science11

Health Care4

Dynamics8

Structural12

Peptide6

Pore9

Folding11

Ligand12

Transmembrane2

Soluble proteins2

Backbone4

Sequence2

Membranes7

Matrix proteins3

Receptor6

Secretion2

Localization1

Bound3

Stability5

Interaction3

Nuclear2

Conformational changes3

Electrostatics1

Yeast2

Macromolecules1

Peptides1

Mediates1

Cytoplasmic1

Simulation3

Phosphorylation2

Small-molecule1

Affinity3

20161

Spectroscopic2

Theoretical1

Translocation1

Interactions3

Characterization1

Mutation2

Adopts2

Residues1

Biochemistry1

Relationship4

Species2

Complexes1

Sequences6

Mechanisms3

19961

Concentrations2

Crystallography1

Subunit1

Antibody3

Endoplasmic reticulum1

Regulatory2

Atomic2

Typically1

Involves1

Segments1

Transition1

Processes1

Targets1

Inhibit1

Chemical structures1

Similarly2

Whole protein1

Macromolecular1

Stable3