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ChlordiazepoxideAnti-Anxiety AgentsBenzodiazepinesGABA ModulatorsMeprobamateDiazepamBromine RadioisotopesMethocarbamolFlumazenilOxazepamHypnotics and SedativesBenzodiazepinonesNitrazepamFlurazepamAzabicyclo CompoundsDextroamphetamineAlcohol Withdrawal DeliriumReinforcement SchedulePentobarbitalTranquilizing AgentsColumbidaeBehavior, AnimalDiscrimination LearningBarbituratesReceptors, Thyrotropin-Releasing HormoneTrazodoneBromthymol BlueAntidepressive Agents, Second-Generation

OxazepamClorazepateLibriumDiazepamBenzodiazepinesAlprazolamSedativeCompoundsDosesMetabolitesValiumCapsulesHalf-lifeAlcoholSeverePrimarily viaChemical nameDrugsEffectTreatmentPatientsPropertiesLossHydrochloride and clidinium bromideMetabolismBenzodiazepineClidiniumAntianxietyCapsuleDiazepam and desmethyldiazepamCapsulesCodeineClonazepamHoursOralLong-termActionDrugPhysicalBlood

Oxazepam2

• Disulfiram may also decrease the clearance of some benzodiazepines (diazepam, oxazepam, and chlordiazepoxide), caffeine, and some tricyclic antidepressants (desipramine and imipramine). (medscape.com)
• Patients should be warned that the effects of alcohol or other CNS -depressant drugs may be additive to those of oxazepam, possibly requiring adjustment of dosage or elimination of such agents. (wikidoc.org)

Clorazepate3

• Unlike chlordiazepoxide, clorazepate, and prazepam, alprazolam has a shorter half-life and metabolites with minimal activity. (itopmeds.com)
• Nordazepam is an active metabolite of diazepam , chlordiazepoxide , clorazepate , prazepam , pinazepam , and medazepam , used primarily in the treatment of anxiety disorders. (nonpsychotoxic.com)
• Active metabolite of Diazepam , Chlordiazepoxide , Clorazepate , among many others, which is where most of its effects come from. (nonpsychotoxic.com)

Librium3

• Librium Tablet has chlordiazepoxide as an active ingredient. (pharmeasy.in)
• The first benzodiazepine, chlordiazepoxide (Librium) was discovered serendipitously in 1954 by the Austrian scientist Leo Sternbach (1908-2005), working for the pharmaceutical company Hoffmann-La Roche . (wikidoc.org)
• Three years later chlordiazepoxide was marketed as a therapeutic benzodiazepine medication under the brand name Librium. (wikidoc.org)

Diazepam3

• Increased fat increases the volume of distribution for highly lipophilic drugs (eg, diazepam, chlordiazepoxide) and may meaningfully increase their elimination half-lives. (msdmanuals.com)
• Following chlordiazepoxide in 1963 diazepam hit the market under the brand name Valium, followed by many further benzodiazepine compounds which were introduced over the subsequent years and decades. (wikidoc.org)
• Diazepam accumulates upon multiple dosing, and there is some evidence that the terminal elimination half-life is slightly prolonged. (medilabcompounding.com)

Benzodiazepines2

• The use of benzodiazepines, including chlordiazepoxide hydrochloride capsules, exposes users to risk of abuse, misuse, and addiction, which can lead to overdose or death. (nih.gov)
• The continued use of benzodiazepines, including chlordiazepoxide hydrochloride capsules, may lead to clinically significant physical dependence. (nih.gov)

Alprazolam1

• Route of elimination: Alprazolam and its metabolites are excreted primarily in the urine. (itopmeds.com)

Sedative1

• Chlordiazepoxide hydrochloride has antianxiety, sedative, appetite-stimulating and weak analgesic actions. (nih.gov)

Compounds2

• Chlordiazepoxide hydrochloride, is the prototype for the benzodiazepine compounds. (nih.gov)
• Chlordiazepoxide hydrochloride is among the safer of the effective psychopharmacologic compounds available, as demonstrated by extensive clinical evidence. (nih.gov)

Doses2

• however, first-order elimination kinetics are still a good approximation for doses up to 650 mg. (drugs.com)
• The elimination of therapeutic doses is through the kidneys either as salicylic acid or other biotransformation products. (drugs.com)

Metabolites4

• The elimination of disulfiram and its numerous metabolites is a very slow process. (medscape.com)
• Elimination of butalbital is primarily via the kidney (59%-88% of the dose) as unchanged drug or metabolites. (drugs.com)
• Elimination of butalbital is primarily via the kidney (59% to 88% of the dose) as unchanged drug or metabolites. (drugcite.com)
• Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. (drugcite.com)

Valium1

• The long elimination half-life of Valium also contributes to the drug's tapering effect, producing a smooth comedown while acting as an effective anticonvulsant. (bedrockrecoverycenter.com)

Capsules5

• Before prescribing chlordiazepoxide hydrochloride capsules and throughout treatment, assess each patient's risk for abuse, misuse, and addiction (see WARNINGS ). (nih.gov)
• Abrupt discontinuation or rapid dosage reduction of chlordiazepoxide hydrochloride capsules after continued use may precipitate acute withdrawal reactions, which can be life-threatening. (nih.gov)
• To reduce the risk of withdrawal reactions, use a gradual taper to discontinue chlordiazepoxide hydrochloride capsules or reduce the dosage (see DOSAGE AND ADMINISTRATION and WARNINGS ). (nih.gov)
• Chlordiazepoxide hydrochloride is available as capsules containing 5 mg, 10 mg or 25 mg chlordiazepoxide hydrochloride. (nih.gov)
• Chlordiazepoxide HCl Capsules are contraindicated in patients with known hypersensitivity to the drug. (minclinic.ru)

Half-life3

• They can be classified into 3 groups according to the time of elimination from the body (said half-life): fast - medium - low elimination. (cmas.org)
• The initial distribution phase is followed by a prolonged terminal elimination phase (half-life up to 48 hours). (medilabcompounding.com)
• The terminal elimination half-life of N-desmethyldiazepam is up to 100 hours. (medilabcompounding.com)

Alcohol1

• Elimination of alcohol withdrawal syndromes. (pharmeasy.in)

Severe1

• Tree elimination, on the various other hand, is a severe therapy taken when a tree can not be maintained or setups a substantial risk. (snowmanshoppe.com)

Primarily via1

• The elimination of codeine is primarily via the kidneys, and about 90% of an oral dose is excreted by the kidneys within 24 hours of dosing. (drugs-library.com)

Chemical name1

• The original chemical name of chlordiazepoxide was methaminodiazepoxide but it was changed to chlordiazepoxide. (wikidoc.org)

Drugs1

• Non-Steroidal anti-inflammatory drugs nsaids may 2021, narcotic pain and thus a short-acting drug elimination change your doctor may not individual health. (myjuicecup.com)

Effect3

• The taming effect of chlordiazepoxide hydrochloride was further demonstrated in rats made vicious by lesions in the septal area of the brain. (nih.gov)
• Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide. (minclinic.ru)
• During studies, chlordiazepoxide induced muscle relaxation and a quieting effect on laboratory animals like mice, rats, cats, and dogs. (wikidoc.org)

Treatment2

• Chlordiazepoxide enabled the treatment of emotional disturbances without a loss of mental acuity or alertness. (wikidoc.org)
• Tree treatment services should stick to also regional in addition to throughout the nation requirements controling tree elimination, conservation, along with urbane preparation job. (snowmanshoppe.com)

Patients1

• Forty-two hospital patients admitted for acute and chronic alcoholism, and various psychoses and neuroses were treated with chlordiazepoxide. (wikidoc.org)

Properties1

• Chlordiazepoxide is similar to phenobarbital in its anticonvulsant properties. (wikidoc.org)

Loss1

• Tree elimination, by its nature, produces the full loss of the tree. (snowmanshoppe.com)

Hydrochloride and clidinium bromide2

• Chlordiazepoxide hydrochloride and clidinium bromide capsules, USP are fixed combination of chlordiazepoxide hydrochloride, a benzodiazepine, and clidinium bromide, an anticholinergic. (nih.gov)
• Each chlordiazepoxide hydrochloride and clidinium bromide capsule, USP contains the active ingredients 5 mg chlordiazepoxide hydrochloride USP and 2.5 mg clidinium bromide USP. (nih.gov)

Metabolism1

• Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. (drugcite.com)

Benzodiazepine4

• Chlordiazepoxide hydrochloride is the prototype for the benzodiazepine compounds. (nih.gov)
• Chlordiazepoxide hydrochloride is 7-chloro-2-(methylamino)-5-phenyl-3 H -1, 4-benzodiazepine 4-oxide hydrochloride. (nih.gov)
• [ 5 ] Midazolam, a short-acting benzodiazepine with an elimination half-life of 1.5-2.5 hours, is commonly used as a premedication. (medscape.com)
• Both chlordiazepoxide and lorazepam belong to the same class called benzodiazepine with similar mode of action. (ndtv.com)

Clidinium3

• Chlordiazepoxide HCl/Clidinium Bromide combines in a single capsule formulation the antianxiety action of chlordiazepoxide hydrochloride and the anticholinergic/spasmolytic effects of clidinium bromide, both exclusive developments of Roche research. (medlibrary.org)
• In combination with chlordiazepoxide, clidinium is indicated to control emotional and somatic factors in gastrointestinal disorders, and is used as adjunctive therapy in the treatment of peptic ulcer, irritable bowel syndrome and acute enterocolitis. (drugbank.com)
• Ingesting alcohol may increase the CNS depressant effects of the combination product Chlordiazepoxide HCl and Clidinium Bromide. (drugbank.com)

Antianxiety1

• Chlordiazepoxide HCI has antianxiety, sedative, appetite-stimulating and weak analgesic actions. (nih.gov)

Capsule1

• This capsule gets metabolized in liver by CYP2C19 with elimination half life of around 5 to 7.5 hours which depends on dose. (actizapharmaceutical.com)

Diazepam and desmethyldiazepam1

• The mean elimination half-life of diazepam and desmethyldiazepam following administration of a 15 mg dose of diazepam rectal gel was found to be about 46 hours (CV=43%) and 71 hours (CV=37%), respectively. (nih.gov)

Capsules3

• Available as capsules for oral administration containing either 5 mg, 10 mg or 25 mg of chlordiazepoxide hydrochloride. (nih.gov)
• Chlordiazepoxide HCI Capsules are indicated for the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. (nih.gov)
• Chlordiazepoxide HCI Capsules are contraindicated in patients with known hypersensitivity to the drug. (nih.gov)

Codeine1

• The elimination of codeine is primarily via the kidneys, and about 90% of an oral dose is excreted by the kidneys within 24 hours of dosing. (drugcite.com)

Clonazepam1

• The elimination half-life of clonazepam is often 30 to forty hours. (postheaven.net)

Hours1

• [6] Its elimination half-life is 51-103 hours. (cloudfront.net)

Oral1

• Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide. (minclinic.ru)

Long-term1

• The effectiveness of chlordiazepoxide in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. (nih.gov)

Action2

• Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. (nih.gov)
• Chlordiazepoxide hydrochloride has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. (nih.gov)

Drug1

• Forced diuresis may be useful in facilitating elimination of the drug. (druginteractionchecker.com)

Physical1

• Chlordiazepoxide may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a vehicle or operating machinery. (nih.gov)

Blood1

• The table below sets out the levels and addresses potential timeframes for elimination from the body/detection in blood (only blood is referred to as this is what will be tested). (release.org.uk)