Administration, OralDrug Administration ScheduleTreatment OutcomeDose-Response Relationship, DrugInjections, IntravenousTime FactorsUnited States Food and Drug AdministrationDrug Administration RoutesRats, Sprague-DawleyDouble-Blind MethodDisease Models, AnimalAdministration, IntranasalRats, WistarInjections, SubcutaneousInjections, IntraperitonealMice, Inbred C57BLAdministration, TopicalDrug Therapy, CombinationInfusions, IntravenousInjections, IntramuscularAdministration, RectalBiological AvailabilityLiverMice, Inbred BALB CDrug CombinationsAntineoplastic AgentsHalf-LifeArea Under CurveDrug InteractionsAdministration, IntravenousAdministration, CutaneousCross-Over StudiesTissue DistributionDogsRandom AllocationInjections, IntraventricularProspective StudiesAdministration, InhalationRecombinant ProteinsAntibodies, MonoclonalRats, Inbred StrainsAdministration, SublingualDrug Evaluation, PreclinicalPlant ExtractsAnti-Bacterial AgentsAnalysis of VarianceBrainDrug ToleranceBlood PressureInjectionsBody WeightPlacebosClinical Trials as TopicKidneyInfusions, ParenteralDrug SynergismMorphineRabbitsBehavior, AnimalAnalgesics, OpioidMice, Inbred ICRPain MeasurementLungMice, NudeDrug Delivery SystemsRandomized Controlled Trials as TopicProdrugsAnti-Inflammatory Agents, Non-SteroidalDelayed-Action PreparationsGenetic TherapyCell Line, TumorAnalgesicsFollow-Up StudiesNeoplasmsPregnancyChromatography, High Pressure LiquidInjections, SpinalRNA, MessengerPiperidinesGenetic VectorsAntineoplastic Combined Chemotherapy ProtocolsMetabolic Clearance RateSafetyPilot ProjectsAnti-Inflammatory AgentsPainXenograft Model Antitumor AssaysEnzyme InhibitorsPhytotherapyRats, Inbred F344Organ SizeDrug CarriersMotor ActivityDrug ApprovalRetrospective StudiesHeart RateCombined Modality TherapyMice, KnockoutPiperazinesEthanol