• Along with individual coxsackievirus (A2-8 A10 A12 A14 and A16) EV71 is certainly classified in to the types individual enterovirus A which is certainly made up of most causative agencies responsible for hands foot and mouth area disease (HFMD) predicated on its genome series1 2 EV71 and CA16 are main etiological agencies for HFMD an exanthematous and self-limited febrile disease. (healthyguide.info)
  • Hand, foot, and mouth disease (HFMD) is a common infection caused by a group of enteroviruses. (wikipedia.org)
  • Enterovirus 71 (EV71) infection may be asymptomatic or may cause diarrhea, rashes, and hand, foot and mouth disease (HFMD). (loinc.org)
  • During 2013 to 2016 prior to the introduction of Enterovirus 71 (EV71) vaccine, the incidence and mortality of HFMD have been leading the type C notifiable infectious diseases, affecting an average of more than 2.2 million children every year in China ( http://www.nhc.gov.cn/ ). (biomedcentral.com)
  • A large number of cases in the current outbreaks of HFMD in Asia are reportedly caused by enterovirus 71 (EV71). (flutrackers.com)
  • However, other strains of enterovirus can also cause HFMD. (flutrackers.com)
  • Of the HFMD cases reported in China, most were in children 5 years of age and younger, and of those tested in laboratories, the majority were caused by EV71. (flutrackers.com)
  • As of July 2, 2008, a total of 100 cases of HFMD have been reported in Hong Kong, with 66 (66%) of the cases caused by EV71. (flutrackers.com)
  • The clinical results showed the efficacy of the vaccine against EV71-associated hand, foot and mouth disease (HFMD), or herpangina, was 94.8% among infants and young children and an anti-EV71 neutralizing antibody titer of 1:16 was associated with protection against EV71 associated HFMD or herpangina. (centerwatch.com)
  • As outlined in the NEJM article, Sinovac's vaccine also demonstrated a 100% efficacy rate against EV71-associated hospitalization and against HFMD with neurologic complications, the main cause of fatalities. (centerwatch.com)
  • The primary endpoint was the occurrence of EV71-associated HFMD, or herpangina. (centerwatch.com)
  • The results showed the vaccine can provide protection against EV71 associated HFMD in infants and children. (centerwatch.com)
  • Fengcai Zhu, M.D., director of Jiangsu Centers for Disease Control and Prevention, co-principal investigator and lead author, said, "This study showed that the EV71 vaccine provides protection to the infants and young children against EV71-associated HFMD and the vaccine candidate has good safety and immunogenicity profile. (centerwatch.com)
  • The successful development of the EV71 vaccine is an exciting achievement by Sinovac, as it will provide an effective tool to protect infants and young children against EV71 associated HFMD, especially at the level of severe cases and potential fatalities. (centerwatch.com)
  • The most dominant epitope was highly conserved among enterovirus species, including HFMD-related coxsackieviruses, HFMD-unrelated echoviruses and polioviruses. (epivax.com)
  • Besides enterovirus 71 (EV71), Coxsackie virus A16 (CVA16) is a major etiologic agent of hand, foot and mouth disease (HFMD), causing infections in millions of children under 5 years of age each year. (omicsonline.org)
  • BEIJING, June 11, 2012 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: SVA), a leading provider of biopharmaceutical products in China, today announced a positive SFDA inspection of the three clinical trial sites being used in the Company's Phase III study of its proprietary inactivated Enterovirus 71 (EV71) vaccine against hand, foot and mouth disease (HFMD). (sinovac.com)
  • HFMD adalah disebabkan oleh virus enterovirus. (azeniahmad.com)
  • The most common strains causing HFMD are Coxsackie A virus and Enterovirus 71 (EV-71). (org.vn)
  • Hand-foot-and-mouth disease (HFMD) is a febrile disorder usually caused by coxsackievirus A16, enterovirus 71, or other enteroviruses. (msdmanuals.com)
  • Immunohistochemical (IHC) staining was positive when using a monoclonal antibody for enterovirus 71 (EV71), a picornavirus associated with HFMD. (cambridge.org)
  • Toddler Yusuf Danial had become the first Malaysian victim of the Enterovirus 71 (EV-71) HFMD strain - a more virulent strain that is also on the increase in Singapore. (maroon-connection.com)
  • So, there were no surprises when a CER colleague sent me a link about the recent Enterovirus 71 (EV71) outbreak. (chinaeconomicreview.com)
  • In March 2008, an EV71 outbreak in Fuyang City of China's Anhui Province caused 23 fatalities, and attracted significant attention from the government and medical communities. (centerwatch.com)
  • This severe form has been associated with infection by EV71 whose outbreak in Cambodia in 2012 killed 52 children in three months. (pasteur.fr)
  • Their study of EV71 began in 1998, when a large EV71 outbreak occurred in Taiwan. (cgu.edu.tw)
  • Changes in expression profiles of 15 representative genes were authenticated by real-time reverse transcription polymerase chain reaction (RT-PCR), which also compared the transcriptional responses of cells infected with EV71 strain 5865/Sin/000009 isolated from a fatal case during the Singapore outbreak in 2000. (drugbank.com)
  • Last week, health authorities concluded that a more virulent subtype of the Enterovirus 71 virus, which causes the disease, is responsible for the recent outbreak in HCMC. (org.vn)
  • Molecular characterization of an outbreak of enterovirus-associated meningitis in Mossel Bay, South Africa, December 2015-January 2016. (omicsdi.org)
  • With the outbreak of the Enterovirus 71 strain in Malaysia and its proportion of cases increasing in Singapore, Talking Point finds out more about the nasty virus and how to protect against it. (maroon-connection.com)
  • Coxsackievirus A16 is the most common cause, and enterovirus 71 is the second-most common cause. (wikipedia.org)
  • Other strains of coxsackievirus and enterovirus can also be responsible. (wikipedia.org)
  • Hand, foot and mouth disease (enteroviral stomatitis ) is caused by Coxsackievirus A16 and enterovirus 71. (dermnetnz.org)
  • Ini termasuk Coxsackievirus A16 (CA16) dan Enterovirus 71 (EV71). (azeniahmad.com)
  • Hand-foot-mouth disease is an acute infectious disease commonly in clinical, which mainly caused by Coxsackievirus A group 16 strain (CVA16), human enterovirus 71 (EV71), with the characteristics of fast infectious speed and complex infectious pathways, especially the highest morbidity for the preschool children under the age of five [ 1 , 2 ]. (biomedres.info)
  • Morbidity and mortality are significantly higher with EV-71 than with coxsackievirus A16 or other enteroviruses. (msdmanuals.com)
  • This acquiring might donate to a better knowledge of anti-EV71 immunity and infections and could end up being helpful for seroepidemiological security and vaccine advancement. (healthyguide.info)
  • Human enteroviruses are distributed worldwide, with two major patterns of infections within a given geographical area: endemic and epidemic. (medscape.com)
  • Enteroviruses usually cause transient, often subclinical, infections. (medscape.com)
  • Enteroviral infections cover a wide range of illnesses that are caused by enteroviruses (EVs). (dermnetnz.org)
  • The teams will also test the efficacy and safety of two molecules (suramin and itraconazole) already used in other human diseases, to treat enteroviruses infections. (pasteur.fr)
  • Enterovirus 71 (EV71) infections typically cause hand, foot, and mouth disease or herpangina, followed by severe central nervous system complications, including aseptic meningitis, encephalitis, poliomyelitis-like paralysis, neurogenic cardiopulmonary failure, and even death in young children. (tmu.edu.tw)
  • Thus far, there is no effective vaccine or antiviral drug available for the clinical treatment of EV71 infections. (tmu.edu.tw)
  • To address this problem, we will use EV71 as a virus model to investigate tissue tropism during viral infections. (tmu.edu.tw)
  • The first aim of this project is (1) to determine the host factors involved in tissue tropism during EV71 infections. (tmu.edu.tw)
  • The second aim is (2) to identify the cis-regulators of EV71 infections. (tmu.edu.tw)
  • Overview of Enterovirus Infections Enteroviruses, along with rhinoviruses (see Common Cold) and human parechoviruses, are a genus of picornaviruses ( pico , or small, RNA viruses). (msdmanuals.com)
  • This project aims to study the pathogenesis of EV71-associated encephalitis. (pasteur.fr)
  • Thus, microarray, real-time RT-PCR and proteomic analyses can elucidate the global view of the numerous and complex cellular responses that contribute towards EV71 pathogenesis. (drugbank.com)
  • Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy by: Chiaho Shih, et al. (uitm.edu.my)
  • Sinovac Biotech , a provider of biopharmaceutical products in China, has announced that Phase III clinical trial results for its proprietary Enterovirus 71 (EV71) vaccine have been published online in the February 27 issue of TheNew England Journal of Medicine (NEJM). (centerwatch.com)
  • The subjects were randomly assigned in a 1:1 ratio to receive two intramuscular doses of either Sinovac's EV71 vaccine or placebo, 28 days apart. (centerwatch.com)
  • As there is no commercialized vaccine and no EV71 specific treatment available, there are increasing unmet medical needs. (centerwatch.com)
  • We are pleased to see that our vaccine is able to provide protection to infants and children against the EV71-associated HMFD. (centerwatch.com)
  • After the inspection, the SFDA expert positively acknowledged the comprehensive surveillance work performed by the clinical sites, and confirmed its importance to the clinical evaluation of the EV71 vaccine. (sinovac.com)
  • Dr. Weidong Yin, Chairman, President and CEO, said, 'With no specific treatments for EV71 and no effective prevention methods, we are continually reminded of the importance of rapidly developing a high quality vaccine against Enterovirus71. (sinovac.com)
  • By simultaneously conducting the EV71 vaccine Phase III trial, maintaining ongoing discussions with the SFDA and preparing our dedicated production facility, we intend to address this unmet need by being well positioned to provide this vaccine to our children soon after it is approved. (sinovac.com)
  • However, this vaccine only protects against EV71 and its use raises many issues for which it is essential to provide scientific data: what immunization strategy must be adopted? (pasteur.fr)
  • It will also study the socio-economic contribution of a vaccination program using the anti-EV71 vaccine already available and it will inform the health authorities on the economic soundness of the establishment a vaccination program using an already developed and tested vaccine. (pasteur.fr)
  • Taken jointly these results first of all characterized the anti-EV71 antibody replies which are mostly against VP1 epitopes predicated on common enterovirus cross-reactive series. (healthyguide.info)
  • Within this research we portrayed the EV71 capsid protein and some BMN-673 8R,9S truncated VP1 protein to systematically analyze the web host antibody response to these protein and confirmed that individual anti-EV71 antibody replies are mostly turned on in response to VP1 especially to epitopes predicated on the normal enterovirus cross-reactive series. (healthyguide.info)
  • Coxsackieviruses, echoviruses, and enterovirus type 71 are also significant causes of cutaneous disease. (medscape.com)
  • Some of the coxsackieviruses, echoviruses and EV71 cause exanthems (skin rash or skin eruption as a symptom of a more general disease) or enanthems (rash on the mucous membranes). (dermnetnz.org)
  • Herpangina Herpangina is a febrile disorder caused by numerous group A coxsackieviruses and occasionally other enteroviruses. (msdmanuals.com)
  • Understanding the molecular mechanisms regulating viral translation and replication in neuron or non-neuron cell lines and the cellular host proteins involved will help identify novel molecular targets for the development of antiviral drugs against enteroviruses. (tmu.edu.tw)
  • Enteroviruses cause outbreaks that range from small, community clusters due to acute hemorrhagic conjunctivitis, to large nationwide human enterovirus 71 epidemics. (medscape.com)
  • EV71 outbreaks have increased over the last five years, with more than 1 million cases identified and 500 to 900 reported fatalities each year. (centerwatch.com)
  • Neutralizing Antibodies to Enterovirus 71 in Belém, Brazil by: Maria de Lourdes C Gomes, et al. (uitm.edu.my)
  • Aerial transmission is another important route by which enterovirus D68 and other serotypes cause respiratory illness. (medscape.com)
  • There are enteroviruses epidemics caused by various serotypes reported in Taiwan every year. (tmu.edu.tw)
  • A total of 437 hospitalized patients were reported, and enteroviruses were detected in the specimens from 84 patients (19.2%) and were identified into 17 serotypes. (omicsdi.org)
  • Multiple serotypes were responsible for enterovirus meningitis in mainland China. (omicsdi.org)
  • and enterovirus 71, the causative agent for hand, foot, and mouth disease in Vietnam associated with severe neurologic disease). (cdc.gov)
  • Notes from the field: enterovirus A71 neurologic disease in children - Colorado, 2018. (msdmanuals.com)
  • Our findings seem to suggest that CD4+ T cell responses to poliovirus following vaccination , or to other enteroviruses to which individuals may be exposed in early childhood, may have a modulating effect on subsequent CD4+ T cell response to EV71 infection . (epivax.com)
  • The most well known of the enteroviruses is the poliovirus (PV) but this has mostly been eradicated. (dermnetnz.org)
  • It results from infection with non-polio enteroviruses such as coxsackie viruses A16, A4, A5, A9, A10, B2 and B5 and enterovirus 71. (canada.ca)
  • Non-polio enteroviruses are common ribonucleic acid ( RNA ) viruses that are found worldwide. (canada.ca)
  • We were recently contacted by researchers at the Pasteur Institute of Beijing (Ruichen Wei, Qiben Leng) who were grappling with an out break of Hand-Foot-Mouth Disease, a serious infection caused by enterovirus 71 (EV71) among other viruses. (epivax.com)
  • Other enteroviruses are the Coxsackie A and B viruses (CVA and CVB) and the echoviruses (ECHO: enteric cytopathic human orphan). (dermnetnz.org)
  • We will also test other enteroviruses or plus-strand RNA viruses for comparison. (tmu.edu.tw)
  • Aseptic meningitis caused by EV71 and coxsackie A viruses-the predominant pathogens for the hand, foot, and mouth disease-is currently an important concern in mainland China. (omicsdi.org)
  • In May 2008, the Chinese Ministry of Health identified EV71 as a Class C infectious disease according to prevention and control regulations. (centerwatch.com)
  • Enterovirus 71 (EV71) is a global infectious disease that affects millions of people. (uitm.edu.my)
  • The National Microbiology Laboratory (NML) in Winnipeg performs typing for enteroviruses and asks that provinces and territories send all isolates to NML as part of ongoing enterovirus surveillance. (canada.ca)
  • As of June 3, 2008, 32% of cases tested this year in the Ministry?s sentinel surveillance system were positive for EV71. (flutrackers.com)
  • As part of the inspection, study investigators from the three sites presented reports on the site's procedures of vaccination, safety monitoring and case surveillance, and the EV71 epidemic situation. (sinovac.com)
  • They subsequently focused on viral-host interactions, in which molecular targets for drug discovery were identified, and series of compounds were developed that inhibit EV71 replication. (cgu.edu.tw)
  • Baisong Zheng , Xiaolei Zhou , Li Tian , Jian Wang , Wenyan Zhang , 2022: IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway, Virologica Sinica, 37, 676-684. (virosin.org)
  • focus on to epitopes predicated on the normal enterovirus cross-reactive series. (healthyguide.info)
  • We applied the iVAX technology to identify promiscuous CD4+ T cell epitopes contained within the sequence of the EV71 polyprotein. (epivax.com)
  • Many enteroviruses cause diseases with associated cutaneous or mucous membrane reactions. (dermnetnz.org)
  • An oligo-based microarray was employed to analyse mRNAs from rhabdomyosarcoma cells infected with the MS/7423/87 strain of enterovirus 71 (EV71) at 20 h post infection. (drugbank.com)
  • the level of cross-protection between different circulating EV71 isolates worldwide. (pasteur.fr)
  • According to an epidemiological study for the period of 2008 to 2012, around 80% of the severe cases and over 90% of fatal cases were caused by the enterovirus 71 (or EV71 ) infection. (centerwatch.com)
  • The ability of EV71 to induce disease depends on both viral genetics and the host environment. (tmu.edu.tw)
  • Dr. Shih was awarded the National Medal for Outstanding Youth in 2004 for contributing to EV71 research in Taiwan. (cgu.edu.tw)
  • Results Creation of recombinant EV71 capsid and truncated VP1 protein As well as the three EV71 capsid protein VP0 VP1 and VP3 we also designed five truncated VP1 protein EV71 VP141-297 VP161-297 VP11-60 VP1134-297 and VP145-58 (Fig. 1a). (healthyguide.info)
  • evidence for efficacy is based on early treatment in animal models infected with enterovirus (EV) D68 and it has not been given in a systematic manner to AFM patients to allow for measurements of efficacy. (cdc.gov)
  • Human enteroviruses (HEVs) are the most frequently reported cause of aseptic meningitis with or without CSF pleocytosis in childhood. (omicsdi.org)
  • Molecular epidemiology of human enterovirus associated with aseptic meningitis in Shandong Province, China, 2006-2012. (omicsdi.org)
  • Human enteroviruses (HEVs) are common causes of acute meningitis. (omicsdi.org)
  • BACKGROUND:Human enteroviruses (HEVs) are common causal agents of aseptic meningitis in young children. (omicsdi.org)
  • Kaw Bing Chua , Rasid Kasri Abdul , 2011: Hand Foot and Mouth Disease Due to Enterovirus 71 in Malaysia, Virologica Sinica, 26, 221-228. (virosin.org)
  • Molecular detection and genotyping of enteroviruses from CSF samples of patients with suspected sepsis-like illness and/or aseptic meningitis from 2012 to 2015 in West Bank, Palestine. (omicsdi.org)
  • To investigate the molecular epidemiology of enteroviruses (EVs) among patients with sepsis-like illness and/or aseptic meningitis admitted to three major hospitals in West Bank, Palestine from 2012 to 2015. (omicsdi.org)
  • Cannan Kindergarten in Whampoa Garden has been advised to suspend classes for a week following the Centre for Health Protection's (CHP) investigation into a fatal case of suspected enterovirus infection involving a 35-year-old woman. (flutrackers.com)
  • Using Statistical Phylogenetics for Investigation of Enterovirus 71 Genotype A Reintroduction into Circulation by: Yulia Vakulenko, et al. (uitm.edu.my)
  • Their participation contributed significantly to the laboratory diagnosis of EV71. (cgu.edu.tw)
  • Weide Su , Jingjiang Qiu , Ying Mei , Xian-En Zhang , Yong He , Feng Li , 2022: A microfluidic cell chip for virus isolation via rapid screening for permissive cells, Virologica Sinica, 37, 547-557. (virosin.org)
  • Research regarding the web host humoral defense replies against EV71 derive from the neutralizing antibody assay primarily. (healthyguide.info)
  • Its most common causes are coxsackie virus A16 (CAV 16) and enterovirus 71 (EV 71). (canada.ca)
  • When maternal enterovirus infection is acquired during late pregnancy, vertical transmission has been shown to be relatively common. (medscape.com)