DNA sequencing revealed a homozygous mutation in ESR1, the gene that encodes the ERα. (wikipedia.org)
However, DAAM2 is a protein coding gene responsible for many processes in the body, and linked to other conditions including kidney disease. (healthline.com)
In particular, the drug Ganetspib, also known as STA-9090, appeared to be effective in killing tumor cells with a mutation in the estrogen receptor gene (ESR1). (usc.edu)
Estrogen1
Estrogen insensitivity syndrome (EIS), or estrogen resistance, is a form of congenital estrogen deficiency or hypoestrogenism which is caused by a defective estrogen receptor (ER) - specifically, the estrogen receptor alpha (ERα) - that results in an inability of estrogen to mediate its biological effects in the body. (wikipedia.org)
Ratio1
BACKGROUND/OBJECTIVES: The waist-to-height ratio (WHtR) estimates cardiometabolic risk in youth without need for growth charts by sex and age. (cdc.gov)
Mass1
Anthropometry included body weight, body height, body mass index (BMI), three skinfold thicknesses, mid-upper arm circumference and mid-upper arm muscle circumference adjusted for age and sex using national standards. (bvsalud.org)
Source1
We are fundamentally electromagnetic, rather than chemical beings, this is how nanobots and nanoparticles can source their energy if inserted into the human body. (blogs.com)
SNPs4
Five SNPs (AHR rs2066853, ATM rs1003623, ESR1 rs2234693, GSTP1 rs1695, and SHBG rs6259) showed generally consistent results in SBCS I and SBCS II and statistically significant associations with breast cancer risk in combined analyses, mostly in subgroups defined by age or menopausal status. (nih.gov)
We have investigated potential interactions between certain known genetic and phenotypic risk factors, specifically nine single nucleotide polymorphisms (SNPs) and height, body mass index (BMI) and hormone replacement therapy (HRT). (medscape.com)
Conclusion: CCSs who are carriers of candidate SNPs in the ESR1 or LRP5 genes seem to have an impaired bone mass at an early adult age. (prinsesmaximacentrum.nl)
We were able to validate SNPs in known genes that have been related to BMI or other adiposity traits, including the ESR1 Xba1 SNP, PPARG , and ADIPOQ . (biomedcentral.com)
Estrogen receptor5
Estrogen insensitivity syndrome (EIS), or estrogen resistance, is a form of congenital estrogen deficiency or hypoestrogenism which is caused by a defective estrogen receptor (ER) - specifically, the estrogen receptor alpha (ERα) - that results in an inability of estrogen to mediate its biological effects in the body. (wikipedia.org)
In addition, estrogen receptor alpha (ESR1)-mediated stimulation of proliferation of the epithelial cells contributes to conversion of DNA damage into mutations (i.e., tumor initiation) as well as tumor promotion and progression (Yager 2015 ). (springer.com)
The purpose of this research study is to find out if the investigational study vaccine, ESR1 peptides, are safe and has beneficial effects in people with Estrogen receptor positive (ER+) breast cancer. (dukecat.com)
Elacestrant is used to treat adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has a genetic variant called estrogen receptor 1 (ESR1). (oralchemoedsheets.com)
Page 1 ELACESTRANT ORAL CHEMOTHERAPY EDUCATION Name of your medication Generic name - elacestrant (EH-lah-KES-trant) Brand name - Orserdu™ (or-SER-doo) Common uses Elacestrant is used to treat adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has a genetic variant called estrogen receptor 1 (ESR1). (oralchemoedsheets.com)
Homozygous1
DNA sequencing revealed a homozygous mutation in ESR1, the gene that encodes the ERα. (wikipedia.org)
Genes1
Growth and metabolism-related genes selected for methylation analysis included imprinted (IGF2, H19) and non-imprinted (PPARA, ESR1) genes along with LINE-1 repetitive elements. (cdc.gov)
Allele1
Results One SNP (rs851987 in ESR1) tended to interact with height, with an increasingly protective effect of the major allele in taller women (p = 0.007) and rs13281615 (on 8q24) tended to confer risk only in non users of HRT (p-for interaction = 0.03). (medscape.com)
Activate2
2007 ). Thus, tumor formation (Yager 2015 ) seems to depend on intramammary levels of both reactive estrogen biotransformation products and free estrogens able to activate ESR1 (Fig. 1 ). (springer.com)
Your immune cells will react to the ESR1 peptides and activate other immune cells to tell them to attack cancer cells expressing ER. (dukecat.com)
Stimulation1
24 h) torpor-like state in mice via closed-loop feedback control of ultrasound stimulation with automated detection of body temperature. (nature.com)
Downstream1
The technique enables scientists to estimate the causal effect of intervening and modifying a health exposure (such as a person's diet or body mass index) on downstream disease outcome (such as the risk of developing Type 2 Diabetes). (exeter.ac.uk)
Genetic1
Conclusions We conclude that much larger sample sets would be necessary to demonstrate interactions between low-risk genetic polymorphisms and the phenotypic variables height, BMI and HRT on the risk for breast cancer. (medscape.com)
Phenotypes1
A broad range of phenotypes were studied and include BMI, WC, height, and radiographic quantification of subcutaneous (SAT) and visceral (VAT) fat. (biomedcentral.com)
Weight and height1
Results: Multivariate analyses revealed that lower BMD was associated with lower weight and height at follow-up, male sex, and previously administered radiotherapy. (prinsesmaximacentrum.nl)
Effects1
The purpose of this study is to find out what effects (good and bad) an investigational cancer vaccine, ESR1 peptides, in combination with GM-CSF and Montanide ISA, may have on your immune system's activity and ability to control your cancer. (dukecat.com)
Years1
His epiphyses were unfused, and there was evidence of still-occurring slow linear growth (for comparison, his height at 16 years of age was 178 cm). (wikipedia.org)
Slow1
Torpor, like hibernation, is a physiological state in which mammals actively suppress metabolism, reduce body temperature and slow down other live processes to conserve energy and survive fatal conditions and cold environmental temperatures 1 . (nature.com)
Conditions1
Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. (nature.com)