Gonadoblastoma has been found in association with androgen insensitivity syndrome, mixed gonadal dysgenesis and Turner syndrome, especially in the presence of Y chromosome-bearing cells. (wikipedia.org)
Malignant7
Gonadoblastomas are by definition benign, but more than 50% have a co-existing dysgerminoma which is malignant, and an additional 10% have other more aggressive malignancies, and as such are often treated as malignant. (wikipedia.org)
Malignant ovarian lesions include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body. (medscape.com)
These tumors can also be broadly classified as teratomas, malignant GCTs, or mixed GCTs. (kaiserpermanente.org)
7 , 8 ] Despite the small percentage of malignant teratomas that occur in this age group, perinatal tumors have a high morbidity rate caused by hydrops fetalis and premature delivery. (kaiserpermanente.org)
To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). (biomedcentral.com)
Malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST) are not common. (biomedcentral.com)
PMID- 5157693 TI - [The place of radiumpuncture in the management of malignant tumors of the bladder. (nih.gov)
Primordial germ1
A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells. (wikipedia.org)
Germ cells2
Gonadoblastomas can contain elements of both germ cells and gonadal stroma. (wikipedia.org)
Gonadoblastoma is a rare gonadal tumor consisting of a mixture of germ cells and sex-cord stromal derivatives resembling immature granulosa and Sertoli cells. (kaiserpermanente.org)
Immature2
Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed. (biomedcentral.com)
SCSTs develop from the gonadal non-germ-cell components [ 1 ], including granulosa cell tumors, granulosa-theca tumors, and Sertoli-Leydig cell tumors. (biomedcentral.com)
Neoplasia compleja compuesta por una mezcla de elementos gonadales, como grandes CÉLULAS GERMINALES primordiales, CÉLULAS DE SERTOLI inmaduras o CÉLULAS DE LA GRANULOSA del cordón sexual. (bvsalud.org)
Ovary4
If the diagnosis of gonadoblastoma is certain, a bilateral salpingo-oophorectomy (BSO) should be performed to remove both the primary tumor and the dysgenic contralateral ovary. (wikipedia.org)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
C124270 Childhood Neuroblastoma C132009 Pediatric Hematology-Oncology Terminology C114801 Childhood Gonadal Germ Cell Tumor Childhood Gonadal Germ Cell Tumor A germ cell tumor that arises from the testis or ovary and occurs during childhood. (nih.gov)
A germ cell tumor that arises from the testis or ovary and occurs during childhood. (nih.gov)
Neoplasms1
Laparoscopy may be an option if the surgeon is particularly skilled in removing ovarian neoplasms via laparoscopy intact. (wikipedia.org)
Gonadoblastoma3
Gonadoblastoma is most often associated with an abnormal chromosomal karyotype, gonadal dysgenesis, or the presence of a Y chromosome in over 90% of cases. (wikipedia.org)
11 ] Gonadal dysgenesis, as well as the presence of Y-chromosome material in an abdominal gonad, also increases the risk of developing a gonadal GCT, especially gonadoblastoma. (kaiserpermanente.org)
Pelvic mass2
Patients with more advanced disease may present with ovarian or pelvic mass, ascites, pleural effusion, or abdominal mass or bowel obstruction. (medscape.com)
Diagnosis of MOGCT or SCST was revealed by pelvic mass, abdominal pain, growing ascites, and arising of tumor markers like α-fetoprotein (AFP), human choionic gonadotophin (HCG) and inhibin. (biomedcentral.com)
Diagnosis5
Fine-needle aspiration (FNA) or percutaneous biopsy of an adnexal mass is not routinely recommended, as it may delay diagnosis and treatment of ovarian cancer. (medscape.com)
Instead, if a clinical suggestion of ovarian cancer is present, the patient should undergo laparoscopic evaluation or laparotomy, based on the presentation, for diagnosis and staging. (medscape.com)
Pathological diagnosis was confirmed according to the 2014 World Health Organization classification of tumors of female reproductive organs by expert gynecological pathologists in our hospital. (biomedcentral.com)
PMID- 5157690 TI - [Percutaneous puncture in the diagnosis of renal tumors]. (nih.gov)
PMID- 5157695 TI - [Cytologic diagnosis of prostatic tumors by transrectal puncture using a Franzen fine needle. (nih.gov)
Tissue2
The presence of advanced ovarian cancer is often suspected on clinical grounds, but it can be confirmed only pathologically by removal of the ovaries or, when the disease is advanced, by sampling tissue or ascitic fluid. (medscape.com)
Well-known functions of IL-8 includes help in angiogenesis, role in tumour progression, tissue remodelling, etc. (bvsalud.org)
Abdominal1
Symptoms independently associated with the presence of ovarian cancer include pelvic and abdominal pain, increased abdominal size and bloating, and difficulty eating or feeling full. (medscape.com)
Primary3
Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)
The incidence of extracranial GCTs according to age group, sex, and gonadal versus extragonadal primary site is shown in Table 1. (kaiserpermanente.org)
Twenty-nine patients in the study had mediastinal primary tumors, and nine patients (31%) had Klinefelter syndrome. (kaiserpermanente.org)
Childhood5
1 , 2 ] Childhood extracranial GCTs can generally be divided into gonadal and extragonadal. (kaiserpermanente.org)
C115195 Childhood Mixed Glioma C9042 Childhood Brain Stem Glioma C132009 Pediatric Hematology-Oncology Terminology C114774 Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified Childhood Supratentorial Primitive Neuroectodermal Tumor Childhood Supratentorial PNET A supratentorial embryonal tumor, not otherwise specified that occurs in childhood. (nih.gov)
A supratentorial, primitive, neuroectodermal tumor that occurs during childhood. (nih.gov)
C5961 Childhood Central Nervous System Primitive Neuroectodermal Tumor C132009 Pediatric Hematology-Oncology Terminology C114775 Childhood Central Nervous System Neuroblastoma Childhood Cerebral Neuroblastoma A neuroblastoma that arises from the cerebral hemispheres and occurs during childhood. (nih.gov)
C68627 Childhood Extracranial Germ Cell Tumor C132009 Pediatric Hematology-Oncology Terminology C114812 Childhood Pineoblastoma Childhood Pineoblastoma A pineoblastoma that occurs during childhood. (nih.gov)
Data1
Based on 2 years of ovarian cancer data, we performed a feasibility test retrospectively and classified the DRPs according to the Pharmaceutical Care Network Europe classification of DRPs version-9.1. (bvsalud.org)
Cancer9
Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
Early ovarian cancer causes minimal, nonspecific, or no symptoms. (medscape.com)
The US Preventive Services Task Force (USPSTF) recommends against screening (with serum CA-125 level or transvaginal ultrasonography) for ovarian cancer in the general population. (medscape.com)
[ 3 ] The US Food & Drug Administration (FDA) recommends against the use of tests marketed for ovarian cancer screening. (medscape.com)
Routine imaging is not required in all patients in whom ovarian cancer is highly suggested. (medscape.com)
According to American National Comprehensive Cancer Network (NCCN) 2017 guideline for ovarian cancer, the standard treatment regimen for MOGCT and stage IA/IC SCST with fertility desiring is fertility-sparing surgery. (biomedcentral.com)
Tumors were staged according to the International Federation of Gynecology and Obstetrics (FIGO) 2000 staging system for ovarian cancer. (biomedcentral.com)
This study aims to develop evidence-based indicators for detecting potential drug-related problems in ovarian cancer patients. (bvsalud.org)
Conclusion: Indicators developed by us effectively identified pDRPs in ovarian cancer patients, which can potentially help healthcare professionals in the early detection, timely management, and attenuating severity of DRPs. (bvsalud.org)
Patients1
15 , 18 ] The age of tumor presentation is younger in patients with Klinefelter syndrome, and testing all younger males for Klinefelter syndrome should be considered. (kaiserpermanente.org)
Often associated1
Gonadoblastomas are most often associated with gonadal dysgenesis, 46, XY. (bvsalud.org)
Female1
These tumors represent approximately 15% of cancers in male adolescents aged 15 to 19 years and 4% of cancers in female adolescents aged 15 to 19 years. (kaiserpermanente.org)
Years1
3 ] For males, there is a peak in incidence in children younger than 2 years for both extragonadal and gonadal sites, which is followed by low rates between the ages of 2 and 12 years, and then higher rates throughout adolescence. (kaiserpermanente.org)
Young1
For females, the peak in young children is present only for extragonadal tumors, with rates increasing after the age of puberty for both extragonadal and gonadal sites. (kaiserpermanente.org)