• Statins
  • In early 2016, the U.S. Food and Drug Administration withdrew approvals for extended-release niacin and delayed-release fenofibric acid (fibrate) in combination with statins based on lack of cardiovascular benefit. (aafp.org)
  • Which statins are most susceptible to drug-drug interactions? (brainscape.com)
  • The benefits of statins and other dyslipidemic drugs appear proportional to the degree of improvement in the TC/HDL ratio, and by far the largest reductions in event rates reported to date occurred with combination statin and niacin therapy, with the attendant profound lowering of the TC/HDL ratio ( 7 ). (onlinejacc.org)
  • The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated. (wikipedia.org)
  • Drugs metabolized by the Cytochrome P450 system include: Many antidepressants Many antipsychotics Many antiepileptics Theophylline and other methylxanthine drugs Several anesthetic agents Oral contraceptive pills Statins Warfarin Selexipag Gemfibrozil has been detected in biosolids (the solids remaining after wastewater treatment) at concentrations up to 2650 ng/g wet weight. (wikipedia.org)
  • Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin), can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor expression. (wikipedia.org)
  • pharmacology
  • If you've ever wondered how drugs work, the role that pharmacology plays in human health, or the kinds of personal skills you'll need to discover and develop the next generation of drugs (including. (purzuit.com)
  • In part 1 of 3, Picmonic's content director Kendall Wyatt MD, RN will help you understand how using drug endings can help you master Pharmacology faster alongside Picmonic's research proven. (purzuit.com)
  • Professor Fink introduces the subject of Pharmacology, including the most prescribed categories of drugs, subdisciplines of Pharmacology, Drug Nomenclature (generic names vs. registered brand. (purzuit.com)
  • therapy
  • Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate. (nih.gov)
  • Lowered TC, either by behavioral intervention or-much more potently-by drug therapy, is a question distinct from naturally low TC. (onlinejacc.org)
  • In only two clinical trials has the issue of the most relevant lipid measure change been addressed, and change in either the TC/HDL ratio ( 5 ) or the apolipoprotein (apo) B/apoA1 ratio ( 6 ) accounted for all the benefit from drug therapy. (onlinejacc.org)
  • PPAR
  • GW501516 (also known as GW-501,516, GW1516, GSK-516 and on the black market as Endurobol) is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs. (wikipedia.org)
  • The World Anti-Doping Agency (WADA) developed a test for GW501516 and other related PPARδ modulators, and added such drugs to the prohibited list in 2009. (wikipedia.org)
  • bile
  • Bile acid sequestrants may cause gastrointestinal problems and may also reduce the absorption of other drugs and vitamins from the gut. (wikipedia.org)
  • diabetes
  • In addition, a prospective observational study of dyslipidemic patients with diabetes or hyperglycemia showed that bezafibrate significantly reduces haemoglobin A1c (HbA1c) concentration as a function of baseline HbA1c levels, regardless of concurrent use of antidiabetic drugs. (wikipedia.org)
  • Primary hyperlipidemia is usually due to genetic causes (such as a mutation in a receptor protein), while secondary hyperlipidemia arises due to other underlying causes such as diabetes. (wikipedia.org)
  • toxicity
  • A significant advantage of drug repositioning over traditional drug development is that since the repositioned drug has already passed a significant number of toxicity and other tests, its safety is known and the risk of failure for reasons of adverse toxicology are reduced. (wikipedia.org)
  • pharmaceutical
  • An oral pharmaceutical composition is provided for treating hypercholestereolemia or hyperlipidemia containing an advantageous formulation for stabilizing the HMG-CoA coenzyme A inhibitor, CI-981 Hemi-Calcium, of formula (IA) ##STR1## with effective amounts of calcium carbonate. (google.co.uk)
  • While these drugs are useful for patients with hyperlipidemia, Tangier's disease patients do not benefit from these pharmaceutical interventions. (wikipedia.org)
  • More than 90% of drugs fail during development, and this is the most significant reason for the high costs of pharmaceutical R&D. In addition, repurposed drugs can bypass much of the early cost and time needed to bring a drug to market. (wikipedia.org)
  • Whilst there are clear advantages to pharmaceutical companies in pursuing the licensing of repurposed drugs there are risks and costs associated with this, for example the introduction of thalidomide for multiple myeloma was seen by many analysts at the time as high risk and even dangerous but has been hugely successful for patients and the company. (wikipedia.org)
  • bezafibrate
  • The Australian biotech company Giaconda combines bezafibrate with chenodeoxycholic acid in an anti-hepatitis C drug combination called Hepaconda. (wikipedia.org)
  • TOPIC
  • Drug repositioning is seen by some as a controversial topic as the costs of an unlicensed product are often much less than a licensed one, especially in the rare disease market. (wikipedia.org)
  • Cancer
  • It later emerged that the drug was discontinued because animal testing showed that the drug caused cancer to develop rapidly in several organs, at dosages of 3 mg/kg/day in both mice and rats. (wikipedia.org)
  • Compounds
  • This s tructure, together with the structures of complexes with substrate and inhibitors, will provide a better understanding of the catalytical mechanism and will make it possible that 'lead compounds', identified via 'random screening' can be optimised into physiologically active drugs. (ugent.be)
  • Computational approaches based on virtual screening of comprehensive libraries of approved and other human use compounds against large numbers of protein targets simultaneously have been developed to enhance the efficiency and success rates of drug repositioning, particularly in terms of high-throughput shotgun repurposing. (wikipedia.org)
  • work
  • the work was widely discussed in popular media, and led to a black market for the drug candidate and to its abuse by athletes as a doping agent. (wikipedia.org)
  • issues
  • On the other hand, drug repositioning faces some challenges itself since the intellectual property issues surrounding the original drug may be complex and from a commercial point of view it may not always make sense to take such a drug to market. (wikipedia.org)
  • design
  • reported that they used "combinatorial chemistry and structure-based drug design" to develop it. (wikipedia.org)
  • clinical
  • http://www.healthnetworkcommunications.com/2012/exploratory-clinical-development-conference/ The Role of the Clinical Pharmacologist in Meeting New Challenges Facing Drug Discovery and Development. (purzuit.com)
  • advantages
  • An upbeat, creative, and informative overview that outlines the advantages of working at the FDA's Center for Drug Evaluation and Research. (purzuit.com)