Drugs humans abnormalities drug induced. Medical search. Frequent questions

In early 1961 doctors noticed an extraordinary increase in documented cases of children with a verity of birth defects, and they soon hypothesized that maternal exposure to Thalidomide during pregnancy caused these often-severe congenital abnormalities. (asu.edu)
A 1962 study titled "Thalidomide and Congenital Abnormalities," by Victor Knapp, George Christie, and Mary Seller, all working in the UK, looked at the teratogenic effects of Thalidomide on rats, mice, and rabbits, and the study reported no abnormalities in the offspring of these animals after researchers had exposed the pregnant females to the drug. (asu.edu)
There is currently no strong evidence linking an increased rate of miscarriages or congenital abnormalities to in utero cannabis exposure. (medscape.com)

CMV infection has been shown to induce transient abnormalities of in vitro cellular-immune function in otherwise healthy human hosts (2,3). (cdc.gov)
Population-based human studies and in vitro animal studies evaluating long-term growth and neurodevelopment after exposure to cannabis in utero have shown an effect on both cognition and behavior. (medscape.com)

Trigeminal neuralgia: Second choice drug to carbamazepine. (wikipedia.org)
Drug Interactions: Use with strong cytochrome P450 enzyme inducers (e.g., rifampicin, phenobarbital, carbamazepine, phenytoin) is not recommended. (nih.gov)

More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. (medscape.com)
A list of drugs that are reported to cause pulmonary toxicity is available on the continually updated Website PNEUMOTOX online . (medscape.com)
Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
The diagnosis of drug-mediated pulmonary toxicity is usually established based on clinical findings. (medscape.com)
Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
Most drug-induced pulmonary toxicities involve the parenchyma, thus, interstitial infiltrates may be demonstrated on radiographs. (medscape.com)
If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
To elucidate the antifibrotic mechanisms of sivelestat, we examined a murine model of bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
In the bleomycin-induced early-stage pulmonary fibrosis model, the neutrophil elastase level was increased in the lungs. (ersjournals.com)
Sivelestat significantly inhibited the increase in lung collagen content, fibrotic changes, the numbers of total cells (including macrophages, neutrophils and lymphocytes), the levels of the active form of TGF-β1 and phospho-Smad2 in bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
These results suggest that sivelestat alleviated bleomycin-induced pulmonary fibrosis via inhibition of both TGF-β activation and inflammatory cell recruitment in the lung. (ersjournals.com)
Pulmonary fibrosis is caused by a variety of insults to the lung, such as acute lung injury, irradiation and drugs [ 1 ]. (ersjournals.com)
Recent studies have suggested that increased collagen turnover and fibrotic changes are earlier events within 14 days in the BLM-induced fibrosis [ 8 - 11 ] and these changes were used commonly as a pulmonary fibrosis model. (ersjournals.com)
pulmonary toxicity due to cytotoxic or immunotherapy drugs, and tumor infiltrates. (msdmanuals.com)

The use of dopamine antagonists as antipsychotics can result in tardive dyskinesia, while drugs such as cocaine that increase striatal dopamine release can cause dependency and addiction (for review, see Hyman, 1996 ). (jneurosci.org)
DESCRIPTION (provided by applicant): The objective of this project is to develop a genetic test, involving the protein, RGS9, to identify patients that are at risk for developing tardive dyskinesia (TD) or L-DOPA induced dyskinesia (LID). (sbir.gov)

line drug in the treatment of tuberculo- antigen showed no abnormalities, 2. (cdc.gov)
Subacute cutaneous lupus erythematosus (SCLE) occurs in genetically predisposed individuals, most often in patients with human leukocyte antigen B8 (HLA-B8), human leukocyte antigen DR3 (HLA-DR3), human leukocyte antigen DRw52 (HLA-DRw52), and human leukocyte antigen DQ1 (HLA-DQ1). (medscape.com)

In utero antiepileptic drug exposure: fetal death and malformations. (emmes.com)
Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach. (emmes.com)
More adverse outcomes were observed in pregnancies with in utero valproate exposure vs the other antiepileptic drugs (AEDs). (emmes.com)
INTERPRETATION: Our study indicates that prenatal AED exposure does not increase the burden of de novo variants, and that this mechanism is not a major contributor to AED-induced BDs. (ox.ac.uk)
Emerg ondary to drug exposure in 5% of pa- in this case. (cdc.gov)
This abnormality is caused by exposure to the drug in a short time period in early human embryonic development. (asu.edu)
A recombinant vesicular stomatitis vaccine vector protected non-human primates in pre- and post-exposure challenge studies. (biomedcentral.com)
Antisense therapies, in which oligonucleotides inhibit viral replication, have shown promising results in non-human primates following post-exposure treatment. (biomedcentral.com)
It is widely accepted, although clouded by the secrecy of war [ 2 ], that the first tentative steps to treating cancer with drugs emanated from the observation that exposure to chemical warfare agents ('poison gases'), such as nitrogen mustards, could limit the proliferative nature of rapidly dividing lymphoid cells. (biomedcentral.com)

Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load. (ox.ac.uk)
The failure of rodent models to inform scientists of Thalidomide's teratogenicity in humans ignited debate about the proper use of cross-species testing during drug development. (asu.edu)
The authors noted that the study provided no grounds to think that drugs containing Thalidomide were safe for human use, and they argued that the only method guaranteed to safely deal with drugs of unknown teratogenicity would be to completely refrain from using them unless absolutely necessary. (asu.edu)

Additional implicated agents include calcium channel blockers, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, antifungal agents (particularly terbinafine), chemotherapy agents, immunotherapies, proton pump inhibitors, and tumor necrosis factor (TNF) antagonists. (medscape.com)

There is evidence that use during pregnancy results in abnormalities in the baby. (wikipedia.org)
However, optimal seizure control is very important during pregnancy so drug may be continued if benefits outweigh the risks. (wikipedia.org)
Due to decreased drug concentrations as a result of plasma volume expansion during pregnancy, dose of phenytoin may need to be increased if only option for seizure control. (wikipedia.org)
Drugs and pregnancy : human teratogenesis and related problems / edited by D. F. Hawkins. (who.int)
Of course, abstinence from drug use during pregnancy is the optimal situation. (medscape.com)
Despite the absence of clinical trial data support for this indication, some women use "medicinal cannabis" for management of pregnancy-induced nausea and vomiting. (medscape.com)

Thus we have identified novel components of a complex, coordinated genetic program that is induced in striatal cells in response to various dopaminergic manipulations. (jneurosci.org)
SB 1457, signed into law April 27 by Gov. Doug Ducey, most notably prohibits abortions done solely because of a nonlethal genetic abnormality, such as Down syndrome. (catholicnewsagency.com)
A doctor who performs an abortion because of a genetic abnormality will be charged with a felony unless it was done "in a medical emergency. (catholicnewsagency.com)

To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should be familiar with the possible adverse effects of the medications they prescribe. (medscape.com)
Detection of human include gastrointestinal discomfort, lular marrow with complete absence bocavirus in Japanese children with lower rash, allergy, hepatitis, and peripheral respiratory tract infections. (cdc.gov)
German children with respiratory tract case of isoniazid-induced PRCA. (cdc.gov)
DESCRIPTION (provided by applicant): The central goal of this application is to develop a combination product comprising two fully human monoclonal antibodies (mAbs) produced in plants for the prevention of serious disease caused by respiratory syncytial virus (RSV). (sbir.gov)

Here we used two-electrode voltage clamp electrophysiology to compare the actions of CBD with those of the major central endocannabinoid, 2-arachidonoyl glycerol (2-AG) on human recombinant GABAA receptors (synaptic α1-6βg2 and extrasynaptic α4β2δ) expressed on Xenopus oocytes. (researchgate.net)

OBJECTIVE: The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. (ox.ac.uk)

Human immunodeficiency virus (HIV) infection is often associated with ITP in both adults and children. (medscape.com)
Pneumocystis jirovecii Pneumonia Pneumocystis jirovecii is a common cause of pneumonia in immunosuppressed patients, especially in those infected with human immunodeficiency virus (HIV) and in those receiving systemic. (msdmanuals.com)

Quantification evaluation of bromodichloromethane metabolism by recombinant rat and human cytochrome P450s. (cdc.gov)
A combination of DNA vaccination and a recombinant adenovirus serotype 5 boost resulted in cross-protective immunity in non-human primates. (biomedcentral.com)

Several antiviral therapies are currently under investigation, but only a few of these have been tested in non-human primate models. (biomedcentral.com)
There are a few high-profile examples of rationally and molecularly targeted therapies, but we need to do much better if we are to shift the entire pattern of treatment to drugs that have high potency but mild side effects. (biomedcentral.com)

The β1-subunit homologous mutant β2(V436T) substantially diminished the efficacy of both drugs to a third of that obtained with wild-type β2 subunit combinations, but without changing potency. (researchgate.net)

High-resolution computed tomography (CT) scanning is more sensitive than chest radiography for defining the radiographic abnormalities. (medscape.com)
If clinical suspicion of pneumonia is high and the chest x-ray shows no or minor abnormalities, a chest CT scan should be done. (msdmanuals.com)

A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)

This condition can be suspected if the patient has been exposed to a likely causative drug, develops new signs and symptoms, and has a remittence of these symptoms once the drug is withheld. (medscape.com)

PRCA occurs sec- suspected this drug to be responsible hospitalized children, South Africa. (cdc.gov)

Bronchoalveolar lavage (BAL) can contribute to the expected clinicopathologic pattern of a given drug-induced lung disease such as identifying eosinophils in a drug-induced eosinophilic pneumonia. (medscape.com)
8. Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. (astrazenecaclinicaltrials.com)

If SCLE is drug-induced, withdrawal of the culprit medication in conjunction with medical therapy is often necessary for disease control. (medscape.com)

The success of thrombopoietin agonist therapy in chronic ITP underscores this mechanism as a major factor in inducing thrombocytopenia. (medscape.com)

Subsequent clinical trials have confirmed the utility of this drug in ERα-positive breast cancer patients and tamoxifen has now been given to millions of women and has saved countless lives. (biomedcentral.com)
Any investigational agents or study drugs from a previous clinical study within 30 days of the first dose of study treatment. (astrazenecaclinicaltrials.com)

Data suggest that AED-induced BDs may result from a genome-wide increase of de novo variants in the embryo, a mechanism that we investigated. (ox.ac.uk)

Any doctor performing an abortion will be required to complete and affadavit stating that they are not aborting the baby because of a nonlethal abnormality, and the doctor must inform the woman it is illegal to do so. (catholicnewsagency.com)

However, in humans Thalidomide interfered with embryonic and fetal development in ways not observed in rodent tests. (asu.edu)

That outrage motivated a scientific debate over the efficacy of using model organisms, like mice and rats, in drug development. (asu.edu)

Following the discovery of chemotherapeutics, the next significant advance came in the 1960s with the straightforward notion of combining drugs. (biomedcentral.com)

On February 16, 1985, Wyeth Laboratories recalled Wyeth human diploid cell rabies vaccine (WYVACTM) from the market. (cdc.gov)

Nursing Mothers: DALIRESP should not be used by women who are nursing as excretion of roflumilast and/or its metabolites into human milk is probable and there are no human studies that have investigated effects of DALIRESP on breast-fed infants. (nih.gov)

Before starting patients on any medication, educate them about the potential adverse effects of the drug. (medscape.com)
Patients who develop drug toxicity should be advised to avoid the drug in the future. (medscape.com)
Vivimusta (bendamustine hydrochloride injection) is an alkylating drug indicated for treatment of patients with chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. (rxlist.com)
Extensive thin-section computed tomographic abnormalities, including traction bronchiolectasis, suggest that fibroproliferative changes were independently predictive of poor prognosis in ARDS patients within 7 days of onset [ 4 ]. (ersjournals.com)
Transforming growth factor (TGF)-β, especially its isoform TGF-β1, is a profibrotic cytokine that is overexpressed in patients with fibrosis and was directly associated with fibrosis in multiple human settings and animal models [ 5 ]. (ersjournals.com)
SCLE may occur in patients with systemic lupus erythematosus (SLE), Sjögren syndrome , deficiency of the second component of complement (C2d), or it may be drug-induced. (medscape.com)
In perhaps as many as 30% of patients with SCLE, drugs may exacerbate or induce their disease. (medscape.com)

The Role of Telomeres in Human Disease. (cdc.gov)

Concomitant use may enhance drug efficacy by mobilizing hepatic stores and elevating plasma concentrations, particularly in very-low-birth-weight (VLBW) neonates with bronchopulmonary dysplasia. (interactionsguide.com)

Proposed molecular mechanisms of oxidative stress-induced Nrf2 activation. (hindawi.com)

Cannabis compounds have a small molecular size and are lipophilic in nature which allows for the drug to readily cross the placental barrier. (medscape.com)

The induced mRNAs include both novel and previously described genes, with diverse time courses of expression. (jneurosci.org)
Phenotypic features include primary hypogonadism, renal abnormalities, and profound short stature. (sbir.gov)
We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood-brain barrier (BBB) leakage. (bmj.com)
In the human cell, antioxidant molecules include both nonenzymatic compounds such as glutathione (GSH), thioredoxin (Trx), ascorbate, α -tocopherol, β -carotene, and coenzyme Q10 and enzymes such as catalase, glutathione peroxidase, and superoxide dismutase (SOD) [ 8 ]. (hindawi.com)

Epidemiological profi le and clini- ceiving antituberculous treatment with Although rechallenge with isoniazid cal associations of human bocavirus and rifampin (400 mg/day), isoniazid (150 could have confi rmed isoniazid as the other human parvoviruses. (cdc.gov)

In 1965, J.D. McColl and colleagues in Canada further illustrated the limitations of animal studies for the use of predicting human responses to potential teratogens. (asu.edu)
This resulted from two postlicensure studies of antibody responses after postexposure prophylaxis with human diploid cell rabies vaccine (HDCV) conducted by CDC over the last 6 months. (cdc.gov)

Similar to Knapp, Christie, and Seller's statement from three years prior, McColl and colleagues stated that the factors involved in embryogenesis and drug interaction are so complex that straightforward predictions from animal models to humans were not possible. (asu.edu)

Although no licensed Ebolavirus vaccines are currently available, vaccine research in non-human primates, the 'gold standard' animal model for Ebolavirus, has produced several promising candidates. (biomedcentral.com)
Here, we discuss how research has driven cancer drug development in the past and describe how recent advances in biology, technology, our conceptual understanding of cell networks and removal of some roadblocks may facilitate therapeutic advances in the (hopefully) near future. (biomedcentral.com)

Oxidative stress can denature lipids and proteins [ 10 , 12 - 14 ], as well as induce DNA and RNA fragmentation [ 15 - 17 ], leading to cell dysfunction, injury, and death. (hindawi.com)

TB389 trade name] is indicated in combination with other tuberculosis medicines for the treatment of drug- resistant tuberculosis caused by Mycobacterium tuberculosis . (who.int)

R torques are mucin degraders that induce an increase in other mucin-using bacteria, which can contribute to gut-barrier compromise. (medscape.com)

In humans limb truncation in offspring is a common congenital abnormality arising from Thalidomide use by pregnant women. (asu.edu)
Serologic abnormalities are common. (medscape.com)

Many of the persistent consequences of dopaminergic drugs appear to result from changes in striatal physiology, including altered sensitivity to neurotransmitters. (jneurosci.org)

U.S. Department of Health and Human Services, Public Health Service. (cdc.gov)

MAC was also found to induce the nuclear factor-κB (NF-κB) p65 activation by phosphorylation and its translocation into the nucleus. (biomedcentral.com)

Anatomy45

Organisms15

Diseases59

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Psychiatry and Psychology12

Phenomena and Processes74

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science7

Named Groups1

Health Care17

Congenital Abnormalities3

Vitro2

Carbamazepine2

Pulmonary15

Tardive dyskinesia2

Antigen2

Exposure9

Teratogenicity3

Nonsteroidal anti-1

Pregnancy6

Genetic3

Respiratory4

Receptors1

Antiepileptic drugs1

Immunodeficiency virus2

Recombinant2

Therapies2

Mutant1

Chest2

Cocaine2

Causative1

Occurs1

Lung2

Withdrawal1

Therapy1

Clinical2

Mechanism1

Inform1

Fetal1

Mice1

Discovery1

19851

Metabolites1

Patients7

Disease1

Efficacy1

Mechanisms1

Molecular1

Include4

Rechallenge1

Responses2

Straightforward1

Research2

Cell1

Treatment1

Increase1

Common2

Result1

Department of Healt1

Activation1