Drosophila proteins. Medical search. Frequent questions

Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel. (nih.gov)
Divergence of Drosophila melanogaster repeatomes in response to a sharp microclimate contrast in Evolution Canyon, Israel. (nih.gov)
Naturally occurring transposable elements disrupt hsp70 promoter function in Drosophila melanogaster. (nih.gov)
Inducing extra copies of the Hsp70 gene in Drosophila melanogaster increases energetic demand. (nih.gov)
Here we report the production of full-length PfRH5 protein using a cGMP-compliant platform called ExpreS 2 , based on a Drosophila melanogaster Schneider 2 (S2) stable cell line system. (nature.com)
We have cloned the oho31 gene of Drosophila melanogaster and determined its nucleotide sequence. (rupress.org)
The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (jefferson.edu)
We apply the method to estimate unfolded SFSs for synonymous and nonsynonymous sites in a population of Drosophila melanogaster from Phase 2 of the Drosophila Population Genomics Project. (ed.ac.uk)
Drosophila melanogaster has two GBA1 orthologs. (tau.ac.il)
Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster. (uchicago.edu)
One species of Drosophila in particular, D. melanogaster, has been heavily used in research in genetics and is a common model organism in developmental biology. (wikipedia.org)
The terms "fruit fly" and "Drosophila" are often used synonymously with D. melanogaster in modern biological literature. (wikipedia.org)
citation needed] Several Drosophila species, including Drosophila melanogaster, D. immigrans, and D. simulans, are closely associated with humans, and are often referred to as domestic species. (wikipedia.org)
The work presented in this PhD thesis focuses on the study of awd (abnormal wing discs) gene function during the development of Drosophila melanogaster. (unibo.it)
Recently, these functions have been genetically dissected in the fruit fly Drosophila melanogaster , revealing a crucial role for cell-surface activation of the downstream effector kinase Akt in many of these processes. (silverchair.com)
The cells in Drosophila melanogaster that produce pheromones are located in the abdomen. (the-scientist.com)
Drosophila melanogaster porcupine and its mouse homologue PORCN gene encode transmembrane bound endoplasmic reticulum proteins needed for the secretion of Wnt (Wingless and INT-1) proteins. (medscape.com)
In Drosophila melanogaster , the PORCN gene is involved in the processing of the wingless protein. (medscape.com)
Using mosaic analysis and RNAi in the model organism Drosophila melanogaster, we show that Dystroglycan is required cell-autonomously for cellular polarity in two different cell types, the epithelial cells (apicobasal polarity) and the oocyte (anteroposterior polarity). (lu.se)
IKEN, H.H. Ecological imprinting and protein biosynthesis experiments on Drosophila melanogaster. (bvsalud.org)

Northern analysis and in situ hybridizations to mRNA indicate that the novel vamp, as well as the genes for synaptotagmin (syt) and rab3 (drab3), is expressed in the Drosophila nervous system. (jneurosci.org)
Because of their distribution in the nervous system and because n-syb, synaptotagmin, and drab3 do not appear to be in a family of functionally redundant homologs, we predict that mutation of these genes will have a profound neurological phenotype and that they are therefore good candidates for a genetic dissection in Drosophila. (jneurosci.org)
The Additional sex combs (Asx) gene of Drosophila is a member of the Polycomb group of genes, which are required for maintenance of stable repression of homeotic and other loci. (ox.ac.uk)
We show that two outgroups are required for accurate estimation of the SFS if there is substantial variation in selective constraints, which is expected to be the case for nonsynonymous sites in protein-coding genes. (ed.ac.uk)
The SALL1 gene is part of a group of related genes that provide instructions for making proteins involved in the formation of tissues and organs before birth. (medlineplus.gov)
These proteins are transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes. (medlineplus.gov)
A shortage of functioning SALL1 protein, due to either type of mutation, likely impairs the regulation of genes that direct the development of many different organs and tissues before birth. (medlineplus.gov)
The gypsy element of Drosophila differs from most LTR retrotransposons in containing a third open reading frame that resembles retroviral env genes. (johnshopkins.edu)
The Polycomb group (PcG) and trithorax group (trxG) genes encode proteins involved in chromatin remodelling. (edu.sa)
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)

One previously reported candidate (syb), a Drosophila homolog of the vamp or synaptobrevin proteins, has been shown to be expressed at very low levels in neurons and is most abundant in the gut. (jneurosci.org)
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
This domain has previously been shown to bind to the b-catenin homolog Armadillo (Arm), raising the possibility that Wg input, in addition to Hh input, modulates the activity of the hybrid CiD protein. (uzh.ch)
Ignesti, Marilena (2017) Uncovering the Relationship between Endocytosis and Awd, the Drosophila Homolog of Nme Metastasis Suppressor Proteins , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
The haploinsuffcient dVHL (von-Hippel Lindau) gene is the Drosophila homolog of the human VHL tumour suppressor gene. (unibo.it)
We report here the characterization of the Drosophila homolog of the onecut homeobox gene, which encodes a protein product with one cut domain and one homeodomain. (psu.edu)

Abstract The Drosophila genome is subject to a high degree of selection, especially unusually widespread negative selection compared to other taxa. (wikipedia.org)
article{5f173e96-c6fe-4b5f-8f37-b070076bc387, abstract = {{The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)

The ci gene in ciD is controlled by the ubiquitous pan promoter and encodes a hybrid Ci protein that carries the N-terminal region of Pan. (uzh.ch)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
The function of the Drosophila extramacrochaetae ( emc ) gene has been characterized almost exclusively in relation to the pat-terning of the fly's sensory organs (chaetae and other types of sensilla). (biologists.com)
The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. (rupress.org)
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin protein of Xenopus (50% identity), the related yeast SRP1 protein, and the mammalian hSRP1 and RCH1 proteins. (rupress.org)
The gene encodes a phosphoprotein of 522 amino acids made of three domains: a central hydrophobic domain of eight repeats of 42-44 amino acids each, displaying similarity to the arm motif found in junctional and nucleopore complex proteins, and flanked by two hydrophilic NH2- and COOH-terminal domains. (rupress.org)
The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. (ox.ac.uk)
Bordet G, Lodhi N, Kossenkov A, Tulin A. Age-Related Changes of Gene Expression Profiles in Drosophila. (jefferson.edu)
Thus far, GBA1b was documented as a bone fide GCase-encoding gene, while the role of GBA1a encoded protein remained unclear. (tau.ac.il)
The SALL1 protein helps turn off (repress) gene activity by interacting with other proteins that alter how tightly regions of DNA are packaged. (medlineplus.gov)
By controlling gene activity, the SALL1 protein plays an important role in development of the hands (particularly the thumbs), ears, anus, kidneys, and other parts of the body before birth. (medlineplus.gov)
Most SALL1 gene mutations involved in this disorder lead to the production of an abnormally short version of the SALL1 protein that malfunctions within cells. (medlineplus.gov)
The malfunctioning protein is thought to interfere with normal copies of the SALL1 protein, which are produced from the other copy of the SALL1 gene that does not have a mutation. (medlineplus.gov)
This interference prevents the normal proteins from entering the nucleus to regulate gene activity. (medlineplus.gov)
Drosophila embryonic dorsal-ventral polarity originates in the ovarian follicle through the restriction of pipe gene expression to a ventral subpopulation of follicle cells. (princeton.edu)
This gene provides instructions for making a protein that is responsible for modifying other proteins, including Wnt proteins. (medscape.com)
PORCN , a member of the porcupine (PORC) gene family, encodes transmembrane endoplasmic reticulum proteins that target Wnt signaling proteins. (medscape.com)

If Extramacrochaetae par-ticipates in cell specification by dimerizing with basic-region-helix-loop-helix proteins, the variety of defects and tissues affected by the insufficiency of extramacrochaetae suggests that helix-loop-helix proteins are involved in many embryonic developmental processes. (biologists.com)
During the interphase of early embryonic cell cycles, the OHO31 protein is present in the cytoplasm and massively accumulates in the nucleus at the onset of mitosis in late interphase and prophase. (rupress.org)
This image shows the embryonic expression pattern of a Drosophila protein called HAIRY (seen in yellow). (dnafromthebeginning.org)
Since Wnt signaling proteins cannot be released without the PORCN protein, and Wnt signaling is important for normal embryonic development, the defects found in this disorder are related to lack of Wnt signaling. (medscape.com)
Wnt proteins are key regulators of embryonic development. (medscape.com)

Using Drosophila oogenesis as a model system, we show that mutations in smn cause abnormal nuclear organization in nurse cells and oocytes. (ox.ac.uk)

Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. (uzh.ch)
Asx was cloned by transposon tagging and encodes a protein of 1668 amino acids containing an unusual cysteine cluster at the carboxy terminus. (ox.ac.uk)
Unlike mammals that have four TIF1 members, Drosophila only encodes one member of the family, Bonus. (elifesciences.org)

and this study sets the stage for analyzing the Dystroglycan complex by using the power of Drosophila molecular genetics. (lu.se)

The activities of the two pathways depend on each other during Drosophila embryogenesis. (uzh.ch)
In the present study, we have investigated the binding of Trithorax (TRX) and Polycomb (PC) protein in the bithorax complex (BX-C) during embryogenesis. (edu.sa)

Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2, the fly homologue of the vertebrate lipid-storage protein perilipin. (silverchair.com)

Here, we demonstrate for the first time that germline, as well as somatic expression, of Drosophila Fmr1 (denoted dFmr1), the Drosophila ortholog of FMRP, are necessary in a pathway mediated by piRNAs. (hal.science)
This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)

It is known from earlier studies that the heat shock (HS) response in Malpighian tubules (MTs) of Drosophila larvae is different from that in other tissues because instead of the Hsp70 and other common heat shock proteins, Hsp64 and certain other new proteins are induced immediately after HS. (bioone.org)
Our results strongly indicated that GBA1a-encoded protein plays a role in midgut maturation during larvae development. (tau.ac.il)
Here we show that a tumour-suppressor protein, Lethal giant larvae (Lgl), is essential for asymmetric cortical localization of all basal determinants in mitotic neuroblasts, and is therefore indispensable for neural fate decisions. (elsevierpure.com)

Bordet G, Lodhi N, Guo D, Kossenkov A, Tulin AV. Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila. (jefferson.edu)

The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway. (ox.ac.uk)

Drosophila Slowpoke (dSlo) calcium-dependent potassium channels bind directly to the catalytic subunit of cAMP-dependent protein kinase (PKAc). (elsevierpure.com)

The antibodies induced by one protein variant were shown to be qualitatively similar to responses induced by other vaccine platforms. (nature.com)

A powerful tool to understand the molecular mechanism of small silencing RNA production by Dicers is an in vitro RNA processing assay using recombinant Dicer proteins. (nih.gov)
Here, we describe methods for in vitro small RNA production assay using recombinant human and Drosophila Dicer proteins. (nih.gov)

Thus, the Hh and the Wg pathways are affected by the ciD mutation, and the CiD fusion protein integrates the activities of both. (uzh.ch)

In Drosophila, the maintenance of developmentally important transcription patterns is controlled at the level of chromatin structure. (edu.sa)

Genomic studies, thus far, have analyzed each protein as a single entity. (escholarship.org)
Non-domain regions of proteins clearly play a major role in adaptive protein evolution on a genomic scale and merit future investigations of their functional properties. (escholarship.org)
We have developed a novel search algorithm, used it to search the Drosophila genomic sequence database, and identified a large multigene family encoding seven transmembrane domain proteins that are expressed in olfactory organs. (edu.au)

Moreover, the cell cycle-dependent accumulation of OHO31 in the nucleus indicates that this protein may be required for critical nuclear reactions occurring at the onset of mitosis. (rupress.org)

Without the bicoid protein, as in the null mutant, anterior structures do not form properly and the embryo eventually dies. (dnafromthebeginning.org)
For example, some research indicates that the abnormally short SALL1 protein interferes with proteins that control the formation of cellular structures called cilia. (medlineplus.gov)

The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded. (ox.ac.uk)

Because synaptic transmission is fundamentally similar between vertebrates and invertebrates, vesicle proteins from vertebrates that are important for synaptic transmission should be present in Drosophila as well. (jneurosci.org)
Several components of the PCP signaling have been characterized in flies and vertebrates, including the heterotrimeric Go protein. (nih.gov)
In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)

We further demonstrate that the activity of Kermit in PCP differentially relies on the motor proteins: the microtubule-based dynein and kinesin motors and the actin-based myosin VI. (nih.gov)

We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). (elifesciences.org)
Moreover, dFmr1 interacts genetically and biochemically with Aubergine, an Argonaute protein and a key player in this pathway. (hal.science)

Proteins that originate from insect species belonging to the genus DROSOPHILA. (jefferson.edu)
Drosophila (/drəˈsɒfɪlə, drɒ-, droʊ-/) is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently)[citation needed] pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit. (wikipedia.org)
Males of this genus are known to have the longest sperm cells of any studied organism on Earth, including one species, Drosophila bifurca, that has sperm cells that are 58 mm (2.3 in) long. (wikipedia.org)
The other members of the genus Drosophila also make relatively few giant sperm cells, with that of D. bifurca being the longest. (wikipedia.org)

Another tumour-suppressor protein, Lethal discs large (Dlg), participates in this process by regulating the localization of Lgl. (elsevierpure.com)
Hyperactivation of IIS has been implicated in the generation of many different human tumours, which are frequently defective for the tumour-suppressor protein PTEN, a PtdIns(3,4,5)- P 3 phosphatase that directly antagonizes the effects of PI3-kinases( Goberdhan and Wilson,2003b ). (silverchair.com)

We demonstrate that a Drosophila Golgi protein, Gorab, is present not only in the trans-Golgi but also in the centriole cartwheel where, complexed to Sas6, it is required for centriole duplication. (uni-koeln.de)
Our findings suggest that during animal evolution, a Golgi protein has arisen with a second, apparently independent, role in centriole duplication. (uni-koeln.de)

In this work we describe a previously unknown role of STING in lipid metabolism in Drosophila . (elifesciences.org)
Together, our results demonstrate a previously undescribed role of STING in lipid metabolism in Drosophila . (elifesciences.org)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
The insulin/insulin-like growth factor signalling (IIS) cascade performs a broad range of evolutionarily conserved functions, including the regulation of growth, developmental timing and lifespan, and the control of sugar, protein and lipid metabolism. (silverchair.com)

These photos show a wild-type Drosophila embryo that developed with normal BICOID levels and a mutant that did not have any BICOID. (dnafromthebeginning.org)
This is a leg from another Drosophila mutant. (dnafromthebeginning.org)
Similarly, Pipe protein exhibits an altered subcellular localization in the follicle cells of females mutant for windbeutel. (princeton.edu)

Drosophila Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)

Drosophila species are small flies, typically pale yellow to reddish brown to black, with red eyes. (wikipedia.org)

This investigation describes Drosophila homologs of vamp, synaptotagmin, and rab3 that are expressed in a pattern consistent with a function in Drosophila neurotransmission. (jneurosci.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
The Drosophila Extramacrochaetae protein antagonizes the proneural function of the Achaete and Scute proteins in the generation of the adult fly sensory organs. (biologists.com)
Drosophila brain structure and function develop and age significantly from larval to adult stage. (wikipedia.org)
The malfunctioning protein may also interact with other proteins, disrupting their function. (medlineplus.gov)
Identification of the essential protein domains for Mib2 function during the development of the Drosophila larval musculature and adult flight muscles. (bvsalud.org)
In this study, we have examined the mechanistic aspects of Mib2 function by performing a detailed functional dissection of the Mib2 protein . (bvsalud.org)
We show that the ankyrin repeats , in its entirety, and the hitherto uncharacterized Mib-specific domains (MIB), are important for the major function of Mib2 in skeletal and visceral muscles in the Drosophila embryo . (bvsalud.org)

We compared the population genetic mechanisms driving sequence polymorphism and divergence in defined protein domains and non-domain regions. (escholarship.org)

and HSPA6 (heat shock protein family A (Hsp70) member 6). (nih.gov)

Proteins associated with synaptic vesicles are likely to control the release of neurotransmitter. (jneurosci.org)
This distribution suggests that these molecules are components of synaptic vesicles in Drosophila. (jneurosci.org)

Drosophila species are found all around the world, with more species in the tropical regions. (wikipedia.org)
Drosophila made their way to the Hawaiian Islands and radiated into over 800 species. (wikipedia.org)
Drosophila species that are fruit-breeding are attracted to various products of fermentation, especially ethanol and methanol. (wikipedia.org)
Fruits exploited by Drosophila species include those with a high pectin concentration, which is an indicator of how much alcohol will be produced during fermentation. (wikipedia.org)

Dicer enzymes produce small silencing RNAs such as microRNAs (miRNAs) and small interfering RNAs (siRNAs), which then are loaded into Argonaute proteins and act as sequence-specific guides. (nih.gov)

The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)

A neuronal Drosophila vamp (n-syb) is described here and is localized to chromosome band 62A. (jneurosci.org)
D-Onecut appears to be a moderate transcriptional activator and functions as a nuclear protein in neuronal tissues of both the CNS and PNS during development and in the adult. (psu.edu)

Comparative analysis of the binding of the two proteins shows that TRX and PC bind target sequences (PcG-regulated elements, PREs) by cellular blastoderm, when BX-C transcription begins. (edu.sa)

Thereafter, the OHO31 protein is predominantly expressed, albeit at reduced levels, in proliferating tissues. (rupress.org)

We present evidence that D-Onecut can bind to similar DNA sequences with high specificity and affinity as other Onecut proteins through the highly conserved cut domain and homeodomain. (psu.edu)

In Drosophila, neuroblasts undergo typical asymmetric divisions to produce another neuroblast and a ganglion mother cell. (elsevierpure.com)

Test results with eight chemicals in a drosophila-based developmental toxicity prescreen. (cdc.gov)

ACC and FASN also interact with each other, indicating that all three proteins may be components of a large multi-enzyme complex. (elifesciences.org)

Anatomy37

Organisms5

Diseases1

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology4

Phenomena and Processes65

Disciplines and Occupations1

Information Science4

Melanogaster20

Genes10

Homolog6

Abstract2

Gene17

Embryonic5

Oogenesis1

Encodes3

Genetics1

Embryogenesis2

Phenotype1

Ortholog2

Larvae3

Genome1

Germline1

Kinase1

Antibodies1

Recombinant2

Pathways1

Chromatin Structure1

Genomic3

Accumulation1

Structures2

Neural1

Vertebrates3

Myosin1

Interacts2

Genus4

Tumour-suppressor protein2

Golgi2

Metabolism4

Mutant3

MeSH1

Flies1

Function8

Divergence1

Hsp701

Synaptic2

Species4

Argonaute1

Transmembrane Protein1

Neuronal2

Transcription1

Tissues1

Specificity1

Neuroblast1

Chemicals1

Complex1