• A recombinant inbred strain or recombinant inbred line (RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. (wikipedia.org)
  • Families of recombinant inbred strains numbering from 25 to 5000 are often used to map the locations of DNA sequence differences (quantitative trait loci) that contributed to differences in phenotype in model organisms. (wikipedia.org)
  • The origins and history of recombinant inbred strains are described by Crow. (wikipedia.org)
  • While the potential utility of recombinant inbred strains in mapping analysis of complex polygenic traits was obvious from the outset, the small number of strains only made it feasible to map quantitative traits with very large effects (quasi-Mendelian loci). (wikipedia.org)
  • One of the initial motivations to use recombinant inbred strains is that expensive genotype data can be accumulated and reused - greatly simplifying mapping studies. (wikipedia.org)
  • As genotyping became progressively less expensive and more accurate the main advantage of using recombinant inbred strains and other genetic reference panels shifted to the ability to assemble massive and coherent databases on phenotypes (e.g., the GeneNetwork web service), and to use these coherent open-source data sets for large-scale collaborative research projects in predictive medicine and plant and animal research. (wikipedia.org)
  • Recombinant inbred strains are now widely used in systems genetics and to study gene-environment interactions. (wikipedia.org)
  • It is possible to accumulate extensive genetic and phenotype data for each member of a family of recombinant inbred strains under several different conditions (e.g., baseline environment versus stressful environment). (wikipedia.org)
  • Chromosomes of recombinant inbred strains typically consist of alternating haplotypes of highly variable length that are inherited intact from the parental strains. (wikipedia.org)
  • All else being equal, the larger the family of recombinant inbred strains, the greater the power and resolution with which phenotypes can be mapped to chromosomal locations. (wikipedia.org)
  • Somewhat larger families of recombinant inbred strains were generated concurrently by Benjamin Taylor to map Mendelian and other major effect loci. (wikipedia.org)
  • In the 1990s the utility of recombinant inbred strains for mapping was significantly improved thanks to higher density genotypes made possible by the use of microsatellite markers. (wikipedia.org)
  • Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)
  • Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)
  • Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
  • Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
  • Rabbits and mice vaccinated with the live recombinant virus produced antibodies that recognized 48K, 57K and 61K mol. (microbiologyresearch.org)
  • pairs of the F2 progeny are then mated to establish inbred strains through long-term inbreeding. (wikipedia.org)
  • The first set of eight strains, the CXB family, were generated by Donald Bailey at the Jackson Laboratory from an intercross between a female BALB/cBy mouse (abbreviated C) and a male C57BL/6By mouse in the 1960s. (wikipedia.org)
  • Nowadays, due to standardized ways of maintaining animal colonies and the availability of mouse strains with known genetic backgrounds and approaches to reduce the variability of tumor size between animals, transplantable mouse tumor models can be widely used in translational cancer research. (bvsalud.org)
  • Our results substantiate the use of a forward-genetics approach for studying sleep behaviours in mice, and demonstrate the role of SIK3 and NALCN in regulating the amount of NREMS and REMS, respectively. (nature.com)
  • In Systems Genetics , Methods in Molecular Biology 1488:75-120 [An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts. (genenetwork.org)
  • Here, we report that mouse haESCs can differentiate in vitro into haploid epiblast stem cells (haEpiSCs), which maintain an intact haploid genome, unlimited self-renewal potential, and durable pluripotency to differentiate into various tissues in vitro and in vivo. (refine.bio)
  • The effect of K(ATP) channels is dependent on the RNA interference genes Dcr-2, AGO2, and r2d2, indicating that an activity associated with this potassium channel participates in this antiviral pathway in Drosophila. (cnrs.fr)
  • The best known genes of microbes, mice and men are those that specify enzymes. (typeset.io)
  • We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3) at transcriptionally repressed promoters in R6/2 mouse and human HD brain. (nih.gov)
  • Joint mouse-human phenome-wide association to test gene function and disease risk. (genenetwork.org)
  • Harenza JL, Muldoon PP, De Biasi M, Damaj MI, Miles MF (2014) Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. (genenetwork.org)
  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. (research.com)
  • However, the mice were grossly normal when dab2 deletion was restricted to the embryo proper and the gene was retained in extraembryonic tissues using Meox2-Cre and Sox2-Cre. (biomedcentral.com)
  • Chaum E, Winborn CS, Bhattacharya S 2015 Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. (genenetwork.org)
  • Indeed, the repressive histone modifications H3K9me3 and H4K20me3 are associated with ERVs in mouse ES cells [12] , [13] . (prolekarniky.cz)
  • In mice, H3K27me3 was found to increase in muscle quiescent stem cells from aged individuals and, thus, is suggested to suppress functions related to stemness [ 17 ]. (aging-us.com)
  • The transformed cells are, however, all oncogenic in the host animal and in immunocompetent mice. (microbiologyresearch.org)
  • Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)
  • We show that the conditional depletion of the m 6 A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. (biomedcentral.com)
  • To examine this phenomenon, we chose two mouse embryonic stem (ES) cell lines that possess insertionally polymorphic retrotransposons (IAP, ETn/MusD, and LINE elements) at specific loci in one cell line but not the other. (prolekarniky.cz)
  • Finally, reduction of SMCX/Jarid1c in primary neurons from BACHD mice or the single Jarid1 in a Drosophila HD model was protective. (nih.gov)
  • In mice, the Coxsackievirus B3 replicates to higher titers in the hearts of mayday mutant animals, which are deficient in the Kir6.1 subunit of K(ATP) channels, than in controls. (cnrs.fr)
  • Animals other than rats and mice used in gerontology studies from 1972 to 1992. (comprehensivephysiology.com)
  • To detect the epigenetic drift of time passing, we determined the genome-wide distributions of mono- and tri-methylated lysine 4 and acetylated and tri-methylated lysine 27 of histone H3 in the livers of healthy 3, 6 and 12 months old C57BL/6 mice. (aging-us.com)
  • Influence of dietary restriction started at 3 wk of age on life span and tumor incidence of female mice from the long‐lived C3B10RF 1 hybrid strain. (comprehensivephysiology.com)
  • Circles show the age of death for tumor‐bearing mice. (comprehensivephysiology.com)
  • Mouse tumor models are essential in cancer research, especially in elucidating malignancy, developing prevention, diagnosis, and new therapeutic approaches. (bvsalud.org)
  • Here, we describe the induction of different subcutaneous tumor models in mice, in particular xenograft and syngeneic that can be used as experimental tumor models. (bvsalud.org)
  • Moreover, feeding mice with caloric restriction diet, a treatment known to retard aging, reduced the extent of changes occurring during the first year of life in these genomic regions. (aging-us.com)
  • Relationship between caloric intake and life span in female C3B10RF 1 mice. (comprehensivephysiology.com)
  • Local application of L-lactate to injured spinal cord promoted corticospinal tract axon regeneration, leading to behavioral recovery in adult mice. (nih.gov)
  • Using pharmacological blockade of neuronal gap junctions combined with electrophysiological recordings, we found that gap junctions play a role in theta rhythm in the vHIP and mPFC of adult mice. (princeton.edu)
  • His Computational biology study integrates concerns from other disciplines, such as Identifier, Phenomics and Laboratory mouse. (research.com)
  • Survival curves for two species of Peromyscus (the white‐footed mouse) and one strain (C57BL/6J) of Mus musculus (the laboratory mouse) under laboratory conditions. (comprehensivephysiology.com)
  • His Genome study combines topics from a wide range of disciplines, such as International Knockout Mouse Consortium, Inbred strain, Replication slippage and Expressivity. (research.com)
  • In a mouse model of LPS-induced acute inflammation, DSO2-ONJ demonstrated anti-inflammatory activity by inhibiting the production of the pro-inflammatory interleukin-6. (cnrs.fr)
  • Figure 2: Increased sleep need and normal wake-promoting response of Sik3 mutant mice. (nature.com)
  • Hillje R , Luzi L , Amatori S , Persico G , Casciaro F , Rusin M , Fanelli M , Pelicci P , Giorgio M , . Time makes histone H3 modifications drift in mouse liver. (aging-us.com)
  • Adult Dab2-deficient mice had a small but statistically significant increase in serum cholesterol levels. (biomedcentral.com)
  • We show that glia can be reprogrammed to promote morphological and functional regeneration after CNS injury in Drosophila via increased glycolysis. (nih.gov)
  • Here, we show that in Drosophila ATP-sensitive potassium channels (K(ATP)) mediate resistance to a cardiotropic RNA virus, Flock House virus (FHV). (cnrs.fr)
  • In mouse, IAPs (Intracisternal A-type Particle elements), long terminal repeats (LTR) retrotransposons (also termed endogenous retroviruses (ERVs)), are highly DNA methylated and the disruption of enzymes responsible for such methylation (DNA methyltransferases Dnmt1 and Dnmt3L) causes global derepression of IAP copies [6] , [7] , albeit only in particular tissues. (prolekarniky.cz)
  • The same methodology was applied to MEL mice treated with the clinically approved anti-fibrotic drug nintedanib. (ibecbarcelona.eu)