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MelanogasterEsteraseDominated by the steroid hormone eEcdysone ReceptorRegulatesProteinLarvalInsectsACHEReproductive2017ProteinsPhysiologyPhysiologicalModulateRegulationHomeostasisPeptideAdultSpeciesDevelopmentColeopteraMechanismFliesMoleculeBrainCircadian

Melanogaster14

• Interestingly, JHAMT In Drosophila melanogaster (DmJHMAT) has been shown to have broad specificity for medium chain free fatty acids when the enzyme is recombinantly expressed in E. coli, converting them into fatty acid methyl esters (FAMEs). (wikipedia.org)
• Experiments have shown that an overexpression of CG17330/DmJHAMT leads to pupal lethality and a misorientation of male genitalia in D. melanogaster, suggesting that proper temporal regulation of this gene is critical for Drosophila development. (wikipedia.org)
• After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)
• We are interested in the population genetics and evolutionary genomics of adaptation , mainly by using the fruit fly Drosophila melanogaster as an experimentally tractable model. (unifr.ch)
• An 85 kDa protein identified in Drosophila melanogaster methoprene-tolerant (Met) mutant binds to JH III with high affinity, and the mutant flies are resistant to juvenile hormone analog (JHA), methoprene. (uky.edu)
• Thanks to the unparalleled genetic tools of the fruit fly Drosophila melanogaster , all key components of the clock seemed to be identified, most of them during a two-decade period from ~1990-2010. (cas.cz)
• Data were compared with equivalent data for two long germ-band holometabolan species Drosophila melanogaster and Drosophila virilis , and the short germ-band holometabolan species Tribolium castaneum . (biomedcentral.com)
• Long germ-band insects, such as the fruit fly Drosophila melanogaster , form most of their segments simultaneously at the blastoderm stage, i.e., before gastrulation. (biomedcentral.com)
• Circadian clocks have been postulated to regulate development time in several species of insects including fruit flies Drosophila melanogaster . (biomedcentral.com)
• Molecular mechanisms regulating the binding capacity of juvenile hormone response region (JHRR) to nuclear proteins in Drosophila melanogaster [J]. , 2016, 59(12): 1325-1331. (insect.org.cn)
• Transcriptome analysis of Drosophila melanogaster third instar larval ring glands points to novel functions and uncovers a cytochrome P450 required for development. (chinaagrisci.com)
• Charles J.-P., Chihara C., Nejad S., Riddiford L.M. (1998) Identification of proteins and developmental expression of RNAs encoded by the 65A cuticle protein gene cluster in Drosophila melanogaster , Insect Biochem. (apidologie.org)
• cg11598 protein , drome-CG11600 Drosophila melanogaster (Fruit fly) cg11600 protein , drome-CG11608 Drosophila melanogaster (Fruit fly) cg11608 protein , drome-CG17097 Drosophila melanogaster (Fruit fly) male accessory gland protein. (inra.fr)
• LIP1 , drome-LIP2 Drosophila melanogaster (Fruit fly) cg17116 protein , drome-lip3 Drosophila melanogaster (Fruit fly) lipase 3. (inra.fr)

Esterase4

• Molecular cloning, sequence analysis and developmental expression of cDNA fragment of juvenile hormone esterase from the whitefly Bemisia tabaci MED (Hemiptera: Aleyrodidae) [J]. , 2013, 56(3): 234-242. (insect.org.cn)
• Drosophila esterase 6, produced in the anterior ejaculatory duct of the male insect reproductive system where it plays an important role in its reproductive biology. (expasy.org)
• Drosophila esterase P. (expasy.org)
• Insect juvenile hormone esterase (JH esterase) (EC 3.1.1.59 ). (expasy.org)

Dominated by the steroid hormone e1

• Insect endocrinology is dominated by the steroid hormone ecdysone and terpenoid hormone juvenile hormone. (cas.cz)

Ecdysone Receptor1

• TAIMAN is closely engaged in both juvenile hormone and ecdysone receptor signaling. (cas.cz)

Regulates3

• Juvenile hormone regulates the development of fruit flies throughout their life, from egg to larvae to adult. (skincare.nz)
• The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. (chinaagrisci.com)
• Apple R.T., Fristrom J.W. (1991) 20-hydroxyecdys-one is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes, Dev. (apidologie.org)

Protein4

• Drosophila protein neurotactin (gene nrt) which may mediate or modulate cell adhesion between embryonic cells during development. (expasy.org)
• Drosophila protein glutactin (gene glt), whose function is not known. (expasy.org)
• Santos A.E., Bitondi M.M.G., Simões Z.L.P. (2001) Hormone-dependent protein patterns in integument and cuticular pigmentation in Apis mellifera during pharate adult development, J. Insect Physiol. (apidologie.org)
• Early studies reported that DOPAL synthase-like protein, alpha methyldopa resistant (AMD-r), in Drosophila is resistant to the toxic compound, AMD. (biomedcentral.com)

Larval4

• The pupal stage starts after the third instar larval stage, lasts for another 4 days, subsequently leading to wing-pigmentation followed by adult emergence, hence the entire pre-adult developmental duration of Drosophila spans ~9 days. (biomedcentral.com)
• Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. (cnrs.fr)
• Rachinsky A., Hartfelder K. (1998) In vitro biosynthesis of juvenile hormone in larval honey bees: comparison of six media, In vitro Cell. (apidologie.org)
• Imaginal discs are very fascinating structures observed in larva of holometabolous insects and can be defined as Clusters of undifferentiated embryonic cells in holometabolous insects that proliferate during larval stages and then differentiate during the pupal stage upon induction by ecdysone but in the absence of juvenile hormone. (iflybio.com)

Insects7

• Juvenile hormone acid O-methyltransferase (JHAMT) is a ~33 kDa enzyme (the molecular mass is species-dependent) that catalyzes the conversion of inactive precursors of Juvenile hormones (JHs) to active JHs in the final stages of JH biosynthesis in the corpora allata of insects. (wikipedia.org)
• Insects of order Lepidoptera first perform an epoxidation by P450 epoxidase to convert farnesoic acid to JHA III, followed by JHAMT-dependent methylation to produce juvenile hormone III. (wikipedia.org)
• These cells classified into several subtypes based on the hormones they produce in both mammals and insects. (bioone.org)
• Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. (rero.ch)
• Various plant species contain terpene secondary metabolites, which disrupt insect growth and development by affecting the activity of juvenile hormone-degrading enzymes, and the juvenile hormone (JH) titers maintained in insects. (mdpi.com)
• Short germ-band development is typical of basal insects such as locusts and cockroaches, whereas more derived species such as those of the genus Drosophila predominantly undergo long germ-band development [ 2 ]. (biomedcentral.com)
• The timing of juvenile hormone signalling supports homology between stages of hemimetabolous and holometabolous insects. (cas.cz)

ACHE1

• Acetylcholinesterase (EC 3.1.1.7 ) (AChE) from vertebrates and from Drosophila. (expasy.org)

Reproductive1

• Effects of application of juvenile hormone and precocene on physiological trade-offs between flight muscle and reproductive development in the wing dimorphic cricket Velarifictorus ornatus (Orthoptera: Gryllidae) (In English) [J]. , 2013, 56(6): 622-629. (insect.org.cn)

20171

• Molecular mechanisms of juvenile hormone in insect metamorphosis [J]. , 2017, 60(5): 594-603. (insect.org.cn)

Proteins1

• These data suggest that the proteins that are involved in signal transduction of ecdysteroids (EcR and USP) and juvenile hormones (Met) interact to mediate cross-talk between these two important hormones. (uky.edu)

Physiology2

• Comparative approaches to the study of physiology: Drosophila as a physiological tool. (nih.gov)
• Circadian clocks often adjust animals' physiology through various hormones and neuropeptides. (cas.cz)

Physiological1

• Ecdysteroids and juvenile hormones (JH) regulate a variety of developmental, physiological, behavioral, and metabolic processes. (uky.edu)

Modulate1

• We assayed the duration of three pre-adult stages in the faster developing (FD) and control (BD) populations under a variety of light regimes that are known to modulate circadian clocks and pre-adult development time of Drosophila to examine the role of circadian clocks in the timing of pre-adult developmental stages. (biomedcentral.com)

Regulation3

• However, gut senescence does not appear to be the direct cause for longevity regulation, as knockdown of both hormone receptors did not affect adult lifespan. (bioone.org)
• Rivera-Pérez C., Clifton M.E., Noriega F., Jindra M. (2020) Juvenile hormone regulation and function. (cas.cz)
• Hiruma K., Riddiford L.M. (1988) Granular phenoloxidase involved in cuticular melanization in the tobacco hornworm: regulation of its synthesis in the epidermis by juvenile hormone, Dev. (apidologie.org)

Homeostasis1

• The brain plays a key role in energy homeostasis, detecting nutrients, metabolites and circulating hormones from peripheral organs and integrating this information to control food intake and energy expenditure. (cnrs.fr)

Peptide2

• We show that midgut-preferential RNA knockdown of the peptide hormones AstA or Dh31 respectively results in decreased or increased adult lifespan. (bioone.org)
• Sex peptide appears to escalate the effects of juvenile hormone, shifting the mated flies' metabolism from healthier processes to metabolic pathways that require more energy to maintain. (skincare.nz)

Adult2

• These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)
• Additionally, Drosophila larvae are known to show rhythmicity in light avoidance behaviour [ 24 ], which is probably the earliest and the only clock-driven pre-adult behaviour reported thus far in Drosophila . (biomedcentral.com)

Species1

• miRNA commonalities between B. germanica and T. castaneum , as opposed to those of the two Drosophila species studied, were assumed to be associated with the germ-band type, whereas those of T. castaneum and the Drosophila species, as opposed to B. germanica , were assumed to be associated with the mode of metamorphosis followed. (biomedcentral.com)

Development2

• Structure and development of the subesophageal zone of the Drosophila brain. (rero.ch)
• Fagan, M. The potential role of variations in juvenile hip geometry on the development of legg-calve-perthes disease: a biomechanical investigation. (isbweb.org)

Coleoptera1

• Reconstruction of insect hormone pathways in an aquatic firefly, Sclerotia aquatilis (Coleoptera: Lampyridae), using RNA-seq. (chinaagrisci.com)

Mechanism1

• This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)

Flies2

• The climbing index in GSO-treated Drosophila was significantly higher than that in the tert-butyl-hydroperoxide-treated flies. (sdbonline.org)
• Studying one of the most common laboratory models used in genetic research - the fruit fly Drosophila - researchers found that the drug mifepristone extends the lives of female flies that have mated. (skincare.nz)

Molecule2

• Two additional residues, Gln-14 and Trp-120, hydrogen bond with the carboxyl group of either farnesoic acid (FA) or juvenile hormone acid III (JHA III) to structurally orient the molecule for catalysis. (wikipedia.org)
• They found that a molecule called juvenile hormone plays a central role. (skincare.nz)

Brain3

• The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
• GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
• The subesophageal zone (SEZ) of the Drosophila brain processes mechanosensory and gustatory sensory input from sensilla located on the head, mouth cavity and trunk. (rero.ch)

Circadian1

• However, the circadian role of TAIMAN presented here modulates the clock in a hormone-independent way. (cas.cz)