• Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster. (uchicago.edu)
  • This study shows that, similarly to H3 , histone H4 is inherited asymmetrically in Drosophila melanogaster male germline stem cells undergoing asymmetric division. (sdbonline.org)
  • The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
  • Potential variance affecting homeotic Ultrabithorax and Antennapedia phenotypes in Drosophila melanogaster. (lookformedical.com)
  • We are a hybrid computational and experimental lab who couple genome-scale computational and experimental analysis of gene regulation in Drosophila melanogaster and Saccharomyces cerevisiae with extensive analysis of comparative sequence data and experimental analysis of species closely related to these model systems. (berkeley.edu)
  • To provide a solid experimental foundation for our evolutionary studies, we are working with several other labs in Berkeley to systematically dissect gene expression and regulation in the early D. melanogaster embryo. (berkeley.edu)
  • My lab is applying the high-resolution fluorescent imaging methods developed for D. melanogaster to systematically analyze gene expression, and dissect regulatory networks, in other Drosophila species and in several inbred lines of D. melanogaster . (berkeley.edu)
  • The detailed experimental data we are generating for D. melanogaster , and the genome sequences of 12 Drosophila species are a tremendous resource for studying the evolution of gene regulation. (berkeley.edu)
  • While it is impractical to repeat every experiment done in D. melanogaster in every other strain and species, we are extending several classes of experiment to selected strains and species so that we can better understand regulatory variation at each of its multiple levels: how sequence variation affects binding, how binding variation affects expression, and how expression variation affects phenotype. (berkeley.edu)
  • Data were compared with equivalent data for two long germ-band holometabolan species Drosophila melanogaster and Drosophila virilis , and the short germ-band holometabolan species Tribolium castaneum . (biomedcentral.com)
  • Long germ-band insects, such as the fruit fly Drosophila melanogaster , form most of their segments simultaneously at the blastoderm stage, i.e., before gastrulation. (biomedcentral.com)
  • Using the fruit fly model organism (Drosophila melanogaster), the researcher investigates how genes are regulated during the embryonic development of the nervous system. (mdc-berlin.de)
  • Here, using the model species Drosophila melanogaster , we used a combination of Genome Wide Association mapping (GWAS) and transcriptomic profiling to characterize whether genes associated with thermal tolerance are primarily involved in dynamic stress responses or preparatory processes that influence physiological condition at the time of thermal stress. (frontiersin.org)
  • Drosophila melanogaster is an excellent model to study the genetic basis of the effects of developmental alcohol exposure since many individuals of the same genotype can be reared under controlled environmental conditions. (biomedcentral.com)
  • We used 96 sequenced, wild-derived inbred lines from the Drosophila melanogaster Genetic Reference Panel (DGRP) to profile genome-wide transcript abundances in young adult flies that developed on ethanol-supplemented medium or standard culture medium. (biomedcentral.com)
  • Drosophila melanogaster presents an advantageous model for studies on the genetic underpinnings associated with symptoms of developmental alcohol exposure. (biomedcentral.com)
  • In D. melanogaster , the eight Hox genes are organized in two separate clusters on chromosome 3R: the Antennapedia cluster (ANT-C) and the Bithorax cluster (BX-C). The 350 kb BX-C contains the Ubx, abd-A and Abd-B genes, which specify the identity of the more posterior embryonic parasegments 5 to 14 (PS5 to PS14). (biorxiv.org)
  • 4) Asx is an Enhancer of position-effect variegation and (5) Asx displays tissue-specific derepression of target genes. (ox.ac.uk)
  • Here we examined quantitatively the relationship between nuclear distribution of the Dorsal transcription factor, boundary positions for several target genes, and DV axis length. (tamu.edu)
  • Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila. (jefferson.edu)
  • At the beta-globin locus, enhancer-promoter interactions appear dynamic and cell-type specific, whereas atthe HoxD locus they are stable and ubiquitous, being present in tissues where the target genes are not expressed. (ens-lyon.fr)
  • Enhancers promote transcription by providing a binding platform for transcription factors [ 12 ] that can act on (distal) target genes through three-dimensional chromatin looping [ 13 - 15 ]. (biomedcentral.com)
  • Size-dependent regulation of dorsal-ventral patterning in the early Drosophila embryo. (tamu.edu)
  • How natural variation in embryo size affects patterning of the Drosophila embryo dorsal-ventral (DV) axis is not known. (tamu.edu)
  • Thus, our results argue against the idea that the Dorsal gradient works as a global system of relative coordinates along the DV axis and suggest that individual targets respond to changes in embryo size in a gene-specific manner. (tamu.edu)
  • O-GlcNAc transferase (OGT) is an X-linked gene product that is essential for normal development of the vertebrate embryo. (rcsb.org)
  • The production of viable offspring requires three key developmental events: oocyte maturation, the oocyte-to-embryo transition (OET), and the maternal-to-zygotic transition (MZT) ( Figure 1A ). (elifesciences.org)
  • Later Drosophila embryo (stage 11, ventral view, anterior left) undergoing developing nervous system. (mdc-berlin.de)
  • The quick developmental progression as well as the excellent genetic and biochemical accessibility of the fruit fly embryo are some of the reasons why Robert considers these insects to be an ideal model organism for his research. (mdc-berlin.de)
  • Using theory and experiment, we have shown that during cellularisation in the Drosophila embryo, cells undergo skew and apical-to-basal neighbour rearrangements to adapt for geometric constraints. (mechanochemistry.org)
  • We have taken advantage of genetically induced smaller embryos in Drosophila to bring new insights into when and where organ scaling occurs in the embryo. (mechanochemistry.org)
  • Prelights article on our paper about scaling in the early Drosophila embryo. (mechanochemistry.org)
  • Our study provides new insight into the rab11 expression and promotes the use of this model organism to tackle future studies on the role of rab11 in embryo development. (researchsquare.com)
  • Hox genes encode crucial developmental regulators that specify segmental identities along the Antero-Posterior (A-P) body axis in the developing embryo of bilaterian species. (biorxiv.org)
  • To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. (stanford.edu)
  • Lack of Hat1 results in the near complete loss of histone H4 lysine (K) 5 and K12 acetylation in embryos, indicating that Hat1 is the main acetyltransferase specific for these marks in this developmental stage. (sdbonline.org)
  • RNA-seq analysis of embryos indicate that in Hat1 mutants over 2000 genes are dysregulated and the observed transcriptional changes imply a delay in the developmental program of gene expression (Varga, 2019). (sdbonline.org)
  • Our data for the remaining seven NKL genes revealed expression in different structures associated with the developing nervous system in embryos of E. rowelli . (biomedcentral.com)
  • For each of the approximately 40 transcription factors critical in shaping anterior-posterior and dorsal-ventral patterns, our goals are to: 1) measure the factor s in vitro affinity to each of its potential target sequences, 2) identify the genomic regions bound by each factor in living embryos, 3) determine the expression pattern of the factor and its targets in three-dimensions at cellular resolution. (berkeley.edu)
  • Different from rab11a and rab11ba, which both have maternal expressions in embryos, rab11bb only expresses during 24hpf to 96hpf. (researchsquare.com)
  • Dr. Benyajati is interested in studying the molecular mechanisms that regulate differential gene expression during development using the Drosophila alcohol dehydrogenase ( Adh ) gene as the model system. (rochester.edu)
  • Our team's research aims to shed light on the molecular basis for growth control and developmental timing at the cellular and tissue/organ level using Drosophila as a model system. (riken.jp)
  • We have demonstrated the molecular mechanism underlying the nutrient-dependent expression of a Dilp gene. (riken.jp)
  • NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. (biomedcentral.com)
  • Comparison of our expression data to those of other bilaterians revealed similar patterns of NK2.1 , vax , BarH and Emx in various aspects of neural development, such as the formation of anterior neurosecretory cells mediated by a conserved molecular mechanism including NK2.1 and vax , and the development of the central and peripheral nervous system involving BarH and Emx . (biomedcentral.com)
  • We are driven by a desire to understand the molecular basis of organismal diversity, and the belief that many differences in physiology, morphology and behavior arise from changes in gene regulation. (berkeley.edu)
  • Although all these studies strongly suggest that TEs may play a role in gene regulation through different molecular mechanisms, detailed analyses that link changes in expression with fitness effects are needed to conclude that TEs have a functional impact on gene expression. (nature.com)
  • Using a transgenic mouse model in which an ALS-like mutation was introduced in the mouse Fus gene, we could show that ALS pathology starts at the neuromuscular juction (the transition between motor nerves and skeletal muscle cells), long before motor neuron cell bodies in the spinal cord degenerate. (europa.eu)
  • Editing this mutation into the Drosophila genome results in global changes in the O-GlcNAc proteome, while in mouse embryonic stem cells it leads to loss of O-GlcNAcase and delayed differentiation down the neuronal lineage. (rcsb.org)
  • These defects are mediated by increased expression of a protein called Xrp1, which is involved in gene expression regulation. (europa.eu)
  • Xrp1 is a DNA-binding protein that is involved in gene expression regulation. (europa.eu)
  • 1990 . Alternative DNA-protein interactions in variable-length internucleosomal regions associated with Drosophila Adh distal promoter expression. (rochester.edu)
  • The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. (ox.ac.uk)
  • Increased sensitivity to cold stress upon STAT5 deficiency was associated with reduced expression of thermogenic markers including uncoupling protein 1 (UCP1), while decreased stimulated lipolysis was linked to decreased protein kinase A (PKA) activity. (bvsalud.org)
  • The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis. (ox.ac.uk)
  • We show that the only PACT domain protein in Drosophila (the Drosophila pericentrin-like protein [D-PLP]) is associated with both the centrioles and the PCM, and is essential for the efficient centrosomal recruitment of all six PCM components that we tested. (ox.ac.uk)
  • sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. (jefferson.edu)
  • Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
  • The v-ets oncogene was originally discovered as part of a fusion protein expressed by a transforming retrovirus (avian E26), and later shown to be transduced from a cellular gene. (embl.de)
  • We constructed sex-specific genetic networks associated with alcohol-dependent modulation of gene expression that include protein-coding genes, Novel Transcribed Regions (NTRs, postulated to encode long non-coding RNAs) and female-specific coordinated regulation of snoRNAs that regulate pseudouridylation of ribosomal RNA. (biomedcentral.com)
  • An overview of this gross morphologic schema provides a framework for further studying the processes of regulation and patterning involved in the development of the lower extremity. (medscape.com)
  • In the Drosophila ovarian germline, BMP ligands secreted by a small population of niche cells maintain germline stem cell (GSC) identity. (manchester.ac.uk)
  • Our work provides a simple unifying framework for a rich repertoire of PRE/TRE functions, and thus provides insights into genome-wide Polycomb/Trithorax regulation. (bvsalud.org)
  • Genome-wide association study in accessions of the mini-core collection of mungbean (Vigna radiata) from the World Vegetable Gene Bank (Taiwan). (compbio.ru)
  • Bordet G, Lodhi N, Guo D, Kossenkov A, Tulin AV. Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila. (jefferson.edu)
  • In this study, we employed a genome-wide CRISPR-Cas9 loss-of-function screen based on cell survival in order to identify genes implicated in the host response to dsRNA. (cnrs.fr)
  • Using a genome-wide screening approach, we set to identify genes involved in dsRNA entry, sensing, and apoptosis induction in human cells. (cnrs.fr)
  • In Xenopus, zebrafish, and Drosophila the major activation of zygotic transcription occurs as the cell cycle lengthens and gastrulation begins, a developmental period referred to as the midblastula transition. (elifesciences.org)
  • We are using Drosophila and Zebrafish to explore how organs adapt to size changes. (mechanochemistry.org)
  • Conclusions: Our results suggest that rab11 genes play important but distinct roles in the development of the nervous system in zebrafish. (researchsquare.com)
  • In the present project, we showed that zebrafish rab11 genes are conserved in vertebrate evolution by in silicon analysis. (researchsquare.com)
  • To better understand the interface between nutrient availability and growth regulation, we are focusing on how nutrition controls systemic growth through Drosophila insulin-like peptides (Dilps). (riken.jp)
  • With this goal, we have generated extensive data on transcriptomics from different cellular fractions, whole cell proteomics and nine histone modifications in twelve time points along the transdifferentiation from pre-B cells into macrophages, and whole tissue transcriptomics and nine histone modification profiles in four Drosophila tissues (wing, eye, leg and antenna) along three developmental stages (third instar larvae, white pupa and late pupa). (crg.es)
  • Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. (jefferson.edu)
  • However, it is unclear whether changes to histone expression could be exploited to ameliorate the effects of ageing in multicellular organisms. (sdbonline.org)
  • In Drosophila , the BX-C cluster contains the three most posterior Hox genes, where their collinear activation incorporates progressive replacement of histone modifications, reorganization of 3D chromatin architecture and sequential activation of boundary elements and cis -regulatory regions. (biorxiv.org)
  • Interestingly, we detected a non-canonical inversion of collinear chromatin dynamics at the Abd-B gene, with the active histone domain decreasing in size. (biorxiv.org)
  • Drosophila willistoni (Sturtevant, 1916) is a species of the willistoni group of Drosophila having wide distribution from the South of USA (Florida) and Mexico to the North of Argentina. (scielo.br)
  • Most species have a standard body size, but developing organisms are also capable of adapting their growth to fluctuating nutritional states through metabolic regulation. (riken.jp)
  • Our goal was to address that issue by studying the changes in miRNA expression along the ontogeny of the German cockroach Blattella germanica , which is a short germ-band and hemimetabolan species. (biomedcentral.com)
  • Short germ-band development is typical of basal insects such as locusts and cockroaches, whereas more derived species such as those of the genus Drosophila predominantly undergo long germ-band development [ 2 ]. (biomedcentral.com)
  • miRNA commonalities between B. germanica and T. castaneum , as opposed to those of the two Drosophila species studied, were assumed to be associated with the germ-band type, whereas those of T. castaneum and the Drosophila species, as opposed to B. germanica , were assumed to be associated with the mode of metamorphosis followed. (biomedcentral.com)
  • A unique feature of Hox genes in most species is that they are organized in clusters, with their relative genomic position corresponding to their order of expression along the A-P axis ( McGinnis and Krumlauf, 1992 ). (biorxiv.org)
  • These findings highlight the complex regulation of the chromatin and epigenetic environments at PRDM9-specified hotspots. (elifesciences.org)
  • Transposable elements are emerging as an important source of cis-acting regulatory sequences and epigenetic marks that could influence gene expression. (nature.com)
  • However, few studies have dissected the role of specific transposable element insertions on epigenetic gene regulation. (nature.com)
  • Gene regulation is a complex process that involves mechanisms at the DNA sequence level and at the epigenetic level. (nature.com)
  • The epigenetic status of TEs can also affect gene regulation. (nature.com)
  • Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers. (jefferson.edu)
  • We now have extensive comparative sequence data for fruitflies (12 Drosophila genomes) and yeasts (many fungal genomes), and are using these data to characterize how the individual building blocks of regulatory sequences (transcription factor binding sites) and higher order structures (e.g. developmental enhancers) evolve. (berkeley.edu)
  • We are particularly interested in understanding how selection to maintain transcription factor binding sites affects the evolution of target sequences, and how the extensive plasticity seen in the organization of developmental enhancers is related to their function. (berkeley.edu)
  • Developmental enhancers initiate transcription and are fundamental to our understanding of developmental networks, evolution and disease. (ens-lyon.fr)
  • Each enhancer contacts multiple enhancers, and promoters with similar expression, suggesting a role in their co-regulation. (ens-lyon.fr)
  • We sequenced small RNA libraries representing 11 developmental stages of B. germanica ontogeny (with especial emphasis on embryogenesis) and the changes in miRNA expression were examined. (biomedcentral.com)
  • Four main waves of miRNA expression were recognized (with most miRNA changes occurring during the embryonic stages): the first from day 0 to day 1 of embryogenesis, the second during mid-embryogenesis (days 0-6), the third (with an acute expression peak) on day 2 of embryonic development, and the fourth during post-embryonic development. (biomedcentral.com)
  • Here we generated a high-resolution map of enhancer three-dimensional contacts during Drosophila embryogenesis, covering two developmental stages and tissue contexts, at unprecedented resolution. (ens-lyon.fr)
  • The B recognition element (BRE) is a DNA sequence found in the promoter region of most[clarification needed] genes in eukaryotes and Archaea. (wikipedia.org)
  • We present a mathematical model comprising a Polycomb/Trithorax response element (PRE/TRE) coupled to a promoter and including Drosophila developmental timing. (bvsalud.org)
  • We further showed that under oxidative stress conditions, H3K4me3 and H3K9me3 spread to the promoter region of Jheh1 gene. (nature.com)
  • Although these genes are found in various metazoans, plants, fungi and even unicellular eukaryotes, bilaterians have evolved the largest diversity of homeobox genes that arose predominantly due to extensive tandem duplications [ 2 , 4 , 5 ]. (biomedcentral.com)
  • The homeobox genes of animals are categorized into eleven classes, with the Antennapedia class (ANTP) being one of the largest, comprising the Hox, ParaHox and NK gene families [ 5 , 9 ]. (biomedcentral.com)
  • Several signaling pathways control blood cell (hemocyte) development in the Drosophila lymph gland. (nih.gov)
  • Genes & Development. (wikipedia.org)
  • We have made some important contributions to the field: the discovery of a role for chromatin structure in the regulation of splicing, that splicing occurs mostly co-transcriptionally, and that genes regulated during development are transcribed in the absence of canonically activating chromatin marks. (crg.es)
  • To better understand this control, we profiled translational efficiencies and poly(A)-tail lengths throughout Drosophila oocyte maturation and early embryonic development. (elifesciences.org)
  • The MZT marks the transfer of control of development from the mother to the zygote as maternal mRNAs are degraded, transcription from the zygotic genome begins, and embryonic development becomes dependent on zygotic gene products ( Tadros and Lipshitz, 2009 ). (elifesciences.org)
  • Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development. (jefferson.edu)
  • The close link between cell and tissue growth control and environmental cues ensures that developmental transitions occur at the appropriate time during animal development. (riken.jp)
  • Because Dilp regulates both growth and metabolism during development, we are analyzing the physiological significance of the regulation of sugar metabolism by insulin/IGF signaling. (riken.jp)
  • These results indicate that the main functions of Fatiga in development, including control of cell size, involve the regulation of dHIF/Sima. (ox.ac.uk)
  • While NK2.1 and vax are expressed in distinct medial regions of the developing protocerebrum early in development, BarH , Bari , Emx , Hhex and Nedx are expressed in late developmental stages, after all major structures of the nervous system have been established. (biomedcentral.com)
  • A conserved role in neural development has also been reported from NK2.2 , suggesting that the NKL genes might have been primarily involved in neural development in the last common ancestor of bilaterians or at least nephrozoans (all bilaterians excluding xenacoelomorphs). (biomedcentral.com)
  • Surkova S, Görne J, Nuzhdin S, Samsonova M. Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research. (compbio.ru)
  • miRNAs follow well-defined patterns of expression over hemimetabolan ontogeny, patterns that are more diverse during embryonic development than during the nymphal stages. (biomedcentral.com)
  • The results suggest that miRNAs play important roles in the developmental transitions between the embryonic stages of development (starting with maternal loading), during which they might influence the germ-band type and metamorphosis mode. (biomedcentral.com)
  • Combinatorial regulation thereby allows hundreds of TFs to control the spatio-temporal transcription of tens of thousands of genes - a prerequisite for the proper development and existence of an organism. (mdc-berlin.de)
  • There is significant and sex-specific natural genetic variation in the transcriptional response to developmental exposure to ethanol in Drosophila that comprises networks of genes affecting nervous system development and ethanol metabolism as well as networks of regulatory non-coding RNAs. (biomedcentral.com)
  • We then analyzed the temporal and spatial expression of rab11a gene in embryonic development by RT-PCR and whole mount in situ hybridization. (researchsquare.com)
  • Accueil / Publications avant IGFL / Y. GHAVI-HELM - Developmental epigenomics / Enhancer loops appear stable during development and are associated with paused polymerase. (ens-lyon.fr)
  • Notably, most interactions appear unchanged between tissue context and across development, arising before gene activation, and are frequently associated with paused RNA polymerase. (ens-lyon.fr)
  • 2016 ) The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. (academictree.org)
  • In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)
  • To take advantage of sequence diversity outside of the genus Drosophila, we are sequencing developmentally important loci from several non-Drosophilid fly families to provide insights into the underlying principles of gene regulation. (berkeley.edu)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)
  • We have explored the role of differential mechanical interactions in the formation of the Drosophila heart. (mechanochemistry.org)
  • We examined the changes in miRNA expression over the ontogeny of the German cockroach Blattella germanica , using 11 small RNA libraries prepared and sequenced in our laboratory, representing developmentally important stages. (biomedcentral.com)
  • Consistent with its expression, removal of betanu only enhanced the phenotype of betaPS in the developing midgut. (nih.gov)
  • Dietary condition-specific phenotype in Drosophila provides new insights into the significance of gene-environment interactions. (riken.jp)
  • Adh is transcribed from 2 tandem promoters ~700 bp apart, each has distinct developmental- and tissue-specific patterns, and each is regulated by a distinct enhancer. (rochester.edu)
  • Specification of motoneuron fate in Drosophila: integration of positive and negative transcription factor inputs by a minimal eve enhancer. (jefferson.edu)
  • This paper reports that loss of function of the Drosophila gene cabeza (the Drosophila equivalent of the human FUS gene, mutations in which can cause a familial form of the motor neurodegenerative disease amyotrophic lateral sclerosis or ALS) induces muscle developmental defects. (europa.eu)
  • We show that dysregulation of appropriate expression of components of the fibroblast growth factor (FGF) pathway contributes to muscle developmental defects in cabeza mutant Drosophila. (europa.eu)
  • Here, we describe novel loss-of-function mutants of fatiga, the gene encoding the Drosophila PHD oxygen sensor, which manifest growth defects and lethality. (ox.ac.uk)
  • Strikingly, loss-of-function mutations of sima rescued the developmental defects observed in fatiga mutants and enabled survival to adulthood. (ox.ac.uk)
  • Most Drosophila olfactory neurons express two types of odorant receptor genes: Or83b, a broadly expressed receptor of unknown function, and one or more members of a family of 61 selectively expressed receptors. (ox.ac.uk)
  • To elucidate its function, we generated null mutations in the gene encoding betanu. (nih.gov)
  • Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
  • Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations. (lookformedical.com)
  • Introgression of homeotic mutations into wild-type genetic backgrounds results in a wide variety of phenotypes and implies that major effect modifiers of extreme phenotypes are not uncommon in natural populations of Drosophila. (lookformedical.com)
  • To understand the role of a gene in adult behavior, it is necessary to control its expression in four dimensions: space and time. (ox.ac.uk)
  • An ectotherm's thermal tolerance is determined by both fixed genetic factors and plastic changes in behavior, morphology, physiology, and gene expression. (frontiersin.org)
  • 2019 ) Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. (academictree.org)
  • 2019 ) Regulation of Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism. (academictree.org)
  • 1. Catinozzi M, Mallik M, Frickenhaus M, Been M, Sijlmans C, Kulshrestha D, Alexopoulos I, Weitkunat M, Schnorrer F, Storkebaum E. The Drosophila FUS ortholog cabeza promotes adult founder myoblast selection by Xrp1-dependent regulation of FGF signaling. (europa.eu)
  • We reared DGRP lines which showed extreme upregulation or downregulation of snoRNA expression during developmental alcohol exposure on standard or ethanol supplemented medium and demonstrated that developmental exposure to ethanol has genotype-specific effects on adult locomotor activity and sleep. (biomedcentral.com)
  • Studies in both vertebrates and Drosophila have shown that neural progenitors are temporally patterned to generate different neural types in a defined order. (illinois.edu)
  • The Additional sex combs (Asx) gene of Drosophila is a member of the Polycomb group of genes, which are required for maintenance of stable repression of homeotic and other loci. (ox.ac.uk)
  • Many TFs act by docking onto certain sections in the DNA and regulating the expression (i.e. transcription) of nearby genes. (mdc-berlin.de)
  • Bari-Jheh is a natural transposon that mediates resistance to oxidative stress by adding cis-regulatory sequences that affect expression of nearby genes. (nature.com)
  • TEs can contain cis-regulatory sequences that affect the expression of nearby genes. (nature.com)
  • In this work, we hypothesized that Bari-Jheh could also be affecting the expression of nearby genes by remodeling the local chromatin state. (nature.com)
  • With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)
  • 2018 ) Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. (academictree.org)
  • Members of the insulin family peptides have conserved roles in the regulation of growth and metabolism in a wide variety of metazoans. (riken.jp)
  • Similarly, the large ribosomal RNA gene clusters that reside on different chromosomes manage to find each other in almost every cell nucleus to form another easily discernable nuclear entity, the nucleolus [ 27 - 29 ]. (biomedcentral.com)
  • AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. (bvsalud.org)
  • The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
  • Elevated expression of H3/H4 in intestinal enterocytes in Drosophila alters chromatin organization, induces intestinal autophagy through transcriptional regulation, prevents age-related decline in the intestine. (sdbonline.org)
  • Histones H3/H4 regulate expression of an autophagy cargo adaptor Blue Cheese ( Bchs (WDFY3 in mammals), increased expression of which in enterocytes mediates increased H3/H4-dependent healthy longevity. (sdbonline.org)
  • To test our hypotheses, we measured the critical thermal minimum (CT min ) and critical thermal maximum (CT max ) of 100 lines of the Drosophila Genetic Reference Panel (DGRP) and used GWAS to identify loci that explain variation in thermal limits. (frontiersin.org)
  • The NKL gene complement of E. rowelli comprises eight genes, including BarH , Bari , Emx , Hhex , Nedx , NK2.1 , vax and NK2.2 , of which only NK2.2 was studied previously. (biomedcentral.com)
  • The integrated approaches will also be used in our investigation of how the sequential expression of transcription factors in neuroblasts generates neural diversity. (illinois.edu)
  • The generation of neural diversity is a key question in developmental neurobiology. (illinois.edu)
  • Ji Y, Thomas C, Tulin N, Lodhi N, Boamah E, Kolenko V, Tulin AV. Charon Mediates Immune Deficiency-Driven PARP-1-Dependent Immune Responses in Drosophila. (jefferson.edu)