Drosophila cell division. Medical search. Frequent questions

Drosophila melanogaster was introduced into the field of genetic experiments by Thomas Hunt Morgan in 1909. (wikipedia.org)
One of the best understood examples of pattern formation is the patterning along the future head to tail (antero-posterior) axis of the fruit fly Drosophila melanogaster. (wikipedia.org)
The aim of this review is to focus the attention on a group of protein-coding genes resident in D. melanogaster constitutive of heterochromatin, which are implicated in different steps of cell division. (uniroma1.it)
The scientists have studied centrosomes in the tracheal cells of the fly Drosophila melanogaster. (sciencedaily.com)
Paper on Drosophila melanogaster centromeres is out! (rochester.edu)
Check out our new paper on the organization of Drosophila melanogaster centromeres . (rochester.edu)
Taylar successfully defended her senior thesis on suppressors of Segregation Distorter in Drosophila melanogaster and is graduating with honors in research this weekend! (rochester.edu)
n a new paper published in eLife , Alokananda Ray, a Ph.D candidate during the time of the study and now graduated, and Xin Li (GNDP), an assistant professor of cell and developmental biology at the University of Illinois Urbana-Champaign, shed light on the process in the optic medulla of Drosophila melanogaster , the fruit fly. (nih.gov)
This is also true for the fruit fly Drosophila melanogaster that serves as model organism to understand the molecular and anatomical bases of the dual-oscillator system. (elsevierpure.com)
Fluorescent micrograph of a Drosophila melanogaster reproductive system highlighting the muscular and neural structure fruitfly ovaries and uterus. (cellimagelibrary.org)
This fluorescent micrograph shows the developing egg chambers within the Drosophila melanogaster (fruit fly) ovary. (cellimagelibrary.org)

Drosophila embryogenesis, the process by which Drosophila (fruit fly) embryos form, is a favorite model system for genetics and developmental biology. (wikipedia.org)
These results where can you get clarinex suggest that PAM-distal cleavage by Cas12a To investigate the effect on pole cell expressing endogenously tagged Osk-sfGFP or Vas-EGFP (Fig 3B) to account for loss of nos and pgc RNA detected pairwise by smFISH in granules in pre-pole bud stage embryos. (billfryer.com)
Early Drosophila embryos undergo 13 rounds of rapid nuclear division before enclosing each nucleus into an individual, membrane-bound cell. (scivee.tv)
The movie shows four individual drosophila embryos at two-cell stage. (rapp-opto.com)
In his embryos, astral microtubules, which extend out to the cortex were primarily responsible for initiating a furrow, however, smaller somatic cells seem to position the furrow through the overlapping antiparallel central spindle. (escholarship.org)
We've all got a lot on our to-do lists these days, but it's nothing compared to the checklist that developing drosophila embryos have to contend with. (epigenie.com)

The germ line segregates from the somatic cells through the formation of pole cells at the posterior end of the embryo. (wikipedia.org)
Germ band elongation involves many rearrangements of cells, and the appearance of distinct differences in the cells of the three germ bands and various regions of the embryo. (wikipedia.org)
Bicoid and Hunchback are the maternal effect genes that are most important for patterning of anterior parts (head and thorax) of the Drosophila embryo. (wikipedia.org)
Nanos and Caudal are maternal effect genes that are important in the formation of more posterior abdominal segments of the Drosophila embryo. (wikipedia.org)
In order to break the initial "egg shape" of the embryo, cells need to polarize in a precise and coordinated manner. (nature.com)
The embryo of the frog Xenopus laevis is widely used as a model of cell polarization, migration, and morphogenesis due to its unique experimental advantages. (nature.com)
During development, the planar polarized distribution of Rho kinase and Myosin II helps Drosophila germ-band cells intercalate so that the embryo extends along its anterior-posterior axis. (scivee.tv)
By using published DNA binding specificity data for five transcription factors active in the early Drosophila embryo, genomic regions containing unusually high concentrations of predicted binding sites were identified for these factors. (sdbonline.org)
The transcription factors Bicoid (Bcd), Caudal (Cad), Hunchback (Hb), Krüppel (Kr), and Knirps (Kni) act at very early stages of Drosophila development to define the anterior-posterior axis of the embryo. (sdbonline.org)
This combination allowed the researchers to get spatial & temporal control of cellular processes, namely the cell division of individual cells of a drosophila embryo during cell division (movie1). (rapp-opto.com)
Furthermore, since the control via ts-mutants is a reversible process, the authors were not just able to stop division of individual cells within the embryo, but also re-initialize cell division at a later point in time (approx. (rapp-opto.com)
In the early Drosophila embryo, nuclei divide within a syncytium yet invaginate cortical actin and membrane, encompassing them, in order to complete mitosis in close proximity to neighboring nuclei. (escholarship.org)
These studies demonstrate that the early Drosophila embryo is primed to form furrows at either the overlapping astral microtubules or central spindle with the shift to the latter being driven in large part by a corresponding shift from maternal-to-zygotic forms of RhoGEF. (escholarship.org)
The spindle of the P 1 cell (right) rotates in a 2-cell worm embryo. (rupress.org)
Video of zebrafish embryo development from a 2-cell egg to fish larva. (cellimagelibrary.org)

Drosophila genes expressed specifically in all motoneurons have not been described, although a growing number of genes are known to be expressed in subsets of motoneurons. (jneurosci.org)
Thus, vertebrate HB9/MNR2 genes are expressed specifically in somatic motoneurons and are essential for distinguishing motoneuron/interneuron cell types. (jneurosci.org)
To generalize and quantify these promising results, a broader collection of 19 well-defined CRMs from 9 Drosophila genes known to be required for proper embryonic development was compiled. (sdbonline.org)
Researchers know that neural stem cells called neuroblasts divide multiple times to sequentially produce neurons of specialized function, but the mechanisms of this process, and how the timing varies for different genes and neuron types, is still not fully understood. (nih.gov)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

name: cell division cycle 20 homolog (S. cerevisiae). (jax.org)
names: atonal homolog 1 (Drosophila) and atonal homolog 2 (Drosophila) respectively. (jax.org)

The building-blocks of anterior-posterior axis patterning in Drosophila are laid out during egg formation (oogenesis), well before the egg is fertilized and deposited. (wikipedia.org)

Here, we characterize Drosophila InsP3R mutants and demonstrate that the InsP3R is essential for embryonic and larval development. (nih.gov)
Interestingly, maternal InsP3R mRNA is sufficient for progression through the embryonic stages, but larval organs show asynchronous and defective cell divisions, and imaginal discs arrest early and fail to differentiate. (nih.gov)
Drosophila display a holometabolous method of development, meaning that they have three distinct stages of their post-embryonic life cycle, each with a radically different body plan: larva, pupa and finally, adult. (wikipedia.org)
The generation of the embryonic CNS is a lineage-based process in which neural progenitors, called neuroblasts (NBs), give rise to largely invariant lineages of neural/glial cells. (biologists.com)
Cell lineage analysis techniques have been used to analyse most of the embryonic NB lineages at the histological level. (biologists.com)
Yet, when these brains form during embryonic development, there is initially only a small pool of cell types to work with. (nih.gov)
The functions of centrosomes and their substructures are important for embryonic development and have been studied extensively using in vitro mammalian cell culture or in vivo using invertebrate models. (bvsalud.org)
We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)
Using the SURVEYOR nuclease assay 13 , we assessed the ability of each Cas9-sgRNA complex to generate indels in human embryonic kidney (HEK) 293FT cells through the induction of DNA doublestranded breaks (DSBs) and subsequent nonhomologous end joining (NHEJ) DNA damage repair (Online Methods). (cdc.gov)

b , A typical epithelial tissue from the Drosophila larval eye disc peripodial epithelium (dPE), coloured according to the number of neighbours per cell. (biorxiv.org)
Here we use light-sheet microscopy to record activity, reported through the genetically encoded calcium indicator GCaMP5G, from the entire volume of the brain of the larval zebrafish in vivo at 0.8 Hz, capturing more than 80% of all neurons at single-cell resolution. (zotero.org)

In juveniles, none of the measured phenotypic characters had significant predictive power for mitosis, whereas in adult animals in moult or in late egg developmental or post-laying stage were more likely to have mitotic storage cells. (researchgate.net)
Increase in storage cell mitoses has been related to moulting and the late developmental stage of eggs (Czernekova and Jönsson 2016). (researchgate.net)
Alokananda Ray, a postdoctoral researcher in the Li lab (left) with Xin Li, an assistant professor of cell and developmental biology. (nih.gov)
Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila. (wikidata.org)
Test results with eight chemicals in a drosophila-based developmental toxicity prescreen. (cdc.gov)

Here, we identify and characterize the single Drosophila ortholog of the HB9/MNR2 gene family. (jneurosci.org)
Here, we characterize SpCas9 targeting specificity in human cells to inform the selection of target sites and avoid off-target effects. (cdc.gov)

Nervous systems diversify from a small pool of neural stem cells to the great diversity of neurons we see in adult brains of higher ordered animals," said Ray. (nih.gov)
Suppression of vinculin slows down the basal-to-apical part of interkinetic nuclear migration (BAINM), arrests neural stem cells (NSCs) in the G2 phase of the cell cycle, and ultimately dismantles the apical actin cytoskeleton. (bvsalud.org)

It also describes the role of stem cells in the formation of tissues, in particular the hematopoietic lineage. (epfl.ch)
We investigate the role of orthodenticle in the specification of an identified neuroblast (neuronal progenitor) lineage in the Drosophila brain. (elifesciences.org)
An analysis of cell lineage and fate mapping and an assessment of methods. (wikidata.org)
In the P 1 lineage, by contrast, divisions are asymmetric but the cells always part along the same axis. (rupress.org)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

In the absence of boi (boi[e] mutant), Hh protein is redistributed from apical cell. (cellimagelibrary.org)
In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)
The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
A multitasking plasma membrane protein coordinates cell division and energy metabolism in healthy-and perhaps also cancerous- Drosophila cells. (the-scientist.com)
Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. (embl-heidelberg.de)
Crystal structure of the bacterial cell-division protein FtsZ. (embl-heidelberg.de)
Bacterial cell division ends with septation, the constriction of the cellwall and cell membranes that leads to the formation of two daughter cells.During septation, FtsZ, a protein of relative molecular mass 40,000 whichis ubiquitous in eubacteria and is also found in archaea and chloroplasts,localizes early at the division site to form a ring-shaped septum. (embl-heidelberg.de)
Temperature-sensitive (ts) mutant proteins are great tools to analyze cell-regulative processes by temporally affected protein interactions. (rapp-opto.com)
The ASPM gene provides instructions for making a protein that is involved in cell division. (medlineplus.gov)
Studies suggest that the ASPM protein helps maintain the orderly division of early brain cells called neural progenitor cells, which ultimately give rise to mature nerve cells (neurons). (medlineplus.gov)
By promoting the division of neural progenitor cells during early brain development, the ASPM protein helps determine the total number of neurons and the overall size of the brain. (medlineplus.gov)
A shortage of functional ASPM protein impairs cell division, especially in neural progenitor cells in the developing brain. (medlineplus.gov)
Because the ASPM protein is found in cells throughout the body, it is unclear why ASPM gene mutations affect neural progenitor cells more severely than other cell types. (medlineplus.gov)
Some researchers believe that neural progenitor cells are more sensitive than other types of cells to a shortage of the ASPM protein. (medlineplus.gov)
Other researchers have suggested that another protein may be able to compensate for the loss of the ASPM protein in cells outside the brain. (medlineplus.gov)
The ASPM gene is upregulated in several types of cancer, which means that it produces more of the ASPM protein than usual in cancer cells. (medlineplus.gov)
It is unclear why the ASPM gene is abnormally active in these cancers or what effects the extra ASPM protein may have in cancer cells. (medlineplus.gov)
BLM encodes 1417 amino acids that code for a protein in the nuclear matrix of growing cells, which is a member of the RecQ family of helicases. (medscape.com)
Effect of cadmium on P53 and mitogen-activated protein kinases in a murine macrophage cell line: relation to apoptosis. (cdc.gov)

NBs divide in an asymmetric manner to bud off a set of ganglion mother cells (GMC), which in turn divide once to produce two postmitotic daughters. (biologists.com)
Cell polarization is essential during gastrulation, driving asymmetric cell division, cell movements, and cell shape changes. (nature.com)
Our studies show that the dynamics of actin polymerization drive centrosome separation and this has important implications for centrosome positioning during processes such as cell migration, cell polarity maintenance, and asymmetric cell division. (escholarship.org)
Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly. (cdc.gov)

Our work aims at providing insights into (1) the interplay between the dynamic organization of cytoskeletal filaments and cell shape changes, and (2) the reciprocal links between tissue growth, morphogenesis and tissue mechanics. (fresnel.fr)
Araújo's team, which works in Jordi Casanova's Development and Morphogenesis in Drosophila Lab, has now addressed the influence of variations in centrosome number on cells that have already divided and differentiated. (sciencedaily.com)

Keep up with the Node 'Lab meeting' posts as the platform regularly highlights development and stem cell biology labs from across the globe and showcases research and researchers from the community. (biologists.com)
Published in Current Biology , a study by Sofia J. Araújo, associate researcher at the Institute for Research in Biomedicine (IRB Barcelona), reveals that the number of centrosomes -- small intracellular structures -- in cells determines the final shape that cells adopt and their function. (sciencedaily.com)
from the May 12, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Stefano. (scivee.tv)
from the April 14, 2014, issue of The Journal of Cell Biology and includes an interview with authors Dylan Burnette (Vanderbilt University School of. (scivee.tv)
from the February 17, 2014, issue of The Journal of Cell Biology and. (scivee.tv)
from the December 23, 2013, issue of The Journal of Cell Biology and includes an interview with. (scivee.tv)
Next up for Taylar is the Cell, Development, Molecular Biology and Biophysics PhD program Johns Hopkins, where she will be a Morgan Fellow. (rochester.edu)
Molecular Biology of the Cell, 10 (8). (kent.ac.uk)
As a graduate student at the MRC Laboratory of Molecular Biology in Cambridge, England, Anthony Hyman showed how the centrosomes' travels set up the division axis in Caenorhabditis elegans ( Hyman and White, 1987 ). (rupress.org)
Consistent with this change in direction, Hyman (now at the Max Planck Institute of Molecular Cell Biology in Dresden, Germany) found that in AB cells the newly duplicated centrosomes migrated to opposite sides of the nucleus before mitosis. (rupress.org)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

BML mutations thus result in defects in DNA repair and genomic instability in the somatic cells, predisposing the patients to cancer development. (medscape.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)
A molecular signature makes it possible to trace the details of hair cell replacement in the mammalian inner ear. (the-scientist.com)

Epigenetic regulation of gene expression is an essential mechanism that guides cell differentiation during development. (elifesciences.org)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Centromeres are genomic regions essential for proper chromosome segregation during cell division. (rochester.edu)

Studies in tissue culture cells indicate that actin- and myosin-based cortical flow is primarily responsible for driving late centrosome separation, whereas other studies suggest that actin plays a more passive role by serving as an attachment site for astral microtubules to pull centrosomes apart. (escholarship.org)

Despite the importance of PtdIns(4,5)P 2 in cytokinesis, the regulation of this lipid in cell division remains poorly understood. (iric.ca)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

The cytoskeleton plays a variety of roles during the cell cycle, none more dramatic than the formation of a bipolar mitotic spindle and the subsequent cleavage of one cell into two. (escholarship.org)
Depending on the position of the mitotic spindle, a dividing cell can split evenly or unevenly, lengthwise or down the middle. (rupress.org)
In dividing cells, the centrosome is known as the spindle pole and nucleates a robust microtubule spindle to separate genetic material equally into two daughter cells. (bvsalud.org)

The occurrence of cell division in storage cells is particularly interesting in light of the important role that these cells play in the physiology of tardigrades. (researchgate.net)

We have developed the Drosophila midgut as a simple invertebrate model to uncover the rules that govern adaptive remodeling. (stanford.edu)

As neuroblasts divide and differentiate, they express transcription factors which ultimately direct the daughter cells on what kind of neuron to be. (nih.gov)

The process of gastrulation is linked to determination of mesodermal cell fates, such that patterning of tissue fates and patterning of cell behavior are interconnected. (nature.com)
Our lab pursues a strongly interdisciplinary approach that bridges the molecular, cellular and tissue scales, combining genetics, biochemical and cell biological approaches with cutting-edge biophysical and live imaging approaches developed in the MOSAIC group. (fresnel.fr)
Based on our theoretical framework, we explain how cell growth and division as well as mechanical constraints act together to drive epithelial tissue organization. (biorxiv.org)
not only can gene expression be manipulated and lineages traced at single-cell and whole-tissue levels, but complete population counts of all cell types are possible. (stanford.edu)

We are interested in how animal cells and tissues generate, maintain and adapt their shape as they grow, divide and reorganize during physiological responses. (fresnel.fr)
We use a variety of model systems ranging from biomimetic systems (in vitro reconstitution of cytoskeleton using purified components) to single cells and developing Drosophila tissues. (fresnel.fr)
Even though the frequencies of the different polygon types differ widely between different epithelial tissues, all epithelia analysed to date indeed meet this topological constraint in that their cells have on average close to six neighbours ( Fig. 1d,e ). (biorxiv.org)
Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues. (chicagobiomedicalconsortium.org)

They demonstrate that centrosomes are also determinant organelles in cells that have already left the cell-division cycle. (sciencedaily.com)
In the article, they demonstrate that cells that hold more than two centrosomes form more branches (a single cell is like a small tree with many branches). (sciencedaily.com)
In direct contrast, here we demonstrate that much of the pattern variability in Drosophila courtship song can be explained by taking into account the dynamic sensory experience of the male. (zotero.org)
Our data not only demonstrate that Drosophila song production is not a fixed action pattern, but establish Drosophila as a valuable new model for studies of rapid decision-making under both social and naturalistic conditions. (zotero.org)

name: ash2 (absent, small, or homeotic)-like (Drosophila). (jax.org)

Limited sequence homology hasbeen found with the proteins FtsZ and Misato, which are involved in celldivision in bacteria and Drosophila, respectively. (embl-heidelberg.de)

The development of Drosophila is particularly well studied, and it is representative of a major class of animals, the insects or insecta. (wikipedia.org)
Furthermore, we show that Notch signalling positively regulates glial cells missing ( gcm ) expression in the context of SPG development. (biologists.com)
We present data on the occurrence of mitosis in storage cells of the eutardigrade Richtersius coronifer (Richters, 1903), and analyse mitotic cells in relation to different body characteristics, including egg development stage, moulting, gut content, body length, number and size of oocytes, and shape and size of the storage cells. (researchgate.net)
However, the specific life cycle of tardigrades, where energy intake and depletion, egg development, and moulting is highly intertwined and synchronized, make conclusions about the functional role of mitosis in storage cells difficult, however, and more studies are needed to reveal the mechanisms inducing mitosis in these interesting cells. (researchgate.net)
defining the role of oriented cell division in development and disease. (unm.edu)
Drosophila HB9 differs from its vertebrate orthologs in several ways: it is not expressed in all somatic motoneurons, it is expressed in a subset of interneurons, and it is required for the proper development of both interneurons and motoneurons. (jneurosci.org)
The early development of mesothoracic compartments in Drosophila. (wikidata.org)

Prior to the clas- sification work, the technical guidance for classification of germ cell mutagens was prepared. (cdc.gov)

Cells that will produce adult structures are put aside in imaginal discs. (wikipedia.org)

p class=\'abstract\'>Barrier epithelial organs face the constant challenge of sealing the interior body from the external environment while simultaneously replacing the cells that contact this environment. (stanford.edu)

Other multicellular organisms sometimes use similar mechanisms for axis formation, although the relative importance of signal transfer between the earliest cells of many developing organisms is greater than in the example described here. (wikipedia.org)
The morphogenetic movements of gastrulation rearrange the three germ layers precursors, positioning mesodermal cells between outer ectodermal and inner endodermal cells to shape the head-to-tail body axis. (nature.com)
The dashed line marks the hexagon fraction for randomly positioned cell division axes, the dotted line marks the hexagon fraction when cells are divided perpendicular to their longest axis. (biorxiv.org)
Hyman was rummaging through the literature when he stumbled across the question of how the cell division axis gets set up. (rupress.org)
This effectively spun the axis of the cell around. (rupress.org)
Tony Hyman investigates how centrosome movements are choreographed, and how they determine the division axis. (rupress.org)

After thirteen mitotic divisions and about 4 hours after fertilization, an estimated 6,000 nuclei accumulate in the unseparated cytoplasm of the oocyte before they migrate to the surface and are encompassed by plasma membranes to form cells surrounding the yolk sac producing a cellular blastoderm. (wikipedia.org)
BN are cells which have two similar-sized nuclei (almost the same size). (bvsalud.org)
For this reason they are not included in the daughter cells' nuclei, thus remaining in the cytoplasm of interphase cells [5, 10, 16, 35]. (bvsalud.org)

J Cell Biol, 2007 Jun 18. (nih.gov)
J Cell Biol (2006) 172 (3): 328. (rupress.org)

Loss of Fry function drastically affects the movement and morphological polarization of cells during gastrulation and disrupts dorsal mesoderm convergent extension, responsible for head-to-tail elongation. (nature.com)
At the beginning of Xenopus gastrulation, the presumptive anterior mesoderm cells located at the dorsal marginal zone (DMZ) roll inward at the midline of the blastopore lip in a process called involution. (nature.com)
Gastrulation movements are orchestrated by a small, heterogeneous group of cells with inductive and morphogenetic properties located in the dorsal lip of the blastopore (DBL) of the amphibian gastrula known as the Spemann-Mangold organizer or dorsal organizer. (nature.com)
Short-Term Integration of Cdc25 Dynamics Controls Mitotic Entry during Drosophila Gastrulation. (princeton.edu)

To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

In the fruit fly Drosophila, it has been suggested that nearly equal numbers of two subtypes of EEs (Allatostatin A: AstA and Diuretic hormone 31 : Dh31) are alternately produced from the intestinal stem cells in the posterior midgut. (bioone.org)

Embryogenesis in Drosophila is unique among model organisms in that cleavage occurs in a multinucleate syncytium (strictly a coenocyte). (wikipedia.org)
Cleavage was performed at where can you get clarinex each Bownes stage from pole cell migration due to the number of plaques formed on lawns of bacteria expressing the MM15 crRNA (15). (billfryer.com)
His test system was the fertilized worm egg, and the AB and P 1 cells that result from its first cleavage. (rupress.org)

Compaction, via activation of Rho-associated kinase (ROCK) and the stress kinase p38, leads to further p53 elevation, causing cell death. (nature.com)
Specifically, we show that scrib KD cells' compaction causes activation of the Rho-associated kinase (ROCK), which in turn activates p38 leading to further p53 elevation and cell death. (nature.com)
reveal that blebs form at the front of chemotaxing Dictyostelium cells, particularly when the cells are faced with a mechanically resistant environment, and that this process is guided by a PI3-kinase-dependent signaling pathway. (scivee.tv)

Boi (green) and Hedgehog (Hh, red) are expressed in apical cells of the Drosophila wild-type germarium (CIL# 13744). (cellimagelibrary.org)
In the absence of boi (boi[e] mutant), Hh is redistributed from apical cells to the. (cellimagelibrary.org)
Hedgehog (Hh, red) is transcribed in apical cells of the Drosophila wild-type germarium (CIL# 13755, 13744). (cellimagelibrary.org)
In the absence of boi (boi[e] mutant), Hedgehog (Hh, red) is redistributed from apical cells to the extracellular space of the local follicle stem cell niche (CIL# 13744, 13745). (cellimagelibrary.org)
One of these regularities is expressed in Lewis' law, which states that the average apical cell area is linearly related to the number of neighbours, such that cells with larger apical area have on average more neighbours. (biorxiv.org)
Lewis' law emerges because the apical cell surfaces then assume the most regular polygonal shapes within a contiguous lattice, thus minimising the average perimeter per cell, and thereby surface energy. (biorxiv.org)
New replacement cells-the progeny of basal stem cells-are born without barrier-forming structures such as a specialized apical membrane and occluding junctions. (stanford.edu)
We find they gestate their future apical membrane in a sublumenal niche created by a transitional occluding junction that envelops the differentiating cell and enables it to form a deep, microvilli-lined apical pit. (stanford.edu)
It binds to ß-catenin/N-cadherin complexes in apical adherens junctions (AJs), which maintain cell-to-cell adhesions, and to talin/integrins in the focal adhesions (FAs) that attach cells to the basal membrane. (bvsalud.org)

Spana and Doe, 1996 ) (mediated by Notch and Delta and cell-cell interaction), are involved in the specification of daughter cell fates. (biologists.com)

Unlike mammals that have four TIF1 members, Drosophila only encodes one member of the family, Bonus. (elifesciences.org)

Germaria from boi[e] mutant in which germ cells (blue, anti-Vasa) and differentiating follicle cells (red, anti-Fas3) are labeled. (cellimagelibrary.org)
Instead, the ultrastructure of the germ cells has been considered in the chapter on reproduction. (researchgate.net)
The division of Drosophila primordial germ cells. (billfryer.com)

To investigate the mechanisms of scrib KD -mediated cell competition, we first asked whether it is mediated by soluble factors, as in other cases of in vitro cell competition 6 , 24 . (nature.com)

Give students a feel for some of the approaches pursued to understand mechanisms underlying cell division innate immunity in Drosophila. (epfl.ch)

Histone variants play important roles in eukaryotic genome organization, the control of gene expression, cell division and DNA repair. (cipsm.de)

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis. (nih.gov)
Binucleated (BN) cells may indicate several kinds of degenerative nuclear changes [10]. (bvsalud.org)

Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. (nih.gov)
green), a downstream effector of Hedgehog (Hh), is expressed in most cells of the wild-type Drosophila germarium including follicle stem cells, but is excluded from Boi- and Hh-expres. (cellimagelibrary.org)
boi controls follicle stem cell proliferation. (cellimagelibrary.org)
The follicle cells that surround it (top) send out long projections that pen. (cellimagelibrary.org)

Our goal is to understand how this nutrient-driven mechanism regulates stem cell behavior for lifelong optimization of organ form and function. (stanford.edu)

Bennett J, Baumgarten SC, Stocco C. GATA4 and GATA6 Silencing in Ovarian Granulosa Cells Affects Levels of mRNAs Involved in Steroidogenesis, Extracellular Structure Organization, IGF-I Activity, and Apoptosis. (chicagobiomedicalconsortium.org)

How cells compete is poorly understood, but it is generally accepted that molecular exchange between cells signals elimination of unfit cells. (nature.com)
Here we show that scrib KD cells are out-competed by wild-type cells through mechanical insults rather than molecular exchange. (nature.com)
A molecular switch that can control cell division (Dev. (princeton.edu)

We show that MDCK cells silenced for the polarity gene scribble ( scrib KD ) are hypersensitive to compaction, that interaction with wild-type cells causes their compaction and that crowding is sufficient for scrib KD cell elimination. (nature.com)
It has recently been reported that Madin-Darby canine kidney (MDCK) epithelial cells silenced for the polarity gene scribble ( scrib KD cells) are eliminated in the presence of wild-type MDCK cells 23 , while they are viable on their own 23 . (nature.com)
Cell polarity controls orientated cell division, cell shape changes, as well as cell movement. (nature.com)

In the Drosophila central nervous system (CNS) glial cells are known to be generated from glioblasts, which produce exclusively glia or neuroglioblasts that bifurcate to produce both neuronal and glial sublineages. (biologists.com)
2001. Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum. (cdc.gov)

1990). Significantly, Plo1 associates inappropriately with the interphase SPB of stf1.1 cells. (kent.ac.uk)

In adult flies, the midgut is a stem cell-based organ analogous to the vertebrate small intestine. (stanford.edu)
Here, we investigate how new progeny acquire barrier structures as they integrate into the intestinal epithelium of adult Drosophila. (stanford.edu)
These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)

Anatomy49

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