Drosophila 1998 bone morphogenetic protein 2. Medical search. Frequent questions

No apparent role for the Wari insulator in transcriptional regulation of the endogenous white gene of Drosophila melanogaster. (unibas.ch)
Gerber AP, Luschnig S, Krasnow MA, Brown PO, Herschlag D "Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster. (openwetware.org)
The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
Potential variance affecting homeotic Ultrabithorax and Antennapedia phenotypes in Drosophila melanogaster. (lookformedical.com)
Because of the availability of remarkably powerful genetic, molecular and cell biological tools, we use the fruitfly, Drosophila melanogaster, as our primary model for investigating the fundamental mechanisms of PCP signaling. (stanford.edu)

It is thought that high levels of SKI protein inactivate tumor suppression by displacement of other proteins and interference with the signaling pathway of TGF- β. (wikipedia.org)
A large scale screen for genes (3rd chromosome) related to Wingless signaling pathway[J]. Journal of Zhejiang University Science A, 2004, 5(2): 186-192. (zju.edu.cn)

Vertebrate neurogenesis requires inhibition of endogenous bone morphogenetic protein (BMP) signals in the ectoderm. (molcells.org)
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)

IHH signal induces activation of Parathyroid Hormone-related Protein (PTHRP) on the articular surface and gets rid of the hypertrophy of chondrocytes [ 49 ]. (regenmedres-journal.org)
17. Wang E. A, Rosen V, D'Alessandro J. S, Bauduy M, Cordes P, Harada T et al Recombinant human bone morphogenetic protein induces bone formation. (ijcrr.com)
Finally, apoptotic cells modulate death or survival balance, as was observed in the Drosophila imaginal disc, by producing the Tie ligand Pvf1, that induces death resistance of neighbouring cells [ 17 ]. (biomedcentral.com)

Shimmi, O., Umulis, D., Othmer, H. & O'Connor, M. B. Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. (nature.com)
In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)

Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)

SKI has been shown to interfere with normal cellular functioning by both directly impeding expression of certain genes inside the nucleus of the cell as well as disrupting signaling proteins that activate genes. (wikipedia.org)
In particular, the present invention provides neurogenesis inducing genes coding for Zic proteins, vectors containing such genes, host cells containing such vectors, proteins produced by such host cells, antibodies raised to such proteins, and therapeutic agents or agents for gene therapy for nervous diseases. (justia.com)
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
Using Affymetrix Gene Chip analysis, we have identified genes linked to regenerative success downstream of BMP signalling, including the BMP inhibitor Gremlin and the stress protein Hsp60 ( no blastema in zebrafish). (biomedcentral.com)
Using DNA microarray analysis, we identified several genes that are regulated by Wnt-5a and Rfz-2 as well as by Wnt-1. (biomedcentral.com)

Systematic gain-of-function genetics in Drosophila.Development,126:1049-1057. (zju.edu.cn)

Many of the mechanistic insights into how niches regulate stem cell maintenance have been obtained using invertebrate models such as Drosophila . (biomedcentral.com)
Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)
Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ]. (biomedcentral.com)

SKI is present in all adult and embryonic cells at low levels, however an over expression of the protein is characteristic of tumor cells. (wikipedia.org)
Fussel-15 has been found to play much the same role as the Ski/Sno proteins, however its expression is not as ubiquitous as the Ski/Sno proteins. (wikipedia.org)
Immunoblot analysis was used to measure the expression of δEF1 at the protein level in δEF1-overexpressing and δEF1-interfered MDA-MB-231 cells. (biomedcentral.com)
Sääf AM, Halbleib JM, Chen X, Tsan Yuen S, Yi Leung S, Nelson WJ, Brown PO "Parallels between Global Transcriptional Programs of Polarizing Caco-2 Intestinal Epithelial Cells In Vitro and Gene Expression Programs in Normal and Colon Cancer. (openwetware.org)
Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.Development,118(2):401-415. (zju.edu.cn)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
To test the hypothesis that a specific cell line can respond to distinct Wnts with different patterns of gene expression, we over-expressed Wnt-5a and Rfz-2 in C57mg mammary epithelial cells and compared this cell line to C57mg cells over-expressing Wnt-1. (biomedcentral.com)

Gen. Mar 1;25(5):936-50, Genetic Interaction of hnRNPA2B1 and DnaJB6 in a Drosophila Model of Multisystem Proteinopathy. (umn.edu)
Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations. (lookformedical.com)
Introgression of homeotic mutations into wild-type genetic backgrounds results in a wide variety of phenotypes and implies that major effect modifiers of extreme phenotypes are not uncommon in natural populations of Drosophila. (lookformedical.com)
Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
A wing specific F1 genetic screen was carried out using the powerful drosophila genetic system, combined with yeast FRT/FLP and GAL4/UAS system. (zju.edu.cn)

In one embodiment, the present invention relates to a recombinant protein having a protein comprising at least a portion of the amino acid sequence set forth in SEQ ID NO:2. (justia.com)

The different domains have different functions, with the primary domains interacting with Smad proteins. (wikipedia.org)
The protein also has hydrophobic regions which come into contact with Smad proteins rich in leucine and phenylalanine amino acid regions. (wikipedia.org)
Signaling is regulated by a family of proteins called the Smad proteins. (wikipedia.org)
The SKI protein and the CPB protein compete for binding with the Smad proteins, specifically competing with the Smad-3 and CReB-binding protein interactions. (wikipedia.org)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
Figure 2: Core signalling in the mammalian TGFβ-SMAD pathways. (nature.com)

Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH 2 -terminal kinase) or the Ca 2+ -dependent (NLK and nuclear factor of activated T cells) signaling cascades. (aacrjournals.org)
Bone Morphogenetic Protein 4) signals by noggin, chordin, etc. (justia.com)

We show that a member of the FK506-binding protein family, FKBP8, is an essential antagonist of SHH signaling in CNS development. (silverchair.com)

Klapholz-Brown Z, Walmsley GG, Nusse YM, Nusse R, Brown PO "Transcriptional program induced by wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. (openwetware.org)
In vivo dissection of Otx1 and Otx2 roles in brain development by using reciprocal knock-in mouse models: definition of extended functional equivalence between OTX1 and OTX2 proteins and the relevance of the Otx1 and Otx2 differential transcriptional control. (cnr.it)

Nanobody-Based GFP Traps to Study Protein Localization and Function in Developmental Biology. (unibas.ch)
The identification of an inactivating missense mutation in NANOS3 suggests a mechanism for POI involving increased primordial germ cells (PGCs) apoptosis during embryonic cell migration and highlights the importance of NANOS proteins in human ovarian biology. (hindawi.com)
She earned SB degrees in Chemical Engineering and Biology at MIT in 1998, a PhD in Biomedical Engineering from the Johns Hopkins University School of Medicine in 2003, followed by postdoctoral training in Life Sciences at Lawrence Berkeley National Laboratory until 2007. (royalsociety.org)

Taken together, the study of the Drosophila ovary and testis has greatly enhanced our understanding of the basic principles that govern niche formation and function. (biomedcentral.com)

Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand. (tamu.edu)
Functional groups contained in this DE gene list include metabolic proteins (including opposing patterns ofCA3andCA4), mitochondrial proteins (CKMT1A), oxidative status (SEPP1,HIG2A) and cholesterol homeostasis (APOA1,INSIG1). (1library.net)

Constam, D. B. & Robertson, E. J. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. (nature.com)
The association between loss or down-regulation of E-cadherin, an epithelial cell-cell adhesion protein, and progression of breast cancer has been extensively documented [ 3 , 4 ]. (biomedcentral.com)
Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase. (tamu.edu)
The TNF-family member Receptor Activator of NF-kappaB (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation. (cnrs.fr)

Based on recent data, a new view is emerging that vertebrate Dachshund(Dach) proteins are components of Six1/6 transcription factor-dependent signaling cascades. (biologists.com)
Although Drosophila data strongly suggest a tight link between Dpp signaling and the Dachshund gene, a functional relationship between vertebrate Dach and BMP signaling remains undemonstrated. (biologists.com)

In some embodiments, the present invention provides a protein which consists of the amino acid sequence shown in SEQ ID NO: 2 having a deletion, substitution, or addition of at least one amino acid and which has neurogenesis inducing activity. (justia.com)
The present invention also relates to a gene which hybridizes with the neurogenesis inducing gene encoding for a protein comprising at least a portion of the amino acid sequence set forth in SEQ ID NO:2. (justia.com)

ISH of soxE and Vasa protein staining at the LG (D) and EPL stages (E). (F-I) Double staining of Vasa protein and ISH of pax6 , six1/2 , eya , and dach at the EPL stage. (echinobase.org)

WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)

Selective modulation of the androgen receptor activation function-2 domain rescues degeneration in spinal bulbar muscular atrophy. (umn.edu)

Mutations affectiong segment number and polarity in Drosophila.Nature,287:795-801. (zju.edu.cn)

The SHH pathway should be off at most of the time, by the inhibition of specific factors such as Patched 1 (PTC1), Protein Kinase A (PKA), Casein Kinase1 (CK1), and Glycogen Synthase Kinase 3 beta (GSK3b), and only valid at precise time points [ 98 ]. (regenmedres-journal.org)

Specifically, avian fibroblasts depend on the SKI protein as a transcription co-regulator inducing transformation. (wikipedia.org)

Bone physiology and metabolism. (ijcrr.com)

The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. (hindawi.com)
XIAP, X-linked mammalian inhibitor of apoptosis protein. (rupress.org)
The X-linked mammalian inhibitor of apoptosis protein (XIAP) has been shown to bind several partners. (rupress.org)
To determine which of these interactions are required for it to inhibit apoptosis, we generated point mutant XIAP proteins and correlated their ability to bind other proteins with their ability to inhibit apoptosis. (rupress.org)
While the function of cell elimination by apoptosis is highly documented, apoptosis seems to have a broader morphogenetic function that goes beyond cells elimination. (biomedcentral.com)
Using a cell apoptosis assay based on stimulation of a RANK:Fas fusion protein, and a cellular NF-kappaB signaling assay, we showed that R12-31 was agonist for both species. (cnrs.fr)

Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)

The name SKI comes from the Sloan-Kettering Institute where the protein was initially discovered. (wikipedia.org)

These models are being used to systematically elucidate proteins required for cutaneous carcinogenesis and to test their potential role as therapeutic targets. (stanford.edu)

Particular syndromes of hamartomatous polyposis are often characterized by the manifestation of similar symptoms, especially at the initial stage of the development of the disease the clinical pictures in many cases do not make it possible to differentiate them (2). (czytelniamedyczna.pl)
Nanos was first identified in Drosophila , where it represses the translation of target mRNAs through binding to their 3′ UTR and has a conserved function in germ cell development across species. (hindawi.com)
In Drosophila, the single Nanos gene (Nos) is required for development of the abdomen as well as for germ line maintenance [ 31 , 32 ]. (hindawi.com)
Development (2004) 131 (2): 299-309. (silverchair.com)
Here, we focus on the Drosophila ovarian germline stem cell niche and review recent studies that have begun to reveal how intricate crosstalk between various signaling pathways regulates stem cell maintenance, how the extracellular matrix modulates the signaling output of the niche and how epigenetic programming influences cell development and function both inside and outside the niche to ensure proper tissue homeostasis. (biomedcentral.com)
The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
Frizzled and DFrizzled-2 function as redundant receptors for Wingless duringDrosophilaembryonic development.Development,126:4175-4186. (zju.edu.cn)

Fundamental and clinical bone physiology. (ijcrr.com)

Proteins found in the nucleus of a cell. (lookformedical.com)
Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)

TGF- β is a protein which regulates cell growth. (wikipedia.org)
Cell reports, 39 (2). (unibas.ch)
The tight junctions protein Claudin-5 limits endothelial cell motility. (unibas.ch)
Primary open angle glaucoma (POAG), the most common form of glaucoma in the Western world, is an age-related, complex disease characterized by progressive irreversible degeneration of the optic nerve due to apoptotic retinal ganglion cell death [2] . (prolekarniky.cz)

The SKI protein has a 728 amino acid sequence, with multiple domains. (wikipedia.org)
In another embodiment, the present invention relates to an isolated nucleic acid encoding a protein having at least a portion of the amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 42 and in SEQ ID NO: 44. (justia.com)

This group of fishes is a significant model of the evolutionary process and the coding of genotype to phenotype, largely because tremendous diversity has evolved in a short period of time among lineages with similar genomes [ 2 - 4 ]. (biomedcentral.com)

1986. "Osseous reconstruction of edentulous bone loss. (ijcrr.com)

It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)

Twenty years following Schofield's seminal publication, Xie and Spradling provided compelling experimental evidence that a cellular niche supports the maintenance of germline stem cells (GSCs) in the Drosophila adult ovary [ 4 ]. (biomedcentral.com)
The Hh gene family encodes a secreted protein that plays a critical regulatory role in the process of embryogenesis and environmental stabilization in adult tissues of invertebrates and vertebrates [ 44 ]. (regenmedres-journal.org)

Recent research shows that the SKI protein in cancerous cells acts as a suppressor, inhibiting transforming growth factor β (TGF- β) signaling. (wikipedia.org)
The skeletal elements of the limb are formed through a process known as endochondral ossification in which condensations of mesenchymal cells differentiate into cartilage and with maturation are replaced by bone. (silverchair.com)
Interestingly, cells within tumors often exhibit a hierarchy of malignant potential, giving rise to the notion that small populations of cancer stem cells may be responsible for propagating certain cancers [ 1 , 2 ]. (biomedcentral.com)
These specialized signalling filopodia transmit signal proteins between communicating cells and allow a high degree of control of propagation speed, direction and concentration of the transmitted ligand. (exeter.ac.uk)
IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. (tamu.edu)

The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. (hindawi.com)
Our review of literature strongly suggests better bone fill, gain in clinical attachment level and reduced probing depths with the use of various grafts as compared to non grafted sites. (ijcrr.com)

Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)

Proteins which bind to DNA. (lookformedical.com)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)

Primary ovarian insufficiency (POI) is characterized by ovarian failure in women under the age of 40 years [ 1 , 2 ]. (hindawi.com)

The SKI-Dachshund homology domain (SKI-DHD) contains the helix turn helix domains of the protein and the beta-alpha-beta turn motifs. (wikipedia.org)
The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)

Anatomy53

Organisms11

Diseases12

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes64

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science4

Melanogaster5

Signaling pathway2

Endogenous2

Induces3

Embryo2

HOMEODOMAIN PROTEINS2

Genes5

Genetics1

Regulate3

Expression8

Genetic6

Recombinant1

Smad6

Signals2

Antagonist1

Transcriptional2

Biology3

Testis1

Mitochondrial2

Regulation4

Vertebrate2

Neurogenesis2

Dach1

Fibroblast1

Receptor1

Polarity1

Inhibition1

Fibroblasts1

Metabolism1

Apoptosis6

Mutations3

Sloan-Kettering1

Targets1

Development7

Physiology1

Nucleus2

Cell4

Amino acid seq2

Lineages1

19861

Fundamental1

Adult2

Cells5

Suggests2

Species1

Bind2

Ovarian1

Homology2