Polymorphism, GeneticPolymorphism, Single NucleotideProtein ConformationModels, MolecularGenetic Predisposition to DiseaseGene FrequencyAllelesMolecular Sequence DataPolymorphism, Single-Stranded ConformationalHaplotypesCase-Control StudiesProtein BindingBinding SitesGenotypePolymerase Chain ReactionProtein Structure, TertiaryProtein Structure, SecondaryAmino Acid SequenceMutationBase SequenceCircular DichroismCrystallography, X-RayMolecular ConformationThermodynamicsKineticsGenetic Association StudiesGenetic VariationLinkage DisequilibriumAsian Continental Ancestry GroupSpectrometry, FluorescenceAmino Acid SubstitutionNucleic Acid ConformationProtein FoldingDNAMagnetic Resonance SpectroscopySequence Analysis, DNAMolecular Dynamics SimulationPhenotypeLigandsNuclear Magnetic Resonance, BiomolecularGenetic MarkersHomozygoteStructure-Activity RelationshipProtein DenaturationModels, ChemicalTemperatureHydrogen-Ion ConcentrationRisk FactorsEscherichia coliDNA PrimersMutagenesis, Site-DirectedComputer SimulationHydrogen BondingPromoter Regions, GeneticMethylenetetrahydrofolate Reductase (NADPH2)European Continental Ancestry GroupRecombinant ProteinsHeterozygoteDNA Mutational AnalysisAmplified Fragment Length Polymorphism AnalysisChinaProtein Structure, QuaternaryPoint MutationBacterial ProteinsExonsTryptophanProteinsDimerizationSolutionsCatalytic DomainAllosteric RegulationChromosome MappingPeptidesGlutathione TransferaseCatalysisFluorescence Resonance Energy TransferOdds RatioMicrosatellite RepeatsSpectrophotometry, UltravioletSequence AlignmentGenetic LinkageCattleAdenosine TriphosphatePhylogenyGenome-Wide Association StudyEpitopesPeptide FragmentsCysteineMutation, MissenseModels, GeneticPeptidyl-Dipeptidase ASubstrate SpecificityMolecular StructureSequence Homology, Amino AcidHydrolysisIntronsProtein MultimerizationStatic ElectricityGenetics, PopulationSolvents