AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureNamed GroupsHealth Care
SirolimusImmunosuppressive AgentsTacrolimusKidney TransplantationCyclosporineMycophenolic AcidCalcineurinGene DosageDosage Compensation, GeneticGraft RejectionDosage FormsDrug SubstitutionLymphangioleiomyomatosisAngiomyolipomaTOR Serine-Threonine KinasesGraft SurvivalDrug Therapy, CombinationTreatment OutcomeLymphangiomyomaInjections, IntraocularCoronary RestenosisTime FactorsChyleDose-Response Relationship, DrugCreatinineLiver TransplantationDrug MonitoringTransplantation, HomologousKidneyPolyenesDrug-Eluting StentsCardiovascular AgentsDrug ImplantsFluorescence Polarization ImmunoassayGlomerular Filtration RateIslets of Langerhans TransplantationAntibiotics, AntineoplasticDrug Administration ScheduleImmunosuppressionAdministration, OralTransplantationDrug InteractionsStentsThrombotic MicroangiopathiesTubulin ModulatorsOxaloacetic AcidAzathioprineFollow-Up StudiesRetrospective StudiesCoated Materials, BiocompatibleCitrus paradisiHeart TransplantationPolycystic Kidney, Autosomal DominantAcetic AnhydridesKidney Function TestsUnrelated DonorsRenal InsufficiencyAntilymphocyte SerumProspective StudiesTuberous SclerosisPaclitaxelAdrenal Cortex HormonesOral UlcerPerivascular Epithelioid Cell NeoplasmsRibosomal Protein S6 Kinases, 70-kDaBiopsyX ChromosomeBiliary FistulaKetoconazoleClinical AuditKidney DiseasesDrug Dosage CalculationsPostoperative ComplicationsTransplantation ConditioningProteinuriaSteroidsOligomenorrheaCytochrome P-450 CYP3ARespiratory System AgentsMucoralesIntention to Treat AnalysisChemistry, PharmaceuticalCoronary AngiographyArea Under CurveAbsorbable ImplantsGraft vs Host DiseaseLiving DonorsBenzenesulfonatesGraft Occlusion, Vascular
TacrolimusRapamuneCyclosporineEverolimusImmunosuppressant used to preventDerivative of sirolimusKnown whether sirolimusTabletsMycophenolate mofetilTabletInhibitorsRenalRapacanInhibitorTransplantSafety and efficacyRejectionCoadministrationInhibitsPregnancyFormulationDoseMedicationCapsuleAfinitorLungSurvivalPatientsAdministrationAdultsTreatmentPregnantDoctorSurgeryYoungerInitiallyHumansInfection
Tacrolimus9
  • A 2019 cohort study of nearly 10,000 lung transplant recipients in the US demonstrated significantly improved long-term survival using sirolimus + tacrolimus instead of mycophenolate mofetil + tacrolimus for immunosuppressive therapy starting at one year after transplant. (wikipedia.org)
  • Sirolimus can also be used alone, or in conjunction with a calcineurin inhibitor (such as tacrolimus), and/or mycophenolate mofetil, to provide steroid-free immunosuppression regimens. (wikipedia.org)
  • Sirolimus plus tacrolimus was associated with a better median survival than MMF plus tacrolimus (8.9 years vs 7.1 years). (sciencedaily.com)
  • Sirolimus plus tacrolimus maintenance therapy was provided to slightly more than 200 patients. (sciencedaily.com)
  • Scholars@Duke publication: Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring. (duke.edu)
  • Alemtuzumab induction with 60 days of tacrolimus treatment and continuous sirolimus treatment prevented acute rejection in nine of 10 consecutive renal allograft recipients. (duke.edu)
  • In summary, the addition of tacrolimus therapy for 2 months to a steroid-free, alemtuzumab induction and sirolimus maintenance protocol limited the previously shown acute rejection development. (duke.edu)
  • Macrolides (ie, cyclosporine, tacrolimus, sirolimus) inhibit production of or use of interleukin-2, thus inhibiting stimulation of a clone of cytotoxic T lymphocytes directed against specific human lymphocyte antigen types. (medscape.com)
  • When administered with NOXAFIL, some drugs such as cyclosporine and tacrolimus required dosage adjustments and frequent monitoring of their levels in the blood as serious side effects of the kidney (nephrotoxicity) or brain (leukoencephalopathy) including deaths have been reported in patients with increased cyclosporine or tacrolimus blood levels. (careerhospital.com)
Rapamune6
  • Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). (wikipedia.org)
  • In the EU, sirolimus, as Rapamune, is indicated for the prophylaxis of organ rejection in adults at low to moderate immunological risk receiving a renal transplant and, as Hyftor, is indicated for the treatment of facial angiofibroma associated with tuberous sclerosis complex. (wikipedia.org)
  • In addition, you can always purchase Sirolimus - Generic, the generic alternative, instead of Rapamune. (qualityprescriptiondrugs.com)
  • Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Rapamune (Sirolimus). (qualityprescriptiondrugs.com)
  • Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Rapamune (Sirolimus). (qualityprescriptiondrugs.com)
  • 1.Rapamune (sirolimus) US prescribing information. (webmd.com)
Cyclosporine3
Everolimus4
  • Recent years have seen the introduction of sirolimus and everolimus, immunosuppressive drugs that act by blocking growth factor-driven cell proliferation. (nih.gov)
  • August 29, 2012 - The US Food and Drug Administration (FDA) announced approval today of a new pediatric dosage form of everolimus for use in very young children with a rare brain tumor. (medscape.com)
  • The new formulation, everolimus tablets for oral suspension ( Afinitor Disperz , Novartis), is the first approved pediatric-specific dosage form developed for pediatric tumors, the FDA notes. (medscape.com)
  • Everolimus is manufactured by Novartis, and is a derivative of sirolimus that inhibits mTOR. (medscape.com)
Immunosuppressant used to prevent1
Derivative of sirolimus1
  • Afinitor is the derivative of sirolimus that works as an inhibitor of mammalian target of rapamycin (mTOR). (wikikenko.com)
Known whether sirolimus2
Tablets1
  • tell your doctor and pharmacist if you are allergic to sirolimus, any other medications, or any of the ingredients in sirolimus tablets or solution. (medlineplus.gov)
Mycophenolate mofetil2
  • The database study compared sirolimus outcomes with the most commonly used cell cycle inhibitor mycophenolate mofetil (MMF). (sciencedaily.com)
  • Mycophenolate mofetil is typically given in a dosage of 1200 mg/m 2 /d PO divided in two doses. (medscape.com)
Tablet5
Inhibitors2
  • The chief advantage sirolimus has over calcineurin inhibitors is its low toxicity toward kidneys. (wikipedia.org)
  • They singled out an immunosuppressive drug called sirolimus, in a class of drugs called cell cycle inhibitors, based on a few small, long-term studies that found dramatically improved survival, reduced incidence of chronic rejection, and improved lung function in lung transplant patients who took sirolimus. (sciencedaily.com)
Renal2
  • However, on 7 October 2008, the FDA approved safety labeling revisions for sirolimus to warn of the risk for decreased renal function associated with its use. (wikipedia.org)
  • It appears that no dosage adjustments are needed, zafirlukast is not significantly eliminated via the renal route. (pdr.net)
Rapacan6
Inhibitor1
  • In 2009, the FDA notified healthcare professionals that a clinical trial conducted by Wyeth showed an increased mortality in stable liver transplant patients after switching from a calcineurin inhibitor-based immunosuppressive regimen to sirolimus. (wikipedia.org)
Transplant5
  • Sirolimus is indicated for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis (LAM). (wikipedia.org)
  • One downside for sirolimus, though, is that it interferes with wound healing, a potentially life-threatening complication if the drug is administered in the initial days and weeks following transplant surgery. (sciencedaily.com)
  • Sirolimus can lower blood cells that help fight infection, and may lead to serious conditions including cancer, severe brain infection causing disability or death, or a viral infection causing kidney transplant failure. (onlinegenericmed.com)
  • You should not use this medicine if you are allergic to sirolimus, or if you have ever had a lung transplant or liver transplant. (onlinegenericmed.com)
  • Dosage varies by transplant center. (medscape.com)
Safety and efficacy1
  • The safety and efficacy of sirolimus treatment of LAM were investigated in clinical trials that compared sirolimus treatment with a placebo group in 89 patients for 12 months. (wikipedia.org)
Rejection2
  • The survival improvement with sirolimus was driven by fewer deaths from the top three causes: chronic rejection, infections, and cancer. (sciencedaily.com)
  • Sirolimus is used in combination with other medications to prevent rejection of kidney transplants. (medlineplus.gov)
Coadministration1
  • If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage reduction of dihydrocodeine until stable drug effects are achieved. (pdr.net)
Inhibits1
  • The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. (bvsalud.org)
Pregnancy1
  • Use effective birth control to prevent pregnancy while you are taking sirolimus, and for at least 12 weeks after your treatment ends. (onlinegenericmed.com)
Formulation1
  • This new dosage formulation is able to dissolve more rapidly and provides for smaller dose increments, thus allowing for greater dosing flexibility. (medscape.com)
Dose1
  • Your doctor will probably adjust your dose of sirolimus during your treatment, usually not more than once every 7 to 14 days. (medlineplus.gov)
Medication1
  • Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. (universaldrugstore.com)
Capsule1
  • The product's dosage form is capsule, and is administered via oral form. (hipaaspace.com)
Afinitor1
  • Appropriate pediatric dosage forms, such as Afinitor Disperz, help to ensure the safe and effective use of oncology drugs in children," said Richard Pazdur, MD, director of the Office of Oncology Drug Products at the FDA's Center for Drug Evaluation and Research, in a statement. (medscape.com)
Lung3
Survival2
  • According to our study, sirolimus appears to offer a survival advantage of almost two years over MMF," said first author Marniker Wijesinha, PhD, a UMSOM post-doctoral fellow. (sciencedaily.com)
  • The researchers accounted for this delayed initiation so sirolimus would not appear to yield a false survival advantage. (sciencedaily.com)
Patients3
  • For pediatric patients aged 12 to 14 years weighing greater than or equal to 50 kg and those aged 15 years and older regardless of body weight use adult dosage. (nih.gov)
  • Despite alloantibody presence in five patients, eight patients remain without the need for specific treatment and only sirolimus monotherapy in decreasing dosage. (duke.edu)
  • Four patients take only 1 mg sirolimus daily with levels of 3-4 ng/mL. (duke.edu)
Administration3
  • The information provided in Dosage (Posology) and method of administration of Kupitral is based on data of another medicine with exactly the same composition as the Kupitral . (pillintrip.com)
  • Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Kupitral directly from the package or from the pharmacist at the pharmacy. (pillintrip.com)
  • General information about the drug product, including the proprietary and established name of the drug, the type of dosage form and route of administration to which the label applies, qualitative and quantitative ingredient information, the pharmacologic or therapeutic class of the drug, and the chemical name and structural formula of the drug. (hipaaspace.com)
Adults1
  • Sirolimus (Fyarro), as protein-bound particles, is indicated for the treatment of adults with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa). (wikipedia.org)
Treatment3
  • While sirolimus was considered for treatment of LAM, it received orphan drug designation status because LAM is a rare condition. (wikipedia.org)
  • The safety of LAM treatment by sirolimus in people younger than 18 years old has not been tested. (wikipedia.org)
  • The dosage is based on your medical condition and response to treatment. (alberta.ca)
Pregnant1
Doctor3
Surgery1
  • For this reason, prophylactic sirolimus maintenance therapy is typically not started until three to 12 months after surgery. (sciencedaily.com)
Younger1
Initially1
  • Sirolimus was initially developed as an antifungal agent. (wikipedia.org)
Humans1
  • The PMP22 gene is located on chromosome 17p11.2 and mutations as well as alterations in the gene dosage are causative for a group of hereditary neuropathies affecting approximately 1 in 2500 humans 2 , 3 . (biorxiv.org)
Infection1
  • Sirolimus may increase the risk that you will develop an infection or cancer, especially lymphoma (cancer of a part of the immune system) or skin cancer. (medlineplus.gov)