Domains nerve tissue proteins. Medical search. Frequent questions

The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. (embl.de)
Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. (embl.de)
NTRK receptors, NTRK1 (TRKA), NTRK2 (TRKB) and NTRK3 (TRKC) are receptor tyrosine kinases activated by ligand binding to their extracellular domain. (reactome.org)
The putative extracellular domain contains three potential glycosaminoglycan attachment sites, as well as a domain rich in Thr and Pro residues. (rupress.org)
Analysis of the cDNA and deduced amino acid sequences revealed a high degree of identity with the transmembrane and cytoplasmic domains of previously described proteoglycans but a unique extracellular domain sequence. (rupress.org)
16 , 17 Tryptase works by cleaving a specific site on the extracellular N-terminal domain of the receptor and releases a new N-terminal domain for the receptor, which acts as a tethered ligand by binding to the second extracellular loop of the receptor to induce intracellular signaling. (asahq.org)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
Some family members, such as latrophilins and gliomedin, are membrane-bound proteins containing the olfactomedin domain in the extracellular N-terminal region, while the intracellular C-terminal domain of these proteins is essential for the transduction of extracellular signals to the intracellular signaling pathway. (nih.gov)
Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION. (bvsalud.org)

Phosphorylated tyrosines in the intracellular domain of the receptor serve as docking sites for adapter proteins, triggering downstream signaling cascades. (reactome.org)
NTRK1 (TRKA) is the receptor for the nerve growth factor (NGF). (reactome.org)
18 PAR-2 is a G protein-coupled receptor that is expressed in the peripheral terminals of sensory neurons and seems to play an important role in inflammatory pain. (asahq.org)
CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. (exbio.cz)
Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. (exbio.cz)
Thompson SJ, Schatteman GC, Gown AM, Bothwell M: A monoclonal antibody against nerve growth factor receptor. (exbio.cz)
Typically, a protein called the glucocorticoid receptor, or GR, binds to cortisol that is released after stress exposure and causes cells to alter activities of the immune system and brain. (asbmb.org)
SARS-CoV-2 infection enters the host cells through the S spike protein by binding to angiotensin converting enzyme 2 (ACE2).2 Mutations in the receptor binding domain and acquisition of a cleavage site in the S spike protein are responsible for high infectivity of this virus. (medscape.com)
This agent binds to receptor sites on the motor nerve terminals and, after uptake, inhibits the release of acetylcholine, blocking the transmission of impulses in neuromuscular tissue. (medscape.com)
Methods Real-time PCR, western blot and ELISA were performed to evaluate NGF, proNGF, their receptor and cytokine expression in synovial tissue and cells of patients with juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA), and controls. (bmj.com)
Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)
Additionally, CGRP might be important in processes such as control of fetoplacental vascular tone, regulation of calcium metabolism and insulin secretion, acetylcholine receptor synthesis, peripheral nerve regeneration, and neurogenic inflammation. (bachem.com)
Recent studies have shown that the previously cloned G protein-coupled orphan receptor, named calcitonin receptor-like receptor (CRLR), can interact with members of a new family of three single-transmembrane domain receptor activity-modifying proteins (RAMPs). (bachem.com)
The largest of the homologs, SorLA is 250 kDa and contains a host of receptor binding domains including 14 different low density lipoprotein receptor sites, and EGF repeat, and a fribronectin type III repeat. (biomedcentral.com)
HTR6 is a serotonin receptor whose activity is mediated by G proteins that stimulate adenylate cyclase. (abic2004.org)
Of greatest interest is the~300 amino acid receptor binding domain (RBD) within the S1 subunit of the spike protein because of its key interaction with the human angiotensin converting enzyme 2 (hACE2) receptor present on many cell types, especially lung epithelial cells. (cdc.gov)

Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)

The peptides contain a snippet of a protein called vascular endothelial growth factor, which stimulates the growth of new blood vessels. (news-medical.net)
Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)

Few genes show differential expression with age in tissues (brain, liver and kidney) of naked mole rats and, contrary to other mammals and short-lived model animals, mitochondrial gene expression does not change with age 13 . (nature.com)

Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. (nature.com)
Gene expression profiles in animals that exhibit slow aging or negligible senescence may reveal distinct insight into potential mechanisms involved in long-term maintenance of tissues and healthy aging. (nature.com)
Gene expression stability during aging was also observed in tissues of the long-lived giant mole-rat ( Fukomys mechowii ) with a maximum lifespan of more than 20 years 14 . (nature.com)
The SLURP1 gene provides instructions for making a protein called secreted Ly6/uPAR-related protein-1 (SLURP-1). (medlineplus.gov)
The SLURP1 gene mutations involved in this condition lead to production of an altered SLURP-1 protein that is unstable and quickly broken down, if any protein is produced at all. (medlineplus.gov)
Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)
Functional groups contained in this DE gene list include metabolic proteins (including opposing patterns ofCA3andCA4), mitochondrial proteins (CKMT1A), oxidative status (SEPP1,HIG2A) and cholesterol homeostasis (APOA1,INSIG1). (1library.net)
This is not surprising given the strong evidence for interaction between myelin and axon gene expression in development and after experimental nerve lesions. (medscape.com)
α-CGRP mRNAs are derived from the calcitonin/CGRP gene by alternative tissue specific splicing of the primary RNA transcripts whereas β-CGRP is encoded by a separate gene with high homology to the calcitonin/CGRP gene. (bachem.com)
gene that encodes the proteins neurofibromin. (abic2004.org)
BCL2L11 expression can be stimulated by nerve growth factor (NGF), in addition to the forkhead transcription factor (FKHR-L1) which proposes a role of the BCL2L11 gene in neuronal and lymphocyte apoptosis. (neuromics.com)
Differing functions, including binding of diverse protein epitopes, viral neutralization, impact on RBD-hACE2 binding, and immunohistochemical staining of infected lung tissue, were correlated with variable gene usage and sequence. (cdc.gov)

Large fibers we affected in axons when morphometry was used and identical pathologies were detected in the sciatic nerves. (wikipedia.org)
We demonstrated that myocilin is involved in myelination of the optic and sciatic nerves acting through different signaling pathways. (nih.gov)

Publications] Kaibuchi,K.: 'Molecular cloning and characterization of the stimulatory GDP/GTP exchange protein(GDS)for smg p21s,ras p21ーlike small GTPーbinding proteins. (nii.ac.jp)
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
Development of tooth results from sequential and reciprocal molecular interactions between epithelial and mesenchymal tissues. (uib.no)
Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)

1992. Auditory event-related potential (P300) in relation to peripheral nerve conduction in workers exposed to lead, zinc, and copper: Effects of lead on cognitive function and central nervous system. (cdc.gov)

In the periphery, CGRP is mainly detected in sensory afferents projecting to the spinal cord, in motor neurons at the neuromuscular junctions and in nerve fibers associated with the vasculature. (bachem.com)
Acute pain , which usually occurs in response to tissue injury, results from activation of peripheral pain receptors and their specific A delta and C sensory nerve fibers (nociceptors). (msdmanuals.com)
related to ongoing tissue injury is presumably caused by persistent activation of these fibers. (msdmanuals.com)
Assessment of the effects of occupational and environmental factors on all faster and slower large myelinated nerve fibers: A study of the distribution of nerve conduction velocities. (cdc.gov)

The result indicated that neuronal expression and regulated proteolysis of prion protein are essential for myelin maintenance. (wikipedia.org)
Neuronal apoptosis inhibitory protein (NAIP) belongs to the family of proteins called the inhibiter of apoptosis family (IAP), these proteins are one of the key regulators of apoptosis. (wikipedia.org)
The interaction between NAIP and hippocalcin, a neuronal calcium-sensor protein, has been observed to take place in the zinc-binding region along with other specific amino acids. (wikipedia.org)
Hippocalcin is a neuronal calcium-sensor protein which has two to three regions that can bind with calcium ions. (wikipedia.org)
Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development. (ox.ac.uk)
A subfamily of MARVEL domain-containing proteins that are found in SYNAPTIC VESICLES, where they may play a role in modulating neuronal signaling. (ouhsc.edu)
Conclusions: The expression domains of the class 4 semaphorins suggest that they may serve both neuronal and non-neuronal functions during odontogenesis. (uib.no)
In the late 1960s, neurophysiologic testing allowed the classification of CMT into 2 groups, one with slow nerve conduction velocities and histologic features of a hypertrophic demyelinating neuropathy (hereditary motor and sensory neuropathy type 1 or CMT1) and another with relatively normal velocities and axonal and neuronal degeneration (hereditary motor and sensory neuropathy type 2 or CMT2). (medscape.com)
Olfactomedin 1 (Olfm1) and the closely related genes Olfactomedin 2 (Olfm2) and Olfactomedin 3 (Olfm3) show overlapping expression patterns demonstrating preferential expression in the developing and adult neuronal tissues. (nih.gov)
We demonstrated that Olfm1 interacts with several proteins essential for neuronal and synaptic activity. (nih.gov)

The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded. (ox.ac.uk)

They are produced, and secreted in minute amounts, by a variety of tissues. (reactome.org)

Publications] Sasaki,T.: 'A mammalian inhibitory GDP/GTP exchange protein(GDI)for smg p25A is active on the yeast SEC4 protein. (nii.ac.jp)
These data indicate that the α- and γ-secretase cleavages of the mammalian Vps10p sorting receptors occur in a fashion analogous to other known γ-secretase substrates, and could possibly regulate the biological functions of these proteins. (biomedcentral.com)
In mammalian cells, FAF2 protein directly interacts with and negatively regulates neurofibromin by promoting its ubiquitin-dependent proteolysis. (abic2004.org)

In sympathetic neurons, the expression of NAIP-BIR3 and hippocalcin did not provide any significant protection from cell death from the withdrawal of nerve growth factor. (wikipedia.org)
When overexpressed, XIAP is able to block caspases extremely well and prevents cell death of sympathetic neurons when nerve growth factors are deprived. (wikipedia.org)
NGF is primarily secreted by tissues that are innervated by sensory and sympathetic neurons. (reactome.org)
The close association between mast cells and nerves in peripheral tissues, and the fact that large amounts of tryptase are released upon mast cell degranulation, makes tryptase an ideal candidate to activate PAR-2 on peripheral neurons. (asahq.org)
GDNF, but not nerve growth factor (NGF), can prevent several axotomy-induced changes in these neurons, including the downregulation of IB4 binding, TMP activity, and somatostatin expression. (jneurosci.org)

Botulinum toxins (BTX) are substances that are poisonous or destructive to nerve tissue and produced by rod-shaped bacteria known as Clostridium botulinum , and related species. (cdc.gov)

Prion protein and antibodies POM1 and POM3, which recognize epitopes in the terminus (around amino acids (aa) 140-152) and charged clusters of prion protein (aa95-100) were used to their role in myelin maintenance. (wikipedia.org)
In this research project, we have investigated the C-terminal structures of small G proteins, purified the regulatory proteins for small G proteins, and made monoclonal antibodies against small G proteins and their regulatory proteins. (nii.ac.jp)
Among these regulatory proteins, we have cloned the cDNAs of smg p21 GDS, smg p25A GDI, and rho GDI, and made monoclonal antibodies against them. (nii.ac.jp)
The resulting antibodies reacted on immunoblots with the core protein of a detergent extracted heparan sulfate proteoglycan. (rupress.org)
When the anti-core protein antibodies were used to stain tissue sections immunoreactivity was present in peripheral nerve, newborn rat brain, heart, aorta, and other neonatal tissues. (rupress.org)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)

These results suggest that smg p21 and smg p25A can be used as potential tumor markers for tumors derived from hematopoietic and neural tissues, respectively. (nii.ac.jp)

Like other Ly6/uPAR-related proteins, SLURP-1 folds into a particular shape and is thought to attach (bind) to other proteins called receptors to carry out signaling within cells. (medlineplus.gov)
Here we present the structure of the majority endosomal region of ASTN-2, showing it to consist of a unique combination of polypeptide folds: a perforin-like domain, a minimal epidermal growth factor-like module, a unique form of fibronectin type III domain and an annexin-like domain. (ox.ac.uk)

We have found that the C-terminal systeine residues of smg p21B, rhoA p21, and smg p25A are geranylgeranylated, and that these prenylation are essential for each small G protein to bind to membranes. (nii.ac.jp)
These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a variety of intracellular sorting and trafficking functions. (biomedcentral.com)

We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)

Misalignment of PLP/DM20 transmembrane domains determines protein misfolding in Pelizaeus-Merzbacher disease. (medscape.com)
Alignment of γ-secretase substrate transmembrane domains provides little insight into the sequence requirements for proteolysis to occur (Figure 1a ) [ 33 ]. (biomedcentral.com)

If a nerve biopsy is deemed necessary, sensory nerves should be sampled. (medscape.com)
The virus then spreads to other mucosal surfaces through centrifugal migration of infectious virions via peripheral autonomic or sensory nerves. (medscape.com)

In contrast, radial nerve showed an unexpected level of complexity with the expression of 3,370 genes significantly altered more than two-fold with age, including genes involved in nerve function, signaling, metabolism, transcriptional regulation and chromatin modification. (nature.com)
Patients with familial Alzheimer's disease inherit the disease due to rare mutations on the amyloid precursor protein (APP), presenilin 1 and 2 (PSEN1 and PSEN2) genes in an autosomal-dominantly fashion with closely 100% penetrance. (bvsalud.org)
Previous studies have shown that a person's genes can influence relative levels of these proteins. (asbmb.org)
We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)
This requires parallel studies on genes that are important for the function of the retina, the optic nerve and aqueous humor outflow system in the normal eye. (nih.gov)
We are particularly interested in genes encoding olfactomedin domain-containing proteins. (nih.gov)
Several genes encoding olfactomedin domain-containing proteins are expressed in the eye. (nih.gov)
We focus our attention on the genes that are expressed in RGCs and eye angle tissues. (nih.gov)

Using a series of fusion proteins corresponding to the different structural domains of TSP, binding of [125I]DCN to TSP was found to be dependent of the N-terminal domain and, to a lesser extent, of the type 1 repeats and the C-terminal domain of TSP. (embl.de)
Activity GNF 5837 displays antiproliferative effects in cellular Ba/F3 assays (IC 50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) 1 . (alomone.com)

Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)

The deduced amino acid sequence predicted a 353 amino acid polypeptide with a single membrane spanning segment and a 34 amino acid hydrophilic COOH-terminal cytoplasmic domain. (rupress.org)
For several substrates the liberated cytoplasmic domain has been shown to translocate to the nucleus where it is involved in nuclear signaling (Notch ErbB4, Delta-1 Jagged, APLP1/2). (biomedcentral.com)

Nerve growth factor (NGF), a high affinity ligand for NTRK1, does not interact with NTRK2. (reactome.org)

Drosophila proteins Slit, Crumbs, Fat. (embl.de)
Drosophila gliotactin (Gli) is a 109-kDa transmembrane, cholinesterase-like adhesion molecule (CLAM), expressed in peripheral glia, that is crucial for formation of the blood-nerve barrier. (ox.ac.uk)

In addition, the UIM is found, often in tandem or triplet arrays, in a variety of proteins either involved in ubiquitination and ubiquitin metabolism, or known to interact with ubiquitin-like modifiers. (embl.de)

Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)

We have also found that smg p25A is mainly detected inneural tissues by use of its specific monoclonal antibody, and that the levels of smg p25A mRNA increase in PC12 cells after their differentiation into neuron-like cells. (nii.ac.jp)
A ribonuclease protection assay was used to quantitate levels of the core protein mRNA. (rupress.org)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)

All identified γ-secretase substrates are type I transmembrane proteins [ 29 ] and contain a putative stop transfer sequence immediately following the transmembrane region [ 30 ]. (biomedcentral.com)
Many groups have evaluated neurofibromin protein framework and putative interacting companions [3,4,5]. (abic2004.org)

Importantly, a single injection of β-NGF loaded PEGDMA microrods resulted in improved fracture healing as indicated by a significant increase in the percent bone in the fracture callus, trabecular connective density, and bone mineral density relative to soluble β-NGF control indicating improved drug retention within the tissue. (frontiersin.org)
Visceral pain receptors are located in most viscera and the surrounding connective tissue. (msdmanuals.com)
Visceral pain due to injury of organ capsules or other deep connective tissues may be more localized and sharp. (msdmanuals.com)

Radial and median nerve conduction velocities in workers exposed to lead, copper, and zinc: A follow-up study for 2 years. (cdc.gov)

Recombinant full length protein corresponding to Human Alpha-synuclein. (abcam.com)
Cells were serum deprived for 2 hrs followed by a 10 min stimulation with 10 ng/ml Recombinant human BDNF protein (#B-250) (lane 2), 10 and 100 µM GNF 5837 (#G-145) preincubated with 10 ng/ml Recombinant human BDNF protein for 10 min (lanes 3 and 4, respectively). (alomone.com)
Control cells incubated without Recombinant human BDNF protein are shown in lane 1. (alomone.com)
tPA produced by such means are referred to as recombinant tissue plasminogen activator ( rtPA ). (wikidoc.org)

Stimulation of these receptors usually produces sharp or dull localized pain, but burning is not uncommon if the skin or subcutaneous tissues are involved. (msdmanuals.com)

A number of mechanisms are likely involved, including tissue injury related to the incision itself, secondary inflammation, and damage to nerves caused by tissue retraction during the surgery. (asahq.org)

The conserved patterns correspond mainly to hydrophobic core residues located in central beta strands of the known three-dimensional structures of two pentraxins, the human C-reactive protein and the serum amyloid P-component. (embl.de)

This RP-box affected the efficiency of filament assembly as well as protein-protein interactions in the filament, as shown by sedimentation assays and electron microscopy. (ox.ac.uk)
In vitro release studies showed there is significant retention of protein within the polymer matrix over 168 hours through physiochemical interactions. (frontiersin.org)

There are no nerve endings or vascular supply. (news-medical.net)
Consequently, levels of cortisol in the blood can rise and potentially cause harm by binding nerve endings and causing pain. (asbmb.org)
Bradykinin and lysyl-bradykinin are generated in the nasal passages of patients with rhinovirus colds, and these mediators stimulate pain nerve endings. (medscape.com)
After HSV enters the mucosal surface, it initiates replication and infects either sensory or autonomic nerve endings. (medscape.com)

There was also an upregulation in expression of positive regulators and key components of the AMPK pathway, autophagy, proteasome function, and the unfolded protein response. (nature.com)
Unlike in rodents, in which uniform expression domains interrupt heterogeneous zones, zebrin II parasagittal stripes in the macaque cerebellum are seen throughout the vermis. (nih.gov)
Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
Conversely, HRS decreased Bcl2-associated X protein expression, cleaved caspase-3, and oxidant-stress product malondialdehyde (MDA) in a Sirt1-dependent manner. (arvojournals.org)

As proteinCprotein connections (PPIs) imply useful cable connections that may impact neurofibromin activity, determining protein with which neurofibromin interacts increase our knowledge of NF1. (abic2004.org)
FAF2 interacts within the GRD domain [6]. (abic2004.org)
BCL2L11 interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and acts as an apoptotic activator. (neuromics.com)

The eukaryotic proteins are more complicated than the bacterial enzyme complexes. (tcdb.org)

Nerve tissue is a biological molecule related to the function and maintenance of normal nervous tissue. (wikipedia.org)
An inorganic ion or a non-protein molecule e.g. coenzyme required for enzyme activity. (flashcardmachine.com)

Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. (abcam.com)
These proteins are highly expressed in the brain. (biomedcentral.com)

Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. (embl.de)
The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, and yet shares no sequence homology with it. (ox.ac.uk)
A cDNA clone coding for a membrane proteoglycan core protein was isolated from a neonatal rat Schwann cell cDNA library by screening with an oligonucleotide based on a conserved sequence in cDNAs coding for previously described proteoglycan core proteins. (rupress.org)
3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)

The perforin-like domain differs from that of other members of the membrane attack complex-perforin (MACPF) protein family in ways that suggest ASTN-2 does not form pores. (ox.ac.uk)
We have investigated and provide evidence for γ-secretase cleavage of this family of proteins. (biomedcentral.com)
The family of olfactomedin domain-containing proteins is one of the main areas of our research. (nih.gov)
Bcl-2-like protein 11 (BCL2L11) is a member of the Bcl-2 family and contains a Bcl-2 homology domain 3 (BH3). (neuromics.com)

Pain is a hallmark of tissue damage and inflammation, which promotes tissue protection and thereby contributes to repair. (jneurosci.org)
Objective To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammation. (bmj.com)
Conclusions Our data suggest that an active proNGF-p75NTR axis promotes proinflammatory mechanisms contributing to chronic tissue inflammation, and that the use of p75NTR inhibitors may represent a new therapeutic approach in chronic arthritis. (bmj.com)

Other nerve and muscle cells lie just under the epithelial layers. (pearltrees.com)

Similar to the functionality of NAIP, the BIR3 domain of XIAP binds to the carboxyl-terminal subunit of caspase-9. (wikipedia.org)
Present in proteasome subunit S5a and other ubiquitin-associated proteins. (embl.de)

Initially, sodium ions gradually enter the cell through the nerve cell membrane. (medscape.com)

Anatomy41

Organisms7

Diseases10

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes28

Disciplines and Occupations2

Technology, Industry, Agriculture2

Extracellular9

Receptor16

Fibrous proteins2

Peptides2

Naked mole1

Gene12

Sciatic2

Molecular4

Peripheral nerve conduction1

Fibers4

Neuronal10

Intracellular domain1

Variety of tissues1

Mammalian3

Neurons5

Substances1

Antibodies8

Neural tissues1

Folds2

Bind2

Mitochondria1

Transmembrane domains2

Sensory nerves2

Genes8

Fusion proteins2

Human tissues1

Cytoplasmic2

Ligand1

Drosophila2

Metabolism1

Amino Acid Seq1

MRNA3

Putative2

Connective3

Conduction velocities1

Recombinant4

Subcutaneous1

Secondary1

Amyloid1

Interactions2

Endings4

Expression4

Interacts3

Eukaryotic1

Molecule2

Brain2

Sequence4

Family4

Inflammation3

Epithelial1

Subunit2

Cell Membrane1