• fetal
  • Fetal growth disorders (both growth restriction and overgrowth) are common pregnancy complications, which carry an increased risk of adverse outcomes in the perinatal period and an increased risk of development of adult disease, including diabetes and cardiovascular disease. (grantome.com)
  • Abnormal fetal growth has been associated with disorders of trophoblastic differentiation and function during early events in placentation, which lead to chronic feto-placental hypoxia. (grantome.com)
  • In addition, both Sirt1-knockout and PPARgamma overstimulation have been shown to cause fetal growth restriction in mice. (grantome.com)
  • Finally, in human placentas, the expression and/or activity of PPARgamma and its endogenous ligands are altered in placentas associated with abnormal fetal growth, including fetal growth restriction, preeclampsia, and gestational diabetes. (grantome.com)
  • The goal of this proposal is to determine the mechanisms by which Sirt1-PPARgamma signaling contribute to trophoblastic differentiation, hypoxia-induced placental injury, and placenta-based fetal growth disorders. (grantome.com)
  • This project explores mechanisms by which one particular signaling pathway in the placenta contributes to fetal growth, focusing on potential therapeutic targets which could improve fetal well-being. (grantome.com)
  • Individuals with 3-M syndrome suffer from severe prenatal growth retardation due to growth delays during fetal development resulting in a low birth weight. (wikipedia.org)
  • puberty
  • Puberty is the stage of your life when sexual development happens, like breast development and menstrual periods in girls and growth of the penis and testicles in boys. (kidshealth.org)
  • One of the body changes that happens during puberty is a big increase in your rate of growth - a growth spurt. (kidshealth.org)
  • When puberty finally occurs, either by itself or with treatment, these teens have a growth spurt and tend to catch up to their peers. (kidshealth.org)
  • They tend to reach puberty later than their peers do, with delay in the onset of sexual development and the pubertal growth spurt. (kidshealth.org)
  • Kids with familial short stature still have growth spurts and enter puberty at normal ages, but they usually will only reach a height similar to that of their parents. (kidshealth.org)
  • DHT is biologically important for sexual differentiation of the male genitalia during embryogenesis, maturation of the penis and scrotum at puberty, growth of facial, body, and pubic hair, and development and maintenance of the prostate gland and seminal vesicles. (wikipedia.org)
  • spurt
  • You may also have inherited the tendency to have your growth spurt earlier or later than most other kids do. (kidshealth.org)
  • skeletal
  • Radio-graphic findings can show the skeletal malformations characteristic with this disorder, however these can only be seen in the individual after the first two years of life. (wikipedia.org)
  • retardation
  • An individual with Mulibrey nanism has growth retardation, a short broad neck, misshapen sternum, small thorax, square shoulders, enlarged liver, and yellowish dots in the ocular fundi. (wikipedia.org)
  • chromosome
  • This means the defective gene responsible for the disorder is located on an autosome (chromosome 17 is an autosome), and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder. (wikipedia.org)
  • treatment
  • With both constitutional growth delay and familial short stature, kids and families need to be reassured that the child does not have a disease or medical condition that poses a threat to health or that requires treatment. (kidshealth.org)
  • The current treatment consists of daily injections of growth hormone for years until the patients reach their adult height. (innovations-report.com)
  • Due lack of effective treatment for panic disorders they are a huge demand for medicinal treatment. (sbwire.com)
  • Because of this reason, key market players are majorly focused on R&D to develop a safe and effective treatment for panic disorders. (sbwire.com)
  • Due to lack of awareness and effective evidence-based medicinal treatment, the growth of the panics disorders market is restrained. (sbwire.com)
  • All three Lagova once-weekly doses demonstrate strong catch-up growth during the six months treatment. (thestreet.com)
  • In terms of treatment/management for those with Mulibrey nanism should have routine medical follow-ups, additionally the following can be done: Growth hormone treatment Regular pelvic exams Pericardiectomy Worldwide, it has been documented in 110 persons, 85 of them Finnish. (wikipedia.org)
  • Finasteride has been found to be effective in the treatment of hirsutism (excessive facial and/or body hair growth) in women. (wikipedia.org)
  • A subsequent 2017 systematic review and meta-analysis of over 3,000 postmenopausal women similarly found that transdermal testosterone was effective in improving multiple domains of sexual function in the short-term treatment of hypoactive sexual desire disorder (also known as female sexual interest/arousal disorder). (wikipedia.org)
  • It is also used in the treatment of androgen-dependent conditions like acne, excessive hair growth, and high androgen levels in women. (wikipedia.org)
  • androgen
  • In addition to normal biological functions, DHT also plays an important causative role in a number of androgen-dependent conditions including hair conditions like hirsutism (excessive facial/body hair growth) and pattern hair loss (androgenic alopecia or pattern baldness) and prostate diseases such as benign prostatic hyperplasia (BPH) and prostate cancer. (wikipedia.org)
  • 5-ARIs are most known for preventing conversion of testosterone, the major androgen sex hormone, to the more potent androgen dihydrotestosterone (DHT), in certain androgen-associated disorders. (wikipedia.org)
  • depends
  • This suggests that the extent of a disorder depends on the combination of parental species and their respective sexes, as demonstrated by the Vrana study. (wikipedia.org)
  • It is also becoming clear that mitosis and apoptosis are toggled or linked in some way and that the balance achieved depends on signals received from appropriate growth or survival factors. (wikipedia.org)
  • behavior
  • One reason for such behavior could be a disorder such as Attention Deficit Disorders (ADD). (purdue.edu)
  • The term fibromatosis refers to a group of soft tissue tumors which have certain characteristics in common, including absence of cytologic and clinical malignant features, a histology consistent with proliferation of well-differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with frequent local recurrence. (wikipedia.org)
  • function
  • Etiology of panic disorders can be neurochemical dysfunction of decreased gamma-amino butyric acidergic tone, diminished benzodiazepine receptor function, autonomic imbalance, disturbances in serotonin, and increased adenosine receptor function. (sbwire.com)
  • In contrast, females are reported to have normal ovarian function with this disorder. (wikipedia.org)
  • Reduced thoracic size can restrict lung growth and reduce pulmonary function. (wikipedia.org)
  • genes
  • Mutations in any one of the following three genes: CUL7, OBSL1, and CCDC8 are responsible for the occurrence of this disorder. (wikipedia.org)
  • defective
  • The study, which was published online Nov. 15 by the journal Endocrinology, shows that RNA interference can "rescue" a strain of mouse that has been genetically engineered to express a defective human hormone that interferes with normal growth. (innovations-report.com)
  • suggests
  • Serotonergic model of panic disorders suggests that insufficient or exaggerated receptor response to synaptic serotonin. (sbwire.com)
  • awareness
  • Globally, demand for Panic Disorders is increasing due to raising awareness and others part of the market, manufacturers are mainly focused on controlled drug delivery systems to control drug abuse. (sbwire.com)
  • sexual
  • Testosterone supplementation in low doses is effective in the short-term for hypoactive sexual desire disorder in women. (wikipedia.org)
  • causes
  • Your doctor or an endocrinologist will look for signs of the many possible causes of short stature and growth failure. (kidshealth.org)
  • brain
  • He lives in Salt Lake City, UT and has global developmental delays (0-6 months-old developmental), brain damage, intractable multifocal epilepsy, peripheral neuropathy, liver damage, osteopenia, cortical visual impairment, movement disorder, and alacrima (lack of tears) resulting in corneal erosion. (overcomingmovementdisorder.com)